31ff175ff20982fa6368e7e22dfcf03c pmc_9105143.pdf c3014bb5efd7acea11d677ee83654a5ddf090cd8 pmc_9105143.pdf 0942aa04882cd9e2afea0fc9cb21d0a2d0d27eec4bb610d74856a8baf182da59 pmc_9105143.pdf Title: Tumor Size and Oncological Outcomes in Patients with Early Cervical Cancer Treated by Fertility Preservation Surgery: A Multicenter Retrospective Cohort Study Subject: Background: The aim of this study was to analyze the impact of tumor size > 2 cm on oncological outcomes of fertility-sparing surgery (FSS) in early cervical cancer in a Spanish cohort. Methods: A multicenter, retrospective cohort study of early cervical cancer (stage IA1 with lymphovascular space invasion -IB1 (FIGO 2009)) patients with gestational desire who underwent FSS at 12 tertiary departments of gynecology oncology between 01/2005 and 01/2019 throughout Spain. Results: A total of 111 patients were included, 82 (73.9%) with tumors < 2 cm and 29 (26.1%) with tumors 2–4 cm. Patients’ characteristics were balanced except from lymphovascular space invasion. All were intraoperative lymph node-negative. Median follow-up was 55.7 and 30.7 months, respectively. Eleven recurrences were diagnosed (9.9%), five (6.0%) and six (21.4%) (p < 0.05). The 3-year progression-free survival (PFS) was 95.7% (95%CI 87.3–98.6) and 76.9% (95% CI 55.2–89.0) (p = 0.011). Only tumor size (<2 cm vs. 2–4 cm) was found to be significant for recurrence. After adjusting for the rest of the variables, tumor size 2–4 cm showed a Hazard Ratio of 5.99 (CI 95% 1.01–35.41, p = 0.036). Conclusions: Tumor size 2 cm is the most important negative prognostic factor in this multicenter cohort of patients with early cervical cancer and gestational desire who underwent FSS in Spain. Keywords: early cervical cancer; fertility-sparing surgery; tumor size Author: Blanca Gil-Ibañez, Antonio Gil-Moreno, Aureli Torné, Angel Martín Jimenez, Mikel Gorostidi, Ignacio Zapardiel, Alvaro Tejerizo Garcia, Berta Diaz-Feijoo and on behalf of SEGO Spain-GOG Cervical Cancer Task Forcé Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat May 7 08:09:14 2022 CEST ModDate: Sat May 7 08:12:00 2022 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 834385 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CNEUYC+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 BGSDTW+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 PLBLSD+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 ALRLBO+CMSY10 Type 1 Builtin yes yes no 23 0 KORLVE+VnURWPalladioL Type 1 Custom yes yes no 27 0 YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 51 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 76 0 DDOBJI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 89 0 DDOBKJ+PalatinoLinotype TrueType WinAnsi yes yes no 92 0 DDOBKL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 95 0 DDOBJI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 103 0 DDOBKJ+PalatinoLinotype TrueType WinAnsi yes yes no 106 0 DDOBKL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 109 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-04-03 02:43:19 CEST RepresentationInformation: pmc_9105143.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-10-07 02:17:26 CEST Size: 834385 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 232 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Children: Item: Title: SURGICAL Results Destination: subsection.3.1 Item: Title: Oncological Results Destination: subsection.3.2 Item: Title: Obstetrics Results Destination: subsection.3.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Tumor Size and Oncological Outcomes in Patients with Early Cervical Cancer Treated by Fertility Preservation Surgery: A Multicenter Retrospective Cohort Study Author: Blanca Gil-Ibañez, Antonio Gil-Moreno, Aureli Torné, Angel Martín Jimenez, Mikel Gorostidi, Ignacio Zapardiel, Alvaro Tejerizo Garcia, Berta Diaz-Feijoo and on behalf of SEGO Spain-GOG Cervical Cancer Task Forcé Subject: Background: The aim of this study was to analyze the impact of tumor size > 2 cm on oncological outcomes of fertility-sparing surgery (FSS) in early cervical cancer in a Spanish cohort. Methods: A multicenter, retrospective cohort study of early cervical cancer (stage IA1 with lymphovascular space invasion -IB1 (FIGO 2009)) patients with gestational desire who underwent FSS at 12 tertiary departments of gynecology oncology between 01/2005 and 01/2019 throughout Spain. Results: A total of 111 patients were included, 82 (73.9%) with tumors < 2 cm and 29 (26.1%) with tumors 2 4 cm. Patients’ characteristics were balanced except from lymphovascular space invasion. All were intraoperative lymph node-negative. Median follow-up was 55.7 and 30.7 months, respectively. Eleven recurrences were diagnosed (9.9%), five (6.0%) and six (21.4%) (p < 0.05). The 3-year progression-free survival (PFS) was 95.7% (95%CI 87.3 98.6) and 76.9% (95% CI 55.2 89.0) (p = 0.011). Only tumor size (<2 cm vs. 2 4 cm) was found to be significant for recurrence. After adjusting for the rest of the variables, tumor size 2 4 cm showed a Hazard Ratio of 5.99 (CI 95% 1.01 35.41, p = 0.036). Conclusions: Tumor size 2 cm is the most important negative prognostic factor in this multicenter cohort of patients with early cervical cancer and gestational desire who underwent FSS in Spain. 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