0dea93e220d040dc615bd3b455857c69 pmc_9114341.pdf a09e6ac216475123a9750d26ed9cd65e181c0e08 pmc_9114341.pdf 339bad7f12d271098345cbd718bbef0f54e9abce7b714115425983ccc147d5c8 pmc_9114341.pdf Title: Conventional and digital Ki67 evaluation and their correlation with molecular prognosis and morphological parameters in luminal breast cancer Subject: Scientific Reports, https://doi.org/10.1038/s41598-022-11411-5 Author: Laura Pons Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon May 16 17:29:21 2022 CEST ModDate: Tue May 17 12:52:00 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1172907 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OXXAPB+Wingdings-Regular Type 1C WinAnsi yes yes yes 275 0 MinionPro-Regular Type 1C Custom yes no yes 53 0 KYTGOE+Corbel-Bold CID TrueType Identity-H yes yes yes 54 0 Corbel2 TrueType WinAnsi yes no yes 55 0 QBYAZS+Corbel CID TrueType Identity-H yes yes yes 56 0 Corbel3 CID TrueType Identity-H yes no yes 308 0 MinionPro-Bold Type 1C Custom yes no yes 75 0 MinionPro-It Type 1C WinAnsi yes no yes 153 0 HWVKTK+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 154 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-29 02:37:47 CEST RepresentationInformation: pmc_9114341.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-09-28 02:19:20 CEST Size: 1172907 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 336 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Conventional and digital Ki67 evaluation and their correlation with molecular prognosis and morphological parameters in luminal breast cancer Children: Item: Title: Materials and methods Children: Item: Title: Patients. Item: Title: Tissue preparation and immunohistochemistry. Item: Title: Conventional and digital Ki67 quantification. Item: Title: Ki67 cut-off point. Item: Title: Oncotype DX recurrence score (RS). Item: Title: Results Children: Item: Title: Ethical approval. Item: Title: Discussion Item: Title: References Item: Title: Acknowledgements Info: Title: Conventional and digital Ki67 evaluation and their correlation with molecular prognosis and morphological parameters in luminal breast cancer Author: Laura Pons Subject: Scientific Reports, https://doi.org/10.1038/s41598-022-11411-5 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon May 16 17:59:21 CEST 2022 ModDate: Tue May 17 12:52:00 CEST 2022 ID: 0x2e6020e2523d3e5e48fd11124caaf273, 0xc04579e0f413c8ca12f331a2e2cb9c8a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1188 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1841 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: KYTGOE+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: QBYAZS+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: OXXAPB+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: OXXAPB+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: HWVKTK+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: HWVKTK+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: KYTGOE+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KYTGOE+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Font: BaseFont: GXDEZM+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GXDEZM+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true XMP: 2022-05-16T20:59:21+05:30 Springer 2022-05-17T12:52:00+02:00 2022-05-17T12:52:00+02:00 application/pdf https://doi.org/10.1038/s41598-022-11411-5 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-022-11411-5 Conventional and digital Ki67 evaluation and their correlation with molecular prognosis and morphological parameters in luminal breast cancer Laura Pons Laura Hernández-León Ahmad Altaleb Esperança Ussene Roman Iglesias Ana Castillo Paula Rodríguez-Martínez Eva Castella Vanesa Quiroga Eudald Felip Beatriz Cirauqui Mireia Margelí Pedro Luis Fernández 10.1038/s41598-022-11411-5 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-022-11411-5 10.1038/s41598-022-11411-5 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-022-11411-5 noindex springer.com springerlink.com VoR uuid:040cb499-4795-4191-b309-f7c699d1227c uuid:cd7c8498-78ae-47f9-b865-c7b2b82debcf default 1 converted uuid:162f1af9-2c46-4a30-8c26-69b515085a89 converted to PDF/A-2b pdfToolbox 2022-05-16T21:00:28+05:30 converted uuid:12e949ab-8ca8-468b-9bbd-91d39d25df53 converted to PDF/A-2b pdfToolbox 2022-05-16T21:01:01+05:30 Adobe PDF Library 15.0; 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