d143216d6d48eed105cab7fca092bca8 pmc_9005794.pdf 76cd8136e04bd3b8dd067287fa0168decbd6414f pmc_9005794.pdf 94b81fe6709825b006b910cc6c73d2045a01833d200de6809daf585357bf8c07 pmc_9005794.pdf Title: Feasibility and Long-Term Compliance to Continuous Positive Airway Pressure Treatment in Adults With Down Syndrome, a Genetic Form of Alzheimer's Disease Subject: Background: Down syndrome (DS) is a genetic form of Alzheimer's disease (AD) with a high prevalence of obstructive sleep apnea (OSA). Keywords: obstructive sleep apnea, CPAP compliance, Down syndrome, Alzheimer's disease, sleep Author: Sandra Giménez Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Thu Mar 24 10:46:13 2022 CET ModDate: Thu Mar 24 10:46:13 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 788801 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GCGOVN+MinionPro-Regular Type 1 Custom yes yes no 24 0 JQJHBR+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 25 0 FRSOJU+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 26 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 31 0 VWUERQ+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 32 0 OGWGHP+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 33 0 XODHDR+RBLMI Type 1 Builtin yes yes no 111 0 CMERJW+MTGU Type 1 Builtin yes yes no 115 0 HXWBGA+MinionPro-Bold Type 1 Custom yes yes no 119 0 CRZVRZ+HelveticaNeueLTStd-Md Type 1 Custom yes yes no 170 0 JKFTQK+MinionPro-It Type 1 Custom yes yes no 178 0 XBRQWI+MTSYN Type 1 Builtin yes yes no 179 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-04-29 02:24:53 CEST RepresentationInformation: pmc_9005794.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-04-26 17:55:19 CEST Size: 788801 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 574 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Feasibility and Long-Term Compliance to Continuous Positive Airway Pressure Treatment in Adults With Down Syndrome, a Genetic Form of Alzheimer's Disease Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Study Population Item: Title: Procedures Children: Item: Title: Continuous Positive Airway Pressure Titration Item: Title: Continuous Positive Airway Pressure Follow up Visits Item: Title: Data Collection/Endpoints Item: Title: Statistical Analyses Item: Title: Results Item: Title: Discussion Item: Title: Disclosure Item: Title: Data Availability Statement Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Supplementary Material Item: Title: References Info: Title: Feasibility and Long-Term Compliance to Continuous Positive Airway Pressure Treatment in Adults With Down Syndrome, a Genetic Form of Alzheimer's Disease Author: Sandra Giménez Subject: Background: Down syndrome (DS) is a genetic form of Alzheimer's disease (AD) with a high prevalence of obstructive sleep apnea (OSA). Keywords: obstructive sleep apnea, CPAP compliance, Down syndrome, Alzheimer's disease, sleep Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Thu Mar 24 11:16:13 CET 2022 ModDate: Thu Mar 24 11:16:13 CET 2022 ID: 0xdc43d1641f5adac5c3e17b9af911e260, 0xdc43d1641f5adac5c3e17b9af911e260 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: VWUERQ+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 39 LastChar: 243 FontDescriptor: FontName: VWUERQ+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OGWGHP+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 233 FontDescriptor: FontName: OGWGHP+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JKFTQK+MinionPro-It FontSubset: true FirstChar: 19 LastChar: 233 FontDescriptor: FontName: JKFTQK+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CMERJW+MTGU FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: CMERJW+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: XBRQWI+MTSYN FontSubset: true FirstChar: 3 LastChar: 20 FontDescriptor: FontName: XBRQWI+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: HXWBGA+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: HXWBGA+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GCGOVN+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: GCGOVN+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JQJHBR+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 39 LastChar: 124 FontDescriptor: FontName: JQJHBR+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FRSOJU+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 233 FontDescriptor: FontName: FRSOJU+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CRZVRZ+HelveticaNeueLTStd-Md FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: CRZVRZ+HelveticaNeueLTStd-Md Flags: Symbolic FontBBox: -165, -221, 1066, 952 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CCVXXJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: CCVXXJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: XODHDR+RBLMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: XODHDR+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true XMP: obstructive sleep apnea, CPAP compliance, Down syndrome, Alzheimer's disease, sleep pdfTeX-1.40.15 1.5 application/pdf Feasibility and Long-Term Compliance to Continuous Positive Airway Pressure Treatment in Adults With Down Syndrome, a Genetic Form of Alzheimer's Disease Background: Down syndrome (DS) is a genetic form of Alzheimer's disease (AD) with a high prevalence of obstructive sleep apnea (OSA). Sandra Giménez obstructive sleep apnea CPAP compliance Down syndrome Alzheimer's disease sleep 2022-03-24T15:16:13+05:30 fnins-16-838412.tex 2022-03-24T15:16:13+05:30 2022-03-24T15:16:13+05:30 2022-03-24T15:16:13+05:30 LaTeX with hyperref package uuid:1dc95fd1-3e46-420a-88d1-8dc4cea88dc4 uuid:d18dc41d-13ea-4efd-84ce-4c9595413e41 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 43, 718, 163, 754 Annotation: Subtype: Link Rect: 474, 736, 551, 745 Annotation: Subtype: Link Rect: 470, 727, 551, 737 Annotation: Subtype: Link Rect: 451, 718, 551, 729 Annotation: Subtype: Link Rect: 86, 442, 160, 452 Annotation: Subtype: Link Rect: 74, 67, 160, 74 Annotation: Subtype: Link Rect: 521, 677, 551, 707 Annotation: Subtype: Link Rect: 176, 508, 551, 621 Annotation: Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 125, 29, 185, 38 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 222, 539, 268, 550 ActionDest: 393 Annotation: Subtype: Link Rect: 270, 539, 290, 550 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 527, 64, 539 ActionDest: 393 Annotation: Subtype: Link Rect: 84, 494, 134, 504 ActionDest: 393 Annotation: Subtype: Link Rect: 136, 494, 156, 504 ActionDest: 393 Annotation: Subtype: Link Rect: 47, 436, 103, 447 ActionDest: 443 Annotation: Subtype: Link Rect: 108, 436, 128, 447 ActionDest: 443 Annotation: Subtype: Link Rect: 278, 424, 292, 436 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 413, 65, 424 ActionDest: 393 Annotation: Subtype: Link Rect: 68, 413, 89, 424 ActionDest: 393 Annotation: Subtype: Link Rect: 133, 402, 178, 413 ActionDest: 443 Annotation: Subtype: Link Rect: 182, 402, 202, 413 ActionDest: 443 Annotation: Subtype: Link Rect: 206, 402, 266, 413 ActionDest: 393 Annotation: Subtype: Link Rect: 270, 402, 290, 413 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 390, 64, 401 ActionDest: 393 Annotation: Subtype: Link Rect: 66, 390, 120, 401 ActionDest: 393 Annotation: Subtype: Link Rect: 123, 390, 143, 401 ActionDest: 393 Annotation: Subtype: Link Rect: 47, 368, 99, 378 ActionDest: 393 Annotation: Subtype: Link Rect: 102, 368, 122, 378 ActionDest: 393 Annotation: Subtype: Link Rect: 47, 310, 95, 321 ActionDest: 393 Annotation: Subtype: Link Rect: 101, 310, 121, 321 ActionDest: 393 Annotation: Subtype: Link Rect: 259, 287, 292, 298 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 275, 95, 287 ActionDest: 393 Annotation: Subtype: Link Rect: 100, 275, 121, 287 ActionDest: 393 Annotation: Subtype: Link Rect: 261, 241, 292, 252 ActionDest: 443 Annotation: Subtype: Link Rect: 43, 230, 63, 241 ActionDest: 443 Annotation: Subtype: Link Rect: 66, 230, 86, 241 ActionDest: 443 Annotation: Subtype: Link Rect: 88, 230, 131, 241 ActionDest: 393 Annotation: Subtype: Link Rect: 133, 230, 153, 241 ActionDest: 393 Annotation: Subtype: Link Rect: 156, 230, 176, 241 ActionDest: 393 Annotation: Subtype: Link Rect: 235, 195, 290, 206 ActionDest: 443 Annotation: Subtype: Link Rect: 43, 184, 64, 195 ActionDest: 443 Annotation: Subtype: Link Rect: 161, 149, 203, 161 ActionDest: 443 Annotation: Subtype: Link Rect: 207, 149, 227, 161 ActionDest: 443 Annotation: Subtype: Link Rect: 243, 126, 290, 138 ActionDest: 443 Annotation: Subtype: Link Rect: 43, 115, 64, 126 ActionDest: 443 Annotation: Subtype: Link Rect: 361, 581, 411, 592 ActionDest: 443 Annotation: Subtype: Link Rect: 414, 581, 435, 592 ActionDest: 443 Annotation: Subtype: Link Rect: 438, 581, 490, 592 ActionDest: 393 Annotation: Subtype: Link Rect: 493, 581, 513, 592 ActionDest: 393 Annotation: Subtype: Link Rect: 371, 535, 429, 546 ActionDest: 393 Annotation: Subtype: Link Rect: 436, 535, 456, 546 ActionDest: 393 Annotation: Subtype: Link Rect: 407, 501, 457, 512 ActionDest: 393 Annotation: Subtype: Link Rect: 463, 501, 483, 512 ActionDest: 393 Annotation: Subtype: Link Rect: 490, 501, 549, 512 ActionDest: 443 Annotation: Subtype: Link Rect: 302, 490, 322, 500 ActionDest: 443 Annotation: Subtype: Link Rect: 372, 455, 417, 466 ActionDest: 393 Annotation: Subtype: Link Rect: 421, 455, 441, 466 ActionDest: 393 Annotation: Subtype: Link Rect: 445, 455, 503, 466 ActionDest: 393 Annotation: Subtype: Link Rect: 507, 455, 527, 466 ActionDest: 393 Annotation: Subtype: Link Rect: 376, 306, 412, 317 ActionDest: 393 Annotation: Subtype: Link Rect: 415, 306, 435, 317 ActionDest: 393 Annotation: Subtype: Link Rect: 437, 306, 490, 317 ActionDest: 393 Annotation: Subtype: Link Rect: 492, 306, 512, 317 ActionDest: 393 Annotation: Subtype: Link Rect: 451, 156, 504, 167 ActionDest: 393 Annotation: Subtype: Link Rect: 507, 156, 527, 167 ActionDest: 393 Annotation: Subtype: Link Rect: 514, 134, 551, 144 ActionDest: 393 Annotation: Subtype: Link Rect: 302, 122, 322, 133 ActionDest: 393 Annotation: Subtype: Link Rect: 325, 122, 345, 133 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 125, 29, 185, 38 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 47, 696, 101, 706 ActionDest: 393 Annotation: Subtype: Link Rect: 103, 696, 124, 706 ActionDest: 393 Annotation: Subtype: Link Rect: 119, 201, 173, 212 ActionDest: 393 Annotation: Subtype: Link Rect: 176, 201, 196, 212 ActionDest: 393 Annotation: Subtype: Link Rect: 529, 626, 551, 637 ActionDest: 443 Annotation: Subtype: Link Rect: 302, 614, 322, 626 ActionDest: 443 Annotation: Subtype: Link Rect: 324, 614, 344, 626 ActionDest: 443 Annotation: Subtype: Link Rect: 350, 378, 389, 388 ActionDest: 443 Annotation: Subtype: Link Rect: 391, 378, 411, 388 ActionDest: 443 Annotation: Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 125, 29, 185, 38 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 406, 419, 436, 431 ActionDest: 192 Annotation: Subtype: Link Rect: 338, 316, 372, 328 ActionDest: 192 Annotation: Subtype: Link Rect: 488, 133, 551, 144 ActionDest: 393 Annotation: Subtype: Link Rect: 302, 122, 335, 133 ActionDest: 393 Annotation: Subtype: Link Rect: 461, 76, 506, 87 ActionDest: 239 Annotation: Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 125, 29, 185, 38 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 124, 306, 160, 317 ActionDest: 305 Annotation: Subtype: Link Rect: 75, 271, 107, 282 ActionDest: 192 Annotation: Subtype: Link Rect: 245, 248, 287, 260 ActionDest: 239 Annotation: Subtype: Link Rect: 248, 202, 279, 214 ActionDest: 192 Annotation: Subtype: Link Rect: 348, 225, 392, 236 ActionDest: 443 Annotation: Subtype: Link Rect: 397, 225, 417, 236 ActionDest: 443 Annotation: Subtype: Link Rect: 305, 202, 357, 213 ActionDest: 443 Annotation: Subtype: Link Rect: 361, 202, 381, 213 ActionDest: 443 Annotation: Subtype: Link Rect: 345, 191, 405, 202 ActionDest: 443 Annotation: Subtype: Link Rect: 408, 191, 428, 202 ActionDest: 443 Annotation: Subtype: Link Rect: 406, 179, 470, 190 ActionDest: 443 Annotation: Subtype: Link Rect: 473, 179, 493, 190 ActionDest: 443 Annotation: Subtype: Link Rect: 497, 179, 549, 190 ActionDest: 393 Annotation: Subtype: Link Rect: 302, 167, 322, 179 ActionDest: 393 Annotation: Subtype: Link Rect: 305, 133, 368, 144 ActionDest: 443 Annotation: Subtype: Link Rect: 371, 133, 392, 144 ActionDest: 443 Annotation: Subtype: Link Rect: 394, 133, 445, 144 ActionDest: 393 Annotation: Subtype: Link Rect: 448, 133, 468, 144 ActionDest: 393 Annotation: Subtype: Link Rect: 471, 133, 522, 144 ActionDest: 393 Annotation: Subtype: Link Rect: 525, 133, 545, 144 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 125, 29, 185, 38 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 218, 351, 263, 363 ActionDest: 443 Annotation: Subtype: Link Rect: 267, 351, 287, 363 ActionDest: 443 Annotation: Subtype: Link Rect: 118, 328, 211, 340 ActionDest: 443 Annotation: Subtype: Link Rect: 215, 328, 236, 340 ActionDest: 443 Annotation: Subtype: Link Rect: 208, 317, 263, 328 ActionDest: 393 Annotation: Subtype: Link Rect: 267, 317, 287, 328 ActionDest: 393 Annotation: Subtype: Link Rect: 250, 294, 290, 305 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 282, 64, 294 ActionDest: 393 Annotation: Subtype: Link Rect: 96, 111, 180, 122 ActionDest: 443 Annotation: Subtype: Link Rect: 185, 111, 206, 122 ActionDest: 443 Annotation: Subtype: Link Rect: 211, 111, 265, 122 ActionDest: 443 Annotation: Subtype: Link Rect: 270, 111, 290, 122 ActionDest: 443 Annotation: Subtype: Link Rect: 43, 99, 89, 110 ActionDest: 443 Annotation: Subtype: Link Rect: 91, 99, 111, 110 ActionDest: 443 Annotation: Subtype: Link Rect: 114, 99, 195, 110 ActionDest: 393 Annotation: Subtype: Link Rect: 197, 99, 218, 110 ActionDest: 393 Annotation: Subtype: Link Rect: 305, 351, 385, 363 ActionDest: 443 Annotation: Subtype: Link Rect: 388, 351, 408, 363 ActionDest: 443 Annotation: Subtype: Link Rect: 414, 351, 468, 363 ActionDest: 443 Annotation: Subtype: Link Rect: 474, 351, 494, 363 ActionDest: 443 Annotation: Subtype: Link Rect: 476, 306, 525, 317 ActionDest: 393 Annotation: Subtype: Link Rect: 528, 306, 549, 317 ActionDest: 393 Annotation: Subtype: Link Rect: 302, 294, 351, 305 ActionDest: 443 Annotation: Subtype: Link Rect: 355, 294, 375, 305 ActionDest: 443 Annotation: Subtype: Link Rect: 431, 248, 476, 259 ActionDest: 393 Annotation: Subtype: Link Rect: 480, 248, 501, 259 ActionDest: 393 Annotation: Subtype: Link Rect: 383, 225, 433, 237 ActionDest: 393 Annotation: Subtype: Link Rect: 439, 225, 459, 237 ActionDest: 393 Annotation: Subtype: Link Rect: 465, 225, 519, 237 ActionDest: 393 Annotation: Subtype: Link Rect: 525, 225, 545, 237 ActionDest: 393 Annotation: Subtype: Link Rect: 443, 191, 502, 202 ActionDest: 443 Annotation: Subtype: Link Rect: 505, 191, 525, 202 ActionDest: 443 Annotation: Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 125, 29, 185, 38 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 138, 695, 193, 706 ActionDest: 393 Annotation: Subtype: Link Rect: 200, 695, 220, 706 ActionDest: 393 Annotation: Subtype: Link Rect: 226, 695, 290, 706 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 683, 64, 694 ActionDest: 393 Annotation: Subtype: Link Rect: 207, 683, 261, 694 ActionDest: 393 Annotation: Subtype: Link Rect: 267, 683, 287, 694 ActionDest: 393 Annotation: Subtype: Link Rect: 47, 637, 145, 648 ActionDest: 393 Annotation: Subtype: Link Rect: 149, 637, 169, 648 ActionDest: 393 Annotation: Subtype: Link Rect: 172, 637, 263, 648 ActionDest: 443 Annotation: Subtype: Link Rect: 267, 637, 287, 648 ActionDest: 443 Annotation: Subtype: Link Rect: 172, 614, 223, 626 ActionDest: 393 Annotation: Subtype: Link Rect: 229, 614, 249, 626 ActionDest: 393 Annotation: Subtype: Link Rect: 256, 614, 292, 626 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 603, 66, 614 ActionDest: 393 Annotation: Subtype: Link Rect: 72, 603, 92, 614 ActionDest: 393 Annotation: Subtype: Link Rect: 222, 465, 266, 477 ActionDest: 393 Annotation: Subtype: Link Rect: 270, 465, 290, 477 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 454, 101, 465 ActionDest: 443 Annotation: Subtype: Link Rect: 103, 454, 123, 465 ActionDest: 443 Annotation: Subtype: Link Rect: 129, 398, 218, 408 ActionDest: 443 Annotation: Subtype: Link Rect: 220, 398, 240, 408 ActionDest: 443 Annotation: Subtype: Link Rect: 278, 339, 292, 351 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 328, 66, 339 ActionDest: 393 Annotation: Subtype: Link Rect: 71, 328, 91, 339 ActionDest: 393 Annotation: Subtype: Link Rect: 96, 328, 151, 339 ActionDest: 443 Annotation: Subtype: Link Rect: 156, 328, 176, 339 ActionDest: 443 Annotation: Subtype: Link Rect: 180, 259, 237, 270 ActionDest: 393 Annotation: Subtype: Link Rect: 241, 259, 262, 270 ActionDest: 393 Annotation: Subtype: Link Rect: 266, 259, 292, 270 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 248, 65, 259 ActionDest: 393 Annotation: Subtype: Link Rect: 70, 248, 90, 259 ActionDest: 393 Annotation: Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 125, 29, 185, 38 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 357, 568, 551, 580 Annotation: Subtype: Link Rect: 302, 557, 465, 568 Annotation: Subtype: Link Rect: 247, 477, 293, 486 Annotation: Subtype: Link Rect: 53, 469, 103, 476 Annotation: Subtype: Link Rect: 197, 439, 272, 448 Annotation: Subtype: Link Rect: 204, 420, 293, 429 Annotation: Subtype: Link Rect: 53, 411, 80, 419 Annotation: Subtype: Link Rect: 103, 373, 200, 382 Annotation: Subtype: Link Rect: 164, 335, 263, 344 Annotation: Subtype: Link Rect: 232, 306, 293, 316 Annotation: Subtype: Link Rect: 53, 299, 75, 306 Annotation: Subtype: Link Rect: 82, 261, 169, 268 Annotation: Subtype: Link Rect: 93, 231, 190, 240 Annotation: Subtype: Link Rect: 135, 202, 231, 212 Annotation: Subtype: Link Rect: 279, 174, 293, 183 Annotation: Subtype: Link Rect: 53, 165, 154, 174 Annotation: Subtype: Link Rect: 170, 137, 284, 145 Annotation: Subtype: Link Rect: 251, 117, 293, 126 Annotation: Subtype: Link Rect: 53, 108, 96, 116 Annotation: Subtype: Link Rect: 184, 70, 255, 79 Annotation: Subtype: Link Rect: 492, 515, 551, 524 Annotation: Subtype: Link Rect: 312, 507, 341, 514 Annotation: Subtype: Link Rect: 487, 439, 551, 448 Annotation: Subtype: Link Rect: 312, 430, 365, 439 Annotation: Subtype: Link Rect: 468, 401, 549, 410 Annotation: Subtype: Link Rect: 312, 365, 406, 373 Annotation: Subtype: Link Rect: 526, 335, 551, 344 Annotation: Subtype: Link Rect: 312, 325, 396, 335 Annotation: Subtype: Link Rect: 494, 297, 551, 306 Annotation: Subtype: Link Rect: 312, 289, 328, 296 Annotation: Subtype: Link Rect: 312, 261, 402, 268 Annotation: Subtype: Link Rect: 537, 231, 551, 240 Annotation: Subtype: Link Rect: 312, 221, 373, 230 Annotation: Subtype: Link Rect: 494, 183, 551, 193 Annotation: Subtype: Link Rect: 312, 176, 337, 183 Annotation: Subtype: Link Rect: 377, 127, 476, 136 Annotation: Subtype: Link Rect: 491, 98, 551, 108 Annotation: Subtype: Link Rect: 312, 91, 334, 97 Annotation: Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 125, 29, 185, 38 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 140, 697, 240, 706 Annotation: Subtype: Link Rect: 192, 669, 289, 678 Annotation: Subtype: Link Rect: 201, 631, 293, 640 Annotation: Subtype: Link Rect: 53, 622, 80, 630 Annotation: Subtype: Link Rect: 279, 593, 293, 602 Annotation: Subtype: Link Rect: 53, 584, 148, 592 Annotation: Subtype: Link Rect: 82, 556, 186, 564 Annotation: Subtype: Link Rect: 191, 517, 287, 526 Annotation: Subtype: Link Rect: 100, 490, 217, 498 Annotation: Subtype: Link Rect: 252, 451, 293, 460 Annotation: Subtype: Link Rect: 53, 441, 86, 450 Annotation: Subtype: Link Rect: 90, 415, 180, 422 Annotation: Subtype: Link Rect: 90, 385, 190, 394 Annotation: Subtype: Link Rect: 399, 697, 497, 706 Annotation: Subtype: Link Rect: 431, 678, 531, 687 Annotation: Subtype: Link Rect: 462, 640, 551, 649 Annotation: Subtype: Link Rect: 312, 632, 339, 640 Annotation: Subtype: Link Rect: 341, 604, 421, 612 Annotation: Subtype: Link Rect: 496, 555, 551, 564 Annotation: Subtype: Link Rect: 312, 546, 361, 554 Annotation: Subtype: Link Rect: 524, 413, 551, 422 Annotation: Subtype: Link Rect: 302, 403, 334, 413 Annotation: Subtype: Link Rect: 335, 403, 370, 413 Annotation: Subtype: Link Rect: 371, 403, 395, 413 Annotation: Subtype: Link Rect: 396, 403, 424, 413 Annotation: Subtype: Link Rect: 43, 29, 122, 38 Annotation: Subtype: Link Rect: 125, 29, 185, 38 Annotation: Subtype: Link Rect: 426, 29, 551, 38 Checksum: 39117b06 Type: CRC32 Checksum: d143216d6d48eed105cab7fca092bca8 Type: MD5 Checksum: 76cd8136e04bd3b8dd067287fa0168decbd6414f Type: SHA-1