dc1b43af468d9ffa51740b87d1652b84 pmc_9067321.pdf 81611ba692e74b8ce579eecd6920f26b444aef61 pmc_9067321.pdf 9ff8dc2449dd3b1ee6eb582ac9d2e32eb08512d7f523b06f97f5c3e2648d448e pmc_9067321.pdf Title: Molecular and Brain Volume Changes Following Aerobic Exercise, Cognitive and Combined Training in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial Subject: Behavioral interventions have shown promising neuroprotective effects, but the cascade of molecular, brain and behavioral changes involved in these benefits remains poorly understood. Keywords: aerobic exercise, computerized cognitive training, combined training, brain volume, BDNF, neuroinflammation Author: Rosalía Dacosta-Aguayo Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.16 CreationDate: Wed Apr 20 10:31:00 2022 CEST ModDate: Wed Apr 20 10:31:00 2022 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 993265 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HMEYEN+MinionPro-Regular Type 1 Custom yes yes no 24 0 GKKRTK+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 25 0 ETULET+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 26 0 SHFHQE+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 31 0 UHTSLB+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 32 0 QQNHSR+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 33 0 GCHJNM+RBLMI Type 1 Builtin yes yes no 34 0 JDKMNY+MTSYN Type 1 Builtin yes yes no 35 0 SMNVTA+MTGU Type 1 Builtin yes yes no 36 0 HLBUGZ+MinionPro-It Type 1 Custom yes yes no 174 0 GMZCDD+MinionPro-Bold Type 1 Custom yes yes no 350 0 ZYSVZX+HelveticaNeueLTStd-Md Type 1 Custom yes yes no 424 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-08 02:47:50 CEST RepresentationInformation: pmc_9067321.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-31 06:22:37 CEST Size: 993265 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1023 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Molecular and Brain Volume Changes Following Aerobic Exercise, Cognitive and Combined Training in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Study Design Item: Title: Participants Item: Title: Interventions Item: Title: Assessment Children: Item: Title: Blood Sample: Biomarkers at Level 1 Item: Title: Neuroimaging: Biomarkers at Level 2 Item: Title: Physical Activity Item: Title: Cardiorespiratory Fitness Item: Title: Cognitive Performance Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: Participants Item: Title: Intervention-Related Changes in Molecular Biomarkers Item: Title: Intervention-Related Changes in Brain Volume Item: Title: Relation Between Biomarkers at Levels 1 and 2 and Changes in Physical Activity Outcomes Item: Title: Sex and Age Moderation Effects on Biomarkers at Levels 1 and 2 Item: Title: Mediation Effects on Intervention-Related Cognitive Benefits Item: Title: Discussion Children: Item: Title: Limitations Item: Title: Conclusion Item: Title: Data Availability Statement Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Supplementary Material Item: Title: References Info: Title: Molecular and Brain Volume Changes Following Aerobic Exercise, Cognitive and Combined Training in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial Author: Rosalía Dacosta-Aguayo Subject: Behavioral interventions have shown promising neuroprotective effects, but the cascade of molecular, brain and behavioral changes involved in these benefits remains poorly understood. 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