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78f5a1b4a6f87a59d3ffcf7388cdd3cf3ff7866c3019e5132361c2952d90671a  pmc_9092259.pdf

Title:           MET Inhibition Sensitizes Rhabdomyosarcoma Cells to NOTCH Signaling Suppression
Subject:         Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma.
Keywords:        rhabdomyosarcoma, NOTCH signaling, MET, soft tissue sarcoma, drug resistance, combination therapy, targeted therapy, γ-secretase
Author:          Clara Perrone
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      Title: MET Inhibition Sensitizes Rhabdomyosarcoma Cells to NOTCH Signaling Suppression
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       Item: 
        Title: Introduction
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       Item: 
        Title: Materials and Methods
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        Children: 
         Item: 
          Title: Cell Culture and Reagents
          Destination: s2_1
         Item: 
          Title: Drugs
          Destination: s2_2
         Item: 
          Title: Determination of the IC50 and Cell Proliferation Assay
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         Item: 
          Title: siRNA Transfection
          Destination: s2_4
         Item: 
          Title: RNA Isolation, cDNA Synthesis and Real-Time qPCR
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          Title: Western Blot
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          Title: Caspase Activity Assay
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         Item: 
          Title: Annexin V Determination
          Destination: s2_8
         Item: 
          Title: Immunofluorescence
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         Item: 
          Title: Cell Migration Assay
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         Item: 
          Title: Colony Formation Assay
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         Item: 
          Title: Soft Agar Colony Formation Assay
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         Item: 
          Title: Spheroid Generation and Image Acquisition
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          Title: Statistical Analysis
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        Title: Results
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         Item: 
          Title: NOTCH Signaling Inhibition Drives MET Activation in RMS Cells
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         Item: 
          Title: Pharmacologic Inhibition of NOTCH Signaling Halts RMS Cells Proliferation
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         Item: 
          Title: MET Inhibition Affects RMS Cells Proliferation
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         Item: 
          Title: Combined Inhibition of NOTCH and MET Signaling Enhances RMS Cells Apoptosis
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         Item: 
          Title: Combined Inhibition of NOTCH and MET Signaling Impairs the Tumorigenic Properties of RMS Cells
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        Title: Discussion
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       Item: 
        Title: Data Availability Statement
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       Item: 
        Title: Author Contributions
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       Item: 
        Title: Funding
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        Title: Acknowledgments
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       Item: 
        Title: Supplementary Material
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       Item: 
        Title: References
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    Title: MET Inhibition Sensitizes Rhabdomyosarcoma Cells to NOTCH Signaling Suppression
    Author: Clara Perrone
    Subject: Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma.
    Keywords: rhabdomyosarcoma, NOTCH signaling, MET, soft tissue sarcoma, drug resistance, combination therapy, targeted therapy, γ-secretase
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  Checksum: 63f39e71
   Type: CRC32
  Checksum: 731d237e80c5727e3e532aaf1b7901d5
   Type: MD5
  Checksum: 73080a9d1ef0b886deec07167fdef35671d7abe4
   Type: SHA-1
  Checksum: 78f5a1b4a6f87a59d3ffcf7388cdd3cf3ff7866c3019e5132361c2952d90671a
   Type: SHA-256