fd4b0105d71126fb8e713af6543963bd pmc_8983313.pdf 0b77d1480430a0f21a856c10e872aafb81fc8d64 pmc_8983313.pdf ae5889acfa21209cdc36432cd0dad21bb4c293fb41954853d8a0e40828145108 pmc_8983313.pdf Title: AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity Subject: Molecular Therapy: Methods & Clinical Development, 25 (2022) 190-204. doi:10.1016/j.omtm.2022.03.007 Author: Estefania Casana Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Mar 31 19:57:07 2022 CEST ModDate: Thu Mar 31 19:59:09 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 3484421 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JPHNAO+AdvHelN-L Type 1C Custom yes yes no 1483 0 JPHNAP+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 1486 0 JPHNBP+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 1488 0 JPHNCA+AdvOT45bf69de.BI Type 1C WinAnsi yes yes no 1491 0 JPHNCB+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 1496 0 JPHNCC+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 1499 0 JPHNCD+AdvPS3F4C13 Type 1C WinAnsi yes yes no 1484 0 JPHNCE+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 1497 0 JPHNCF+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 1504 0 JPHNEG+AdvPSSym Type 1C WinAnsi yes yes no 1508 0 JPHNHG+AdvP4C4E74 Type 1C Custom yes yes yes 1007 0 JPHNHF+AdvPSA189 Type 1C MacRoman yes yes no 1013 0 JPHOCD+Helvetica-Bold Type 1C WinAnsi yes yes no 1041 0 JPHODE+AdvHelN-LI Type 1C WinAnsi yes yes no 1036 0 JPHODF+AdvPSA183 Type 1C WinAnsi yes yes no 1039 0 JPHOPB+AdvPS4721B4 Type 1C WinAnsi yes yes no 1071 0 JPIAJI+Advhelvneue-italic Type 1C WinAnsi yes yes no 1105 0 JPIEJB+AdvP4C4E59 Type 1C WinAnsi yes yes no 1183 0 JPIEJC+AdvTimes Type 1C WinAnsi yes yes no 1181 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-04-21 02:26:51 CEST RepresentationInformation: pmc_8983313.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-04-26 17:56:55 CEST Size: 3484421 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib6' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib29' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib34' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib35' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib36' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib36' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib36' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib37' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib46' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib36' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib47' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib48' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib49' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib50' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib51' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib53' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib54' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib57' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib58' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib59' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib72' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib73' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib76' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib77' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib74' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib75' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib78' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib79' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib80' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib81' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib82' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib83' cannot be found Offset: 3439336 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib84' cannot be found Offset: 3439336 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1570 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Liver-specific BMP7 overexpression mediates persistent reversion of obesity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: AAV-BMP7 reverses HFD-associated WAT hypertrophy and inflammation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Treatment with AAV-BMP7 enhances energy expenditure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: AAV-BMP7 ameliorates hepatic steatosis and counteracts insulin resistance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Treatment of ob/ob mice with AAV-BMP7 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Animals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Recombinant AAV vectors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Administration of AAV vectors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Immunohistochemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Measurement of the adipocyte area Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: RNA analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Vector genome copy number Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Western blot analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Hormone and metabolite assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Insulin tolerance test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Glucose tolerance test Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Indirect calorimetry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Supplemental information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Declaration of interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Info: Title: AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity Author: Estefania Casana Subject: Molecular Therapy: Methods & Clinical Development, 25 (2022) 190-204. doi:10.1016/j.omtm.2022.03.007 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Mar 31 20:27:07 CEST 2022 ModDate: Thu Mar 31 20:29:09 CEST 2022 ID: 0x1deea68004d886150d8d6ef7fbce11cd, 0x7f315577106f804597613e0c0c92adce Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode FilterPipeline: CCITTFaxDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 69 ImageHeight: 68 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 134 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 305 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 258 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 349 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 367 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 24 ImageHeight: 123 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 174 ImageHeight: 155 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 116 ImageHeight: 18 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 355 ImageHeight: 58 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 207 ImageHeight: 33 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 431 ImageHeight: 329 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 289 ImageHeight: 40 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 28 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 28 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 10 ImageHeight: 21 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 126 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 184 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 77 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 18 ImageHeight: 37 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 58 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 58 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 386 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 59 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 58 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 431 ImageHeight: 329 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 431 ImageHeight: 329 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 22 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 386 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 203 ImageHeight: 28 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 385 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 203 ImageHeight: 24 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 37 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 38 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 46 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 37 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 345 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 355 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 124 ImageHeight: 118 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 346 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 37 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 124 ImageHeight: 118 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 24 ImageHeight: 171 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 346 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 124 ImageHeight: 118 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 10 ImageHeight: 22 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 345 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 15 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 2 ImageHeight: 2 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 123 ImageHeight: 118 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 345 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 345 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 38 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 38 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 38 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 46 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 44 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 36 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 36 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 51 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 44 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 525 ImageHeight: 447 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 43 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 349 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 346 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 10 ImageHeight: 21 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 525 ImageHeight: 447 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 525 ImageHeight: 447 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 43 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 346 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 212 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 346 ImageHeight: 295 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 43 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 28 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 28 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 20 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 67 ImageHeight: 27 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 54 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 20 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 14 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 19 ImageHeight: 15 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 34 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 43 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 354 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 354 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 348 ImageHeight: 414 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 28 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 348 ImageHeight: 11 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 28 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 349 ImageHeight: 11 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 348 ImageHeight: 414 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 348 ImageHeight: 11 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 349 ImageHeight: 414 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 348 ImageHeight: 10 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 348 ImageHeight: 414 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 10 ImageHeight: 22 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 354 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 348 ImageHeight: 414 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 348 ImageHeight: 12 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 44 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 348 ImageHeight: 414 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 44 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 348 ImageHeight: 11 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 22 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 70 ImageHeight: 30 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 44 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 354 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 24 ImageHeight: 284 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 354 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 381 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 65 ImageHeight: 24 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 21 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 368 ImageHeight: 303 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/png ImageWidth: 72 ImageHeight: 948 BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 72 ImageHeight: 816 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 32 ImageHeight: 147 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 56 ImageHeight: 970 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 368 ImageHeight: 303 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 72 ImageHeight: 376 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 48 ImageHeight: 267 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 56 ImageHeight: 111 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 40 ImageHeight: 153 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 72 ImageHeight: 1062 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 72 ImageHeight: 1305 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 370 ImageHeight: 28 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 376 ImageHeight: 29 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 56 ImageHeight: 832 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 72 ImageHeight: 687 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 72 ImageHeight: 368 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 40 ImageHeight: 141 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 32 ImageHeight: 147 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 32 ImageHeight: 147 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT 1D ImageWidth: 32 ImageHeight: 144 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/png ImageWidth: 371 ImageHeight: 34 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 373 ImageHeight: 37 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 374 ImageHeight: 35 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 372 ImageHeight: 25 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: JPHNCF+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JPHNCF+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JPHNEG+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: JPHNEG+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPHNAO+AdvHelN-L FontSubset: true FirstChar: 30 LastChar: 150 FontDescriptor: FontName: JPHNAO+AdvHelN-L Flags: Nonsymbolic FontBBox: -156, -208, 1041, 802 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: JPHNCD+AdvPS3F4C13 FontSubset: true FirstChar: 68 LastChar: 109 FontDescriptor: FontName: JPHNCD+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPHODE+AdvHelN-LI FontSubset: true FirstChar: 47 LastChar: 118 FontDescriptor: FontName: JPHODE+AdvHelN-LI Flags: Nonsymbolic FontBBox: -156, -197, 1093, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPHNAP+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: JPHNAP+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPHNHG+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 48 FontDescriptor: FontName: JPHNHG+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JPHODF+AdvPSA183 FontSubset: true FirstChar: 177 LastChar: 177 FontDescriptor: FontName: JPHODF+AdvPSA183 Flags: Nonsymbolic FontBBox: -156, -208, 1072, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPHOPB+AdvPS4721B4 FontSubset: true FirstChar: 97 LastChar: 103 FontDescriptor: FontName: JPHOPB+AdvPS4721B4 Flags: Nonsymbolic FontBBox: 0, -208, 843, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPHNBP+AdvOTb65e897d.B FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: JPHNBP+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPHOCD+Helvetica-Bold FontSubset: true FirstChar: 65 LastChar: 77 FontDescriptor: FontName: JPHOCD+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPIAJI+Advhelvneue-italic FontSubset: true FirstChar: 40 LastChar: 120 FontDescriptor: FontName: JPIAJI+Advhelvneue-italic Flags: Nonsymbolic FontBBox: -156, -208, 1104, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPHNCA+AdvOT45bf69de.BI FontSubset: true FirstChar: 55 LastChar: 80 FontDescriptor: FontName: JPHNCA+AdvOT45bf69de.BI Flags: Nonsymbolic FontBBox: -135, -250, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPHNHF+AdvPSA189 FontSubset: true FirstChar: 44 LastChar: 223 FontDescriptor: FontName: JPHNHF+AdvPSA189 Flags: Nonsymbolic FontBBox: -156, -208, 1072, 802 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: JPHNCB+AdvOTb65e897d.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JPHNCB+AdvOTb65e897d.B+fb Flags: Symbolic FontBBox: 0, -10, 843, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JPHNCE+AdvOT7d6df7ab.I FontSubset: true FirstChar: 44 LastChar: 118 FontDescriptor: FontName: JPHNCE+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPHNCC+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: JPHNCC+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPIEJC+AdvTimes FontSubset: true FirstChar: 45 LastChar: 45 FontDescriptor: FontName: JPIEJC+AdvTimes Flags: Nonsymbolic FontBBox: -217, -212, 1005, 766 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JPIEJB+AdvP4C4E59 FontSubset: true FirstChar: 125 LastChar: 125 FontDescriptor: FontName: JPIEJB+AdvP4C4E59 Flags: Nonsymbolic FontBBox: -31, -250, 1000, 750 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.omtm.2022.03.007 AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity Estefania Casana Veronica Jimenez Claudia Jambrina Victor Sacristan Sergio Muñoz Jordi Rodo Ignasi Grass Miquel Garcia Cristina Mallol Xavier León Alba Casellas Víctor Sánchez Sylvie Franckhauser Tura Ferré Sara Marcó Fatima Bosch AAV gene therapy obesity type 2 diabetes BMP7 insulin resistance Molecular Therapy: Methods & Clinical Development, 25 (2022) 190-204. doi:10.1016/j.omtm.2022.03.007 The Authors journal Molecular Therapy: Methods & Clinical Development © 2022 The Authors. 2329-0501 25 09 June 2022 2022-06-09 190-204 190 204 10.1016/j.omtm.2022.03.007 https://doi.org/10.1016/j.omtm.2022.03.007 2010-04-23 true 10.1016/j.omtm.2022.03.007 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.omtm.2022.03.007 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2022-03-31T23:27:07+05:30 2022-03-31T23:29:09+05:30 2022-03-31T23:29:09+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:7f26842e-2ee0-43ac-9f7e-2ea453eb57f1 uuid:dfb2f80f-f00f-47fe-ac74-d7534bacc59a http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 190 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 125, 599, 131, 610 Destination: 1380 Annotation: Subtype: Link Rect: 131, 599, 136, 610 Destination: 1380 Annotation: Subtype: Link Rect: 136, 599, 142, 610 Destination: 1380 Annotation: Subtype: Link Rect: 142, 599, 146, 610 Destination: null Annotation: Subtype: Link Rect: 229, 599, 235, 610 Destination: 1380 Annotation: Subtype: Link Rect: 235, 599, 241, 610 Destination: 1380 Annotation: Subtype: Link Rect: 241, 599, 246, 610 Destination: 1380 Annotation: Subtype: Link Rect: 246, 599, 250, 610 Destination: null Annotation: Subtype: Link Rect: 333, 599, 339, 610 Destination: 1380 Annotation: Subtype: Link Rect: 339, 599, 344, 610 Destination: 1380 Annotation: Subtype: Link Rect: 344, 599, 348, 610 Destination: 1380 Annotation: Subtype: Link Rect: 424, 599, 430, 610 Destination: 1380 Annotation: Subtype: Link Rect: 430, 599, 434, 610 Destination: 1380 Annotation: Subtype: Link Rect: 501, 599, 506, 610 Destination: 1380 Annotation: Subtype: Link Rect: 506, 599, 512, 610 Destination: 1380 Annotation: Subtype: Link Rect: 512, 599, 516, 610 Destination: 1380 Annotation: Subtype: Link Rect: 99, 585, 104, 596 Destination: 1380 Annotation: Subtype: Link Rect: 104, 585, 108, 596 Destination: 1380 Annotation: Subtype: Link Rect: 168, 585, 173, 596 Destination: 1380 Annotation: Subtype: Link Rect: 173, 585, 177, 596 Destination: 1380 Annotation: Subtype: Link Rect: 246, 585, 252, 596 Destination: 1380 Annotation: Subtype: Link Rect: 252, 585, 257, 596 Destination: 1380 Annotation: Subtype: Link Rect: 257, 585, 261, 596 Destination: 1380 Annotation: Subtype: Link Rect: 333, 585, 339, 596 Destination: 1380 Annotation: Subtype: Link Rect: 339, 585, 342, 596 Destination: 1380 Annotation: Subtype: Link Rect: 401, 585, 407, 596 Destination: 1380 Annotation: Subtype: Link Rect: 407, 585, 413, 596 Destination: 1380 Annotation: Subtype: Link Rect: 413, 585, 416, 596 Destination: 1380 Annotation: Subtype: Link Rect: 480, 585, 486, 596 Destination: 1380 Annotation: Subtype: Link Rect: 486, 585, 492, 596 Destination: 1380 Annotation: Subtype: Link Rect: 492, 585, 496, 596 Destination: 1380 Annotation: Subtype: Link Rect: 117, 571, 123, 582 Destination: 1380 Annotation: Subtype: Link Rect: 123, 571, 127, 582 Destination: 1380 Annotation: Subtype: Link Rect: 220, 571, 225, 582 Destination: 1380 Annotation: Subtype: Link Rect: 225, 571, 231, 582 Destination: 1380 Annotation: Subtype: Link Rect: 231, 571, 235, 582 Destination: 1380 Annotation: Subtype: Link Rect: 288, 571, 293, 582 Destination: 1380 Annotation: Subtype: Link Rect: 293, 571, 299, 582 Destination: 1380 Annotation: Subtype: Link Rect: 299, 571, 303, 582 Destination: 1380 Annotation: Subtype: Link Rect: 359, 571, 365, 582 Destination: 1380 Annotation: Subtype: Link Rect: 365, 571, 370, 582 Destination: 1380 Annotation: Subtype: Link Rect: 370, 571, 374, 582 Destination: 1380 Annotation: Subtype: Link Rect: 456, 571, 462, 582 Destination: 1380 Annotation: Subtype: Link Rect: 462, 571, 468, 582 Destination: 1380 Annotation: Subtype: Link Rect: 468, 571, 472, 582 Destination: 1380 Annotation: Subtype: Link Rect: 100, 117, 110, 126 Destination: 451 Annotation: Subtype: Link Rect: 527, 409, 540, 418 Destination: null Annotation: Subtype: Link Rect: 514, 352, 520, 361 Destination: null Annotation: Subtype: Link Rect: 522, 352, 528, 361 Destination: null Annotation: Subtype: Link Rect: 323, 318, 329, 327 Destination: null Annotation: Subtype: Link Rect: 331, 318, 337, 327 Destination: null Annotation: Subtype: Link Rect: 537, 295, 554, 304 Destination: null Annotation: Subtype: Link Rect: 490, 272, 496, 281 Destination: null Annotation: Subtype: Link Rect: 498, 272, 504, 281 Destination: null Annotation: Subtype: Link Rect: 547, 260, 554, 269 Destination: null Annotation: Subtype: Link Rect: 381, 215, 388, 223 Destination: null Annotation: Subtype: Link Rect: 389, 215, 396, 223 Destination: null Annotation: Subtype: Link Rect: 491, 157, 498, 166 Destination: null Annotation: Subtype: Link Rect: 499, 157, 506, 166 Destination: null Annotation: Subtype: Link Rect: 308, 106, 438, 114 Annotation: Subtype: Link Rect: 333, 56, 395, 64 Annotation: Subtype: Link Rect: 538, 23, 554, 39 Annotation: Subtype: Link Rect: 295, 15, 471, 23 Page: Label: 191 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 151, 491, 181, 500 Destination: 40 Annotation: Subtype: Link Rect: 276, 484, 282, 493 Destination: null Annotation: Subtype: Link Rect: 156, 308, 187, 317 Destination: 40 Annotation: Subtype: Link Rect: 240, 274, 272, 283 Destination: 40 Annotation: Subtype: Link Rect: 48, 262, 57, 271 Destination: 451 Annotation: Subtype: Link Rect: 219, 239, 251, 248 Destination: 40 Annotation: Subtype: Link Rect: 275, 239, 284, 248 Destination: 451 Annotation: Subtype: Link Rect: 192, 205, 223, 214 Destination: 40 Annotation: Subtype: Link Rect: 246, 205, 255, 214 Destination: 451 Annotation: Subtype: Link Rect: 72, 171, 100, 180 Destination: 40 Annotation: Subtype: Link Rect: 220, 136, 248, 145 Destination: 40 Annotation: Subtype: Link Rect: 95, 113, 123, 122 Destination: 40 Annotation: Subtype: Link Rect: 488, 667, 504, 676 Destination: null Annotation: Subtype: Link Rect: 382, 629, 410, 638 Destination: 40 Annotation: Subtype: Link Rect: 464, 594, 493, 603 Destination: 40 Annotation: Subtype: Link Rect: 500, 572, 530, 580 Destination: 40 Annotation: Subtype: Link Rect: 448, 549, 477, 558 Destination: 40 Annotation: Subtype: Link Rect: 421, 537, 450, 546 Destination: 40 Annotation: Subtype: Link Rect: 466, 491, 498, 500 Destination: 40 Annotation: Subtype: Link Rect: 519, 491, 528, 500 Destination: 451 Annotation: Subtype: Link Rect: 311, 468, 345, 477 Destination: 451 Annotation: Subtype: Link Rect: 375, 438, 381, 447 Destination: null Annotation: Subtype: Link Rect: 387, 434, 420, 443 Destination: 40 Annotation: Subtype: Link Rect: 376, 377, 408, 386 Destination: 72 Annotation: Subtype: Link Rect: 387, 331, 420, 340 Destination: 72 Annotation: Subtype: Link Rect: 311, 297, 344, 306 Destination: 72 Annotation: Subtype: Link Rect: 472, 278, 478, 287 Destination: null Annotation: Subtype: Link Rect: 398, 228, 431, 237 Destination: 72 Annotation: Subtype: Link Rect: 425, 205, 457, 214 Destination: 72 Annotation: Subtype: Link Rect: 431, 117, 438, 126 Destination: null Annotation: Subtype: Link Rect: 439, 117, 446, 126 Destination: null Annotation: Subtype: Link Rect: 407, 90, 440, 99 Destination: 72 Annotation: Subtype: Link Rect: 439, 60, 445, 69 Destination: null Annotation: Subtype: Link Rect: 48, 725, 141, 733 Page: Label: 192 Sequence: 3 Page: Label: 193 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 48, 725, 141, 733 Page: Label: 194 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 254, 663, 287, 672 Destination: 163 Annotation: Subtype: Link Rect: 65, 652, 73, 661 Destination: 451 Annotation: Subtype: Link Rect: 195, 629, 226, 638 Destination: 163 Annotation: Subtype: Link Rect: 100, 583, 133, 592 Destination: 163 Annotation: Subtype: Link Rect: 144, 583, 152, 592 Destination: 451 Annotation: Subtype: Link Rect: 106, 560, 143, 569 Destination: 451 Annotation: Subtype: Link Rect: 176, 480, 206, 489 Destination: 163 Annotation: Subtype: Link Rect: 236, 457, 271, 466 Destination: 163 Annotation: Subtype: Link Rect: 249, 423, 284, 432 Destination: 451 Annotation: Subtype: Link Rect: 79, 342, 109, 351 Destination: 214 Annotation: Subtype: Link Rect: 51, 308, 84, 317 Destination: 214 Annotation: Subtype: Link Rect: 170, 285, 203, 294 Destination: 214 Annotation: Subtype: Link Rect: 111, 262, 145, 271 Destination: 451 Annotation: Subtype: Link Rect: 78, 228, 111, 237 Destination: 214 Annotation: Subtype: Link Rect: 237, 228, 270, 237 Destination: 214 Annotation: Subtype: Link Rect: 140, 205, 174, 214 Destination: 214 Annotation: Subtype: Link Rect: 218, 148, 251, 157 Destination: 214 Annotation: Subtype: Link Rect: 275, 148, 283, 157 Destination: 451 Annotation: Subtype: Link Rect: 221, 125, 253, 134 Destination: 214 Annotation: Subtype: Link Rect: 275, 125, 283, 134 Destination: 451 Annotation: Subtype: Link Rect: 216, 79, 249, 88 Destination: 214 Annotation: Subtype: Link Rect: 274, 79, 283, 88 Destination: 451 Annotation: Subtype: Link Rect: 347, 640, 380, 649 Destination: 451 Annotation: Subtype: Link Rect: 345, 576, 352, 584 Destination: null Annotation: Subtype: Link Rect: 337, 564, 343, 573 Destination: null Annotation: Subtype: Link Rect: 483, 514, 516, 523 Destination: 309 Annotation: Subtype: Link Rect: 539, 503, 554, 512 Destination: 309 Annotation: Subtype: Link Rect: 308, 491, 328, 500 Destination: 309 Annotation: Subtype: Link Rect: 311, 457, 344, 466 Destination: 309 Annotation: Subtype: Link Rect: 384, 457, 392, 466 Destination: 451 Annotation: Subtype: Link Rect: 477, 446, 510, 454 Destination: 451 Annotation: Subtype: Link Rect: 473, 423, 507, 432 Destination: 309 Annotation: Subtype: Link Rect: 534, 423, 543, 432 Destination: 451 Annotation: Subtype: Link Rect: 472, 400, 501, 409 Destination: 309 Annotation: Subtype: Link Rect: 333, 377, 363, 386 Destination: 309 Annotation: Subtype: Link Rect: 343, 354, 380, 363 Destination: 451 Annotation: Subtype: Link Rect: 512, 319, 545, 328 Destination: 309 Annotation: Subtype: Link Rect: 308, 308, 317, 317 Destination: 451 Annotation: Subtype: Link Rect: 345, 274, 374, 283 Destination: 309 Annotation: Subtype: Link Rect: 454, 262, 490, 271 Destination: 309 Annotation: Subtype: Link Rect: 539, 251, 554, 260 Destination: 309 Annotation: Subtype: Link Rect: 308, 239, 326, 248 Destination: 309 Annotation: Subtype: Link Rect: 416, 182, 451, 191 Destination: 357 Annotation: Subtype: Link Rect: 458, 159, 488, 168 Destination: 357 Annotation: Subtype: Link Rect: 413, 136, 448, 145 Destination: 357 Annotation: Subtype: Link Rect: 405, 113, 436, 122 Destination: 357 Annotation: Subtype: Link Rect: 379, 71, 385, 80 Destination: null Page: Label: 195 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 48, 725, 141, 733 Page: Label: 196 Sequence: 7 Page: Label: 197 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 69, 663, 101, 672 Destination: 357 Annotation: Subtype: Link Rect: 242, 553, 249, 562 Destination: null Annotation: Subtype: Link Rect: 64, 484, 80, 493 Destination: null Annotation: Subtype: Link Rect: 112, 450, 128, 458 Destination: null Annotation: Subtype: Link Rect: 129, 438, 145, 447 Destination: null Annotation: Subtype: Link Rect: 191, 415, 197, 424 Destination: null Annotation: Subtype: Link Rect: 199, 415, 205, 424 Destination: null Annotation: Subtype: Link Rect: 202, 346, 219, 355 Destination: null Annotation: Subtype: Link Rect: 233, 335, 250, 344 Destination: null Annotation: Subtype: Link Rect: 130, 312, 136, 321 Destination: null Annotation: Subtype: Link Rect: 138, 312, 144, 321 Destination: null Annotation: Subtype: Link Rect: 146, 312, 152, 321 Destination: null Annotation: Subtype: Link Rect: 277, 312, 283, 321 Destination: null Annotation: Subtype: Link Rect: 233, 278, 240, 287 Destination: null Annotation: Subtype: Link Rect: 241, 278, 248, 287 Destination: null Annotation: Subtype: Link Rect: 191, 216, 222, 225 Destination: 40 Annotation: Subtype: Link Rect: 157, 163, 164, 172 Destination: null Annotation: Subtype: Link Rect: 233, 140, 239, 149 Destination: null Annotation: Subtype: Link Rect: 434, 621, 440, 630 Destination: null Annotation: Subtype: Link Rect: 441, 621, 448, 630 Destination: null Annotation: Subtype: Link Rect: 327, 598, 334, 607 Destination: null Annotation: Subtype: Link Rect: 382, 576, 389, 585 Destination: null Annotation: Subtype: Link Rect: 339, 541, 346, 550 Destination: null Annotation: Subtype: Link Rect: 347, 541, 354, 550 Destination: null Annotation: Subtype: Link Rect: 547, 495, 554, 504 Destination: null Annotation: Subtype: Link Rect: 331, 450, 347, 458 Destination: null Annotation: Subtype: Link Rect: 336, 427, 342, 436 Destination: null Annotation: Subtype: Link Rect: 479, 404, 485, 413 Destination: null Annotation: Subtype: Link Rect: 328, 381, 344, 390 Destination: null Annotation: Subtype: Link Rect: 350, 369, 367, 378 Destination: 829 Annotation: Subtype: Link Rect: 498, 312, 504, 321 Destination: 829 Annotation: Subtype: Link Rect: 384, 278, 390, 287 Destination: 829 Annotation: Subtype: Link Rect: 365, 255, 371, 264 Destination: 829 Annotation: Subtype: Link Rect: 373, 255, 379, 264 Destination: 829 Annotation: Subtype: Link Rect: 430, 232, 437, 241 Destination: 829 Annotation: Subtype: Link Rect: 438, 232, 445, 241 Destination: 829 Annotation: Subtype: Link Rect: 539, 209, 546, 218 Destination: 829 Annotation: Subtype: Link Rect: 547, 209, 554, 218 Destination: 829 Annotation: Subtype: Link Rect: 431, 186, 437, 195 Destination: 829 Annotation: Subtype: Link Rect: 407, 175, 413, 184 Destination: 829 Annotation: Subtype: Link Rect: 325, 152, 332, 161 Destination: null Annotation: Subtype: Link Rect: 433, 152, 449, 161 Destination: 829 Annotation: Subtype: Link Rect: 368, 129, 374, 138 Destination: null Annotation: Subtype: Link Rect: 48, 725, 141, 733 Page: Label: 198 Sequence: 9 Page: Label: 199 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 276, 71, 282, 80 Destination: null Annotation: Subtype: Link Rect: 378, 117, 385, 126 Destination: null Annotation: Subtype: Link Rect: 450, 83, 457, 92 Destination: null Annotation: Subtype: Link Rect: 48, 725, 141, 733 Page: Label: 200 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 76, 656, 82, 665 Destination: null Annotation: Subtype: Link Rect: 208, 610, 214, 619 Destination: null Annotation: Subtype: Link Rect: 123, 553, 130, 562 Destination: null Annotation: Subtype: Link Rect: 131, 553, 137, 562 Destination: null Annotation: Subtype: Link Rect: 100, 530, 116, 539 Destination: null Annotation: Subtype: Link Rect: 103, 472, 109, 481 Destination: null Annotation: Subtype: Link Rect: 110, 472, 117, 481 Destination: null Annotation: Subtype: Link Rect: 264, 450, 270, 458 Destination: null Annotation: Subtype: Link Rect: 272, 450, 278, 458 Destination: null Annotation: Subtype: Link Rect: 279, 450, 286, 458 Destination: null Annotation: Subtype: Link Rect: 287, 450, 293, 458 Destination: null Annotation: Subtype: Link Rect: 197, 335, 203, 344 Destination: null Annotation: Subtype: Link Rect: 116, 312, 122, 321 Destination: null Annotation: Subtype: Link Rect: 123, 312, 130, 321 Destination: null Annotation: Subtype: Link Rect: 69, 278, 76, 287 Destination: null Annotation: Subtype: Link Rect: 70, 243, 76, 252 Destination: null Annotation: Subtype: Link Rect: 237, 94, 243, 103 Destination: null Annotation: Subtype: Link Rect: 245, 94, 251, 103 Destination: null Annotation: Subtype: Link Rect: 340, 667, 346, 676 Destination: null Annotation: Subtype: Link Rect: 348, 667, 354, 676 Destination: null Annotation: Subtype: Link Rect: 522, 656, 529, 665 Destination: null Annotation: Subtype: Link Rect: 433, 633, 440, 642 Destination: null Annotation: Subtype: Link Rect: 340, 587, 346, 596 Destination: null Annotation: Subtype: Link Rect: 547, 576, 554, 585 Destination: null Annotation: Subtype: Link Rect: 398, 140, 405, 149 Destination: null Page: Label: 201 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 160, 541, 167, 550 Destination: null Annotation: Subtype: Link Rect: 140, 301, 147, 309 Destination: null Annotation: Subtype: Link Rect: 531, 301, 537, 309 Destination: null Annotation: Subtype: Link Rect: 48, 725, 141, 733 Page: Label: 202 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 229, 366, 293, 375 Annotation: Subtype: Link Rect: 48, 354, 139, 363 Annotation: Subtype: Link Rect: 320, 618, 554, 625 Annotation: Subtype: Link Rect: 320, 609, 471, 616 Annotation: Subtype: Link Rect: 320, 597, 554, 604 Annotation: Subtype: Link Rect: 320, 588, 459, 595 Annotation: Subtype: Link Rect: 320, 576, 554, 583 Annotation: Subtype: Link Rect: 320, 567, 554, 574 Annotation: Subtype: Link Rect: 320, 558, 464, 565 Annotation: Subtype: Link Rect: 320, 546, 554, 553 Annotation: Subtype: Link Rect: 320, 537, 550, 544 Annotation: Subtype: Link Rect: 320, 524, 554, 531 Annotation: Subtype: Link Rect: 320, 515, 473, 522 Annotation: Subtype: Link Rect: 320, 503, 554, 510 Annotation: Subtype: Link Rect: 320, 494, 554, 501 Annotation: Subtype: Link Rect: 320, 485, 535, 492 Annotation: Subtype: Link Rect: 320, 473, 554, 480 Annotation: Subtype: Link Rect: 320, 464, 554, 471 Annotation: Subtype: Link Rect: 320, 455, 522, 462 Annotation: Subtype: Link Rect: 320, 443, 554, 450 Annotation: Subtype: Link Rect: 320, 434, 554, 441 Annotation: Subtype: Link Rect: 320, 425, 405, 432 Annotation: Subtype: Link Rect: 421, 395, 526, 402 Annotation: Subtype: Link Rect: 320, 382, 554, 389 Annotation: Subtype: Link Rect: 320, 373, 481, 380 Annotation: Subtype: Link Rect: 480, 343, 554, 350 Annotation: Subtype: Link Rect: 320, 334, 370, 341 Annotation: Subtype: Link Rect: 320, 322, 554, 329 Annotation: Subtype: Link Rect: 320, 313, 554, 320 Annotation: Subtype: Link Rect: 320, 304, 554, 311 Annotation: Subtype: Link Rect: 320, 292, 554, 299 Annotation: Subtype: Link Rect: 320, 283, 463, 290 Annotation: Subtype: Link Rect: 320, 270, 554, 277 Annotation: Subtype: Link Rect: 320, 261, 554, 268 Annotation: Subtype: Link Rect: 320, 252, 554, 259 Annotation: Subtype: Link Rect: 320, 243, 554, 250 Annotation: Subtype: Link Rect: 320, 234, 452, 241 Annotation: Subtype: Link Rect: 320, 222, 554, 229 Annotation: Subtype: Link Rect: 320, 213, 554, 220 Annotation: Subtype: Link Rect: 320, 204, 468, 211 Annotation: Subtype: Link Rect: 320, 192, 554, 199 Annotation: Subtype: Link Rect: 320, 183, 554, 190 Annotation: Subtype: Link Rect: 320, 174, 554, 181 Annotation: Subtype: Link Rect: 320, 165, 352, 172 Annotation: Subtype: Link Rect: 320, 153, 554, 160 Annotation: Subtype: Link Rect: 320, 144, 554, 151 Annotation: Subtype: Link Rect: 320, 135, 554, 142 Annotation: Subtype: Link Rect: 320, 126, 481, 133 Annotation: Subtype: Link Rect: 320, 114, 554, 121 Annotation: Subtype: Link Rect: 320, 105, 554, 112 Annotation: Subtype: Link Rect: 320, 96, 554, 103 Annotation: Subtype: Link Rect: 320, 87, 396, 94 Annotation: Subtype: Link Rect: 320, 74, 554, 81 Annotation: Subtype: Link Rect: 320, 65, 554, 72 Annotation: Subtype: Link Rect: 320, 56, 514, 63 Page: Label: 203 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 60, 665, 293, 672 Annotation: Subtype: Link Rect: 60, 656, 238, 663 Annotation: Subtype: Link Rect: 60, 644, 293, 651 Annotation: Subtype: Link Rect: 60, 635, 293, 642 Annotation: Subtype: Link Rect: 60, 626, 167, 633 Annotation: Subtype: Link Rect: 60, 614, 293, 621 Annotation: Subtype: Link Rect: 60, 605, 293, 612 Annotation: Subtype: Link Rect: 60, 596, 205, 603 Annotation: Subtype: Link Rect: 60, 584, 293, 591 Annotation: Subtype: Link Rect: 60, 575, 293, 582 Annotation: Subtype: Link Rect: 60, 566, 264, 573 Annotation: Subtype: Link Rect: 60, 554, 293, 561 Annotation: Subtype: Link Rect: 60, 545, 293, 552 Annotation: Subtype: Link Rect: 60, 536, 293, 543 Annotation: Subtype: Link Rect: 60, 524, 293, 531 Annotation: Subtype: Link Rect: 60, 515, 264, 522 Annotation: Subtype: Link Rect: 60, 503, 293, 510 Annotation: Subtype: Link Rect: 60, 494, 265, 501 Annotation: Subtype: Link Rect: 60, 482, 293, 489 Annotation: Subtype: Link Rect: 60, 473, 293, 480 Annotation: Subtype: Link Rect: 60, 464, 139, 471 Annotation: Subtype: Link Rect: 60, 452, 294, 459 Annotation: Subtype: Link Rect: 60, 443, 293, 450 Annotation: Subtype: Link Rect: 60, 434, 254, 441 Annotation: Subtype: Link Rect: 60, 422, 293, 429 Annotation: Subtype: Link Rect: 60, 413, 293, 420 Annotation: Subtype: Link Rect: 60, 404, 98, 411 Annotation: Subtype: Link Rect: 60, 392, 293, 399 Annotation: Subtype: Link Rect: 60, 383, 271, 390 Annotation: Subtype: Link Rect: 60, 371, 293, 378 Annotation: Subtype: Link Rect: 60, 362, 293, 369 Annotation: Subtype: Link Rect: 60, 353, 293, 360 Annotation: Subtype: Link Rect: 60, 344, 114, 351 Annotation: Subtype: Link Rect: 60, 332, 293, 339 Annotation: Subtype: Link Rect: 60, 323, 292, 330 Annotation: Subtype: Link Rect: 60, 311, 293, 318 Annotation: Subtype: Link Rect: 60, 302, 293, 309 Annotation: Subtype: Link Rect: 60, 293, 85, 300 Annotation: Subtype: Link Rect: 60, 281, 294, 288 Annotation: Subtype: Link Rect: 60, 272, 293, 279 Annotation: Subtype: Link Rect: 60, 263, 241, 270 Annotation: Subtype: Link Rect: 60, 251, 293, 258 Annotation: Subtype: Link Rect: 60, 242, 293, 249 Annotation: Subtype: Link Rect: 60, 233, 100, 240 Annotation: Subtype: Link Rect: 60, 221, 293, 228 Annotation: Subtype: Link Rect: 60, 212, 293, 219 Annotation: Subtype: Link Rect: 60, 203, 286, 210 Annotation: Subtype: Link Rect: 60, 191, 293, 198 Annotation: Subtype: Link Rect: 60, 182, 293, 189 Annotation: Subtype: Link Rect: 60, 173, 293, 180 Annotation: Subtype: Link Rect: 60, 164, 143, 171 Annotation: Subtype: Link Rect: 60, 152, 293, 159 Annotation: Subtype: Link Rect: 60, 143, 293, 150 Annotation: Subtype: Link Rect: 60, 134, 293, 141 Annotation: Subtype: Link Rect: 60, 125, 194, 132 Annotation: Subtype: Link Rect: 60, 113, 293, 120 Annotation: Subtype: Link Rect: 60, 104, 293, 111 Annotation: Subtype: Link Rect: 60, 95, 215, 102 Annotation: Subtype: Link Rect: 60, 83, 293, 90 Annotation: Subtype: Link Rect: 60, 74, 293, 81 Annotation: Subtype: Link Rect: 60, 65, 293, 72 Annotation: Subtype: Link Rect: 60, 56, 216, 63 Annotation: Subtype: Link Rect: 320, 665, 554, 672 Annotation: Subtype: Link Rect: 320, 656, 554, 663 Annotation: Subtype: Link Rect: 320, 647, 554, 654 Annotation: Subtype: Link Rect: 320, 638, 554, 645 Annotation: Subtype: Link Rect: 320, 629, 335, 636 Annotation: Subtype: Link Rect: 320, 617, 554, 624 Annotation: Subtype: Link Rect: 320, 608, 554, 615 Annotation: Subtype: Link Rect: 320, 599, 554, 606 Annotation: Subtype: Link Rect: 320, 590, 352, 597 Annotation: Subtype: Link Rect: 320, 578, 554, 585 Annotation: Subtype: Link Rect: 320, 569, 554, 576 Annotation: Subtype: Link Rect: 320, 560, 405, 567 Annotation: Subtype: Link Rect: 320, 548, 554, 555 Annotation: Subtype: Link Rect: 320, 539, 554, 546 Annotation: Subtype: Link Rect: 320, 530, 554, 537 Annotation: Subtype: Link Rect: 320, 521, 421, 528 Annotation: Subtype: Link Rect: 320, 509, 554, 516 Annotation: Subtype: Link Rect: 320, 500, 430, 507 Annotation: Subtype: Link Rect: 320, 488, 554, 495 Annotation: Subtype: Link Rect: 320, 479, 554, 486 Annotation: Subtype: Link Rect: 320, 470, 554, 477 Annotation: Subtype: Link Rect: 320, 461, 554, 468 Annotation: Subtype: Link Rect: 320, 452, 335, 459 Annotation: Subtype: Link Rect: 320, 440, 554, 447 Annotation: Subtype: Link Rect: 320, 431, 554, 438 Annotation: Subtype: Link Rect: 320, 422, 554, 429 Annotation: Subtype: Link Rect: 320, 413, 554, 420 Annotation: Subtype: Link Rect: 320, 404, 345, 411 Annotation: Subtype: Link Rect: 320, 392, 554, 399 Annotation: Subtype: Link Rect: 320, 383, 554, 390 Annotation: Subtype: Link Rect: 320, 374, 554, 381 Annotation: Subtype: Link Rect: 320, 365, 378, 372 Annotation: Subtype: Link Rect: 320, 353, 554, 360 Annotation: Subtype: Link Rect: 320, 344, 554, 351 Annotation: Subtype: Link Rect: 320, 335, 486, 342 Annotation: Subtype: Link Rect: 320, 323, 543, 330 Annotation: Subtype: Link Rect: 546, 323, 554, 330 Annotation: Subtype: Link Rect: 320, 314, 474, 321 Annotation: Subtype: Link Rect: 476, 314, 554, 321 Annotation: Subtype: Link Rect: 320, 305, 554, 312 Annotation: Subtype: Link Rect: 320, 296, 425, 303 Annotation: Subtype: Link Rect: 320, 284, 554, 291 Annotation: Subtype: Link Rect: 320, 275, 554, 282 Annotation: Subtype: Link Rect: 320, 266, 554, 273 Annotation: Subtype: Link Rect: 320, 258, 479, 264 Annotation: Subtype: Link Rect: 320, 245, 554, 252 Annotation: Subtype: Link Rect: 320, 236, 539, 243 Annotation: Subtype: Link Rect: 320, 224, 554, 231 Annotation: Subtype: Link Rect: 320, 215, 554, 222 Annotation: Subtype: Link Rect: 320, 206, 412, 213 Annotation: Subtype: Link Rect: 320, 194, 554, 201 Annotation: Subtype: Link Rect: 320, 185, 554, 192 Annotation: Subtype: Link Rect: 320, 176, 430, 183 Annotation: Subtype: Link Rect: 320, 164, 554, 171 Annotation: Subtype: Link Rect: 320, 155, 554, 162 Annotation: Subtype: Link Rect: 320, 146, 545, 153 Annotation: Subtype: Link Rect: 320, 134, 554, 141 Annotation: Subtype: Link Rect: 320, 125, 554, 132 Annotation: Subtype: Link Rect: 320, 116, 526, 123 Annotation: Subtype: Link Rect: 320, 104, 554, 111 Annotation: Subtype: Link Rect: 320, 94, 335, 101 Annotation: Subtype: Link Rect: 335, 99, 552, 106 Annotation: Subtype: Link Rect: 552, 95, 554, 102 Annotation: Subtype: Link Rect: 320, 86, 401, 93 Annotation: Subtype: Link Rect: 320, 74, 554, 81 Annotation: Subtype: Link Rect: 320, 65, 554, 72 Annotation: Subtype: Link Rect: 320, 56, 461, 63 Annotation: Subtype: Link Rect: 48, 725, 141, 733 Page: Label: 204 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 60, 665, 293, 672 Annotation: Subtype: Link Rect: 60, 656, 293, 663 Annotation: Subtype: Link Rect: 60, 647, 262, 654 Annotation: Subtype: Link Rect: 60, 635, 293, 642 Annotation: Subtype: Link Rect: 60, 626, 293, 633 Annotation: Subtype: Link Rect: 60, 617, 293, 624 Annotation: Subtype: Link Rect: 60, 608, 146, 615 Annotation: Subtype: Link Rect: 60, 596, 293, 603 Annotation: Subtype: Link Rect: 60, 587, 141, 594 Annotation: Subtype: Link Rect: 60, 576, 293, 582 Annotation: Subtype: Link Rect: 60, 566, 293, 573 Annotation: Subtype: Link Rect: 60, 558, 285, 565 Annotation: Subtype: Link Rect: 60, 546, 293, 553 Annotation: Subtype: Link Rect: 60, 537, 293, 544 Annotation: Subtype: Link Rect: 60, 528, 95, 535 Annotation: Subtype: Link Rect: 60, 516, 293, 523 Annotation: Subtype: Link Rect: 60, 507, 293, 514 Annotation: Subtype: Link Rect: 60, 498, 293, 505 Annotation: Subtype: Link Rect: 60, 489, 95, 496 Annotation: Subtype: Link Rect: 60, 477, 293, 484 Annotation: Subtype: Link Rect: 60, 468, 293, 475 Annotation: Subtype: Link Rect: 60, 459, 293, 466 Annotation: Subtype: Link Rect: 60, 450, 201, 457 Annotation: Subtype: Link Rect: 60, 438, 293, 445 Annotation: Subtype: Link Rect: 60, 429, 293, 436 Annotation: Subtype: Link Rect: 60, 420, 293, 427 Annotation: Subtype: Link Rect: 60, 411, 88, 418 Annotation: Subtype: Link Rect: 60, 399, 293, 406 Annotation: Subtype: Link Rect: 60, 390, 293, 397 Annotation: Subtype: Link Rect: 60, 381, 293, 388 Annotation: Subtype: Link Rect: 60, 372, 88, 379 Annotation: Subtype: Link Rect: 60, 360, 293, 367 Annotation: Subtype: Link Rect: 60, 351, 293, 358 Annotation: Subtype: Link Rect: 60, 342, 246, 349 Annotation: Subtype: Link Rect: 60, 330, 293, 337 Annotation: Subtype: Link Rect: 60, 321, 293, 328 Annotation: Subtype: Link Rect: 60, 312, 293, 319 Annotation: Subtype: Link Rect: 60, 303, 118, 310 Annotation: Subtype: Link Rect: 60, 292, 293, 298 Annotation: Subtype: Link Rect: 60, 283, 293, 290 Annotation: Subtype: Link Rect: 60, 274, 184, 281 Annotation: Subtype: Link Rect: 60, 262, 293, 269 Annotation: Subtype: Link Rect: 60, 253, 293, 260 Annotation: Subtype: Link Rect: 60, 244, 268, 251 Annotation: Subtype: Link Rect: 320, 665, 554, 672 Annotation: Subtype: Link Rect: 320, 656, 541, 663 Annotation: Subtype: Link Rect: 320, 642, 554, 649 Annotation: Subtype: Link Rect: 320, 633, 554, 640 Annotation: Subtype: Link Rect: 320, 624, 554, 631 Annotation: Subtype: Link Rect: 320, 615, 335, 622 Annotation: Subtype: Link Rect: 320, 601, 554, 608 Annotation: Subtype: Link Rect: 320, 592, 554, 599 Annotation: Subtype: Link Rect: 320, 583, 554, 590 Annotation: Subtype: Link Rect: 320, 574, 539, 581 Annotation: Subtype: Link Rect: 320, 560, 554, 567 Annotation: Subtype: Link Rect: 320, 551, 554, 558 Annotation: Subtype: Link Rect: 320, 542, 549, 549 Annotation: Subtype: Link Rect: 320, 528, 554, 535 Annotation: Subtype: Link Rect: 320, 519, 554, 526 Annotation: Subtype: Link Rect: 320, 510, 554, 517 Annotation: Subtype: Link Rect: 320, 501, 516, 508 Annotation: Subtype: Link Rect: 320, 487, 554, 494 Annotation: Subtype: Link Rect: 320, 478, 554, 485 Annotation: Subtype: Link Rect: 320, 469, 480, 476 Annotation: Subtype: Link Rect: 320, 454, 554, 461 Annotation: Subtype: Link Rect: 320, 445, 554, 452 Annotation: Subtype: Link Rect: 320, 436, 437, 443 Annotation: Subtype: Link Rect: 320, 422, 554, 429 Annotation: Subtype: Link Rect: 320, 413, 554, 420 Annotation: Subtype: Link Rect: 320, 404, 487, 411 Annotation: Subtype: Link Rect: 320, 390, 554, 397 Annotation: Subtype: Link Rect: 320, 381, 533, 388 Annotation: Subtype: Link Rect: 320, 367, 554, 374 Annotation: Subtype: Link Rect: 320, 358, 554, 365 Annotation: Subtype: Link Rect: 320, 349, 554, 356 Annotation: Subtype: Link Rect: 320, 340, 388, 347 Annotation: Subtype: Link Rect: 320, 326, 554, 333 Annotation: Subtype: Link Rect: 320, 317, 554, 324 Annotation: Subtype: Link Rect: 320, 308, 554, 315 Annotation: Subtype: Link Rect: 320, 299, 494, 306 Annotation: Subtype: Link Rect: 320, 285, 554, 292 Annotation: Subtype: Link Rect: 320, 276, 434, 283 Annotation: Subtype: Link Rect: 439, 276, 547, 283 Annotation: Subtype: Link Rect: 320, 262, 554, 269 Annotation: Subtype: Link Rect: 320, 253, 554, 260 Annotation: Subtype: Link Rect: 320, 244, 338, 251 Checksum: 29114130 Type: CRC32 Checksum: fd4b0105d71126fb8e713af6543963bd Type: MD5 Checksum: 0b77d1480430a0f21a856c10e872aafb81fc8d64 Type: SHA-1