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Keywords: SARS-CoV-2, non-seroconvertor, cellular immunity, T cell subsets, immune activation, function Author: Athina Kilpeläinen Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Tue May 10 06:10:21 2022 CEST ModDate: Tue May 10 06:25:07 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 3867705 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MBAGLH+AdvOT1deab444.I+01 Type 1C MacRoman yes yes no 733 0 MBAGMI+AdvPSA323 Type 1C WinAnsi yes yes no 732 0 MBAGIN+AdvOT34fe1490.B Type 1C WinAnsi yes yes no 708 0 MBAGIO+AdvOT01861455.I Type 1C WinAnsi yes yes no 709 0 MBAGIP+AdvOT01861455.I+01 Type 1C MacRoman yes yes no 710 0 MBAGJA+AdvPSA18C Type 1C WinAnsi yes yes no 711 0 MBAGJB+AdvOT1deab444.I Type 1C WinAnsi yes yes no 712 0 MBAGJC+AdvOT1deab444.I+20 Type 1C WinAnsi yes yes no 713 0 MBAGJD+AdvOT6e5d2ec0 Type 1C WinAnsi yes yes no 714 0 MBAGKE+AdvOT6e5d2ec0+fb Type 1C Custom yes yes yes 715 0 MBAGKF+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 716 0 MBAGKG+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 725 0 MBAGLG+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 726 0 MBAHAH+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 351 0 MBAHBI+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 352 0 MBAHBJ+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 355 0 HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no no 365 0 MBAMEL+AdvOT6e5d2ec0+20 Type 1C WinAnsi yes yes no 366 0 MBAMFM+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 372 0 MBAMFN+AdvOT1deab444.I+fb Type 1C Custom yes yes yes 370 0 MBAMJM+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 374 0 MBAMJN+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 376 0 MBAMJO+AdvOT34fe1490.B+fb Type 1C Custom yes yes yes 379 0 MBBEMN+AdvOTd877c31c+03 Type 1C Custom yes yes yes 383 0 MBBEPN+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 386 0 MBBEPO+AdvTT58d178b9+03 Type 1C Custom yes yes yes 391 0 MBBFBO+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 392 0 MBBFBP+AdvOT7d6df7ab.I+01 Type 1C MacRoman yes yes no 393 0 MBBFCA+AdvTT02dee1cd.I+03 Type 1C Custom yes yes yes 394 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-29 02:37:41 CEST RepresentationInformation: pmc_9128381.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-09-28 02:19:16 CEST Size: 3867705 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'B60' cannot be found Offset: 3838768 MIMEtype: application/pdf PDFMetadata: Objects: 797 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Study Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Determination of Anti-SARS-CoV-2 Antibodies by Enzyme-Linked Immunosorbent Assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Immunophenotype of SARS-CoV-2 T-Cell Responses and Proliferation Assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Statistical Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Non-Seroconvertors Present Skewed T Cell Distribution Towards Higher Naïve and Lower Effector CD8+ T Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Non-Seroconvertors Display Lower Levels of T-Cell Activation-Induced Markers and PD-1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Functional SARS-CoV-2-Specific CD4+ and CD8+ T Cell Responses in Non-Seroconvertors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Info: Title: Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors Author: Athina Kilpeläinen Subject: The role of T cells in the control of SARS-CoV-2 infection has been underestimated in favor of neutralizing antibodies. 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SARS-CoV-2, non-seroconvertor, cellular immunity, T cell subsets, immune activation, function 2022-05-10T12:25:07+08:00 2022-05-10T12:10:21+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2022-05-10T12:25:07+08:00 application/pdf The role of T cells in the control of SARS-CoV-2 infection has been underestimated in favor of neutralizing antibodies. Skewed Cellular Distribution and Low Activation of Functional T-Cell Responses in SARS-CoV-2 Non-Seroconvertors Athina Kilpeläinen Esther Jimenez-Moyano Oscar Blanch-Lombarte Dan Ouchi Ruth Peña Bibiana Quirant-Sanchez Raul Perez-Caballero Anna Chamorro Ignacio Blanco Eva Mart&iacute nez-Caceres Roger Paredes Lourdes Mateu Jorge Carrillo Juli&agrave Blanco Christian Brander Marta Massanella Bonaventura Clotet Julia G. Prado SARS-CoV-2 non-seroconvertor cellular immunity T cell subsets immune activation function uuid:7e77781e-faba-4e16-9ed5-364962b2e8c7 uuid:43780ee2-23c7-4424-bb76-c67fa39cbb9a Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 617, 507, 638 Annotation: Subtype: Link Rect: 175, 594, 464, 615 Annotation: Subtype: Link Rect: 175, 571, 508, 592 Annotation: Subtype: Link Rect: 175, 548, 378, 569 Annotation: Subtype: Link Rect: 482, 64, 486, 74 Destination: 254 Annotation: Subtype: Link Rect: 45, 29, 116, 36 Annotation: Subtype: Link Rect: 125, 29, 183, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Annotation: Subtype: Link Rect: 87, 464, 158, 472 Annotation: Subtype: Link Rect: 84, 315, 158, 322 Annotation: Subtype: Link Rect: 57, 64, 158, 71 Annotation: Subtype: Link Rect: 475, 736, 549, 743 Annotation: Subtype: Link Rect: 477, 728, 549, 735 Annotation: Subtype: Link Rect: 448, 720, 549, 727 Annotation: Subtype: Link Rect: 45, 726, 229, 742 Annotation: 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