622ab954fb1e9b60654a7c4ecef70110 pmc_9095637.pdf bf87153d27619be56c2eadcb09546bc0117c0838 pmc_9095637.pdf 431d0ee5b55049a6926eeb0b8dec591bb9439d53f0fae26ecdb01da74d66cb1b pmc_9095637.pdf Title: Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients Subject: Nature Communications, doi:10.1038/s41467-022-29911-3 Keywords: Author: Pere Millat-Martinez Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Apr 29 14:42:09 2022 CEST ModDate: Thu May 5 13:54:05 2022 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1493546 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LEKMLE+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 47 0 Arial-BoldMT Type 1C WinAnsi yes no no 497 0 LEKMLC+AdvOTf23bb480 Type 1C WinAnsi yes yes no 220 0 LEKMLD+AdvOTf23bb480+fb Type 1C Custom yes yes yes 498 0 LEKKNG+AdvOTea1a7398 Type 1C WinAnsi yes yes no 49 0 LEKMHN+AdvTT2876772e+27 Type 1C Custom yes yes yes 204 0 LEKMHO+AdvOTea1a7398+fb Type 1C Custom yes yes yes 80 0 LEKMHP+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 499 0 LEKMIA+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 81 0 LEKMIB+AdvOTcb88df00 Type 1C WinAnsi yes yes no 56 0 LEKMOE+AdvOT125c650c Type 1C WinAnsi yes yes no 48 0 LEKMOJ+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 50 0 LEKMOK+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 51 0 LEKMOH+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 52 0 LEKMOI+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 53 0 LEKMOF+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 54 0 LEKMOG+AdvOT1ef757c0+20 Type 1C Custom yes yes yes 55 0 LEKONB+AdvTTab7e17fd Type 1C WinAnsi yes yes no 77 0 LEKOLP+AdvOTcb88df00+fb Type 1C Custom yes yes yes 78 0 LEKOMA+AdvOTe75a9404.I Type 1C WinAnsi yes yes no 79 0 LELBFD+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 103 0 LELBJC+Helvetica-Bold Type 1C WinAnsi yes yes no 104 0 LELBJD+Helvetica Type 1C Custom yes yes no 105 0 LELBMD+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 130 0 LELCBC+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 205 0 LELCGB+AdvOTf23bb480+20 Type 1C WinAnsi yes yes no 221 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-29 02:37:50 CEST RepresentationInformation: pmc_9095637.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-09-28 02:19:22 CEST Size: 1493546 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 936747 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 936747 MIMEtype: application/pdf PDFMetadata: Objects: 625 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Trials profile Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Study patients and recruitment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Primary endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Secondary endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Safety Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Overview of study design and research partners Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Study patients and selection criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Intervention Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Ethical approval Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Code availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Additional information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Info: Title: Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients Author: Pere Millat-Martinez Subject: Nature Communications, doi:10.1038/s41467-022-29911-3 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Apr 29 15:12:09 CEST 2022 ModDate: Thu May 05 13:54:05 CEST 2022 ID: 0x2c8c787f06c976fa9b5eaf26354cf04a, 0x539f2b1a79a46d398fad10eff0d710b8 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1982 ImageHeight: 1462 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: LELBMD+AdvOT9bd21c25.I FontSubset: true FirstChar: 110 LastChar: 112 FontDescriptor: FontName: LELBMD+AdvOT9bd21c25.I Flags: Nonsymbolic FontBBox: -83, -197, 1010, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LEKMHN+AdvTT2876772e+27 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LEKMHN+AdvTT2876772e+27 Flags: Symbolic FontBBox: 0, -197, 968, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LEKONB+AdvTTab7e17fd FontSubset: true FirstChar: 61 LastChar: 61 FontDescriptor: FontName: LEKONB+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LELCBC+AdvOTb65e897d.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: LELCBC+AdvOTb65e897d.B+20 Flags: Nonsymbolic FontBBox: -125, -177, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LEKOLP+AdvOTcb88df00+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LEKOLP+AdvOTcb88df00+fb Flags: Symbolic FontBBox: 0, -197, 895, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LEKOMA+AdvOTe75a9404.I FontSubset: true FirstChar: 110 LastChar: 110 FontDescriptor: FontName: LEKOMA+AdvOTe75a9404.I Flags: Nonsymbolic FontBBox: -83, -197, 1020, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LEKMHO+AdvOTea1a7398+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LEKMHO+AdvOTea1a7398+fb Flags: Symbolic FontBBox: 0, -197, 750, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LEKMIA+AdvOTea1a7398+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: LEKMIA+AdvOTea1a7398+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LEKMLC+AdvOTf23bb480 FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: LEKMLC+AdvOTf23bb480 Flags: Nonsymbolic FontBBox: -31, -197, 968, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LELCGB+AdvOTf23bb480+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: LELCGB+AdvOTf23bb480+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LELBFD+AdvOT7d6df7ab.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: LELBFD+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LELBJC+Helvetica-Bold FontSubset: true FirstChar: 49 LastChar: 57 FontDescriptor: FontName: LELBJC+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LELBJD+Helvetica FontSubset: true FirstChar: 21 LastChar: 122 FontDescriptor: FontName: LELBJD+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LEKMLE+AdvTTda6f6cb8.B FontSubset: true FirstChar: 49 LastChar: 57 FontDescriptor: FontName: LEKMLE+AdvTTda6f6cb8.B Flags: Nonsymbolic FontBBox: -72, -218, 895, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LEKMOE+AdvOT125c650c FontSubset: true FirstChar: 84 LastChar: 84 FontDescriptor: FontName: LEKMOE+AdvOT125c650c Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LEKKNG+AdvOTea1a7398 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: LEKKNG+AdvOTea1a7398 Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LEKMLD+AdvOTf23bb480+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LEKMLD+AdvOTf23bb480+fb Flags: Symbolic FontBBox: 0, -197, 718, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LEKMOJ+AdvOTb65e897d.B FontSubset: true FirstChar: 49 LastChar: 121 FontDescriptor: FontName: LEKMOJ+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LEKMHP+AdvOT8608a8d1+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LEKMHP+AdvOT8608a8d1+22 Flags: Symbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LEKMOK+AdvOTb65e897d.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LEKMOK+AdvOTb65e897d.B+fb Flags: Symbolic FontBBox: 0, -10, 843, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LEKMOH+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LEKMOH+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LEKMOI+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LEKMOI+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LEKMOF+AdvOT1ef757c0 FontSubset: true FirstChar: 37 LastChar: 243 FontDescriptor: FontName: LEKMOF+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LEKMOG+AdvOT1ef757c0+20 FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: LEKMOG+AdvOT1ef757c0+20 Flags: Symbolic FontBBox: -135, -187, 1010, 833 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LEKMIB+AdvOTcb88df00 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: LEKMIB+AdvOTcb88df00 Flags: Nonsymbolic FontBBox: -41, -197, 968, 906 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-022-29911-3 Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients Pere Millat-Martinez Arvind Gharbharan Andrea Alemany Casper Rokx Corine Geurtsvankessel Grigorios Papageourgiou Nan Geloven Carlijn Jordans Geert Groeneveld Francis Swaneveld Ellen Schoot Marc Corbacho-Monné Dan Ouchi Francini Piccolo Ferreira Pierre Malchair Sebastian Videla Vanesa García García Anna Ruiz-Comellas Anna Ramírez-Morros Joana Rodriguez Codina Rosa Amado Simon Joan-Ramon Grifols Julian Blanco Ignacio Blanco Jordi Ara Quique Bassat Bonaventura Clotet Bàrbara Baro Andrea Troxel Jaap Jan Zwaginga Oriol Mitjà Bart J. A. Rijnders Arvind Gharbharan Casper Rokx Carlijn Jordans Corine Geurtsvankessel Grigorios Papageourgiou Bart Rijnders Peter Katsikis Yvonne Müller Marion Koopmans Susanne Bogers Jelle Miedema Henk Russcher Cees Scherpenisse Rene van Engen Ayten Karisli Hannelore Götz Jelle Struik Lotte Rokx-Niemantsverdriet Nan van Geloven Geert Groeneveld Jaap Jan Zwaginga Lisa Zwaginga Josine Oud Romy Meier Erik van Zwet Simon Mooijaart Arjan Albersen Francis Swaneveld Ellen van der Schoot Hans Vrielink Leo van de Watering Boris Hogema Peter van Wijngaarden Ronald van Etten Adriaan van Gammeren Nanda Maas Betty van Ginneken Jan den Hollander Jose Verstijnen Juliette van den Berg – Rahman Faiz Karim Siepke Hiddema Kim van Elst Elena van Leeuwen-Segarceanu Annette Reitsma Karin Molenkamp Robert Soetekouw Caterina Band José de Droog Jolanda Lammers Lonneke Buitenhuis Douwe Postma David Koster Michaèl Lukens Thea Scholtens Maartje van den Boomgaard Machiel Vonk Linda Kampschreur Marit van Vonderen Loes Vrolijk Chantal Reusken Johan Reimerink Heli Harvala Andrea Alemany Marc Corbacho-Monné Dan Ouchi Bonaventura Clotet Oriol Mitjà Gèlia Costes Mar Capdevila-Jáuregui Pamela Torrano-Soler Alba San José Zahida Jiménez Ferran Ramírez-Viaplana Susana Ferrer Mireia Gallardo Maria Ubals Camila González-Beiras Martí Vall-Mayans Miquel Angel Rodriguez-Arias Clara Suñer Jordi Puig Aroa Nieto Ivan Galvan-Femenia Xavier Comas-Leon Pere Millat-Martínez Quique Bassat Bàrbara Baro Ignacio Blanco Jordi Ara Glòria Bonet Papell Maria Delgado Capel Beatriz Díez Sánchez Maria Pons Barber Cristian Gonzalez Ruiz Laura Navarrete Gonzalez David González García Ainhoa Vivero Larraza Victor Carceles Peiró Clàudia Roquer López Magí Ferrer Pierre Malchair Sebastian Videla Vanesa García García Carlota Gudiol Aurema Otero Jose Carlos Ruibal Suarez Alvaro Zarauza Pellejero Ferran Llopis Roca Orlando Rodriguez Cortez Pablo Casares Gonzalez Gemma Arcos Vila Begoña Flores Aguilera Graciela Rodríguez-Sevilla Macarena Dastis Arias Anna Ruiz-Comellas Anna Ramírez-Morros Judit Roca Font Katherine M. Carrasco Matos Glòria Saüch Valmaña Carla Vidal Obradors Joana Rodríguez Codina Rosa Amado Simon Silvia Tarres García Margarida Curriu Sabatès Raquel Nieto Rodríguez Joan-Ramon Grífols Anna Millan Enric Contreras Àgueda Ancochea Rosa Línio Miriam Fornos Natàlia Casamitjana Eva Alonso Núria Martinez Laura Analía Maglio Laura Comellas Fernandez Nadia Garcia Luis Hernández María Isabel González Anna Bravo Yolanda García Núria Prat Joaquim Verdaguer Thatiana Vértiz Guidotti Sergio Benavent Andrea Sofia Bianco Ney Nicanor Briones Zambrano Maria Viozquez Meya Anna Forcada Josep Vidal-Alaball Montserrat Giménez Alexa París Gema Fernández Rivas Cristina Casañ Lopez Águeda Hernández Antoni E. Bordoy Victoria González Soler Julian Blanco Edwars Pradenas Silvia Marfil Benjamin Trinité Francini Piccolo Ferreira Mireia Bonet Jordi Cantoni Michael Marks Springer US Nature Communications, doi:10.1038/s41467-022-29911-3 Springer 2022-05-05T13:54:05+02:00 2022-04-29T18:12:09+05:30 2022-05-05T13:54:05+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) uuid:c56208b9-e331-4cd2-97e7-e29f855ea6ac uuid:e2de8669-a59d-4334-827d-b0a597ece07d default 1 converted uuid:9d6bef20-6972-4cb3-b328-8509d8a0dc43 converted to PDF/A-2b pdfToolbox 2022-04-29T18:12:58+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 473, 640, 475, 671 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 473, 643, 508, 674 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 640, 551, 650 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 640, 551, 650 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 444, 513, 445, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 444, 513, 445, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 453, 513, 454, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 443, 513, 454, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 454, 513, 457, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 151, 497, 152, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 151, 497, 152, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 160, 497, 161, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 151, 497, 161, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 161, 497, 164, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 378, 497, 379, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 378, 497, 379, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 386, 497, 387, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 377, 497, 387, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 387, 497, 390, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 523, 481, 524, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 523, 481, 524, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 532, 481, 533, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 522, 481, 533, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 533, 481, 536, 492 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 153, 465, 154, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 153, 465, 154, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 162, 465, 163, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 152, 465, 163, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 163, 465, 166, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 340, 465, 341, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 340, 465, 341, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 349, 465, 350, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 339, 465, 350, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 350, 465, 352, 476 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 136, 449, 137, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 136, 449, 137, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 145, 449, 146, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 135, 449, 146, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 146, 449, 149, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 287, 449, 288, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 287, 449, 288, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 296, 449, 297, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 286, 449, 297, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 297, 449, 299, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 214, 433, 216, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 214, 433, 216, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 223, 433, 224, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 214, 433, 224, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 224, 433, 227, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 308, 433, 309, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 308, 433, 309, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 317, 433, 318, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 308, 433, 318, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 318, 433, 321, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 474, 433, 475, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 474, 433, 475, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 483, 433, 484, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 473, 433, 484, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 484, 433, 487, 444 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 229, 418, 230, 428 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 229, 418, 230, 428 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 238, 418, 239, 428 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 228, 418, 239, 428 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 239, 418, 241, 428 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 125, 402, 126, 413 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 125, 402, 126, 413 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 134, 402, 135, 413 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 124, 402, 135, 413 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 135, 402, 138, 413 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 198, 113, 314, 122 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 371, 23, 486, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 237, 684, 241, 691 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 245, 684, 248, 691 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 109, 631, 113, 639 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 117, 631, 120, 639 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 230, 590, 233, 597 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 235, 590, 239, 597 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 271, 569, 278, 576 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 282, 569, 289, 576 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 63, 527, 70, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 63, 495, 70, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 109, 454, 117, 461 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 62, 255, 70, 262 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 153, 203, 160, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 542, 443, 549, 451 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 542, 391, 549, 398 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 414, 145, 418, 155 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 331, 51, 335, 61 Flags: Print AppearanceDictionary: true Destination: 63 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 148, 91, 152, 100 Flags: Print AppearanceDictionary: true Destination: 93 Annotation: Subtype: Link Rect: 190, 91, 195, 100 Flags: Print AppearanceDictionary: true Destination: 93 Annotation: Subtype: Link Rect: 371, 23, 486, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 213, 136, 218, 146 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 403, 109, 408, 118 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 156, 223, 164, 231 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 166, 203, 174, 210 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 94, 140, 102, 147 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 86, 129, 93, 137 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 177, 77, 185, 85 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 371, 23, 486, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 221, 454, 228, 461 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 192, 401, 195, 409 Flags: Print AppearanceDictionary: true Destination: 159 Annotation: Subtype: Link Rect: 197, 401, 204, 409 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 55, 339, 63, 346 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 151, 234, 158, 241 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 270, 102, 291, 109 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 94, 129, 101 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 182, 94, 247, 101 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 162, 313, 266, 321 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 57, 305, 86, 312 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 164, 113, 268, 120 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 58, 104, 86, 112 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 490, 496, 544, 504 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 318, 487, 397, 495 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 535, 235, 551, 242 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 226, 352, 233 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 371, 23, 486, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 189, 688, 253, 695 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 337, 705, 460, 712 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 457, 636, 546, 643 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 501, 551, 508 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 492, 346, 499 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 262, 163, 345, 171 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 371, 23, 486, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 82c69bdc Type: CRC32 Checksum: 622ab954fb1e9b60654a7c4ecef70110 Type: MD5 Checksum: bf87153d27619be56c2eadcb09546bc0117c0838 Type: SHA-1