95829ea4774ae6b158d34bad6bf71e45 pmc_9145992.pdf 31c6b3427372cf6617a94d0479e8d5fbe17ac3bb pmc_9145992.pdf 14373c0db98e35dffe2d8b52314eee8c2e52ad2fb9c100ecfdbefa05e0a23c11 pmc_9145992.pdf Title: Calicivirus Infection in Cats Subject: Feline calicivirus (FCV) is a common pathogen in domestic cats that is highly contagious, resistant to many disinfectants and demonstrates a high genetic variability. FCV infection can lead to serious or even fatal diseases. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of experts in feline medicine from 11 European countries, presents the current knowledge of FCV infection and fills gaps with expert opinions. FCV infections are particularly problematic in multicat environments. FCV-infected cats often show painful erosions in the mouth and mild upper respiratory disease and, particularly in kittens, even fatal pneumonia. However, infection can be associated with chronic gingivostomatitis. Rarely, highly virulent FCV variants can induce severe systemic disease with epizootic spread and high mortality. FCV can best be detected by reverse-transcriptase PCR. However, a negative result does not rule out FCV infection and healthy cats can test positive. All cats should be vaccinated against FCV (core vaccine); however, vaccination protects cats from disease but not from infection. Considering the high variability of FCV, changing to different vaccine strain(s) may be of benefit if disease occurs in fully vaccinated cats. Infection-induced immunity is not life-long and does not protect against all strains; therefore, vaccination of cats that have recovered from caliciviral disease is recommended. Keywords: FCV; feline; multicat environment; genetic variability; virulent systemic; diagnosis; vaccination; vaccine strains; tenacity; treatment Author: Regina Hofmann-Lehmann, Margaret J. Hosie, Katrin Hartmann, Herman Egberink, Uwe Truyen, Séverine Tasker, Sándor Belák, Corine Boucraut-Baralon, Tadeusz Frymus, Albert Lloret, Fulvio Marsilio, Maria Grazia Pennisi, Diane D. Addie, Hans Lutz, Etienne Thiry, Alan D. Radford and Karin Möstl Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Apr 29 12:49:05 2022 CEST ModDate: Fri Apr 29 13:28:23 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 31 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 4532547 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IODWWR+VnURWPalladioL Type 1 Custom yes yes no 10 0 JZZSJJ+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 HBGKQB+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 CXNLYY+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 GIFXFT+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 HOWKDX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 UUYVLP+CMSY10 Type 1 Builtin yes yes no 74 0 GCOOEG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 103 0 GCOOEH+PalatinoLinotype CID TrueType Identity-H yes yes 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Treatment of Cats with Acute Upper Respiratory Tract or Oral Disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Antiviral Therapy of Acute Upper Respiratory Disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Treatment of Cats with FCGS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Other Management Considerations for FCV Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Treatment of Cats with VS-FCV Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: General Recommendations on Vaccine Type and Vaccination Protocol Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Different FCV Strains Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Vaccination and VS-FC Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Primary Vaccination Course Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Revaccinations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Disease Control in Specific Situations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Shelters Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Breeding Catteries Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: VS-FCV Outbreaks Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Info: Title: Calicivirus Infection in Cats Author: Regina Hofmann-Lehmann, Margaret J. Hosie, Katrin Hartmann, Herman Egberink, Uwe Truyen, Séverine Tasker, Sándor Belák, Corine Boucraut-Baralon, Tadeusz Frymus, Albert Lloret, Fulvio Marsilio, Maria Grazia Pennisi, Diane D. Addie, Hans Lutz, Etienne Thiry, Alan D. Radford and Karin Möstl Subject: Feline calicivirus (FCV) is a common pathogen in domestic cats that is highly contagious, resistant to many disinfectants and demonstrates a high genetic variability. FCV infection can lead to serious or even fatal diseases. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of experts in feline medicine from 11 European countries, presents the current knowledge of FCV infection and fills gaps with expert opinions. FCV infections are particularly problematic in multicat environments. FCV-infected cats often show painful erosions in the mouth and mild upper respiratory disease and, particularly in kittens, even fatal pneumonia. However, infection can be associated with chronic gingivostomatitis. Rarely, highly virulent FCV variants can induce severe systemic disease with epizootic spread and high mortality. FCV can best be detected by reverse-transcriptase PCR. However, a negative result does not rule out FCV infection and healthy cats can test positive. All cats should be vaccinated against FCV (core vaccine); however, vaccination protects cats from disease but not from infection. Considering the high variability of FCV, changing to different vaccine strain(s) may be of benefit if disease occurs in fully vaccinated cats. Infection-induced immunity is not life-long and does not protect against all strains; therefore, vaccination of cats that have recovered from caliciviral disease is recommended. 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