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Title:          Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice
Subject:        Cell Death and Disease, doi:10.1038/s41419-022-04725-9
Keywords:       
Author:         Yuan Zhang
Creator:        Springer
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      Title: Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice
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       Item: 
        Title: Introduction
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       Item: 
        Title: Results
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         Item: 
          Title: Acox2 loss induces liver cancer in mice
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         Item: 
          Title: Acox2 Interacts with methylcrotonoyl-CoA carboxylase
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          Title: Kcr changes are associated with liver cancer progression in Acox2−/− mice
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          Title: Downregulation of non-histone Kcr in Acox2 mice
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          Title: Histone (H2b) K86cr was upregulated in Acox2−/− mice
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          Title: Downregulated non-histone Kcr sites on metabolic enzymes
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          Title: Validation of Kcr changes on Ehhadh and Crot
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          Title: Site-specific regulatory role of Ehhadh Kcr on the transcriptome in’vitro
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        Title: Discussion
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        Title: Materials and methods
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         Item: 
          Title: Generation of Acox2 knockout mice
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         Item: 
          Title: Immunofluorescence and immunohistochemistry
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         Item: 
          Title: Tandem affinity purification
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          Title: Kcr peptide enrichment
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         Item: 
          Title: Tandem mass tagging proteomic analysis
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         Item: 
          Title: Co-immunoprecipitation
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         Item: 
          Title: Site-directed mutagenesis and immunoprecipitation
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         Item: 
          Title: RNA sequencing
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          Title: cDNA amplification and RT-qPCR
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          Title: Immunoblotting
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          Title: Statistics
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        Title: References
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