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Title:           MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment
Subject:         Cell Death Discovery, doi:10.1038/s41420-022-00959-w
Keywords:        
Author:          Clara Alcon
Creator:         Springer
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     Item: 
      Title: MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment
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      Children: 
       Item: 
        Title: Introduction
        Destination: A1
       Item: 
        Title: Results
        Destination: A2
        Children: 
         Item: 
          Title: Identification of new potential targeted agents to treat RMS using DBP
          Destination: B1
         Item: 
          Title: Combination of S63845 with MEK1/2 inhibitors to overcome therapy-induced resistance in RMS
          Destination: B2
         Item: 
          Title: BCL-xL and MCL-1 are key players in RMS cell death resistance
          Destination: B3
         Item: 
          Title: Trametinib promotes a protective decrease in NOXA: MCL-1 binding
          Destination: B4
         Item: 
          Title: Effective therapeutic combination of trametinib with the MCL-1 inhibitor S63845 in a PDX model of RMS
          Destination: B5
       Item: 
        Title: Discussion
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       Item: 
        Title: Materials and methods
        Destination: A4
        Children: 
         Item: 
          Title: Cell lines and treatments
          Destination: B6
         Item: 
          Title: Dynamic BH3 profiling
          Destination: B7
         Item: 
          Title: Cell death analysis
          Destination: B8
         Item: 
          Title: Protein extraction and quantification
          Destination: B9
         Item: 
          Title: Immunoprecipitation
          Destination: B10
         Item: 
          Title: Immunoblotting
          Destination: B11
         Item: 
          Title: Animals and human tissue
          Destination: B12
         Item: 
          Title: Development of rhabdomyosarcoma orthoxenograft mouse model
          Destination: B13
         Item: 
          Title: Drug treatment in ERMS RMSX2 orthoxenograft tumor
          Destination: B14
         Item: 
          Title: PDX cell isolation
          Destination: B15
         Item: 
          Title: Statistical analysis
          Destination: B16
       Item: 
        Title: References
        Destination: A5
       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Conflict of interest
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       Item: 
        Title: ACKNOWLEDGMENTS
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       Item: 
        Title: ADDITIONAL INFORMATION
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