5b47988f17e4535093619716b7389191 pmc_9099725.pdf 3d56e4b66d12cae85d866b2cf64844e07849a01f pmc_9099725.pdf 2aa09e4cd09606bdaf34ec82f180499e36a98c2e77ce37f9a89b184fdb46cf01 pmc_9099725.pdf Title: Seroprevalence of SARS-CoV-2 in a Cohort of Patients with Multiple Sclerosis under Disease-Modifying Therapies Subject: Background: Disease-modifying therapies (DMTs) used to treat multiple sclerosis (MS) alter the immune system and therefore increase the risk of infection. There is growing concern about the impact of COVID-19 on patients with MS (pwMS), especially those treated with DMTs. Methods: This is a single-center prospective observational study based on data from the Esclerosis Múltiple y COVID-19 (EMCOVID-19) study. Demographic characteristics, MS history, laboratory data and SARS-CoV-2 serology, and symptoms of COVID-19 in pwMS treated with any DTM were extracted. The relationship among demographics, MS status, DMT, and COVID-19 was evaluated. Results: A total of 259 pwMS were included. The administration of interferon was significantly associated with the presence of SARS-CoV-2 antibodies (26.4% vs. 10.7%, p = 0.006). Although patients taking interferon were significantly older (49.1 vs. 43.5, p = 0.003), the association of interferon with the presence of SARS-CoV-2 antibodies was still significant in the multivariate analysis (OR 2.99 (1.38; 6.36), p = 0.006). Conclusions: According to our data, pwMS present a higher risk of COVID-19 infection compared with results obtained from the general population. There is no evidence of a worse COVID-19 outcome in pwMS. DMTs did not significantly change the frequency of COVID-19, except for interferon; however, these findings must be interpreted with caution given the small sample of pwMS taking each DMT. Keywords: multiple sclerosis; COVID-19; SARS-CoV-2; DMT; seroprevalence Author: Agustín Sancho-Saldaña, Anna Gil Sánchez, Bibiana Quirant-Sánchez, Lara Nogueras, Silvia Peralta, Maria José Solana, Cristina González-Mingot, Yhovanni Gallego, Laura Quibus, Cristina Ramo, Silvia Presas-Rodríguez, Eva Martínez-Cáceres, Pascual Torres, José Vicente Hervás, Joan Valls and Luis Brieva Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon May 9 04:30:37 2022 CEST ModDate: Mon May 9 04:40:43 2022 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 279923 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ACKGZT+VnURWPalladioL Type 1 Custom yes yes no 10 0 BHVKJR+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 MCRCRK+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 IGMVPX+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 IOJCNK+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 49 0 UFKNXE+CMSY10 Type 1 Builtin yes yes no 74 0 CAMXTK+EURM10 Type 1 Builtin yes yes no 78 0 FAECIJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 85 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-11 02:49:03 CEST RepresentationInformation: pmc_9099725.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-31 06:22:00 CEST Size: 279923 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 221 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Children: Item: Title: Study Design and Patients Destination: subsection.2.1 Item: Title: Blood Samples Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: section.4 Info: Title: Seroprevalence of SARS-CoV-2 in a Cohort of Patients with Multiple Sclerosis under Disease-Modifying Therapies Author: Agustín Sancho-Saldaña, Anna Gil Sánchez, Bibiana Quirant-Sánchez, Lara Nogueras, Silvia Peralta, Maria José Solana, Cristina González-Mingot, Yhovanni Gallego, Laura Quibus, Cristina Ramo, Silvia Presas-Rodríguez, Eva Martínez-Cáceres, Pascual Torres, José Vicente Hervás, Joan Valls and Luis Brieva Subject: Background: Disease-modifying therapies (DMTs) used to treat multiple sclerosis (MS) alter the immune system and therefore increase the risk of infection. There is growing concern about the impact of COVID-19 on patients with MS (pwMS), especially those treated with DMTs. Methods: This is a single-center prospective observational study based on data from the Esclerosis Múltiple y COVID-19 (EMCOVID-19) study. Demographic characteristics, MS history, laboratory data and SARS-CoV-2 serology, and symptoms of COVID-19 in pwMS treated with any DTM were extracted. The relationship among demographics, MS status, DMT, and COVID-19 was evaluated. Results: A total of 259 pwMS were included. The administration of interferon was significantly associated with the presence of SARS-CoV-2 antibodies (26.4% vs. 10.7%, p = 0.006). Although patients taking interferon were significantly older (49.1 vs. 43.5, p = 0.003), the association of interferon with the presence of SARS-CoV-2 antibodies was still significant in the multivariate analysis (OR 2.99 (1.38; 6.36), p = 0.006). Conclusions: According to our data, pwMS present a higher risk of COVID-19 infection compared with results obtained from the general population. There is no evidence of a worse COVID-19 outcome in pwMS. DMTs did not significantly change the frequency of COVID-19, except for interferon; however, these findings must be interpreted with caution given the small sample of pwMS taking each DMT. 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