63b706fa59c08b9728bb4846a3cc726c pmc_9091996.pdf d037397a343790fa5beb3388f36254276275d93f pmc_9091996.pdf b1d2ec7a29388d5b18c0cd43c38cd21b0b6eca2820f9a17c72eb4caaabd0a8bd pmc_9091996.pdf Title: Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non‐cell‐autonomous neuronal damage Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sat Apr 30 11:48:08 2022 CEST ModDate: Sat Apr 30 11:48:49 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 4692411 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GECGPC+STIXTwoText Type 1C Custom yes yes yes 238 0 GECHHA+STIXTwoText-Bold Type 1C Custom yes yes yes 243 0 GECHIB+STIXTwoText-Italic Type 1C Custom yes yes yes 248 0 GECOLG+STIXTwoMath Type 1C WinAnsi yes yes no 143 0 GEEMBC+STIX-Regular Type 1C Custom yes yes yes 146 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-22 02:32:38 CEST RepresentationInformation: pmc_9091996.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-06-16 02:18:30 CEST Size: 4692411 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ctm2837-supitem-0001' cannot be found Offset: 4671939 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ctm2837-supitem-0001' cannot be found Offset: 4671939 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ctm2837-supitem-0001' cannot be found Offset: 4671939 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ctm2837-supitem-0001' cannot be found Offset: 4671939 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ctm2837-supitem-0001' cannot be found Offset: 4671939 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ctm2837-supitem-0001' cannot be found Offset: 4671939 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ctm2837-supitem-0001' cannot be found Offset: 4671939 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ctm2837-supitem-0001' cannot be found Offset: 4671939 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ctm2837-supitem-0001' cannot be found Offset: 4671939 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 292 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non-cell-autonomous neuronal damage Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: CONFLICT OF INTEREST Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: FUNDING INFORMATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: ORCID Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: REFERENCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: SUPPORTING INFORMATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Info: Title: Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non‐cell‐autonomous neuronal damage Author: Subject: Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sat Apr 30 12:18:08 CEST 2022 ModDate: Sat Apr 30 12:18:49 CEST 2022 ID: 0xfa9945f816de144730b9aa1b0d00b786, 0xcfbf42deb8fd6131e53a1084bb456513 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 642 ImageHeight: 96 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2100 ImageHeight: 1964 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 642 ImageHeight: 96 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1913 ImageHeight: 2144 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 642 ImageHeight: 96 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1913 ImageHeight: 2074 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 642 ImageHeight: 96 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2100 ImageHeight: 2567 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 642 ImageHeight: 96 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 642 ImageHeight: 96 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 642 ImageHeight: 96 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 642 ImageHeight: 96 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: GEEMBC+STIX-Regular FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: GEEMBC+STIX-Regular Flags: Symbolic FontBBox: 62, 0, 665, 674 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GECHHA+STIXTwoText-Bold FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: GECHHA+STIXTwoText-Bold Flags: Serif, Symbolic FontBBox: -948, -434, 1429, 1047 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GECHIB+STIXTwoText-Italic FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: GECHIB+STIXTwoText-Italic Flags: Serif, Symbolic, Italic FontBBox: -893, -367, 1298, 1047 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GECGPC+STIXTwoText FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: GECGPC+STIXTwoText Flags: Serif, Symbolic FontBBox: -948, -373, 1297, 1047 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GECOLG+STIXTwoMath FontSubset: true FirstChar: 60 LastChar: 215 FontDescriptor: FontName: GECOLG+STIXTwoMath Flags: Nonsymbolic FontBBox: 43, -26, 658, 547 FontFile3: true Encoding: WinAnsiEncoding XMP: 2022-04-30T15:18:08+05:30 2022-04-30T15:18:49+05:30 2022-04-30T15:18:49+05:30 LaTeX with hyperref package Acrobat Distiller 10.0.0 (Windows) 10.1002/ctm2.837 10.1002/(ISSN)2001-1326 3 VoR 10.1002/ctm2.837 application/pdf Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non‐cell‐autonomous neuronal damage uuid:a86f7ccc-a830-34ec-a9ef-702c6852ad7d uuid:fb84aea9-682c-4f06-94b7-aa8661ac6714 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 185, 510, 189, 517 Destination: 37 Annotation: Subtype: Link Rect: 139, 351, 150, 360 Destination: null Annotation: Subtype: Link Rect: 223, 338, 236, 347 Destination: 1 Annotation: Subtype: Link Rect: 79, 312, 91, 321 Destination: 1 Annotation: Subtype: Link Rect: 77, 272, 101, 282 Destination: 1 Annotation: Subtype: Link Rect: 260, 259, 283, 269 Destination: 1 Annotation: Subtype: Link Rect: 131, 225, 137, 232 Destination: 37 Annotation: Subtype: Link Rect: 80, 183, 93, 191 Destination: 5 Annotation: Subtype: Link Rect: 144, 183, 155, 192 Destination: null Annotation: Subtype: Link Rect: 113, 143, 139, 153 Destination: 5 Annotation: Subtype: Link Rect: 102, 130, 126, 140 Destination: 5 Annotation: Subtype: Link Rect: 197, 71, 291, 78 Annotation: Subtype: Link Rect: 444, 558, 458, 567 Destination: 9 Annotation: Subtype: Link Rect: 403, 519, 414, 528 Destination: null Annotation: Subtype: Link Rect: 362, 468, 375, 476 Destination: 9 Annotation: Subtype: Link Rect: 494, 432, 500, 439 Destination: 37 Annotation: Subtype: Link Rect: 472, 420, 477, 426 Destination: 37 Annotation: Subtype: Link Rect: 494, 403, 508, 412 Destination: 9 Annotation: Subtype: Link Rect: 305, 390, 317, 399 Destination: null Annotation: Subtype: Link Rect: 366, 351, 379, 360 Destination: 9 Annotation: Subtype: Link Rect: 533, 286, 547, 295 Destination: 9 Annotation: Subtype: Link Rect: 389, 273, 402, 282 Destination: 9 Annotation: Subtype: Link Rect: 472, 247, 484, 256 Destination: 9 Annotation: Subtype: Link Rect: 404, 235, 418, 243 Destination: 9 Annotation: Subtype: Link Rect: 387, 172, 398, 180 Destination: 132 Annotation: Subtype: Link Rect: 532, 105, 544, 114 Destination: null Annotation: Subtype: Link Rect: 405, 31, 516, 39 Annotation: Subtype: Link Rect: 44, 21, 141, 29 Thumb: true Page: Label: 2 Thumb: true Page: Label: 3 Thumb: true Page: Label: 4 Thumb: true Page: Label: 5 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 269, 699, 283, 708 Destination: 9 Annotation: Subtype: Link Rect: 180, 637, 190, 645 Destination: 132 Annotation: Subtype: Link Rect: 199, 599, 204, 606 Destination: 132 Annotation: Subtype: Link Rect: 153, 452, 180, 462 Destination: 13 Annotation: Subtype: Link Rect: 78, 350, 92, 359 Destination: 13 Annotation: Subtype: Link Rect: 139, 350, 150, 359 Destination: null Annotation: Subtype: Link Rect: 157, 301, 166, 308 Destination: 132 Annotation: Subtype: Link Rect: 100, 285, 113, 294 Destination: 13 Annotation: Subtype: Link Rect: 114, 272, 126, 281 Destination: null Annotation: Subtype: Link Rect: 394, 729, 403, 736 Destination: 132 Annotation: Subtype: Link Rect: 441, 725, 455, 734 Destination: 13 Annotation: Subtype: Link Rect: 539, 702, 550, 710 Destination: 132 Annotation: Subtype: Link Rect: 340, 687, 353, 695 Destination: 13 Annotation: Subtype: Link Rect: 407, 686, 419, 695 Destination: null Annotation: Subtype: Link Rect: 384, 648, 397, 656 Destination: 13 Annotation: Subtype: Link Rect: 449, 609, 463, 618 Destination: 13 Annotation: Subtype: Link Rect: 459, 531, 473, 540 Destination: 13 Annotation: Subtype: Link Rect: 472, 479, 485, 488 Destination: null Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 273, 641, 278, 648 Destination: 37 Annotation: Subtype: Link Rect: 278, 638, 289, 649 Annotation: Subtype: Link Rect: 260, 628, 266, 635 Destination: 37 Annotation: Subtype: Link Rect: 266, 628, 272, 635 Destination: 37 Annotation: Subtype: Link Rect: 272, 628, 278, 635 Destination: 37 Annotation: Subtype: Link Rect: 278, 625, 289, 636 Annotation: Subtype: Link Rect: 273, 615, 278, 622 Destination: 37 Annotation: Subtype: Link Rect: 278, 612, 289, 623 Annotation: Subtype: Link Rect: 272, 602, 278, 609 Destination: 37 Annotation: Subtype: Link Rect: 278, 599, 289, 610 Annotation: Subtype: Link Rect: 272, 589, 278, 596 Destination: 37 Annotation: Subtype: Link Rect: 278, 586, 289, 597 Annotation: Subtype: Link Rect: 272, 576, 278, 583 Destination: 37 Annotation: Subtype: Link Rect: 278, 573, 289, 584 Annotation: Subtype: Link Rect: 283, 564, 288, 570 Destination: 37 Annotation: Subtype: Link Rect: 260, 551, 266, 558 Destination: 37 Annotation: Subtype: Link Rect: 266, 551, 272, 558 Destination: 37 Annotation: Subtype: Link Rect: 272, 551, 278, 558 Destination: 37 Annotation: Subtype: Link Rect: 278, 547, 289, 558 Annotation: Subtype: Link Rect: 273, 538, 278, 545 Destination: 37 Annotation: Subtype: Link Rect: 278, 534, 289, 545 Annotation: Subtype: Link Rect: 273, 525, 278, 532 Destination: 37 Annotation: Subtype: Link Rect: 278, 521, 289, 532 Annotation: Subtype: Link Rect: 272, 512, 278, 518 Destination: 37 Annotation: Subtype: Link Rect: 278, 508, 289, 519 Annotation: Subtype: Link Rect: 273, 499, 278, 506 Destination: 37 Annotation: Subtype: Link Rect: 278, 495, 289, 506 Annotation: Subtype: Link Rect: 266, 486, 272, 493 Destination: 37 Annotation: Subtype: Link Rect: 272, 486, 278, 493 Destination: 37 Annotation: Subtype: Link Rect: 278, 482, 289, 493 Annotation: Subtype: Link Rect: 260, 473, 266, 480 Destination: 37 Annotation: Subtype: Link Rect: 266, 473, 272, 480 Destination: 37 Annotation: Subtype: Link Rect: 272, 473, 278, 480 Destination: 37 Annotation: Subtype: Link Rect: 278, 469, 289, 480 Annotation: Subtype: Link Rect: 272, 460, 278, 467 Destination: 37 Annotation: Subtype: Link Rect: 278, 456, 289, 467 Annotation: Subtype: Link Rect: 273, 447, 278, 454 Destination: 37 Annotation: Subtype: Link Rect: 278, 443, 289, 454 Annotation: Subtype: Link Rect: 273, 434, 278, 441 Destination: 37 Annotation: Subtype: Link Rect: 278, 430, 289, 441 Annotation: Subtype: Link Rect: 426, 684, 547, 696 Annotation: Subtype: Link Rect: 454, 671, 550, 683 Annotation: Subtype: Link Rect: 394, 635, 405, 637 Annotation: Subtype: Link Rect: 404, 634, 548, 641 Annotation: Subtype: Link Rect: 305, 621, 328, 628 Annotation: Subtype: Link Rect: 365, 609, 376, 611 Annotation: Subtype: Link Rect: 375, 608, 540, 615 Annotation: Subtype: Link Rect: 380, 596, 391, 598 Annotation: Subtype: Link Rect: 391, 595, 534, 602 Annotation: Subtype: Link Rect: 305, 582, 326, 589 Annotation: Subtype: Link Rect: 365, 570, 376, 572 Annotation: Subtype: Link Rect: 376, 569, 541, 577 Annotation: Subtype: Link Rect: 426, 557, 437, 559 Annotation: Subtype: Link Rect: 436, 556, 536, 564 Annotation: Subtype: Link Rect: 305, 543, 370, 551 Annotation: Subtype: Link Rect: 419, 531, 430, 533 Annotation: Subtype: Link Rect: 429, 530, 528, 538 Annotation: Subtype: Link Rect: 305, 517, 372, 525 Annotation: Subtype: Link Rect: 403, 505, 414, 507 Annotation: Subtype: Link Rect: 414, 505, 537, 512 Annotation: Subtype: Link Rect: 305, 492, 347, 499 Annotation: Subtype: Link Rect: 395, 479, 406, 481 Annotation: Subtype: Link Rect: 405, 479, 529, 486 Annotation: Subtype: Link Rect: 305, 466, 348, 473 Annotation: Subtype: Link Rect: 367, 453, 378, 455 Annotation: Subtype: Link Rect: 378, 453, 541, 460 Annotation: Subtype: Link Rect: 408, 440, 419, 442 Annotation: Subtype: Link Rect: 419, 440, 542, 447 Annotation: Subtype: Link Rect: 305, 427, 347, 434 Annotation: Subtype: Link Rect: 380, 415, 391, 417 Annotation: Subtype: Link Rect: 390, 414, 533, 421 Annotation: Subtype: Link Rect: 305, 401, 325, 408 Annotation: Subtype: Link Rect: 368, 389, 379, 391 Annotation: Subtype: Link Rect: 379, 388, 542, 395 Annotation: Subtype: Link Rect: 361, 376, 372, 378 Annotation: Subtype: Link Rect: 371, 375, 535, 382 Annotation: Subtype: Link Rect: 387, 363, 398, 365 Annotation: Subtype: Link Rect: 398, 362, 544, 369 Annotation: Subtype: Link Rect: 305, 349, 329, 356 Annotation: Subtype: Link Rect: 381, 337, 392, 339 Annotation: Subtype: Link Rect: 391, 336, 538, 343 Annotation: Subtype: Link Rect: 305, 323, 325, 330 Annotation: Subtype: Link Rect: 385, 311, 396, 313 Annotation: Subtype: Link Rect: 395, 310, 540, 317 Annotation: Subtype: Link Rect: 305, 297, 325, 304 Annotation: Subtype: Link Rect: 427, 217, 548, 224 Annotation: Subtype: Link Rect: 442, 171, 550, 179 Annotation: Subtype: Link Rect: 322, 160, 350, 167 Annotation: Subtype: Link Rect: 418, 114, 550, 121 Annotation: Subtype: Link Rect: 322, 103, 351, 110 Annotation: Subtype: Link Rect: 322, 57, 491, 64 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 152, 691, 287, 698 Annotation: Subtype: Link Rect: 140, 645, 271, 652 Annotation: Subtype: Link Rect: 164, 576, 289, 583 Annotation: Subtype: Link Rect: 61, 565, 92, 572 Annotation: Subtype: Link Rect: 464, 702, 550, 709 Annotation: Subtype: Link Rect: 322, 691, 358, 698 Annotation: Subtype: Link Rect: 322, 645, 475, 652 Annotation: Subtype: Link Rect: 395, 611, 528, 618 Thumb: true Checksum: 8ca08ec9 Type: CRC32 Checksum: 63b706fa59c08b9728bb4846a3cc726c Type: MD5 Checksum: d037397a343790fa5beb3388f36254276275d93f Type: SHA-1