a778ead24eedb60d47e582c528cf097e pmc_9100536.pdf 7a54beffb122a0d980cc34d0ce0406766d44ffcb pmc_9100536.pdf a6a7e9d35e85064f92bc357aeb9f46ca05e2ad63c1e641f7f4c4599a41dc5493 pmc_9100536.pdf Title: Incidence, Treatment and Clinical Impact of Iron Deficiency in Chronic Heart Failure: A Longitudinal Analysis Subject: In patients with heart failure (HF), iron deficiency (ID) is a well-recognized therapeutic target; information about its incidence, patterns of iron repletion, and clinical impact is scarce. This single-centre longitudinal cohort study assessed the rates of ID testing and diagnosis in patients with stable HF, patterns of treatment with intravenous iron, and clinical impact of intravenous iron on HF rehospitalization risk. We included 711 consecutive outpatients (4400 visits) with stable chronic HF from 2014 to 2019 (median [interquartile range] visits per patient: 2 [2–7]. ID was defined as serum ferritin <100 g/L, or 100–299 g/L with transferrin saturation (TSAT) < 20%. During a median follow-up of 2.20 (1.11–3.78) years, ferritin and TSAT were measured at 2230 (50.7%) and 2183 visits (49.6%), respectively. ID was found at 846 (37.9%) visits, with ferritin and TSAT available (2230/4400), and intravenous iron was administered at 321/4400 (7.3%) visits; 233 (32.8%) patients received intravenous iron during follow-up. After multivariate analyses, iron repletion at any time during follow-up was associated with a lower risk of recurrent HF hospitalization (hazard ratio [HR] = 0.50, 95% confidence interval [CI] = 0.28–0.88; p = 0.016). Thus, ID was a frequent finding in patients with HF, and its repletion reduced the risk of recurrent HF hospitalizations. Keywords: iron deficiency; heart failure; prevalence; treatment Author: Gema Miñana, Miguel Lorenzo, Antonio Ramirez de Arellano, Sandra Wächter, Rafael de la Espriella, Clara Sastre, Anna Mollar, Eduardo Núñez, Vicent Bodí, Juan Sanchis, Antoni Bayés-Genís and Julio Núñez Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon May 2 12:39:34 2022 CEST ModDate: Mon May 2 12:44:29 2022 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 7750839 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NBDQEL+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 15 0 EFJEYK+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 WUIMMR+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 IOGJFZ+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 MYTFKK+VnURWPalladioL Type 1 Custom yes yes no 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 50 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 53 0 TNBSFT+CMSY10 Type 1 Builtin yes yes no 75 0 XZCORQ+URWPalladioL-BoldItal Type 1 Custom yes yes no 82 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-05 02:46:59 CEST RepresentationInformation: pmc_9100536.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-10-09 02:23:48 CEST Size: 7750839 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 233 FreeObjects: 7 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Iron Deficiency Parameters’ Assessment and Definitions Destination: subsection.2.1 Item: Title: Intravenous Iron Treatment Destination: subsection.2.2 Item: Title: Endpoints Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Longitudinal Cohort Characteristics Destination: subsection.3.1 Item: Title: Iron Deficiency Assessment and Diagnosis Destination: subsection.3.2 Item: Title: Intravenous Iron Treatment Destination: subsection.3.3 Item: Title: Adverse Clinical Events Destination: subsection.3.4 Item: Title: Iron Deficiency and HF Rehospitalizations Destination: subsection.3.5 Item: Title: Intravenous Iron and Adverse Clinical Events Destination: subsection.3.6 Item: Title: Discussion Destination: section.4 Children: Item: Title: ID Testing and Treatment in Daily Clinical Practice Destination: subsection.4.1 Item: Title: ID and Its Treatment and Adverse Clinical Events: Evidence from Real-World Data Destination: subsection.4.2 Item: Title: Limitations Destination: subsection.4.3 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Incidence, Treatment and Clinical Impact of Iron Deficiency in Chronic Heart Failure: A Longitudinal Analysis Author: Gema Miñana, Miguel Lorenzo, Antonio Ramirez de Arellano, Sandra Wächter, Rafael de la Espriella, Clara Sastre, Anna Mollar, Eduardo Núñez, Vicent Bodí, Juan Sanchis, Antoni Bayés-Genís and Julio Núñez Subject: In patients with heart failure (HF), iron deficiency (ID) is a well-recognized therapeutic target; information about its incidence, patterns of iron repletion, and clinical impact is scarce. This single-centre longitudinal cohort study assessed the rates of ID testing and diagnosis in patients with stable HF, patterns of treatment with intravenous iron, and clinical impact of intravenous iron on HF rehospitalization risk. We included 711 consecutive outpatients (4400 visits) with stable chronic HF from 2014 to 2019 (median [interquartile range] visits per patient: 2 [2 7]. ID was defined as serum ferritin <100 g/L, or 100 299 g/L with transferrin saturation (TSAT) < 20%. During a median follow-up of 2.20 (1.11 3.78) years, ferritin and TSAT were measured at 2230 (50.7%) and 2183 visits (49.6%), respectively. ID was found at 846 (37.9%) visits, with ferritin and TSAT available (2230/4400), and intravenous iron was administered at 321/4400 (7.3%) visits; 233 (32.8%) patients received intravenous iron during follow-up. After multivariate analyses, iron repletion at any time during follow-up was associated with a lower risk of recurrent HF hospitalization (hazard ratio [HR] = 0.50, 95% confidence interval [CI] = 0.28 0.88; p = 0.016). Thus, ID was a frequent finding in patients with HF, and its repletion reduced the risk of recurrent HF hospitalizations. 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