2aa654dd518057d56637bc3c3cce5618  pmc_8942827.pdf
c673551341b55846a9515c2786f81e8cba742d48  pmc_8942827.pdf
040514ccf7f1e0e08af323e2e7395301a7aa5e6ea4e34401925a9558450f0e90  pmc_8942827.pdf

Title:           The effects of diet and chronic exercise on skeletal muscle ghrelin response
Subject:         Metabolism Open, 14 (2022) 100182. doi:10.1016/j.metop.2022.100182
Keywords:        Ghrelin,Skeletal muscle,Lipid oxidation,Glucose transport,High-fat diet,Exercise training
Author:          Andrew J. Lovell
Creator:         Elsevier
Producer:        Acrobat Distiller 8.1.0 (Windows)
CreationDate:    Mon Mar 21 11:56:06 2022 CET
ModDate:         Mon Mar 21 20:14:49 2022 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           11
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       4801578 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
FUONUB+CharisSIL                     CID TrueType      Identity-H       yes yes yes    671  0
TTPVAP+Univers                       Type 1C           Builtin          yes yes yes    676  0
QGFUNN+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    680  0
NZFWLF+CharisSIL-Bold                CID TrueType      Identity-H       yes yes yes    685  0
VMKXXX+STIX-Regular                  Type 1C           Custom           yes yes yes    690  0
QMLPWC+CharisSIL                     CID TrueType      Identity-H       yes yes yes    662  0
QBKAFZ+TeX_CM_Maths_Symbols          Type 1C           Builtin          yes yes yes    296  0
ZVOWZP+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    288  0
VVCCGG+TeX_CM_Maths_Italic           Type 1C           Builtin          yes yes yes    301  0
WPGYEC+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes    161  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-05-07 04:28:28 CEST
 RepresentationInformation: pmc_8942827.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2022-03-28 07:45:09 CEST
  Size: 4801578
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 756
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: The effects of diet and chronic exercise on skeletal muscle ghrelin response
      Destination: mk:title
      Children: 
       Item: 
        Title: 1 Introduction
        Destination: mk:H1_1
       Item: 
        Title: 2 Methods
        Destination: mk:H1_2
        Children: 
         Item: 
          Title: 2.1 Materials and reagents
          Destination: mk:H2_1
         Item: 
          Title: 2.2 Animals
          Destination: mk:H2_2
         Item: 
          Title: 2.3 Exercise training
          Destination: mk:H2_3
         Item: 
          Title: 2.4 Glucose tolerance tests
          Destination: mk:H2_4
         Item: 
          Title: 2.5 Fatty acid oxidation
          Destination: mk:H2_5
         Item: 
          Title: 2.6 Insulin stimulated glucose uptake
          Destination: mk:H2_6
         Item: 
          Title: 2.7 Western blotting
          Destination: mk:H2_7
         Item: 
          Title: 2.8 Statistics
          Destination: mk:H2_8
       Item: 
        Title: 3 Results
        Destination: mk:H1_3
        Children: 
         Item: 
          Title: 3.1 5d LFD and HFD experiments
          Destination: mk:H2_9
          Children: 
           Item: 
            Title: 3.1.1 Body weight and caloric intake
            Destination: mk:H3_10
           Item: 
            Title: 3.1.2 Stimulation of FAO by UnAG
            Destination: mk:H3_11
         Item: 
          Title: 3.2 6w diet and exercise training experiments
          Destination: mk:H2_12
          Children: 
           Item: 
            Title: 3.2.1 Body weight, caloric intake, and whole-body glucose tolerance
            Destination: mk:H3_13
           Item: 
            Title: 3.2.2 Mitochondrial markers, GLUT 4 and FAT/CD36 transporter content in LFD-sedentary, HFD-sedentary, and HFD-exercised rats
            Destination: mk:H3_14
           Item: 
            Title: 3.2.3 UnAG improves insulin-stimulated glucose uptake during high palmitate exposure, but only in exercised rats
            Destination: mk:H3_15
           Item: 
            Title: 3.2.4 Improvement in insulin-stimulated glucose uptake by UnAG coincides with further stimulation of FAO
            Destination: mk:H3_16
           Item: 
            Title: 3.2.5 Ghrelin receptor content in skeletal muscle of LFD-SED, HFD-SED, and HFD-EX rats
            Destination: mk:H3_17
       Item: 
        Title: 4 Discussion
        Destination: mk:H1_4
        Children: 
         Item: 
          Title: 4.1 Overall findings
          Destination: mk:H2_18
         Item: 
          Title: 4.2 Ghrelin resistance in skeletal muscle
          Destination: mk:H2_19
         Item: 
          Title: 4.3 Ghrelin signaling in skeletal muscle
          Destination: mk:H2_20
       Item: 
        Title: 5 Limitations and considerations
        Destination: mk:H1_5
       Item: 
        Title: 6 Conclusions
        Destination: mk:H1_6
       Item: 
        Title: Funding
        Destination: mk:H1_7
       Item: 
        Title: CRediT authorship contribution statement
        Destination: mk:H1_8
       Item: 
        Title: Declaration of competing interest
        Destination: mk:HH1_2
       Item: 
        Title: Acknowledgements
        Destination: mk:HH1_3
       Item: 
        Title: References
        Destination: mk:HH2_1
   Info: 
    Title: The effects of diet and chronic exercise on skeletal muscle ghrelin response
    Author: Andrew J. Lovell
    Subject: Metabolism Open, 14 (2022) 100182. doi:10.1016/j.metop.2022.100182
    Keywords: Ghrelin,Skeletal muscle,Lipid oxidation,Glucose transport,High-fat diet,Exercise training
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Mon Mar 21 11:56:06 CET 2022
    ModDate: Mon Mar 21 20:14:49 CET 2022
   ID: 0x275487b864ea166d0c343366275e10a7, 0xebd33b17ff55e387a1afee294d02661e
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 236
      ImageHeight: 298
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 248
      ImageHeight: 271
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: WPGYEC+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: QGFUNN+CharisSIL-Italic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: NZFWLF+CharisSIL-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: FUONUB+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: VMKXXX+STIX-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 7
      FontDescriptor: 
       FontName: VMKXXX+STIX-Regular
       Flags: Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: TTPVAP+Univers
      FontSubset: true
      FirstChar: 32
      LastChar: 251
      FontDescriptor: 
       FontName: TTPVAP+Univers
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: QBKAFZ+TeX_CM_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: QBKAFZ+TeX_CM_Maths_Symbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: VVCCGG+TeX_CM_Maths_Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 127
      FontDescriptor: 
       FontName: VVCCGG+TeX_CM_Maths_Italic
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: FUONUB+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: FUONUB+CharisSIL
       Flags: Nonsymbolic
       FontBBox: -692, -533, 1623, 1319
       FontFile2: true
     Font: 
      BaseFont: WPGYEC+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: WPGYEC+TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
     Font: 
      BaseFont: QGFUNN+CharisSIL-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: QGFUNN+CharisSIL-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -716, -533, 1627, 1318
       FontFile2: true
     Font: 
      BaseFont: NZFWLF+CharisSIL-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: NZFWLF+CharisSIL-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -720, -533, 1759, 1320
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 5.1.2">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1016/j.metop.2022.100182</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier Inc.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Metabolism Open, 14 (2022) 100182. doi:10.1016/j.metop.2022.100182</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Ghrelin</rdf:li>
               <rdf:li>Skeletal muscle</rdf:li>
               <rdf:li>Lipid oxidation</rdf:li>
               <rdf:li>Glucose transport</rdf:li>
               <rdf:li>High-fat diet</rdf:li>
               <rdf:li>Exercise training</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">The effects of diet and chronic exercise on skeletal muscle ghrelin response</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Andrew J. Lovell</rdf:li>
               <rdf:li>Evan M. Hoecht</rdf:li>
               <rdf:li>Barbora Hucik</rdf:li>
               <rdf:li>Daniel T. Cervone</rdf:li>
               <rdf:li>David J. Dyck</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Metabolism Open</prism:publicationName>
         <prism:copyright>© 2022 Published by Elsevier Inc.</prism:copyright>
         <prism:issn>2589-9368</prism:issn>
         <prism:volume>14</prism:volume>
         <prism:coverDisplayDate>1 June 2022</prism:coverDisplayDate>
         <prism:coverDate>2022-06-01</prism:coverDate>
         <prism:pageRange>100182</prism:pageRange>
         <prism:startingPage>100182</prism:startingPage>
         <prism:doi>10.1016/j.metop.2022.100182</prism:doi>
         <prism:url>https://doi.org/10.1016/j.metop.2022.100182</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.metop.2022.100182</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.metop.2022.100182</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CreationDate--Text>22nd March 2022</pdfx:CreationDate--Text>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2022-03-21T19:14:49</xmp:ModifyDate>
         <xmp:CreateDate>2022-03-21T10:56:06</xmp:CreateDate>
         <xmp:MetadataDate>2022-03-21T19:14:49</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>22nd March 2022</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
         <pdf:Keywords>Ghrelin,Skeletal muscle,Lipid oxidation,Glucose transport,High-fat diet,Exercise training</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:b6ed5266-03cb-4855-90c0-636283357f42</xmpMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 447, 596, 451, 601
       Flags: Print
       Destination: 647
      Annotation: 
       Subtype: Link
       Rect: 447, 589, 451, 599
       Flags: Print
       Destination: 647
      Annotation: 
       Subtype: Link
       Rect: 67, 227, 72, 235
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 93, 206, 97, 214
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 240, 186, 253, 194
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 223, 165, 228, 173
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 452, 269, 457, 277
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 459, 269, 464, 277
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 410, 227, 428, 235
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 309, 186, 314, 194
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 411, 165, 415, 173
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 98, 104, 162, 111
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 722, 369, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 242, 667, 429, 675
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 87, 186, 94
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 297, 749, 300, 757
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 239, 748, 355, 760
      Annotation: 
       Subtype: Link
       Rect: 499, 616, 528, 645
      Annotation: 
       Subtype: Link
       Rect: 386, 59, 552, 70
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 278, 730, 283, 738
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 112, 689, 117, 696
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 124, 668, 133, 676
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 180, 668, 189, 676
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 274, 605, 283, 613
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 104, 573, 113, 581
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 309, 573, 318, 581
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 520, 333, 529, 341
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 531, 333, 540, 341
       Flags: Print
       Destination: 221
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 228, 552, 232, 560
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 234, 552, 243, 560
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 246, 552, 255, 560
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 213, 280, 222, 288
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 526, 572, 552, 580
       Flags: Print
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 513, 561, 539, 569
       Flags: Print
       Destination: 15
      Annotation: 
       Subtype: Link
       Rect: 306, 509, 326, 517
       Flags: Print
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 464, 407, 483, 415
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 476, 376, 496, 384
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 464, 355, 484, 363
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 331, 334, 351, 342
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 399, 313, 419, 321
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 513, 302, 533, 310
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 378, 281, 400, 289
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 328, 250, 348, 258
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 349, 198, 369, 206
       Flags: Print
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 412, 198, 432, 206
       Flags: Print
       Destination: 113
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 191, 510, 210, 518
       Flags: Print
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 161, 458, 183, 466
       Flags: Print
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 70, 426, 90, 434
       Flags: Print
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 98, 353, 118, 361
       Flags: Print
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 197, 322, 216, 330
       Flags: Print
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 204, 311, 225, 319
       Flags: Print
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 96, 217, 116, 225
       Flags: Print
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 146, 186, 167, 194
       Flags: Print
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 87, 165, 108, 173
       Flags: Print
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 37, 154, 57, 162
       Flags: Print
       Destination: 88
      Annotation: 
       Subtype: Link
       Rect: 184, 102, 204, 110
       Flags: Print
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 419, 458, 423, 466
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 426, 458, 430, 466
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 432, 458, 437, 466
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 439, 458, 448, 466
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 450, 458, 472, 466
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 337, 437, 355, 445
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 546, 437, 555, 445
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 306, 426, 315, 434
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 381, 406, 386, 414
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 388, 406, 397, 414
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 501, 374, 506, 382
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 420, 301, 429, 309
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 309, 280, 318, 288
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 473, 154, 478, 162
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 492, 60, 512, 68
       Flags: Print
       Destination: 153
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 482, 136, 501, 143
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 40, 127, 58, 134
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 116, 127, 134, 134
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 243, 127, 261, 134
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 329, 127, 347, 134
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 113, 98, 132, 105
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 463, 98, 482, 105
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 491, 98, 510, 105
       Flags: Print
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 232, 88, 250, 96
       Flags: Print
       Destination: 72
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 114, 249, 123, 257
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 126, 249, 135, 257
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 137, 249, 146, 257
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 148, 249, 157, 257
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 179, 228, 188, 236
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 40, 208, 49, 216
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 117, 197, 126, 205
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 202, 145, 211, 153
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 213, 145, 222, 153
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 274, 124, 283, 132
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 274, 61, 283, 69
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 326, 187, 335, 195
       Flags: Print
       Destination: 221
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 281, 87, 286, 95
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 37, 76, 46, 84
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 257, 76, 266, 84
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 245, 66, 249, 74
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 40, 55, 49, 63
       Flags: Print
       Destination: 221
      Annotation: 
       Subtype: Link
       Rect: 367, 76, 376, 84
       Flags: Print
       Destination: 153
      Annotation: 
       Subtype: Link
       Rect: 333, 66, 342, 74
       Flags: Print
       Destination: 153
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 126, 202, 131, 210
       Flags: Print
       Destination: 153
    Page: 
     Label: 9
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 322, 374, 555, 381
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 366, 481, 373
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 358, 545, 365
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 350, 462, 357
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 342, 533, 349
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 334, 549, 341
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 327, 437, 333
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 319, 531, 325
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 311, 549, 317
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 303, 480, 309
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 295, 550, 301
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 287, 553, 293
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 279, 350, 285
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 271, 545, 277
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 263, 440, 269
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 255, 551, 261
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 247, 555, 253
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 239, 407, 245
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 231, 555, 237
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 223, 555, 229
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 215, 533, 221
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 207, 549, 213
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 199, 555, 205
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 191, 469, 197
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 183, 555, 189
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 175, 551, 181
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 167, 439, 173
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 159, 555, 165
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 151, 526, 158
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 143, 555, 150
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 135, 442, 142
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 127, 555, 134
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 119, 546, 126
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 111, 374, 118
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 103, 546, 110
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 95, 555, 102
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 87, 426, 94
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 79, 555, 86
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 71, 555, 78
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 63, 507, 70
       Flags: Print
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 732, 283, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 724, 281, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 716, 119, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 708, 284, 714
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 700, 264, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 692, 286, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 684, 286, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 676, 176, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 668, 284, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 660, 108, 666
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 652, 285, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 644, 286, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 636, 285, 643
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 628, 75, 635
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 620, 286, 627
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 612, 267, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 604, 129, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 596, 282, 603
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 588, 275, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 580, 75, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 732, 539, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 724, 551, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 716, 488, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 708, 552, 714
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 700, 548, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 692, 340, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 684, 555, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 676, 404, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 668, 550, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 660, 555, 666
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 652, 368, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 644, 553, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 636, 503, 643
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 628, 555, 635
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 620, 546, 627
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 612, 397, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 604, 555, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 596, 537, 603
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 588, 552, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 580, 388, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 572, 555, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 565, 413, 571
       Flags: Print
  Checksum: 1f8d0f77
   Type: CRC32
  Checksum: 2aa654dd518057d56637bc3c3cce5618
   Type: MD5
  Checksum: c673551341b55846a9515c2786f81e8cba742d48
   Type: SHA-1
  Checksum: 040514ccf7f1e0e08af323e2e7395301a7aa5e6ea4e34401925a9558450f0e90
   Type: SHA-256