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Keywords: perineuronal nets, CSPGs, spinal cord injury, plasticity, stability, ChABC Author: Esther Udina Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Mon May 16 04:36:57 2022 CEST ModDate: Mon May 16 04:44:29 2022 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 2920388 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- RTIQCY+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 34 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 46 0 KLIODN+HelveticaNeueLTStd-LtIt Type 1C WinAnsi yes yes no 48 0 KDNHYA+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 53 0 WTLAEE+MinionPro-Regular Type 1C Custom yes yes no 55 0 UQOVUV+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 29 0 GUOSZT+MinionPro-Bold Type 1C Custom yes yes no 146 0 TXJOWD+MTGU Type 1C Custom yes yes no 159 0 FNROYJ+MinionPro-It Type 1C WinAnsi yes yes no 187 0 MYRYVT+MTSY Type 1C Custom yes yes no 253 0 OBAZBH+RMTMI Type 1C WinAnsi yes yes no 687 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-07-03 02:37:28 CEST RepresentationInformation: pmc_9163449.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-30 02:39:11 CEST Size: 2920388 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 873 FreeObjects: 20 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: The Role and Modulation of Spinal Perineuronal Nets in the Healthy and Injured Spinal Cord Destination: ariclecounter.1 Children: Item: Title: Introduction Destination: section*.2 Item: Title: Perineuronal Nets Destination: section*.3 Children: Item: Title: Distribution Destination: section*.4 Item: Title: Composition and Structure Destination: section*.5 Item: Title: Function Destination: section*.6 Item: Title: Development: PNN Formation Destination: section*.7 Item: Title: Mature Nervous System: PNN Function and Modulation Destination: section*.8 Item: Title: Injured Nervous System: Spinal Cord Injury Destination: section*.9 Children: Item: Title: Fibro-Glial Scar in the Injury Site Destination: section*.10 Item: Title: Spinal PNN After SCI Destination: section*.11 Item: Title: Therapeutical Manipulations of the ECM After SCI Destination: section*.12 Item: Title: Closing Remarks Destination: section*.13 Item: Title: Author Contributions Destination: section*.14 Item: Title: Funding Destination: section*.15 Item: Title: References Destination: section*.16 Info: Title: The Role and Modulation of Spinal Perineuronal Nets in the Healthy and Injured Spinal Cord Author: Esther Udina Subject: Rather than being a stable scaffold, perineuronal nets (PNNs) are a dynamic and specialized extracellular matrix involved in plasticity modulation. Keywords: perineuronal nets, CSPGs, spinal cord injury, plasticity, stability, ChABC Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Mon May 16 05:06:57 CEST 2022 ModDate: Mon May 16 05:14:29 CEST 2022 ID: 0xcd7c07c115c3950ad04354c0d5e63cdc, 0x50053495fc24044a9ba55757ddbac3a6 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2229 ImageHeight: 1525 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1890 ImageHeight: 2480 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1814 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1610 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: KLIODN+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: KLIODN+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: RTIQCY+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 225 FontDescriptor: FontName: RTIQCY+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -30, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GUOSZT+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 117 FontDescriptor: FontName: GUOSZT+MinionPro-Bold Flags: Symbolic FontBBox: 0, -244, 724, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KDNHYA+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 225 FontDescriptor: FontName: KDNHYA+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -49, -160, 891, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: WTLAEE+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: WTLAEE+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 811 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: FNROYJ+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 225 FontDescriptor: FontName: FNROYJ+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: UQOVUV+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 40 LastChar: 124 FontDescriptor: FontName: UQOVUV+HelveticaNeueLTStd-Bd Flags: Nonsymbolic FontBBox: -19, -214, 848, 786 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MYRYVT+MTSY FontSubset: true FirstChar: 0 LastChar: 67 FontDescriptor: FontName: MYRYVT+MTSY Flags: Symbolic FontBBox: 0, -83, 724, 583 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PIAOFJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PIAOFJ+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: TXJOWD+MTGU FontSubset: true FirstChar: 97 LastChar: 115 FontDescriptor: FontName: TXJOWD+MTGU Flags: Symbolic FontBBox: 0, -206, 519, 683 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OBAZBH+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: OBAZBH+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 683, 455 FontFile3: true Encoding: WinAnsiEncoding XMP: 2022-05-16T08:06:57+05:30 LaTeX with hyperref package + hypdvips 2022-05-16T08:14:29+05:30 2022-05-16T08:14:29+05:30 application/pdf Rather than being a stable scaffold, perineuronal nets (PNNs) are a dynamic and specialized extracellular matrix involved in plasticity modulation. 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285, 527 Destination: External Annotation: Subtype: Link Rect: 262, 481, 65, 481 Destination: External Annotation: Subtype: Link Rect: 70, 470, 90, 481 Destination: External Annotation: Subtype: Link Rect: 237, 458, 289, 470 Destination: External Annotation: Subtype: Link Rect: 43, 447, 64, 458 Destination: External Annotation: Subtype: Link Rect: 67, 447, 119, 458 Destination: External Annotation: Subtype: Link Rect: 122, 447, 143, 458 Destination: External Annotation: Subtype: Link Rect: 227, 424, 289, 435 Destination: External Annotation: Subtype: Link Rect: 43, 412, 64, 424 Destination: External Annotation: Subtype: Link Rect: 154, 401, 233, 412 Destination: External Annotation: Subtype: Link Rect: 237, 401, 257, 412 Destination: External Annotation: Subtype: Link Rect: 261, 401, 63, 401 Destination: External Annotation: Subtype: Link Rect: 66, 390, 86, 401 Destination: External Annotation: Subtype: Link Rect: 128, 367, 171, 378 Destination: External Annotation: Subtype: Link Rect: 174, 367, 194, 378 Destination: External Annotation: Subtype: Link Rect: 197, 367, 262, 378 Destination: External Annotation: Subtype: Link Rect: 265, 367, 285, 378 Destination: External Annotation: Subtype: Link Rect: 47, 332, 102, 344 Destination: External Annotation: Subtype: Link Rect: 106, 332, 126, 344 Destination: External Annotation: Subtype: Link Rect: 131, 332, 207, 344 Destination: External Annotation: Subtype: Link Rect: 212, 332, 232, 344 Destination: External Annotation: Subtype: Link Rect: 237, 332, 74, 332 Destination: External Annotation: Subtype: Link Rect: 78, 321, 98, 332 Destination: External Annotation: Subtype: Link Rect: 70, 286, 117, 298 Destination: External Annotation: Subtype: Link Rect: 120, 286, 140, 298 Destination: External Annotation: Subtype: Link Rect: 248, 229, 65, 229 Destination: External Annotation: Subtype: Link Rect: 69, 217, 89, 229 Destination: External Annotation: Subtype: Link Rect: 148, 206, 206, 217 Destination: External Annotation: Subtype: Link Rect: 211, 206, 231, 217 Destination: External Annotation: Subtype: Link Rect: 69, 171, 159, 183 Destination: External Annotation: Subtype: Link Rect: 162, 171, 182, 183 Destination: External Annotation: Subtype: Link Rect: 247, 148, 69, 148 Destination: External Annotation: Subtype: Link Rect: 71, 137, 91, 148 Destination: External Annotation: Subtype: Link Rect: 147, 77, 182, 87 Destination: External Annotation: Subtype: Link Rect: 191, 79, 234, 91 Destination: External Annotation: Subtype: Link Rect: 238, 79, 258, 91 Destination: External Annotation: Subtype: Link Rect: 262, 79, 66, 79 Destination: External Annotation: Subtype: Link Rect: 70, 68, 90, 79 Destination: External Annotation: Subtype: Link Rect: 95, 68, 150, 79 Destination: External Annotation: Subtype: Link Rect: 155, 68, 175, 79 Destination: External Annotation: Subtype: Link Rect: 531, 674, 364, 674 Destination: External Annotation: Subtype: Link Rect: 368, 662, 388, 674 Destination: External Annotation: Subtype: Link Rect: 442, 640, 521, 651 Destination: External Annotation: Subtype: Link Rect: 525, 640, 546, 651 Destination: External Annotation: Subtype: Link Rect: 307, 617, 407, 628 Destination: External Annotation: Subtype: Link Rect: 410, 617, 430, 628 Destination: External Annotation: Subtype: Link Rect: 474, 617, 549, 628 Destination: External Annotation: Subtype: Link Rect: 304, 605, 324, 617 Destination: External Annotation: Subtype: Link Rect: 379, 571, 447, 582 Destination: External Annotation: Subtype: Link Rect: 451, 571, 471, 582 Destination: External Annotation: Subtype: Link Rect: 363, 559, 441, 571 Destination: External Annotation: Subtype: Link Rect: 444, 559, 464, 571 Destination: External Annotation: Subtype: Link Rect: 477, 376, 525, 388 Destination: External Annotation: Subtype: Link Rect: 529, 376, 549, 388 Destination: External Annotation: Subtype: Link Rect: 304, 365, 354, 376 Destination: External Annotation: Subtype: Link Rect: 356, 365, 376, 376 Destination: External Annotation: Subtype: Link Rect: 506, 330, 549, 342 Destination: External Annotation: Subtype: Link Rect: 304, 319, 324, 330 Destination: External Annotation: Subtype: Link Rect: 327, 319, 378, 330 Destination: External Annotation: Subtype: Link Rect: 380, 319, 401, 330 Destination: External Annotation: Subtype: Link Rect: 404, 319, 445, 330 Destination: External Annotation: Subtype: Link Rect: 448, 319, 468, 330 Destination: External Annotation: Subtype: Link Rect: 471, 319, 522, 330 Destination: External Annotation: Subtype: Link Rect: 525, 319, 546, 330 Destination: External Annotation: Subtype: Link Rect: 384, 250, 466, 261 Destination: External Annotation: Subtype: Link Rect: 470, 250, 490, 261 Destination: External Annotation: Subtype: Link Rect: 307, 216, 355, 227 Destination: External Annotation: Subtype: Link Rect: 358, 216, 378, 227 Destination: External Annotation: Subtype: Link Rect: 342, 170, 391, 181 Destination: External Annotation: Subtype: Link Rect: 396, 170, 416, 181 Destination: External Annotation: Subtype: Link Rect: 383, 135, 442, 147 Destination: External Annotation: Subtype: Link Rect: 446, 135, 467, 147 Destination: External Annotation: Subtype: Link Rect: 354, 124, 402, 135 Destination: External Annotation: Subtype: Link Rect: 407, 124, 428, 135 Destination: External Annotation: Subtype: Link Rect: 43, 30, 145, 38 Annotation: Subtype: Link Rect: 149, 29, 209, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 47, 178, 119, 189 Destination: External Annotation: Subtype: Link Rect: 123, 178, 143, 189 Destination: External Annotation: Subtype: Link Rect: 147, 178, 196, 189 Destination: External Annotation: Subtype: Link Rect: 200, 178, 220, 189 Destination: External Annotation: Subtype: Link Rect: 68, 144, 118, 155 Destination: External Annotation: Subtype: Link Rect: 122, 144, 142, 155 Destination: External Annotation: Subtype: Link Rect: 120, 75, 208, 86 Destination: External Annotation: Subtype: Link Rect: 210, 75, 230, 86 Destination: External Annotation: Subtype: Link Rect: 397, 109, 454, 121 Destination: External Annotation: Subtype: Link Rect: 461, 109, 481, 121 Destination: External Annotation: Subtype: Link Rect: 307, 98, 382, 109 Destination: External Annotation: Subtype: Link Rect: 390, 98, 410, 109 Destination: External Annotation: Subtype: Link Rect: 527, 98, 328, 98 Destination: External Annotation: Subtype: Link Rect: 335, 86, 355, 98 Destination: External Annotation: Subtype: Link Rect: 420, 86, 485, 98 Destination: External Annotation: Subtype: Link Rect: 492, 86, 512, 98 Destination: External Annotation: Subtype: Link Rect: 43, 30, 145, 38 Annotation: Subtype: Link Rect: 149, 29, 209, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 236, 489, 289, 500 Destination: External Annotation: Subtype: Link Rect: 43, 477, 64, 489 Destination: External Annotation: Subtype: Link Rect: 67, 477, 111, 489 Destination: External Annotation: Subtype: Link Rect: 114, 477, 135, 489 Destination: External Annotation: Subtype: Link Rect: 138, 477, 179, 489 Destination: External Annotation: Subtype: Link Rect: 182, 477, 202, 489 Destination: External Annotation: Subtype: Link Rect: 109, 466, 176, 477 Destination: External Annotation: Subtype: Link Rect: 180, 466, 200, 477 Destination: External Annotation: Subtype: Link Rect: 280, 454, 104, 454 Destination: External Annotation: Subtype: Link Rect: 108, 443, 128, 454 Destination: External Annotation: Subtype: Link Rect: 132, 443, 182, 454 Destination: External Annotation: Subtype: Link Rect: 186, 443, 206, 454 Destination: External Annotation: Subtype: Link Rect: 244, 397, 289, 409 Destination: External Annotation: Subtype: Link Rect: 43, 386, 64, 397 Destination: External Annotation: Subtype: Link Rect: 66, 386, 119, 397 Destination: External Annotation: Subtype: Link Rect: 121, 386, 141, 397 Destination: External Annotation: Subtype: Link Rect: 195, 351, 266, 363 Destination: External Annotation: Subtype: Link Rect: 268, 351, 289, 363 Destination: External Annotation: Subtype: Link Rect: 43, 340, 84, 351 Destination: External Annotation: Subtype: Link Rect: 86, 340, 106, 351 Destination: External Annotation: Subtype: Link Rect: 47, 250, 103, 261 Destination: External Annotation: Subtype: Link Rect: 107, 250, 127, 261 Destination: External Annotation: Subtype: Link Rect: 186, 250, 251, 261 Destination: External Annotation: Subtype: Link Rect: 255, 250, 275, 261 Destination: External Annotation: Subtype: Link Rect: 97, 239, 149, 250 Destination: External Annotation: Subtype: Link Rect: 154, 239, 175, 250 Destination: External Annotation: Subtype: Link Rect: 263, 239, 63, 239 Destination: External Annotation: Subtype: Link Rect: 67, 227, 87, 239 Destination: External Annotation: Subtype: Link Rect: 145, 158, 198, 170 Destination: External Annotation: Subtype: Link Rect: 202, 158, 222, 170 Destination: External Annotation: Subtype: Link Rect: 104, 90, 195, 101 Destination: External Annotation: Subtype: Link Rect: 199, 90, 219, 101 Destination: External Annotation: Subtype: Link Rect: 214, 78, 263, 90 Destination: External Annotation: Subtype: Link Rect: 265, 78, 285, 90 Destination: External Annotation: Subtype: Link Rect: 519, 708, 325, 708 Destination: External Annotation: Subtype: Link Rect: 330, 697, 350, 708 Destination: External Annotation: Subtype: Link Rect: 485, 662, 549, 674 Destination: External Annotation: Subtype: Link Rect: 304, 651, 324, 662 Destination: External Annotation: Subtype: Link Rect: 470, 582, 525, 594 Destination: External Annotation: Subtype: Link Rect: 529, 582, 549, 594 Destination: External Annotation: Subtype: Link Rect: 304, 571, 346, 582 Destination: External Annotation: Subtype: Link Rect: 350, 571, 370, 582 Destination: External Annotation: Subtype: Link Rect: 307, 536, 397, 548 Destination: External Annotation: Subtype: Link Rect: 400, 536, 420, 548 Destination: External Annotation: Subtype: Link Rect: 449, 479, 497, 491 Destination: External Annotation: Subtype: Link Rect: 500, 479, 520, 491 Destination: External Annotation: Subtype: Link Rect: 524, 479, 349, 479 Destination: External Annotation: Subtype: Link Rect: 353, 468, 373, 479 Destination: External Annotation: Subtype: Link Rect: 377, 468, 467, 479 Destination: External Annotation: Subtype: Link Rect: 471, 468, 491, 479 Destination: External Annotation: Subtype: Link Rect: 502, 456, 325, 456 Destination: External Annotation: Subtype: Link Rect: 328, 445, 348, 456 Destination: External Annotation: Subtype: Link Rect: 352, 445, 372, 456 Destination: External Annotation: Subtype: Link Rect: 376, 445, 466, 456 Destination: External Annotation: Subtype: Link Rect: 469, 445, 489, 456 Destination: External Annotation: Subtype: Link Rect: 307, 422, 379, 433 Destination: External Annotation: Subtype: Link Rect: 383, 422, 403, 433 Destination: External Annotation: Subtype: Link Rect: 407, 422, 428, 433 Destination: External Annotation: Subtype: Link Rect: 432, 422, 496, 433 Destination: External Annotation: Subtype: Link Rect: 500, 422, 520, 433 Destination: External Annotation: Subtype: Link Rect: 307, 330, 377, 342 Destination: External Annotation: Subtype: Link Rect: 380, 330, 400, 342 Destination: External Annotation: Subtype: Link Rect: 403, 330, 493, 342 Destination: External Annotation: Subtype: Link Rect: 496, 330, 516, 342 Destination: External Annotation: Subtype: Link Rect: 348, 294, 382, 304 Destination: External Annotation: Subtype: Link Rect: 307, 273, 395, 284 Destination: External Annotation: Subtype: Link Rect: 397, 273, 417, 284 Destination: External Annotation: Subtype: Link Rect: 475, 261, 549, 273 Destination: External Annotation: Subtype: Link Rect: 304, 250, 324, 261 Destination: External Annotation: Subtype: Link Rect: 377, 216, 465, 227 Destination: External Annotation: Subtype: Link Rect: 468, 216, 488, 227 Destination: External Annotation: Subtype: Link Rect: 383, 193, 456, 204 Destination: External Annotation: Subtype: Link Rect: 459, 193, 479, 204 Destination: External Annotation: Subtype: Link Rect: 355, 135, 446, 147 Destination: External Annotation: Subtype: Link Rect: 450, 135, 470, 147 Destination: External Annotation: Subtype: Link Rect: 43, 30, 145, 38 Annotation: Subtype: Link Rect: 149, 29, 209, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 255, 219, 87, 219 Destination: External Annotation: Subtype: Link Rect: 90, 208, 110, 219 Destination: External Annotation: Subtype: Link Rect: 113, 208, 181, 219 Destination: External Annotation: Subtype: Link Rect: 185, 208, 205, 219 Destination: External Annotation: Subtype: Link Rect: 208, 208, 288, 219 Destination: External Annotation: Subtype: Link Rect: 43, 196, 64, 208 Destination: External Annotation: Subtype: Link Rect: 68, 196, 111, 208 Destination: External Annotation: Subtype: Link Rect: 115, 196, 136, 208 Destination: External Annotation: Subtype: Link Rect: 140, 196, 191, 208 Destination: External Annotation: Subtype: Link Rect: 195, 196, 215, 208 Destination: External Annotation: Subtype: Link Rect: 47, 162, 104, 174 Destination: External Annotation: Subtype: Link Rect: 107, 162, 127, 174 Destination: External Annotation: Subtype: Link Rect: 69, 104, 132, 116 Destination: External Annotation: Subtype: Link Rect: 136, 104, 156, 116 Destination: External Annotation: Subtype: Link Rect: 47, 70, 132, 81 Destination: External Annotation: Subtype: Link Rect: 135, 70, 155, 81 Destination: External Annotation: Subtype: Link Rect: 307, 160, 362, 171 Destination: External Annotation: Subtype: Link Rect: 365, 160, 385, 171 Destination: External Annotation: Subtype: Link Rect: 476, 148, 512, 160 Destination: External Annotation: Subtype: Link Rect: 515, 148, 535, 160 Destination: External Annotation: Subtype: Link Rect: 393, 114, 476, 125 Destination: External Annotation: Subtype: Link Rect: 480, 114, 500, 125 Destination: External Annotation: Subtype: Link Rect: 504, 114, 326, 114 Destination: External Annotation: Subtype: Link Rect: 331, 102, 351, 114 Destination: External Annotation: Subtype: Link Rect: 526, 91, 325, 91 Destination: External Annotation: Subtype: Link Rect: 330, 79, 350, 91 Destination: External Annotation: Subtype: Link Rect: 437, 79, 490, 91 Destination: External Annotation: Subtype: Link Rect: 494, 79, 514, 91 Destination: External Annotation: Subtype: Link Rect: 43, 30, 145, 38 Annotation: Subtype: Link Rect: 149, 29, 209, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 10 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 47, 708, 87, 720 Destination: External Annotation: Subtype: Link Rect: 89, 708, 109, 720 Destination: External Annotation: Subtype: Link Rect: 170, 708, 216, 720 Destination: External Annotation: Subtype: Link Rect: 219, 708, 239, 720 Destination: External Annotation: Subtype: Link Rect: 241, 708, 64, 708 Destination: External Annotation: Subtype: Link Rect: 67, 697, 88, 708 Destination: External Annotation: Subtype: Link Rect: 171, 697, 222, 708 Destination: External Annotation: Subtype: Link Rect: 226, 697, 246, 708 Destination: External Annotation: Subtype: Link Rect: 125, 651, 170, 662 Destination: External Annotation: Subtype: Link Rect: 174, 651, 194, 662 Destination: External Annotation: Subtype: Link Rect: 149, 617, 203, 628 Destination: External Annotation: Subtype: Link Rect: 208, 617, 229, 628 Destination: External Annotation: Subtype: Link Rect: 224, 548, 289, 559 Destination: External Annotation: Subtype: Link Rect: 43, 536, 64, 548 Destination: External Annotation: Subtype: Link Rect: 67, 536, 127, 548 Destination: External Annotation: Subtype: Link Rect: 131, 536, 151, 548 Destination: External Annotation: Subtype: Link Rect: 155, 536, 207, 548 Destination: External Annotation: Subtype: Link Rect: 210, 536, 230, 548 Destination: External Annotation: Subtype: Link Rect: 234, 536, 289, 548 Destination: External Annotation: Subtype: Link Rect: 43, 525, 64, 536 Destination: External Annotation: Subtype: Link Rect: 240, 502, 289, 514 Destination: External Annotation: Subtype: Link Rect: 43, 491, 64, 502 Destination: External Annotation: Subtype: Link Rect: 150, 456, 221, 468 Destination: External Annotation: Subtype: Link Rect: 224, 456, 244, 468 Destination: External Annotation: Subtype: Link Rect: 247, 456, 289, 468 Destination: External Annotation: Subtype: Link Rect: 43, 445, 64, 456 Destination: External Annotation: Subtype: Link Rect: 66, 445, 112, 456 Destination: External Annotation: Subtype: Link Rect: 114, 445, 134, 456 Destination: External Annotation: Subtype: Link Rect: 137, 445, 184, 456 Destination: External Annotation: Subtype: Link Rect: 187, 445, 207, 456 Destination: External Annotation: Subtype: Link Rect: 209, 445, 254, 456 Destination: External Annotation: Subtype: Link Rect: 256, 445, 276, 456 Destination: External Annotation: Subtype: Link Rect: 263, 365, 90, 365 Destination: External Annotation: Subtype: Link Rect: 95, 353, 115, 365 Destination: External Annotation: Subtype: Link Rect: 119, 353, 168, 365 Destination: External Annotation: Subtype: Link Rect: 172, 353, 193, 365 Destination: External Annotation: Subtype: Link Rect: 197, 353, 289, 365 Destination: External Annotation: Subtype: Link Rect: 43, 342, 64, 353 Destination: External Annotation: Subtype: Link Rect: 196, 342, 266, 353 Destination: External Annotation: Subtype: Link Rect: 268, 342, 289, 353 Destination: External Annotation: Subtype: Link Rect: 43, 330, 88, 342 Destination: External Annotation: Subtype: Link Rect: 90, 330, 110, 342 Destination: External Annotation: Subtype: Link Rect: 112, 330, 158, 342 Destination: External Annotation: Subtype: Link Rect: 160, 330, 180, 342 Destination: External Annotation: Subtype: Link Rect: 43, 296, 116, 307 Destination: External Annotation: Subtype: Link Rect: 119, 296, 139, 307 Destination: External Annotation: Subtype: Link Rect: 181, 227, 228, 239 Destination: External Annotation: Subtype: Link Rect: 231, 227, 251, 239 Destination: External Annotation: Subtype: Link Rect: 103, 193, 191, 204 Destination: External Annotation: Subtype: Link Rect: 193, 193, 213, 204 Destination: External Annotation: Subtype: Link Rect: 47, 170, 94, 181 Destination: External Annotation: Subtype: Link Rect: 97, 170, 117, 181 Destination: External Annotation: Subtype: Link Rect: 121, 170, 191, 181 Destination: External Annotation: Subtype: Link Rect: 195, 170, 215, 181 Destination: External Annotation: Subtype: Link Rect: 218, 170, 265, 181 Destination: External Annotation: Subtype: Link Rect: 268, 170, 289, 181 Destination: External Annotation: Subtype: Link Rect: 43, 158, 131, 170 Destination: External Annotation: Subtype: Link Rect: 134, 158, 154, 170 Destination: External Annotation: Subtype: Link Rect: 165, 135, 238, 147 Destination: External Annotation: Subtype: Link Rect: 242, 135, 262, 147 Destination: External Annotation: Subtype: Link Rect: 266, 135, 63, 135 Destination: External Annotation: Subtype: Link Rect: 65, 124, 86, 135 Destination: External Annotation: Subtype: Link Rect: 88, 124, 134, 135 Destination: External Annotation: Subtype: Link Rect: 137, 124, 157, 135 Destination: External Annotation: Subtype: Link Rect: 159, 124, 247, 135 Destination: External Annotation: Subtype: Link Rect: 249, 124, 269, 135 Destination: External Annotation: Subtype: Link Rect: 497, 708, 344, 708 Destination: External Annotation: Subtype: Link Rect: 346, 697, 366, 708 Destination: External Annotation: Subtype: Link Rect: 348, 514, 402, 525 Destination: External Annotation: Subtype: Link Rect: 405, 514, 425, 525 Destination: External Annotation: Subtype: Link Rect: 449, 468, 524, 479 Destination: External Annotation: Subtype: Link Rect: 529, 468, 549, 479 Destination: External Annotation: Subtype: Link Rect: 304, 456, 354, 468 Destination: External Annotation: Subtype: Link Rect: 360, 456, 380, 468 Destination: External Annotation: Subtype: Link Rect: 444, 456, 522, 468 Destination: External Annotation: Subtype: Link Rect: 527, 456, 548, 468 Destination: External Annotation: Subtype: Link Rect: 508, 376, 549, 388 Destination: External Annotation: Subtype: Link Rect: 304, 365, 324, 376 Destination: External Annotation: Subtype: Link Rect: 429, 330, 481, 342 Destination: External Annotation: Subtype: Link Rect: 485, 330, 505, 342 Destination: External Annotation: Subtype: Link Rect: 508, 330, 328, 330 Destination: External Annotation: Subtype: Link Rect: 331, 319, 351, 330 Destination: External Annotation: Subtype: Link Rect: 530, 307, 324, 307 Destination: External Annotation: Subtype: Link Rect: 327, 296, 347, 307 Destination: External Annotation: Subtype: Link Rect: 522, 261, 323, 261 Destination: External Annotation: Subtype: Link Rect: 326, 250, 346, 261 Destination: External Annotation: Subtype: Link Rect: 43, 30, 145, 38 Annotation: Subtype: Link Rect: 149, 29, 209, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 11 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 47, 605, 78, 617 Destination: External Annotation: Subtype: Link Rect: 85, 605, 105, 617 Destination: External Annotation: Subtype: Link Rect: 207, 582, 262, 594 Destination: External Annotation: Subtype: Link Rect: 268, 582, 289, 594 Destination: External Annotation: Subtype: Link Rect: 43, 571, 111, 582 Destination: External Annotation: Subtype: Link Rect: 116, 571, 136, 582 Destination: External Annotation: Subtype: Link Rect: 141, 571, 206, 582 Destination: External Annotation: Subtype: Link Rect: 212, 571, 232, 582 Destination: External Annotation: Subtype: Link Rect: 95, 432, 160, 439 Annotation: Subtype: Link Rect: 158, 403, 239, 411 Annotation: Subtype: Link Rect: 119, 373, 213, 383 Annotation: Subtype: Link Rect: 95, 337, 153, 344 Annotation: Subtype: Link Rect: 184, 307, 241, 316 Annotation: Subtype: Link Rect: 95, 269, 194, 279 Annotation: Subtype: Link Rect: 102, 242, 200, 250 Annotation: Subtype: Link Rect: 165, 213, 264, 222 Annotation: Subtype: Link Rect: 149, 185, 258, 193 Annotation: Subtype: Link Rect: 110, 147, 218, 155 Annotation: Subtype: Link Rect: 102, 119, 176, 127 Annotation: Subtype: Link Rect: 150, 91, 235, 98 Annotation: Subtype: Link Rect: 95, 62, 194, 70 Annotation: Subtype: Link Rect: 363, 440, 471, 449 Annotation: Subtype: Link Rect: 356, 403, 410, 411 Annotation: Subtype: Link Rect: 415, 375, 468, 382 Annotation: Subtype: Link Rect: 403, 337, 514, 344 Annotation: Subtype: Link Rect: 449, 307, 519, 316 Annotation: Subtype: Link Rect: 359, 279, 458, 288 Annotation: Subtype: Link Rect: 363, 241, 435, 250 Annotation: Subtype: Link Rect: 552, 193, 313, 213 Annotation: Subtype: Link Rect: 408, 167, 472, 174 Annotation: Subtype: Link Rect: 552, 128, 313, 147 Annotation: Subtype: Link Rect: 410, 100, 518, 108 Annotation: Subtype: Link Rect: 363, 62, 471, 70 Annotation: Subtype: Link Rect: 43, 29, 145, 37 Annotation: Subtype: Link Rect: 149, 28, 209, 36 Annotation: Subtype: Link Rect: 433, 28, 551, 37 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 95, 680, 172, 687 Annotation: Subtype: Link Rect: 95, 641, 194, 649 Annotation: Subtype: Link Rect: 102, 603, 211, 611 Annotation: Subtype: Link Rect: 198, 574, 267, 583 Annotation: Subtype: Link Rect: 95, 538, 153, 545 Annotation: Subtype: Link Rect: 95, 509, 180, 517 Annotation: Subtype: Link Rect: 95, 480, 194, 489 Annotation: Subtype: Link Rect: 88, 460, 159, 469 Annotation: Subtype: Link Rect: 102, 433, 211, 441 Annotation: Subtype: Link Rect: 203, 405, 260, 413 Annotation: Subtype: Link Rect: 196, 367, 268, 375 Annotation: Subtype: Link Rect: 102, 339, 214, 346 Annotation: Subtype: Link Rect: 92, 300, 191, 309 Annotation: Subtype: Link Rect: 110, 262, 189, 271 Annotation: Subtype: Link Rect: 95, 225, 158, 233 Annotation: Subtype: Link Rect: 95, 195, 179, 205 Annotation: Subtype: Link Rect: 217, 178, 270, 185 Annotation: Subtype: Link Rect: 132, 139, 222, 148 Annotation: Subtype: Link Rect: 95, 110, 179, 119 Annotation: Subtype: Link Rect: 174, 92, 273, 101 Annotation: Subtype: Link Rect: 395, 689, 481, 696 Annotation: Subtype: Link Rect: 391, 651, 449, 659 Annotation: Subtype: Link Rect: 351, 612, 444, 621 Annotation: Subtype: Link Rect: 356, 576, 407, 583 Annotation: Subtype: Link Rect: 356, 536, 464, 545 Annotation: Subtype: Link Rect: 363, 498, 466, 507 Annotation: Subtype: Link Rect: 451, 471, 520, 479 Annotation: Subtype: Link Rect: 403, 443, 455, 450 Annotation: Subtype: Link Rect: 363, 413, 471, 422 Annotation: Subtype: Link Rect: 356, 375, 438, 384 Annotation: Subtype: Link Rect: 393, 348, 466, 356 Annotation: Subtype: Link Rect: 438, 320, 514, 327 Annotation: Subtype: Link Rect: 363, 281, 471, 289 Annotation: Subtype: Link Rect: 363, 244, 434, 252 Annotation: Subtype: Link Rect: 356, 205, 451, 214 Annotation: Subtype: Link Rect: 356, 178, 468, 185 Annotation: Subtype: Link Rect: 552, 129, 313, 149 Annotation: Subtype: Link Rect: 337, 93, 415, 101 Annotation: Subtype: Link Rect: 43, 30, 145, 38 Annotation: Subtype: Link Rect: 149, 29, 209, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 13 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 95, 679, 194, 687 Annotation: Subtype: Link Rect: 102, 642, 214, 649 Annotation: Subtype: Link Rect: 84, 604, 162, 612 Annotation: Subtype: Link Rect: 95, 574, 172, 583 Annotation: Subtype: Link Rect: 106, 536, 162, 545 Annotation: Subtype: Link Rect: 113, 508, 189, 517 Annotation: Subtype: Link Rect: 102, 471, 175, 479 Annotation: Subtype: Link Rect: 95, 441, 193, 451 Annotation: Subtype: Link Rect: 91, 415, 169, 422 Annotation: Subtype: Link Rect: 107, 385, 176, 394 Annotation: Subtype: Link Rect: 95, 339, 166, 346 Annotation: Subtype: Link Rect: 169, 309, 277, 318 Annotation: Subtype: Link Rect: 95, 272, 194, 280 Annotation: Subtype: Link Rect: 95, 244, 169, 252 Annotation: Subtype: Link Rect: 102, 215, 225, 223 Annotation: Subtype: Link Rect: 292, 177, 52, 196 Annotation: Subtype: Link Rect: 102, 139, 206, 148 Annotation: Subtype: Link Rect: 102, 112, 165, 119 Annotation: Subtype: Link Rect: 149, 73, 258, 81 Annotation: Subtype: Link Rect: 449, 689, 514, 696 Annotation: Subtype: Link Rect: 348, 659, 441, 668 Annotation: Subtype: Link Rect: 363, 621, 442, 630 Annotation: Subtype: Link Rect: 363, 575, 485, 583 Annotation: Subtype: Link Rect: 355, 538, 425, 545 Annotation: Subtype: Link Rect: 373, 498, 450, 507 Annotation: Subtype: Link Rect: 348, 470, 438, 479 Annotation: Subtype: Link Rect: 430, 433, 539, 441 Annotation: Subtype: Link Rect: 363, 395, 485, 403 Annotation: Subtype: Link Rect: 358, 357, 480, 365 Annotation: Subtype: Link Rect: 363, 319, 485, 327 Annotation: Subtype: Link Rect: 363, 281, 453, 290 Annotation: Subtype: Link Rect: 395, 254, 447, 261 Annotation: Subtype: Link Rect: 363, 214, 445, 223 Annotation: Subtype: Link Rect: 471, 187, 517, 195 Annotation: Subtype: Link Rect: 453, 157, 547, 167 Annotation: Subtype: Link Rect: 363, 120, 471, 129 Annotation: Subtype: Link Rect: 445, 91, 504, 100 Annotation: Subtype: Link Rect: 43, 30, 145, 38 Annotation: Subtype: Link Rect: 149, 29, 209, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 14 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 95, 699, 165, 706 Annotation: Subtype: Link Rect: 95, 669, 192, 678 Annotation: Subtype: Link Rect: 84, 632, 157, 640 Annotation: Subtype: Link Rect: 117, 602, 186, 611 Annotation: Subtype: Link Rect: 137, 576, 222, 583 Annotation: Subtype: Link Rect: 169, 555, 259, 564 Annotation: Subtype: Link Rect: 95, 527, 177, 536 Annotation: Subtype: Link Rect: 197, 490, 270, 498 Annotation: Subtype: Link Rect: 181, 471, 257, 479 Annotation: Subtype: Link Rect: 211, 442, 291, 450 Annotation: Subtype: Link Rect: 102, 394, 206, 403 Annotation: Subtype: Link Rect: 221, 367, 267, 375 Annotation: Subtype: Link Rect: 119, 338, 215, 347 Annotation: Subtype: Link Rect: 102, 311, 188, 318 Annotation: Subtype: Link Rect: 149, 281, 258, 289 Annotation: Subtype: Link Rect: 95, 253, 194, 261 Annotation: Subtype: Link Rect: 102, 205, 206, 214 Annotation: Subtype: Link Rect: 91, 129, 192, 138 Annotation: Subtype: Link Rect: 194, 101, 289, 110 Annotation: Subtype: Link Rect: 174, 74, 250, 81 Annotation: Subtype: Link Rect: 356, 678, 445, 687 Annotation: Subtype: Link Rect: 392, 661, 445, 668 Annotation: Subtype: Link Rect: 348, 621, 453, 631 Annotation: Subtype: Link Rect: 451, 602, 531, 611 Annotation: Subtype: Link Rect: 423, 564, 479, 573 Annotation: Subtype: Link Rect: 472, 536, 550, 545 Annotation: Subtype: Link Rect: 385, 500, 453, 508 Annotation: Subtype: Link Rect: 337, 471, 415, 479 Annotation: Subtype: Link Rect: 327, 443, 442, 450 Annotation: Subtype: Link Rect: 394, 413, 489, 422 Annotation: Subtype: Link Rect: 363, 376, 471, 384 Annotation: Subtype: Link Rect: 356, 347, 455, 356 Annotation: Subtype: Link Rect: 345, 311, 434, 318 Annotation: Subtype: Link Rect: 363, 273, 434, 280 Annotation: Subtype: Link Rect: 363, 244, 434, 252 Annotation: Subtype: Link Rect: 397, 216, 475, 224 Annotation: Subtype: Link Rect: 383, 176, 468, 185 Annotation: Subtype: Link Rect: 366, 139, 448, 148 Annotation: Subtype: Link Rect: 363, 101, 471, 110 Annotation: Subtype: Link Rect: 402, 72, 461, 81 Annotation: Subtype: Link Rect: 43, 30, 145, 38 Annotation: Subtype: Link Rect: 149, 29, 209, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Page: Label: 15 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 157, 689, 246, 696 Annotation: Subtype: Link Rect: 102, 650, 225, 659 Annotation: Subtype: Link Rect: 88, 623, 144, 630 Annotation: Subtype: Link Rect: 292, 582, 52, 603 Annotation: Subtype: Link Rect: 146, 566, 210, 573 Annotation: Subtype: Link Rect: 106, 527, 220, 536 Annotation: Subtype: Link Rect: 95, 490, 180, 498 Annotation: Subtype: Link Rect: 467, 689, 542, 696 Annotation: Subtype: Link Rect: 363, 661, 473, 668 Annotation: Subtype: Link Rect: 405, 537, 431, 544 Annotation: Subtype: Link Rect: 431, 537, 463, 544 Annotation: Subtype: Link Rect: 463, 537, 499, 544 Annotation: Subtype: Link Rect: 499, 537, 522, 544 Annotation: Subtype: Link Rect: 522, 536, 549, 544 Annotation: Subtype: Link Rect: 43, 30, 145, 38 Annotation: Subtype: Link Rect: 149, 29, 209, 37 Annotation: Subtype: Link Rect: 433, 29, 551, 38 Checksum: 13bd9e43 Type: CRC32 Checksum: 1bc1a83098d503c9ccfdb3363b529e1f Type: MD5 Checksum: 8471630419b88af8128f8d9f0abc34fa2feffb09 Type: SHA-1 Checksum: d783527cd6e00b006babef5ed37c6c8548998a076b937e533ba6145fa4148578 Type: SHA-256