3b8f63335bcfa872299218a89ac1865e pmc_9009260.pdf 34ff510acde6496f9943e9cc2871deb969cdf118 pmc_9009260.pdf 4e5a1f17c099dbcffc0be5e4fd8386faa44182836ed7742911dc361988167b92 pmc_9009260.pdf Title: Poly-L-Lysine-Based αGal-Glycoconjugates for Treating Anti-αGal IgE-Mediated Diseases Subject: Anti-αGal IgE antibodies mediate a spreading allergic condition known as αGal-syndrome (AGS) Keywords: αGal-syndrome, poly-L-lysine-based αGal-glycoconjugates, anti-αGal IgE inhibition, GalT-KO mice, immunotherapy Author: Sara Olivera-Ardid Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed Mar 30 06:26:37 2022 CEST ModDate: Wed Mar 30 08:07:33 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 4482341 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ 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Type 1C Custom yes yes yes 423 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-07 02:29:16 CEST RepresentationInformation: pmc_9009260.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-04-26 17:54:45 CEST Size: 4482341 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B6' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B10' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B11' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B12' 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B53' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B74' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B67' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B71' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B75' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B76' cannot be 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B81' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B82' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B83' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B67' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B80' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B67' cannot be 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indirect destination - referenced object 'B15' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B80' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B46' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B86' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B15' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B53' cannot be found Offset: 4452026 ID: PDF-HUL-122 ErrorMessage: 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edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Human Serum Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: In Vitro Inhibition of Anti-αGal With Polymeric αGal-Glycoconjugates Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: α1,3-Galactosyltransferase Knocked Out (GalT-KO) Mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Amblyomma sculptum Salivary Gland Extract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: GalT-KO Mice Sensitization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Total Circulating Mouse IgM, IgG1, IgG2a, IgG2b, IgG3, and IgE by ELISA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: White Blood Cells by Flow Cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Prevalence of Anti-αGal IgE in αGal-Sensitized Subjects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Influence of the Multivalent αGal Exposure on the Inhibition of Anti-αGal IgE Antibodies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: In Vivo Inhibition of Anti-αGal IgE in Sensitized Mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Impact of Sensitization and Treatment With DP1000-RA0118 on Humoral and Cellular Immune Mediators Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Influence of Degree of Polymerization on the Differential Inhibition of Anti-αGal Isotypes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: DP1000-Glycopolymers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: DP600-Glycopolymers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: DP100-Glycopolymers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Supplementary Material Destination: 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Araujo Yara Ferrero-Alves Blanca Esther Garc&iacute a Figueroa Moisés Labrador-Horrillo Ana L. Garc&iacute a-Pérez Nicolai Bovin Rafael Mañez Anti-αGal IgE antibodies mediate a spreading allergic condition known as αGal-syndrome (AGS) αGal-syndrome poly-L-lysine-based αGal-glycoconjugates anti-αGal IgE inhibition GalT-KO mice immunotherapy uuid:864ccbcf-2611-49a7-af71-d8508942a58c uuid:e77981f0-d5bc-4d7c-90a3-8b36e8c679cd Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 611, 443, 632 Annotation: Subtype: Link Rect: 175, 588, 518, 609 Annotation: Subtype: Link Rect: 175, 565, 458, 586 Annotation: Subtype: Link Rect: 45, 29, 116, 36 Annotation: Subtype: Link Rect: 125, 29, 183, 36 Annotation: Subtype: Link Rect: 420, 29, 549, 36 Annotation: Subtype: Link Rect: 87, 424, 158, 432 Annotation: Subtype: Link Rect: 80, 265, 158, 272 Annotation: Subtype: Link Rect: 57, 64, 158, 71 Annotation: Subtype: Link Rect: 475, 736, 549, 743 Annotation: Subtype: Link Rect: 470, 728, 549, 735 Annotation: Subtype: Link Rect: 448, 720, 549, 727 Annotation: Subtype: Link Rect: 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