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Title:           Protein-conjugated microbubbles for the selective targeting of S. aureus biofilms
Subject:         Biofilm, 4 (2022) 100074. doi:10.1016/j.bioflm.2022.100074
Keywords:        Ultrasound contrast agents,Biofilm,Staphylococcus aureus,Molecular targeting,Affimer protein,Sonobactericide,Ultrasound
Author:          Jack A. Caudwell
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      Title: Protein-conjugated microbubbles for the selective targeting of S. aureus biofilms
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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          Title: 2.1 Microfluidic platform for biofilm studies
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          Title: 2.2 Microfluidic biofilm cultivation
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          Title: 2.3 Fluorescent staining and biofilm imaging
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          Title: 2.4 Selection of anti-clumping factor A Affimer (AClfA1) proteins
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          Title: 2.5 Production of Affimer proteins AClfA1 and AAC
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          Title: 2.6 Isothermal titration calorimetry (ITC)
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          Title: 2.7 Polystyrene bead   Affimer conjugation
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          Title: 2.8 Lipid preparation
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          Title: 2.9 Microbubble production and sample quantification
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          Title: 2.10 Microbubble   Affimer attachment and washing
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          Title: 2.11 Affimer   microbubble (and Affimer   bead) interactions with biofilms
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          Title: 2.12 Biofilm viability and analysis
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          Title: 2.13 Ultrasound exposure and microbubble destruction
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        Title: 3 Results
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          Title: 3.1 Production of S. aureus biofilm under flow conditions
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          Title: 3.2 Affimer screening and selection
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          Title: 3.3 Characterization of the binding kinetics of AClfA1 to clumping factor A (ClfA)
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          Title: 3.4 AClfA1 and AAC functionalized micro-bead binding to biofilms
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          Title: 3.5 AClfA1 and AAC functionalized MB binding to biofilms
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          Title: 3.6 Effect of targeted microbubbles and ultrasound exposure on S. aureus biofilms
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          Title: 4.1 Microfluidics for biofilm study
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          Title: 4.2 AClfA1 and ClfA binding kinetics
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          Title: 4.3 AClfA1 and AAC binding when conjugated to beads and microbubbles
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          Title: 4.4 Effect of microbubble destruction on biofilm viability
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          Title: 4.5 Limitations of the study
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        Title: 5 Conclusions
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        Title: Funding
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        Title: Data availability statement
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        Title: CRediT authorship contribution statement
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        Title: Declaration of competing interest
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        Title: Acknowledgments
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        Title: Appendix A Supplementary data
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        Title: References
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   Type: CRC32
  Checksum: fb9dc72ad3b6756da3b5fa3631c047e7
   Type: MD5
  Checksum: 68e52ac40d448168768cf8d0f015468910691215
   Type: SHA-1
  Checksum: dda486cf1294e033e795f8f43907fc047e887fd11347730fd58874e4c30907ba
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