dd3b1a0c34461c5629af8a9c214bcb04 pmc_9028514.pdf 5fa6426ca45a3ebd9f3295ac10c83b9b966e8752 pmc_9028514.pdf eda3149b94971a30d41e150453633c6f18a22b0714ce890e342fdcff78b80b82 pmc_9028514.pdf Title: Avian Neuropeptide Y: Beyond Feed Intake Regulation Subject: Neuropeptide Y (NPY) is one of the most abundant and ubiquitously expressed neuropeptides in both the central and peripheral nervous systems, and its regulatory effects on feed intake and appetite- have been extensively studied in a wide variety of animals, including mammalian and non-mammalian species. Indeed, NPY has been shown to be involved in the regulation of feed intake and energy homeostasis by exerting stimulatory effects on appetite and feeding behavior in several species including chickens, rabbits, rats and mouse. More recent studies have shown that this neuropeptide and its receptors are expressed in various peripheral tissues, including the thyroid, heart, spleen, adrenal glands, white adipose tissue, muscle and bone. Although well researched centrally, studies investigating the distribution and function of peripherally expressed NPY in avian (non-mammalian vertebrates) species are very limited. Thus, peripherally expressed NPY merits more consideration and further in-depth exploration to fully elucidate its functions, especially in non-mammalian species. The aim of the current review is to provide an integrated synopsis of both centrally and peripherally expressed NPY, with a special focus on the distribution and function of the latter. Keywords: neuropeptide Y; feed intake regulation; adipose tissue; liver; immune system; gut; muscle; bone; chickens Author: Elizabeth S. Greene, Nedra Abdelli, Jalila S. Dridi and Sami Dridi Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Apr 1 12:08:23 2022 CEST ModDate: Fri Apr 1 12:11:33 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1817971 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GKJMJP+VnURWPalladioL Type 1 Custom yes yes no 10 0 NAYAEY+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 GLPYGD+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 MJHKWQ+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 32 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 36 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 40 0 CTCXDQ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 52 0 GOCQIR+EURM10 Type 1 Builtin yes yes no 69 0 NFOLJJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 79 0 NFOLJK+PalatinoLinotype CID TrueType Identity-H yes yes yes 82 0 NFOLJL+PalatinoLinotype TrueType WinAnsi yes yes no 88 0 NFOLJN+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 91 0 NFOLJJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 101 0 NFOLJK+PalatinoLinotype CID TrueType Identity-H yes yes yes 104 0 NFOLJL+PalatinoLinotype TrueType WinAnsi yes yes no 110 0 NFOLJN+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 113 0 NFOLJJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 126 0 NFOLJK+PalatinoLinotype CID TrueType Identity-H yes yes yes 129 0 NFOLJL+PalatinoLinotype TrueType WinAnsi yes yes no 135 0 NFOLJN+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 138 0 NFOLJJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 148 0 NFOLJL+PalatinoLinotype TrueType WinAnsi yes yes no 151 0 NFOLJN+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 154 0 XYPWHM+CMSY10 Type 1 Builtin yes yes no 161 0 KWZIYW+SFRM1000 Type 1 Custom yes yes no 171 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-12-23 02:27:15 CET RepresentationInformation: pmc_9028514.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-12-14 02:19:05 CET Size: 1817971 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 670 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4923ab24 Item: Title: Structure of NPY Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: NPY Receptors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: NPY Downstream Signaling Cascades Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Tissue Distribution of NPY System Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Physiological Functions of NPY Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Children: Item: Title: Central Functions of NPY Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Peripheral Functions of NPY Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: NPY in Adipose Tissue Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: NPY in the Liver Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: NPY in the Muscle Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: NPY in the Bone Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: NPY in Macrophage and Immune System Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: NPY in the Gut Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Regulation of Avian NPY Expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Conclusions and Perspectives Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Info: Title: Avian Neuropeptide Y: Beyond Feed Intake Regulation Author: Elizabeth S. Greene, Nedra Abdelli, Jalila S. Dridi and Sami Dridi Subject: Neuropeptide Y (NPY) is one of the most abundant and ubiquitously expressed neuropeptides in both the central and peripheral nervous systems, and its regulatory effects on feed intake and appetite- have been extensively studied in a wide variety of animals, including mammalian and non-mammalian species. Indeed, NPY has been shown to be involved in the regulation of feed intake and energy homeostasis by exerting stimulatory effects on appetite and feeding behavior in several species including chickens, rabbits, rats and mouse. More recent studies have shown that this neuropeptide and its receptors are expressed in various peripheral tissues, including the thyroid, heart, spleen, adrenal glands, white adipose tissue, muscle and bone. Although well researched centrally, studies investigating the distribution and function of peripherally expressed NPY in avian (non-mammalian vertebrates) species are very limited. Thus, peripherally expressed NPY merits more consideration and further in-depth exploration to fully elucidate its functions, especially in non-mammalian species. The aim of the current review is to provide an integrated synopsis of both centrally and peripherally expressed NPY, with a special focus on the distribution and function of the latter. 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