78ddc34f01f125bb99245342f5b78e8c pmc_8954080.pdf d36b52fd6f7785e9b6fa756222d4bff384305e59 pmc_8954080.pdf 725067495b276e91ebb817ee2ef924af5185cb92b1628aa0c3622650eab0d7a2 pmc_8954080.pdf Title: Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate Subject: The rheological properties of blood depend highly on the properties of its red blood cells: concentration, membrane elasticity, and aggregation. These properties affect the viscosity of blood as well as its shear thinning behavior. Using an experimental analysis of the interface advancement of blood in a microchannel, we determine the viscosity of different samples of blood. In this work, we present two methods that successfully normalize the viscosity of blood for a single and for different donors, first according to the concentration of erythrocytes and second according to the shear rate. The proposed methodology is able to predict the health conditions of the blood samples by introducing a non-dimensional coefficient that accounts for the response to shear rate of the different donors blood samples. By means of these normalization methods, we were able to determine the differences between the red blood cells of the samples and define a range where healthy blood samples can be described by a single behavior. Keywords: blood; viscosity; microfluidics; hematocrit; shear rate Author: Claudia Trejo-Soto and Aurora Hernández-Machado Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Feb 24 11:22:14 2022 CET ModDate: Thu Feb 24 11:25:44 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1423526 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LXLSWG+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 UMWRHO+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 OZQWZI+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 27 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 31 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 35 0 BEQZXU+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 YTCXAO+PazoMath-Italic Type 1 Builtin yes yes no 69 0 HVSBKL+PazoMath Type 1 Builtin yes yes no 73 0 SOSTRQ+CMR10 Type 1 Builtin yes yes no 77 0 HIUTOY+CMSY10 Type 1 Builtin yes yes no 81 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 85 0 XVHUAV+CMEX10 Type 1 Builtin yes yes no 103 0 SYFPBV+CMMI10 Type 1 Builtin yes yes no 110 0 MFOFUQ+Symbol Type 1C Custom yes yes no 120 0 ORTWXI+Helvetica Type 1C WinAnsi yes yes no 124 0 MFOFUQ+Symbol Type 1C Custom yes yes no 130 0 NTJYAT+Helvetica Type 1C WinAnsi yes yes no 134 0 OOTDBR+Symbol Type 1C Custom yes yes no 143 0 VQSCTP+Helvetica Type 1C WinAnsi yes yes no 147 0 OOTDBR+Symbol Type 1C Custom yes yes no 156 0 ETWYCJ+Helvetica Type 1C WinAnsi yes yes no 160 0 OOTDBR+Symbol Type 1C Custom yes yes no 169 0 MRTJZZ+Helvetica Type 1C WinAnsi yes yes no 173 0 OOTDBR+Symbol Type 1C Custom yes yes no 182 0 WIPNDP+Helvetica Type 1C WinAnsi yes yes no 186 0 OOTDBR+Symbol Type 1C Custom yes yes no 195 0 NGIJLS+Helvetica Type 1C WinAnsi yes yes no 199 0 OOTDBR+Symbol Type 1C Custom yes yes no 205 0 NCXKHG+Helvetica Type 1C WinAnsi yes yes no 209 0 OOTDBR+Symbol Type 1C Custom yes yes no 219 0 SMSYHE+Helvetica Type 1C Custom yes yes no 223 0 LJOYHS+Symbol Type 1C Custom yes yes no 236 0 EPSJFX+Helvetica Type 1C WinAnsi yes yes no 240 0 LJOYHS+Symbol Type 1C Custom yes yes no 249 0 VQPHGN+Helvetica Type 1C WinAnsi yes yes no 253 0 EUQOAW+EURM7 Type 1 Builtin yes yes no 259 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-04-29 02:33:08 CEST RepresentationInformation: pmc_8954080.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-04-26 17:59:46 CEST Size: 1423526 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 560 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Theoretical Model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Children: Item: Title: Effective Viscosity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Normalization of Blood Viscosity According to the Hematocrit Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Effective Viscosity and Red Blood Cells Concentration of the Same Donor: A Linear Approach Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Viscosity and Red Blood Cell Concentration for Different Donors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Non-Linear Scaling According to the Hematocrit Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Normalization of Blood Viscosity for Different Donors According to the Shear Rate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Comparison with Weissenberg Rabinowitch Mooney Correction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Info: Title: Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate Author: Claudia Trejo-Soto and Aurora Hernández-Machado Subject: The rheological properties of blood depend highly on the properties of its red blood cells: concentration, membrane elasticity, and aggregation. These properties affect the viscosity of blood as well as its shear thinning behavior. Using an experimental analysis of the interface advancement of blood in a microchannel, we determine the viscosity of different samples of blood. In this work, we present two methods that successfully normalize the viscosity of blood for a single and for different donors, first according to the concentration of erythrocytes and second according to the shear rate. The proposed methodology is able to predict the health conditions of the blood samples by introducing a non-dimensional coefficient that accounts for the response to shear rate of the different donors blood samples. By means of these normalization methods, we were able to determine the differences between the red blood cells of the samples and define a range where healthy blood samples can be described by a single behavior. 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Link Rect: 160, 228, 196, 238 Annotation: Subtype: Link Rect: 163, 204, 201, 215 Annotation: Subtype: Link Rect: 163, 181, 201, 192 Annotation: Subtype: Link Rect: 131, 159, 168, 169 Checksum: f1832158 Type: CRC32 Checksum: 78ddc34f01f125bb99245342f5b78e8c Type: MD5 Checksum: d36b52fd6f7785e9b6fa756222d4bff384305e59 Type: SHA-1