d1a35d12da3839519acf68cdfe2468b1 pmc_8956509.pdf b127cb7d7c1472675051de43f365c3e573971d20 pmc_8956509.pdf 275f9163c480b612438d3b3ffb3f0384e1ecc46c7e0b4d1a626fa27a6507485d pmc_8956509.pdf Title: Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression Subject: Oncogene, doi:10.1038/s41388-022-02221-0 Keywords: Author: Alba Mota Creator: Springer CreationDate: Tue Mar 15 12:19:59 2022 CET ModDate: Tue Mar 15 12:21:57 2022 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 5615537 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KFPNAG+AdvTT5afe5d37.B Type 1C WinAnsi yes yes no 814 0 KFPPGB+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 828 0 KFPPGC+AdvOTa20b42a7 Type 1C WinAnsi yes yes no 841 0 Arial-BoldMT Type 1C WinAnsi yes no no 815 0 KFPOCC+AdvOT46dcae81 Type 1C WinAnsi yes yes no 821 0 KFPOCD+AdvTT6780a46b Type 1C WinAnsi yes yes no 822 0 KFPPEN+AdvTT2876772e+27 Type 1C Custom yes yes yes 829 0 KFPPEO+AdvOT46dcae81+fb Type 1C Custom yes yes yes 830 0 KFPPFO+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 831 0 KFPPFP+AdvMyriad_I Type 1C WinAnsi yes yes no 827 0 KFPPGA+AdvMyriad_R Type 1C WinAnsi yes yes no 832 0 KFPPLB+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 352 0 KFPPMC+AdvOT919a0533.B Type 1C WinAnsi yes yes no 348 0 KFPPMD+AdvOT3b30f6db.B+fb Type 1C Custom yes yes yes 357 0 KFPPME+AdvTTab7e17fd Type 1C WinAnsi yes yes no 355 0 KFPPMF+AdvTT6780a46b+20 Type 1C WinAnsi yes yes no 342 0 KFPPNG+AdvOT7d2ebc01 Type 1C WinAnsi yes yes no 345 0 KGBLBP+AdvTT6780a46b+fb Type 1C Custom yes yes yes 408 0 KGJKNP+AdvOT46dcae81+01 Type 1C Custom yes yes yes 518 0 KGJKPA+AdvOT3b30f6db.B+20 Type 1C WinAnsi yes yes no 517 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-06-02 02:42:48 CEST RepresentationInformation: pmc_8956509.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-04-26 17:59:21 CEST Size: 5615537 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR3' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR9' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR33' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR34' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR39' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR44' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR46' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR47' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR48' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR49' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR51' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR52' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR53' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR54' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR55' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR56' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR57' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR59' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR60' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR61' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR62' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR63' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR64' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR65' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR66' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR67' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR68' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR69' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR71' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR52' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR70' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR65' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR72' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR76' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR77' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR80' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR81' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR82' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR83' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR85' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR86' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR87' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR44' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR46' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR88' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR89' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR90' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR91' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR92' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR93' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR94' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR95' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR96' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR97' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR77' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR88' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR77' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR77' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR100' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR101' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR102' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR104' cannot be found Offset: 5577334 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR105' cannot be found Offset: 5577334 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 933 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: Clinicopathological characteristics of ECs included in this study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: The mutational repertoire identified by WES reveals a profile consistent with EECs and SECs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Clonality analysis reveals a mainly monophyletic evolution of metastatic ECs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Decoding the ITGH in EC by targeted massively parallel sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: High somatic copy number alterations ITGH in SECs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Children: Item: Title: AEC characterization for personalized treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: WES revealed ATM mutations in all AEC tumor regions analyzed Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Targeted validation of the AEC, including uterine aspirates and PDX Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Olaparib as a potential treatment for the AEC patient Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Human samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Whole-exome sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Bioinformatics analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Phylogenetic tree generation and clonality study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: In silico prediction of drug treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Patient-derived xenografts: generation and treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: ADDITIONAL INFORMATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Info: Title: Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression Author: Alba Mota Subject: Oncogene, doi:10.1038/s41388-022-02221-0 Keywords: Creator: Springer CreationDate: Tue Mar 15 12:49:59 CET 2022 ModDate: Tue Mar 15 12:51:57 CET 2022 ID: 0xa2af25059bcb88f643af6f005e1f8827, 0x6b0d2c3c3c42d6478d2263560167b603 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1778 ImageHeight: 632 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 10 ImageHeight: 24 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1570 ImageHeight: 2474 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 947 ImageHeight: 1643 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1641 ImageHeight: 2464 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1741 ImageHeight: 1356 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1676 ImageHeight: 1457 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1896 ImageHeight: 1182 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: KFPPGA+AdvMyriad_R FontSubset: true FirstChar: 40 LastChar: 150 FontDescriptor: FontName: KFPPGA+AdvMyriad_R Flags: Nonsymbolic FontBBox: -41, -239, 1125, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KFPPLB+AdvOT65f8a23b.I FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: KFPPLB+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KFPPME+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: KFPPME+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KFPPMD+AdvOT3b30f6db.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KFPPMD+AdvOT3b30f6db.B+fb Flags: Symbolic FontBBox: 0, 0, 833, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KGJKPA+AdvOT3b30f6db.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: KGJKPA+AdvOT3b30f6db.B+20 Flags: Nonsymbolic FontBBox: -10, -197, 1250, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KGJKNP+AdvOT46dcae81+01 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KGJKNP+AdvOT46dcae81+01 Flags: Symbolic FontBBox: -41, -218, 854, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KFPPGC+AdvOTa20b42a7 FontSubset: true FirstChar: 48 LastChar: 121 FontDescriptor: FontName: KFPPGC+AdvOTa20b42a7 Flags: Serif, Nonsymbolic FontBBox: -72, -239, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KFPNAG+AdvTT5afe5d37.B FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: KFPNAG+AdvTT5afe5d37.B Flags: Nonsymbolic FontBBox: -31, -250, 895, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KFPOCC+AdvOT46dcae81 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: KFPOCC+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KFPOCD+AdvTT6780a46b FontSubset: true FirstChar: 37 LastChar: 243 FontDescriptor: FontName: KFPOCD+AdvTT6780a46b Flags: Nonsymbolic FontBBox: -41, -250, 875, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KFPPMF+AdvTT6780a46b+20 FontSubset: true FirstChar: 150 LastChar: 151 FontDescriptor: FontName: KFPPMF+AdvTT6780a46b+20 Flags: Nonsymbolic FontBBox: 0, -114, 1156, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KGBLBP+AdvTT6780a46b+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KGBLBP+AdvTT6780a46b+fb Flags: Symbolic FontBBox: 9, 0, 875, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KFPPNG+AdvOT7d2ebc01 FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: KFPPNG+AdvOT7d2ebc01 Flags: Nonsymbolic FontBBox: -31, -208, 958, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KFPPFP+AdvMyriad_I FontSubset: true FirstChar: 79 LastChar: 111 FontDescriptor: FontName: KFPPFP+AdvMyriad_I Flags: Nonsymbolic FontBBox: -104, -239, 1083, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KFPPGB+AdvOT3b30f6db.B FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: KFPPGB+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KFPPMC+AdvOT919a0533.B FontSubset: true FirstChar: 46 LastChar: 108 FontDescriptor: FontName: KFPPMC+AdvOT919a0533.B Flags: Nonsymbolic FontBBox: -31, -250, 656, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KFPPEN+AdvTT2876772e+27 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KFPPEN+AdvTT2876772e+27 Flags: Symbolic FontBBox: 0, -197, 968, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KFPPEO+AdvOT46dcae81+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: KFPPEO+AdvOT46dcae81+fb Flags: Symbolic FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KFPPFO+AdvOT46dcae81+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: KFPPFO+AdvOT46dcae81+20 Flags: Nonsymbolic FontBBox: 0, -197, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41388-022-02221-0 Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression Alba Mota Sara S. Oltra Pier Selenica Cristian P. Moiola Carlos Casas-Arozamena Carlos López-Gil Eva Diaz Sonia Gatius María Ruiz-Miro Ana Calvo Alejandro Rojo-Sebastián Pablo Hurtado Roberto Piñeiro Eva Colas Antonio Gil-Moreno Jorge S. Reis-Filho Laura Muinelo-Romay Miguel Abal Xavier Matias-Guiu Britta Weigelt Gema Moreno-Bueno Springer US Oncogene, doi:10.1038/s41388-022-02221-0 Springer 2022-03-15T16:51:57+05:30 2022-03-15T16:49:59+05:30 2022-03-15T16:51:57+05:30 True uuid:94978ca7-5380-475b-aeb7-df7274ef33f0 uuid:ff444819-a6c8-428d-8d0f-6ed049aef74b default 1 converted uuid:2c6d121e-549e-4dc4-ab6a-32bb69e9d192 converted to PDF/A-2b pdfToolbox 2022-03-15T16:51:57+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Label: 1835 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 478, 689, 480, 721 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 478, 695, 534, 727 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 403, 628, 404, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 403, 628, 404, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 413, 628, 416, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 406, 628, 413, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 413, 628, 414, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 457, 617, 458, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 457, 617, 458, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 467, 617, 470, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 460, 617, 467, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 467, 617, 468, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 113, 606, 114, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 113, 606, 114, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 123, 606, 125, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 115, 606, 123, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 123, 606, 123, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 215, 606, 216, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 215, 606, 216, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 225, 606, 227, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 217, 606, 225, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 225, 606, 225, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 378, 606, 379, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 378, 606, 379, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 388, 606, 391, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 381, 606, 388, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 388, 606, 388, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 195, 595, 196, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 195, 595, 196, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 205, 595, 208, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 198, 595, 205, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 205, 595, 206, 604 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 170, 408, 336, 417 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 81, 320, 85, 329 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 209, 300, 213, 309 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 218, 300, 222, 309 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 89, 280, 93, 289 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 155, 181, 160, 190 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 168, 181, 173, 190 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 366, 340, 371, 349 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 375, 340, 380, 349 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 304, 320, 308, 329 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 315, 320, 319, 329 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 495, 310, 499, 319 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 504, 310, 508, 319 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 464, 300, 469, 309 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 444, 290, 449, 299 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 499, 191, 504, 200 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 508, 191, 517, 200 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 507, 181, 516, 190 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 523, 181, 532, 190 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 461, 80, 522, 87 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 474, 749, 549, 757 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 1836 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 217, 723, 226, 732 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 253, 653, 262, 662 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 266, 653, 275, 662 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 280, 653, 289, 662 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 98, 275, 102, 284 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Rect: 84, 265, 93, 274 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 97, 265, 106, 274 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 238, 215, 243, 224 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Rect: 114, 175, 123, 184 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 128, 175, 137, 184 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 122, 115, 131, 124 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 1837 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 224, 723, 233, 732 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 162, 643, 167, 652 Flags: Print AppearanceDictionary: true Destination: 198 Annotation: Subtype: Link Rect: 251, 643, 260, 652 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 165, 484, 175, 493 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 273, 374, 278, 383 Flags: Print AppearanceDictionary: true Destination: 48 Annotation: Subtype: Link Rect: 121, 354, 130, 363 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 35, 255, 40, 264 Flags: Print AppearanceDictionary: true Destination: 48 Annotation: Subtype: Link Rect: 124, 205, 133, 214 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 137, 205, 147, 214 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 170, 205, 175, 214 Flags: Print AppearanceDictionary: true Destination: 48 Annotation: Subtype: Link Rect: 268, 165, 273, 174 Flags: Print AppearanceDictionary: true Destination: 48 Annotation: Subtype: Link Rect: 38, 55, 47, 64 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 51, 55, 60, 64 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 83, 55, 87, 64 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 536, 573, 545, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 486, 563, 495, 572 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 545, 504, 549, 513 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 342, 484, 347, 493 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 394, 444, 399, 453 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 321, 324, 325, 333 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 485, 265, 489, 274 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 392, 175, 401, 184 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 1838 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 93, 208, 102, 217 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 279, 89, 289, 98 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 371, 356, 380, 365 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 384, 356, 393, 365 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 1839 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 38, 85, 47, 94 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 1840 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 155, 474, 159, 483 Flags: Print AppearanceDictionary: true Destination: 108 Annotation: Subtype: Link Rect: 283, 444, 288, 453 Flags: Print AppearanceDictionary: true Destination: 108 Annotation: Subtype: Link Rect: 132, 294, 137, 303 Flags: Print AppearanceDictionary: true Destination: 108 Annotation: Subtype: Link Rect: 198, 245, 203, 254 Flags: Print AppearanceDictionary: true Destination: 108 Annotation: Subtype: Link Rect: 131, 145, 136, 154 Flags: Print AppearanceDictionary: true Destination: 108 Annotation: Subtype: Link Rect: 162, 115, 167, 124 Flags: Print AppearanceDictionary: true Destination: 108 Annotation: Subtype: Link Rect: 267, 105, 272, 114 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 330, 703, 334, 712 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 334, 683, 338, 692 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 459, 663, 464, 672 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 447, 434, 451, 443 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 331, 354, 335, 363 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 416, 284, 421, 293 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 487, 245, 492, 254 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 344, 195, 353, 204 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 311, 185, 315, 194 Flags: Print AppearanceDictionary: true Destination: 48 Annotation: Subtype: Link Rect: 311, 175, 315, 184 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 313, 135, 322, 144 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 327, 135, 336, 144 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 341, 135, 350, 144 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 447, 115, 452, 124 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 329, 105, 338, 114 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 544, 75, 549, 84 Flags: Print AppearanceDictionary: true Destination: 133 Thumb: true Page: Label: 1841 Sequence: 7 Thumb: true Page: Label: 1842 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 436, 79, 440, 88 Flags: Print AppearanceDictionary: true Destination: 198 Thumb: true Page: Label: 1843 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 35, 84, 40, 93 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 320, 174, 324, 183 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 317, 114, 325, 123 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 439, 94, 447, 103 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 452, 94, 461, 103 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 465, 94, 474, 103 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 304, 64, 313, 73 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 317, 64, 326, 73 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 1844 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 162, 673, 167, 682 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 153, 573, 158, 582 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 279, 554, 288, 562 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 279, 544, 283, 552 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 278, 444, 283, 453 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 92, 404, 102, 413 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 160, 284, 169, 293 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 283, 265, 288, 274 Flags: Print AppearanceDictionary: true Destination: 198 Annotation: Subtype: Link Rect: 89, 205, 94, 214 Flags: Print AppearanceDictionary: true Destination: 133 Annotation: Subtype: Link Rect: 313, 663, 322, 672 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 493, 613, 502, 622 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 507, 613, 516, 622 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 354, 583, 363, 592 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 370, 583, 379, 592 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 394, 554, 399, 562 Flags: Print AppearanceDictionary: true Destination: 198 Annotation: Subtype: Link Rect: 501, 474, 510, 483 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 514, 474, 523, 483 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 376, 454, 385, 463 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 532, 364, 541, 373 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 545, 364, 555, 373 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 335, 354, 344, 363 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 351, 354, 360, 363 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 400, 354, 409, 363 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 414, 354, 423, 363 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 476, 354, 486, 363 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 492, 354, 501, 363 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 344, 344, 353, 353 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 358, 344, 368, 353 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 402, 334, 411, 343 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 332, 324, 341, 333 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 345, 324, 355, 333 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 313, 265, 323, 274 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 329, 265, 338, 274 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 424, 245, 434, 254 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 438, 245, 447, 254 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 434, 185, 443, 194 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 1845 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 191, 116, 200, 125 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 230, 116, 239, 125 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 38, 106, 47, 115 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 226, 96, 236, 105 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 96, 56, 105, 65 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 346, 182, 355, 191 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 1846 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 47, 723, 56, 732 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 82, 573, 92, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 96, 573, 105, 582 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 147, 554, 156, 562 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 161, 554, 170, 562 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 47, 125, 56, 134 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 128, 85, 138, 94 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 142, 85, 151, 94 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 480, 713, 489, 722 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 374, 603, 379, 612 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 383, 603, 388, 612 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 461, 464, 471, 473 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 478, 464, 487, 473 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 471, 444, 480, 453 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 484, 444, 494, 453 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 545, 384, 555, 393 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 482, 324, 492, 333 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 482, 304, 491, 313 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 354, 165, 363, 174 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 368, 165, 377, 174 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 1847 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 164, 370, 169, 379 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 140, 241, 149, 250 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 139, 211, 148, 220 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 140, 181, 144, 190 Flags: Print AppearanceDictionary: true Destination: 243 Annotation: Subtype: Link Rect: 392, 356, 396, 364 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Rect: 399, 293, 407, 301 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 432, 284, 440, 292 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 304, 77, 312, 85 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 316, 77, 324, 85 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 538, 68, 546, 76 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 1848 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 47, 723, 55, 731 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 73, 714, 81, 722 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 141, 714, 149, 722 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 261, 696, 269, 704 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 164, 678, 172, 686 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 175, 678, 183, 686 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 187, 678, 195, 686 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 117, 660, 126, 668 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 129, 660, 137, 668 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 102, 624, 110, 632 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 47, 557, 55, 565 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 151, 539, 159, 547 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 103, 521, 111, 529 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 47, 503, 55, 511 Flags: Print AppearanceDictionary: true Destination: 303 Annotation: Subtype: Link Rect: 105, 503, 117, 511 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 207, 503, 219, 511 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 141, 471, 203, 479 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 252, 471, 293, 479 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 45, 462, 74, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 83, 462, 95, 470 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 99, 462, 111, 470 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 195, 255, 207, 263 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 203, 228, 293, 236 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 45, 219, 104, 227 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 1849 Sequence: 15 Thumb: true Page: Label: 1850 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 347, 347, 475, 354 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 488, 302, 559, 309 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 311, 293, 333, 300 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 487, 141, 559, 148 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 311, 132, 368, 139 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 106c04b2 Type: CRC32 Checksum: d1a35d12da3839519acf68cdfe2468b1 Type: MD5 Checksum: b127cb7d7c1472675051de43f365c3e573971d20 Type: SHA-1