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Title:           Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa
Subject:         Cell Death and Disease, doi:10.1038/s41419-022-04839-0
Keywords:        
Author:          Alonso Sánchez-Cruz
Creator:         Springer
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     Item: 
      Title: Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa
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       Item: 
        Title: Introduction
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       Item: 
        Title: Materials and methods
        Destination: A2
        Children: 
         Item: 
          Title: Animals
          Destination: B1
         Item: 
          Title: Generation and administration of adeno-associated viral vectors
          Destination: B2
         Item: 
          Title: Measurement of proinsulin, insulin, and glycaemia
          Destination: B3
         Item: 
          Title: RNA isolation and RT-PCR
          Destination: B4
         Item: 
          Title: Immunofluorescence and image analysis
          Destination: B5
         Item: 
          Title: Transmission electron microscopy
          Destination: B6
         Item: 
          Title: ERG recordings and optomotor tests
          Destination: B7
         Item: 
          Title: Cell death analysis
          Destination: B8
         Item: 
          Title: Statistical analysis
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       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: Insulin receptor expression and signaling in WT and rd10 mouse retinas
          Destination: B10
         Item: 
          Title: Analysis of synaptic ultrastructure in the OPL of WT and rd10 mouse retinas
          Destination: B11
         Item: 
          Title: Systemically-provided human proinsulin reaches the retina and exerts no metabolic effect
          Destination: B12
         Item: 
          Title: AAV-hPi treatment in rd10 mice preserves photoreceptors and photoreceptor synaptic connectivity
          Destination: B13
         Item: 
          Title: AAV-hPi treatment in rd10 mice preserves visual function
          Destination: B14
       Item: 
        Title: Discussion
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       Item: 
        Title: References
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       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Funding
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       Item: 
        Title: Competing interests
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        Title: Ethics statement
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        Title: ADDITIONAL INFORMATION
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