69d6855c689f63b1ef44205aadb95756 pmc_9015758.pdf 5d3a88dad2c3bf0cfa3bfb038ae2b3a355e6fb9d pmc_9015758.pdf 061847570dcc8c74dfe5f6b7460c12c7386a15de1d59542e140b8ab9b1d22521 pmc_9015758.pdf Title: Untitled Author: Unknown Creator: XEP 3.8.4 Server Stamped Producer: XEP PDF Generator – RenderX, Inc. CreationDate: Thu Mar 31 11:00:55 2022 CEST ModDate: Thu Mar 31 11:00:55 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 832950 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Helvetica Type 1 Standard no no yes 8 0 Times-Roman Type 1 Standard no no yes 9 0 Times-Roman Type 1 Custom no no yes 10 0 Times-Bold Type 1 Standard no no yes 11 0 Helvetica-Oblique Type 1 Standard no no yes 12 0 Times-Italic Type 1 Standard no no yes 13 0 Helvetica-Bold Type 1 Standard no no yes 17 0 Times-BoldItalic Type 1 Standard no no yes 22 0 GFEDCB+�S CID TrueType Identity-H yes yes yes 23 0 Symbol Type 1 Symbol no no yes 42 0 Times-Italic Type 1 Custom no no yes 190 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-05-24 02:25:06 CEST RepresentationInformation: pmc_9015758.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-04-26 17:54:18 CEST Size: 832950 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 321 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Info: Title: Untitled Author: Unknown Creator: XEP 3.8.4 Server Stamped Producer: XEP PDF Generator   RenderX, Inc. CreationDate: Thu Mar 31 09:00:55 CEST 2022 ModDate: Thu Mar 31 09:00:55 CEST 2022 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1170 ImageHeight: 1200 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1000 ImageHeight: 1200 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1080 ImageHeight: 540 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1200 ImageHeight: 736 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type0: Font: BaseFont: GFEDCB+ÑS Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: Helvetica-Bold FirstChar: 32 LastChar: 251 FontDescriptor: FontName: Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 ToUnicode: true Font: BaseFont: Times-BoldItalic FirstChar: 32 LastChar: 251 FontDescriptor: FontName: Times-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -200, -218, 996, 921 ToUnicode: true Font: BaseFont: Helvetica FirstChar: 32 LastChar: 251 FontDescriptor: FontName: Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 ToUnicode: true Font: BaseFont: Times-Roman FirstChar: 32 LastChar: 251 FontDescriptor: FontName: Times-Roman Flags: Nonsymbolic FontBBox: -168, -218, 1000, 898 ToUnicode: true Font: BaseFont: Times-Roman FirstChar: 0 LastChar: 10 FontDescriptor: FontName: Times-Roman Flags: Nonsymbolic FontBBox: -168, -218, 1000, 898 EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Symbol FirstChar: 32 LastChar: 254 FontDescriptor: FontName: Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 ToUnicode: true Font: BaseFont: Times-Bold FirstChar: 32 LastChar: 251 FontDescriptor: FontName: Times-Bold Flags: Nonsymbolic, ForceBold FontBBox: -168, -218, 1000, 935 ToUnicode: true Font: BaseFont: Helvetica-Oblique FirstChar: 32 LastChar: 251 FontDescriptor: FontName: Helvetica-Oblique Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 ToUnicode: true Font: BaseFont: Times-Italic FirstChar: 32 LastChar: 251 FontDescriptor: FontName: Times-Italic Flags: Nonsymbolic, Italic FontBBox: -169, -217, 1010, 883 ToUnicode: true Font: BaseFont: Times-Italic FirstChar: 0 LastChar: 0 FontDescriptor: FontName: Times-Italic Flags: Nonsymbolic, Italic FontBBox: -169, -217, 1010, 883 EncodingDictionary: Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: GFEDCB+ÑS CIDSystemInfo: Registry: Adobe Registry: Supplement: 0 FontDescriptor: FontName: GFEDCB+ÑS Flags: Symbolic FontBBox: -11, -156, 996, 859 FontFile2: true Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 71, 377, 137, 386 Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 214, 685, 274, 694 Annotation: Subtype: Link Rect: 280, 497, 285, 506 Destination: 127 Annotation: Subtype: Link Rect: 160, 473, 165, 482 Destination: 127 Annotation: Subtype: Link Rect: 94, 449, 99, 458 Destination: 127 Annotation: Subtype: Link Rect: 103, 449, 108, 458 Destination: 127 Annotation: Subtype: Link Rect: 164, 401, 169, 410 Destination: 127 Annotation: Subtype: Link Rect: 132, 299, 137, 308 Destination: 127 Annotation: Subtype: Link Rect: 107, 239, 112, 248 Destination: 127 Annotation: Subtype: Link Rect: 67, 215, 72, 224 Destination: 127 Annotation: Subtype: Link Rect: 250, 101, 255, 110 Destination: 127 Annotation: Subtype: Link Rect: 475, 253, 485, 262 Destination: 127 Annotation: Subtype: Link Rect: 369, 193, 379, 202 Destination: 127 Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 489, 592, 499, 601 Destination: 127 Annotation: Subtype: Link Rect: 351, 508, 361, 517 Destination: 127 Annotation: Subtype: Link Rect: 452, 434, 483, 443 Destination: 49 Annotation: Subtype: Link Rect: 391, 386, 424, 395 Destination: 55 Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 98, 720, 132, 729 Destination: 55 Annotation: Subtype: Link Rect: 147, 660, 157, 669 Destination: 127 Annotation: Subtype: Link Rect: 160, 660, 170, 669 Destination: 127 Annotation: Subtype: Link Rect: 67, 342, 100, 351 Destination: 55 Annotation: Subtype: Link Rect: 262, 284, 272, 293 Destination: 127 Annotation: Subtype: Link Rect: 275, 272, 285, 281 Destination: 127 Annotation: Subtype: Link Rect: 343, 736, 353, 745 Destination: 127 Annotation: Subtype: Link Rect: 412, 712, 422, 721 Destination: 127 Annotation: Subtype: Link Rect: 536, 676, 546, 685 Destination: 127 Annotation: Subtype: Link Rect: 521, 604, 531, 613 Destination: 127 Annotation: Subtype: Link Rect: 421, 526, 455, 535 Destination: 80 Annotation: Subtype: Link Rect: 482, 298, 515, 307 Destination: 80 Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 265, 732, 291, 741 Destination: 87 Annotation: Subtype: Link Rect: 42, 720, 47, 729 Destination: 87 Annotation: Subtype: Link Rect: 373, 291, 406, 300 Destination: 97 Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 425, 115, 435, 124 Destination: 127 Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 263, 604, 273, 613 Destination: 127 Annotation: Subtype: Link Rect: 275, 604, 285, 613 Destination: 186 Annotation: Subtype: Link Rect: 117, 414, 122, 423 Destination: 127 Annotation: Subtype: Link Rect: 151, 378, 161, 387 Destination: 186 Annotation: Subtype: Link Rect: 164, 378, 174, 387 Destination: 186 Annotation: Subtype: Link Rect: 65, 354, 70, 363 Destination: 127 Annotation: Subtype: Link Rect: 165, 264, 175, 273 Destination: 127 Annotation: Subtype: Link Rect: 460, 748, 470, 757 Destination: 186 Annotation: Subtype: Link Rect: 472, 748, 482, 757 Destination: 186 Annotation: Subtype: Link Rect: 473, 712, 483, 721 Destination: 186 Annotation: Subtype: Link Rect: 486, 712, 496, 721 Destination: 186 Annotation: Subtype: Link Rect: 333, 610, 343, 619 Destination: 186 Annotation: Subtype: Link Rect: 378, 388, 388, 397 Destination: 186 Annotation: Subtype: Link Rect: 390, 388, 400, 397 Destination: 186 Annotation: Subtype: Link Rect: 362, 318, 372, 327 Destination: 186 Annotation: Subtype: Link Rect: 375, 318, 385, 327 Destination: 186 Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 87, 736, 202, 745 Annotation: Subtype: Link Rect: 249, 736, 289, 745 Annotation: Subtype: Link Rect: 69, 700, 130, 709 Annotation: Subtype: Link Rect: 157, 700, 217, 709 Annotation: Subtype: Link Rect: 265, 700, 305, 709 Annotation: Subtype: Link Rect: 510, 676, 552, 685 Annotation: Subtype: Link Rect: 66, 664, 81, 673 Annotation: Subtype: Link Rect: 108, 664, 242, 673 Annotation: Subtype: Link Rect: 290, 664, 330, 673 Annotation: Subtype: Link Rect: 261, 640, 321, 649 Annotation: Subtype: Link Rect: 349, 640, 483, 649 Annotation: Subtype: Link Rect: 66, 628, 106, 637 Annotation: Subtype: Link Rect: 340, 604, 398, 613 Annotation: Subtype: Link Rect: 423, 604, 549, 613 Annotation: Subtype: Link Rect: 108, 592, 148, 601 Annotation: Subtype: Link Rect: 445, 568, 505, 577 Annotation: Subtype: Link Rect: 66, 556, 126, 565 Annotation: Subtype: Link Rect: 174, 556, 214, 565 Annotation: Subtype: Link Rect: 379, 532, 507, 541 Annotation: Subtype: Link Rect: 66, 520, 106, 529 Annotation: Subtype: Link Rect: 69, 496, 130, 505 Annotation: Subtype: Link Rect: 157, 496, 277, 505 Annotation: Subtype: Link Rect: 325, 496, 365, 505 Annotation: Subtype: Link Rect: 69, 460, 130, 469 Annotation: Subtype: Link Rect: 157, 460, 217, 469 Annotation: Subtype: Link Rect: 265, 460, 305, 469 Annotation: Subtype: Link Rect: 469, 436, 528, 445 Annotation: Subtype: Link Rect: 66, 424, 171, 433 Annotation: Subtype: Link Rect: 219, 424, 259, 433 Annotation: Subtype: Link Rect: 347, 400, 449, 409 Annotation: Subtype: Link Rect: 463, 376, 530, 385 Annotation: Subtype: Link Rect: 333, 364, 434, 373 Annotation: Subtype: Link Rect: 358, 340, 418, 349 Annotation: Subtype: Link Rect: 444, 340, 549, 349 Annotation: Subtype: Link Rect: 108, 328, 148, 337 Annotation: Subtype: Link Rect: 168, 292, 228, 301 Annotation: Subtype: Link Rect: 255, 292, 353, 301 Annotation: Subtype: Link Rect: 401, 292, 441, 301 Annotation: Subtype: Link Rect: 229, 268, 393, 277 Annotation: Subtype: Link Rect: 440, 268, 480, 277 Annotation: Subtype: Link Rect: 296, 244, 416, 253 Annotation: Subtype: Link Rect: 464, 244, 504, 253 Annotation: Subtype: Link Rect: 236, 232, 552, 241 Annotation: Subtype: Link Rect: 66, 220, 143, 229 Annotation: Subtype: Link Rect: 347, 196, 407, 205 Annotation: Subtype: Link Rect: 434, 196, 503, 205 Annotation: Subtype: Link Rect: 66, 184, 106, 193 Annotation: Subtype: Link Rect: 87, 148, 220, 157 Annotation: Subtype: Link Rect: 390, 124, 450, 133 Annotation: Subtype: Link Rect: 66, 112, 201, 121 Annotation: Subtype: Link Rect: 249, 112, 289, 121 Annotation: Subtype: Link Rect: 164, 76, 225, 85 Annotation: Subtype: Link Rect: 273, 76, 313, 85 Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 349, 748, 410, 757 Annotation: Subtype: Link Rect: 437, 748, 539, 757 Annotation: Subtype: Link Rect: 108, 736, 148, 745 Annotation: Subtype: Link Rect: 449, 712, 533, 721 Annotation: Subtype: Link Rect: 108, 700, 148, 709 Annotation: Subtype: Link Rect: 148, 676, 209, 685 Annotation: Subtype: Link Rect: 236, 676, 356, 685 Annotation: Subtype: Link Rect: 404, 676, 444, 685 Annotation: Subtype: Link Rect: 284, 652, 399, 661 Annotation: Subtype: Link Rect: 447, 652, 487, 661 Annotation: Subtype: Link Rect: 342, 628, 401, 637 Annotation: Subtype: Link Rect: 427, 628, 549, 637 Annotation: Subtype: Link Rect: 108, 616, 148, 625 Annotation: Subtype: Link Rect: 239, 592, 299, 601 Annotation: Subtype: Link Rect: 326, 592, 461, 601 Annotation: Subtype: Link Rect: 508, 592, 548, 601 Annotation: Subtype: Link Rect: 277, 556, 337, 565 Annotation: Subtype: Link Rect: 363, 556, 462, 565 Annotation: Subtype: Link Rect: 509, 556, 549, 565 Annotation: Subtype: Link Rect: 471, 544, 552, 553 Annotation: Subtype: Link Rect: 66, 532, 403, 541 Annotation: Subtype: Link Rect: 336, 508, 427, 517 Annotation: Subtype: Link Rect: 474, 508, 514, 517 Annotation: Subtype: Link Rect: 193, 484, 313, 493 Annotation: Subtype: Link Rect: 361, 484, 396, 493 Annotation: Subtype: Link Rect: 69, 448, 130, 457 Annotation: Subtype: Link Rect: 157, 448, 217, 457 Annotation: Subtype: Link Rect: 265, 448, 305, 457 Annotation: Subtype: Link Rect: 479, 424, 539, 433 Annotation: Subtype: Link Rect: 87, 412, 148, 421 Annotation: Subtype: Link Rect: 196, 412, 236, 421 Annotation: Subtype: Link Rect: 93, 184, 232, 191 Annotation: Subtype: Link Rect: 88, 174, 139, 181 Annotation: Subtype: Link Rect: 98, 163, 132, 171 Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 6, 17, 49, 40 Annotation: Subtype: Link Rect: 6, 5, 49, 17 Checksum: 69b00712 Type: CRC32 Checksum: 69d6855c689f63b1ef44205aadb95756 Type: MD5 Checksum: 5d3a88dad2c3bf0cfa3bfb038ae2b3a355e6fb9d Type: SHA-1