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Abou Baker Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Sat Mar 19 16:45:14 2022 CET ModDate: Sun Mar 20 09:19:35 2022 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 25 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 12159633 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WPMJAD+CharisSIL CID TrueType Identity-H yes yes yes 3189 0 POOVYJ+Univers Type 1C Builtin yes yes yes 3194 0 XKKLYE+CharisSIL-Italic CID TrueType Identity-H yes yes yes 3198 0 FAPMJC+CharisSIL-Bold CID TrueType Identity-H yes yes yes 3203 0 UFAZTV+STIX-Regular Type 1C Custom yes yes yes 3208 0 STEWQP+CharisSIL CID TrueType Identity-H yes yes yes 3180 0 IDOVYO+STIX-Italic Type 1C Custom yes yes yes 9 0 ENKKTJ+CharisSIL-Italic CID TrueType Identity-H yes yes yes 1534 0 XBEAVY+TeX_CM_Roman Type 1C Builtin yes yes yes 1542 0 SSHIIE+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 1546 0 ZESOGU+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 1551 0 GBHHIH+Calibri-Bold TrueType WinAnsi yes yes no 197 0 GBHHIH+Calibri-Bold CID TrueType Identity-H yes yes yes 200 0 FODVZD+Calibri-Bold TrueType WinAnsi yes yes no 251 0 VMFNPX+Calibri-Bold CID TrueType Identity-H yes yes yes 254 0 XVHPGU+Calibri-Bold TrueType WinAnsi yes yes no 365 0 XVHPGU+Calibri-Bold CID TrueType Identity-H yes yes yes 368 0 LNJQBH+Helvetica-Bold TrueType WinAnsi yes yes no 427 0 WYOTOF+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 1568 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-07 04:28:10 CEST RepresentationInformation: pmc_8943219.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2022-03-28 07:46:13 CEST Size: 12159633 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 3284 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: An ethnopharmacological review on the therapeutical properties of flavonoids and their mechanisms of actions: A comprehensi ... Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Structure of flavonoids Destination: mk:H1_2 Item: Title: 3 Therapeutical potential of flavonoids Destination: mk:H1_3 Children: Item: Title: 3.1 Potential against Alzheimer’s disease Destination: mk:H2_1 Children: Item: Title: 3.1.1 Anti-Alzheimer mechanism of action Destination: mk:H3_2 Item: Title: 3.1.2 Structure activity relationship for anti-Alzheimer activity Destination: mk:H3_3 Item: Title: 3.2 Potential against depression Destination: mk:H2_4 Children: Item: Title: 3.2.1 Structure-activity relationship Destination: mk:H3_5 Item: Title: 3.2.2 Anti-depressant mechanism of action Destination: mk:H3_6 Item: Title: 3.3 Antioxidant potential Destination: mk:H2_7 Children: Item: Title: 3.3.1 Mechanism of antioxidant action Destination: mk:H3_8 Item: Title: 3.3.2 Structure activity relationship for antioxidant activity Destination: mk:H3_9 Item: Title: 3.4 Potential against inflammation Destination: mk:H2_10 Children: Item: Title: 3.4.1 Anti-inflammatory mechanism of action Destination: mk:H3_11 Item: Title: 3.4.2 Structure activity relationship for anti-inflammatory Destination: mk:H3_12 Item: Title: 3.5 Hepatoprotective activity Destination: mk:H2_13 Children: Item: Title: 3.5.1 Hepatoprotective mechanism of action Destination: mk:H3_14 Item: Title: 3.5.2 Structure activity relationship for hepatoprotective activity Destination: mk:H3_15 Item: Title: 3.6 Potential against hypertension Destination: mk:H2_16 Children: Item: Title: 3.6.1 Antihypertensive mechanism of action Destination: mk:H3_17 Item: Title: 3.6.2 Structure activity relationship Destination: mk:H3_18 Item: Title: 3.7 Potential against cardiovascular disease Destination: mk:H2_19 Children: Item: Title: 3.7.1 Cardioprotective mechanism of action Destination: mk:H3_20 Item: Title: 3.7.2 Structure activity relationship for cardioprotective activity Destination: mk:H3_21 Item: Title: 3.8 Potential against ulcers Destination: mk:H2_22 Children: Item: Title: 3.8.1 Antiulcer mechanism of action Destination: mk:H3_23 Item: Title: 3.8.2 Structure activity relationship Destination: mk:H3_24 Item: Title: 3.9 Potential against diabetes Destination: mk:H2_25 Children: Item: Title: 3.9.1 Antidiabetes mechanism of action Destination: mk:H3_26 Item: Title: 3.9.2 Structure activity relationship for Anti-diabetes Destination: mk:H3_27 Item: Title: 3.10 Potential against fungal infections Destination: mk:H2_28 Children: Item: Title: 3.10.1 Antifungal mechanism of action Destination: mk:H3_29 Item: Title: 3.10.2 Structure activity relationship for antifungal activity Destination: mk:H3_30 Item: Title: 3.11 Potential against cancer Destination: mk:H2_31 Children: Item: Title: 3.11.1 Anticancer mechanism of action Destination: mk:H3_32 Item: Title: 3.11.2 Structure activity relationship for anticancer activity Destination: mk:H3_33 Item: Title: 3.12 Potential against bacterial infection Destination: mk:H2_34 Children: Item: Title: 3.12.1 Antibacterial mechanism of action Destination: mk:H3_35 Item: Title: 3.12.2 Structure activity relationship for antibacterial activity Destination: mk:H3_36 Item: Title: 3.13 Potential against viral infection Destination: mk:H2_37 Children: Item: Title: 3.13.1 Flavonoids potentiality against CoVs Destination: mk:H3_38 Item: Title: 3.13.2 Structure activity relationship for antiviral activity Destination: mk:H3_39 Item: Title: 4 Conclusion and future approaches Destination: mk:H1_4 Item: Title: Conflict of interests Destination: mk:H1_5 Item: Title: Declaration of Competing Interest Destination: mk:HH1_2 Item: Title: References Destination: mk:HH2_1 Info: Title: An ethnopharmacological review on the therapeutical properties of flavonoids and their mechanisms of actions: A comprehensive review based on up to date knowledge Author: Doha H. 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Toxicology Reports, 9 (2022) 445-469. doi:10.1016/j.toxrep.2022.03.011 Flavonoids Structure Therapeutical activities Mechanism of action Structure activity relationship An ethnopharmacological review on the therapeutical properties of flavonoids and their mechanisms of actions: A comprehensive review based on up to date knowledge Doha H. Abou Baker journal Toxicology Reports © 2022 The Author(s). Published by Elsevier B.V. 2214-7500 9 20 March 2022 2022-01-01 445-469 445 469 10.1016/j.toxrep.2022.03.011 https://doi.org/10.1016/j.toxrep.2022.03.011 2010-04-23 true 10.1016/j.toxrep.2022.03.011 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by/4.0/ VoR 7.0 10.1016/j.toxrep.2022.03.011 noindex 2010-04-23 true 20th March 2022 sciencedirect.com elsevier.com Elsevier 2022-03-20T08:19:35 2022-03-19T15:45:14 2022-03-20T08:19:35 True 20th March 2022 Acrobat Distiller 8.1.0 (Windows) Flavonoids,Structure,Therapeutical activities,Mechanism of action,Structure activity relationship uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 445 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 136, 554, 141, 565 Flags: Print Destination: 3165 Annotation: Subtype: Link Rect: 412, 275, 432, 283 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 516, 223, 536, 231 Flags: Print Destination: 1228 Annotation: Subtype: 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