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Fernández Montes Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Fri Jan 7 08:08:46 2022 CET ModDate: Fri May 6 19:14:39 2022 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 6 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 698310 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C WinAnsi yes no yes 132 0 MyriadPro-Semibold Type 1C Custom yes no yes 133 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 134 0 BWFFCI+MyriadPro-SemiboldSemiCnIt Type 1C WinAnsi yes yes yes 135 0 MyriadPro-Bold Type 1C Custom yes no yes 136 0 AKFATT+STIX-Regular Type 1C Custom yes yes yes 137 0 STIX-Italic Type 1C WinAnsi yes no yes 138 0 BFTXKL+Wingdings-Regular Type 1C WinAnsi yes yes yes 159 0 Springnew-Regular Type 1C WinAnsi yes no yes 170 0 MyriadPro-BoldSemiCn Type 1C WinAnsi yes no yes 64 0 NETOYJ+MyriadPro-BoldSemiCnIt Type 1C WinAnsi yes yes yes 63 0 Springnew-Regular2 Type 1C WinAnsi yes no yes 70 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-18 03:25:09 CEST RepresentationInformation: pmc_9107427.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-18 02:37:23 CEST Size: 698310 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 231 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer Children: Item: Title: Abstract Children: Item: Title: Purpose Item: Title: Methods Item: Title: Results Item: Title: Conclusion Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Patients Item: Title: Study design Item: Title: Solid RAS mutations analyses Item: Title: Plasma ctDNA RAS mutations analyses Item: Title: Statistical analysis Item: Title: Results Item: Title: Discussion Item: Title: Conclusion Item: Title: Acknowledgements Item: Title: References Info: Title: Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer Author: A. Fernández Montes Subject: Clinical and Translational Oncology, https://doi.org/10.1007/s12094-021-02767-7 Keywords: Metastatic colorectal cancer,Circulating tumor DNA,Liquid biopsy,RAS mutant,EGFR inhibitors Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Fri Jan 07 08:38:46 CET 2022 ModDate: Fri May 06 19:44:39 CEST 2022 ID: 0x09cbe0bf98d20c48827226d9384b1314, 0x9f16495af4e372498f2a030fcda78501 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1501 ImageHeight: 807 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: MyriadPro-BoldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldSemiCn Flags: Nonsymbolic FontBBox: -133, -250, 1161, 894 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -128, -250, 1059, 876 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BWFFCI+MyriadPro-SemiboldSemiCnIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: BWFFCI+MyriadPro-SemiboldSemiCnIt Flags: Nonsymbolic, Italic FontBBox: -156, -250, 1096, 876 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AKFATT+STIX-Regular FontSubset: true FirstChar: 27 LastChar: 243 FontDescriptor: FontName: AKFATT+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: STIX-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: BFTXKL+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: BFTXKL+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: NETOYJ+MyriadPro-BoldSemiCnIt FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: NETOYJ+MyriadPro-BoldSemiCnIt Flags: Nonsymbolic, Italic FontBBox: -197, -250, 1145, 978 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true XMP: 2022-01-07T12:38:46+05:30 Springer 2022-05-06T22:44:39+05:30 2022-05-06T22:44:39+05:30 Acrobat Distiller 10.1.8 (Windows) Metastatic colorectal cancer,Circulating tumor DNA,Liquid biopsy,RAS mutant,EGFR inhibitors application/pdf https://doi.org/10.1007/s12094-021-02767-7 Springer International Publishing Clinical and Translational Oncology, https://doi.org/10.1007/s12094-021-02767-7 Metastatic colorectal cancer Circulating tumor DNA Liquid biopsy RAS mutant EGFR inhibitors Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer A. Fernández Montes E. Élez A. Vivancos N. Martínez P. González M. Covela J. de la Cámara A. Cousillas J. C. Méndez B. Graña E. Aranda 10.1007/s12094-021-02767-7 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s12094-021-02767-7 10.1007/s12094-021-02767-7 1699-3055 24 6 1209 1214 journal Clinical and Translational Oncology The Author(s) 2010-04-23 true 10.1007/s12094-021-02767-7 noindex springer.com springerlink.com VoR uuid:c2f38d46-aab6-4880-b218-cc58ad1414a0 uuid:ddfa6339-7ba2-4d9a-8368-220098475d8e default 1 converted uuid:378ba1bd-521e-4d39-9829-f5ec27cca729 converted to PDF/A-2b pdfToolbox 2022-05-06T22:44:14+05:30 converted uuid:a99341aa-017f-4a24-b538-d38d54f3ea1a converted to PDF/A-2b pdfToolbox 2022-05-06T22:44:39+05:30 2 B A. 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