e095a785045af36d04b2be6898faee8f pmc_9168966.pdf 18efe878a1b9b8f0be70ee0f4454a4b029edc177 pmc_9168966.pdf 7a71804033c5fd45416a49ad4a9fed3cd59b2b4ec90d456ce18ff33b2651f484 pmc_9168966.pdf Title: Dual inhibition of TGF‐β and PD‐L1: a novel approach to cancer treatment Creator: Arbortext Advanced Print Publisher 9.1.531/W Unicode Producer: Acrobat Distiller 10.1.16 (Windows) CreationDate: Wed Jun 1 05:25:48 2022 CEST ModDate: Wed Jun 1 05:25:48 2022 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1006323 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PLALEG+AdvPSUnv Type 1C WinAnsi yes yes no 890 0 PLALJN+AdvPSSym Type 1C Custom yes yes yes 910 0 PLALJO+AdvPSUnv-LO Type 1C WinAnsi yes yes no 915 0 PLALEH+AdvPS-UVBL Type 1C MacRoman yes yes no 893 0 PLALEI+AdvPSMP11 Type 1C WinAnsi yes yes no 894 0 PLALII+AdvPSUnv-L Type 1C Custom yes yes no 895 0 PLALIJ+AdvPSUnv-B Type 1C WinAnsi yes yes no 896 0 PLALIK+AdvPSMP13 Type 1C WinAnsi yes yes no 897 0 PLALJK+AdvTTec369687 Type 1C WinAnsi yes yes no 905 0 PLALJL+AdvTimes Type 1C MacRoman yes yes no 906 0 PLALJM+AdvTTec369687+20 Type 1C WinAnsi yes yes no 907 0 PLAMCM+AdvTimes-i Type 1C WinAnsi yes yes no 509 0 PLAMCN+AdvTTec369687+22 Type 1C Custom yes yes yes 504 0 PLAOLN+HelveticaNeueLTStd-BdCn Type 1C MacRoman yes yes no 63 0 PLAPEK+HelveticaNeueLTStd-MdCn Type 1C WinAnsi yes yes no 62 0 PLAPEL+MyriadPro-Regular Type 1C Custom yes yes yes 61 0 PLAPFM+MyriadPro-Bold Type 1C Custom yes yes yes 60 0 PLBAGG+MyriadPro-Regular Type 1C WinAnsi yes yes no 138 0 PLBAGH+MyriadPro-Bold Type 1C Custom yes yes yes 137 0 PLBLPM+AdvTimes-b Type 1C WinAnsi yes yes no 517 0 PLBLPN+AdvP4C4E59 Type 1C Custom yes yes yes 512 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-12 02:45:13 CEST RepresentationInformation: pmc_9168966.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-30 02:39:08 CEST Size: 1006323 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 927 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseThumbs Outlines: Item: Title: Outline placeholder Destination: unknown Children: Item: Title: mol213146-aff-0001 Destination: lmol213146-aff-0001 Item: Title: mol213146-aff-0002 Destination: lmol213146-aff-0002 Item: Title: mol213146-aff-0003 Destination: lmol213146-aff-0003 Item: Title: mol213146-aff-0004 Destination: lmol213146-aff-0004 Item: Title: mol213146-aff-0005 Destination: lmol213146-aff-0005 Item: Title: mol213146-aff-0006 Destination: lmol213146-aff-0006 Item: Title: mol213146-aff-0007 Destination: lmol213146-aff-0007 Item: Title: mol213146-fig-0001 Destination: lmol213146-fig-0001 Item: Title: mol213146-fig-0002 Destination: lmol213146-fig-0002 Item: Title: mol213146-fig-0003 Destination: lmol213146-fig-0003 Item: Title: mol213146-tbl-0001 Destination: lmol213146-tbl-0001 Item: Title: mol213146-bib-0001 Destination: lmol213146-bib-0001 Item: Title: mol213146-bib-0002 Destination: lmol213146-bib-0002 Item: Title: mol213146-bib-0003 Destination: lmol213146-bib-0003 Item: Title: mol213146-bib-0004 Destination: lmol213146-bib-0004 Item: Title: mol213146-bib-0005 Destination: lmol213146-bib-0005 Item: Title: mol213146-bib-0006 Destination: lmol213146-bib-0006 Item: Title: mol213146-bib-0007 Destination: lmol213146-bib-0007 Item: Title: mol213146-bib-0008 Destination: lmol213146-bib-0008 Item: Title: mol213146-bib-0009 Destination: lmol213146-bib-0009 Item: Title: mol213146-bib-0010 Destination: lmol213146-bib-0010 Item: Title: mol213146-bib-0011 Destination: lmol213146-bib-0011 Item: Title: mol213146-bib-0012 Destination: lmol213146-bib-0012 Item: Title: mol213146-bib-0013 Destination: lmol213146-bib-0013 Item: Title: mol213146-bib-0014 Destination: lmol213146-bib-0014 Item: Title: mol213146-bib-0015 Destination: lmol213146-bib-0015 Item: Title: mol213146-bib-0016 Destination: lmol213146-bib-0016 Item: Title: mol213146-bib-0017 Destination: lmol213146-bib-0017 Item: Title: mol213146-bib-0018 Destination: lmol213146-bib-0018 Item: Title: mol213146-bib-0019 Destination: lmol213146-bib-0019 Item: Title: mol213146-bib-0020 Destination: lmol213146-bib-0020 Item: Title: mol213146-bib-0021 Destination: lmol213146-bib-0021 Item: Title: mol213146-bib-0022 Destination: lmol213146-bib-0022 Item: Title: mol213146-bib-0023 Destination: lmol213146-bib-0023 Item: Title: mol213146-bib-0024 Destination: lmol213146-bib-0024 Item: Title: mol213146-bib-0025 Destination: lmol213146-bib-0025 Item: Title: mol213146-bib-0026 Destination: lmol213146-bib-0026 Item: Title: mol213146-bib-0027 Destination: lmol213146-bib-0027 Item: Title: mol213146-bib-0028 Destination: lmol213146-bib-0028 Item: Title: mol213146-bib-0029 Destination: lmol213146-bib-0029 Item: Title: mol213146-bib-0030 Destination: lmol213146-bib-0030 Item: Title: mol213146-bib-0031 Destination: lmol213146-bib-0031 Item: Title: mol213146-bib-0032 Destination: lmol213146-bib-0032 Item: Title: mol213146-bib-0033 Destination: lmol213146-bib-0033 Item: Title: mol213146-bib-0034 Destination: lmol213146-bib-0034 Item: Title: mol213146-bib-0035 Destination: lmol213146-bib-0035 Item: Title: mol213146-bib-0036 Destination: lmol213146-bib-0036 Item: Title: mol213146-bib-0037 Destination: lmol213146-bib-0037 Item: Title: mol213146-bib-0038 Destination: lmol213146-bib-0038 Item: Title: mol213146-bib-0039 Destination: lmol213146-bib-0039 Item: Title: mol213146-bib-0040 Destination: lmol213146-bib-0040 Item: Title: mol213146-bib-0041 Destination: lmol213146-bib-0041 Item: Title: mol213146-bib-0042 Destination: lmol213146-bib-0042 Item: Title: mol213146-bib-0043 Destination: lmol213146-bib-0043 Item: Title: mol213146-bib-0044 Destination: lmol213146-bib-0044 Item: Title: mol213146-bib-0045 Destination: lmol213146-bib-0045 Item: Title: mol213146-bib-0046 Destination: lmol213146-bib-0046 Item: Title: mol213146-bib-0047 Destination: lmol213146-bib-0047 Item: Title: mol213146-bib-0048 Destination: lmol213146-bib-0048 Item: Title: mol213146-bib-0049 Destination: lmol213146-bib-0049 Item: Title: mol213146-bib-0050 Destination: lmol213146-bib-0050 Item: Title: mol213146-bib-0051 Destination: lmol213146-bib-0051 Item: Title: mol213146-bib-0052 Destination: lmol213146-bib-0052 Item: Title: mol213146-bib-0053 Destination: lmol213146-bib-0053 Item: Title: mol213146-bib-0054 Destination: lmol213146-bib-0054 Item: Title: mol213146-bib-0055 Destination: lmol213146-bib-0055 Item: Title: mol213146-bib-0056 Destination: lmol213146-bib-0056 Item: Title: mol213146-bib-0057 Destination: lmol213146-bib-0057 Item: Title: mol213146-bib-0058 Destination: lmol213146-bib-0058 Item: Title: mol213146-bib-0059 Destination: lmol213146-bib-0059 Item: Title: mol213146-bib-0060 Destination: lmol213146-bib-0060 Item: Title: mol213146-bib-0061 Destination: lmol213146-bib-0061 Item: Title: mol213146-bib-0062 Destination: lmol213146-bib-0062 Item: Title: mol213146-bib-0063 Destination: lmol213146-bib-0063 Item: Title: mol213146-bib-0064 Destination: lmol213146-bib-0064 Item: Title: mol213146-bib-0065 Destination: lmol213146-bib-0065 Item: Title: mol213146-bib-0066 Destination: lmol213146-bib-0066 Item: Title: mol213146-bib-0067 Destination: lmol213146-bib-0067 Item: Title: mol213146-bib-0068 Destination: lmol213146-bib-0068 Item: Title: mol213146-bib-0069 Destination: lmol213146-bib-0069 Item: Title: mol213146-bib-0070 Destination: lmol213146-bib-0070 Item: Title: mol213146-bib-0071 Destination: lmol213146-bib-0071 Item: Title: mol213146-bib-0072 Destination: lmol213146-bib-0072 Item: Title: mol213146-bib-0073 Destination: lmol213146-bib-0073 Item: Title: mol213146-bib-0074 Destination: lmol213146-bib-0074 Item: Title: mol213146-bib-0075 Destination: lmol213146-bib-0075 Item: Title: mol213146-bib-0076 Destination: lmol213146-bib-0076 Item: Title: mol213146-bib-0077 Destination: lmol213146-bib-0077 Item: Title: mol213146-bib-0078 Destination: lmol213146-bib-0078 Item: Title: mol213146-bib-0079 Destination: lmol213146-bib-0079 Item: Title: mol213146-bib-0080 Destination: lmol213146-bib-0080 Item: Title: mol213146-bib-0081 Destination: lmol213146-bib-0081 Item: Title: mol213146-bib-0082 Destination: lmol213146-bib-0082 Item: Title: mol213146-bib-0083 Destination: lmol213146-bib-0083 Item: Title: mol213146-bib-0084 Destination: lmol213146-bib-0084 Item: Title: mol213146-bib-0085 Destination: lmol213146-bib-0085 Item: Title: mol213146-bib-0086 Destination: lmol213146-bib-0086 Item: Title: mol213146-bib-0087 Destination: lmol213146-bib-0087 Item: Title: mol213146-bib-0088 Destination: lmol213146-bib-0088 Item: Title: mol213146-bib-0089 Destination: lmol213146-bib-0089 Item: Title: mol213146-bib-0090 Destination: lmol213146-bib-0090 Item: Title: mol213146-bib-0091 Destination: lmol213146-bib-0091 Item: Title: mol213146-bib-0092 Destination: lmol213146-bib-0092 Item: Title: mol213146-bib-0093 Destination: lmol213146-bib-0093 Item: Title: mol213146-bib-0094 Destination: lmol213146-bib-0094 Item: Title: mol213146-bib-0095 Destination: lmol213146-bib-0095 Item: Title: mol213146-bib-0096 Destination: lmol213146-bib-0096 Item: Title: mol213146-bib-0097 Destination: lmol213146-bib-0097 Item: Title: mol213146-bib-0098 Destination: lmol213146-bib-0098 Item: Title: mol213146-bib-0099 Destination: lmol213146-bib-0099 Item: Title: mol213146-bib-0100 Destination: lmol213146-bib-0100 Item: Title: mol213146-bib-0101 Destination: lmol213146-bib-0101 Item: Title: mol213146-bib-0102 Destination: lmol213146-bib-0102 Item: Title: mol213146-bib-0103 Destination: lmol213146-bib-0103 Item: Title: mol213146-bib-0104 Destination: lmol213146-bib-0104 Item: Title: mol213146-bib-0105 Destination: lmol213146-bib-0105 Item: Title: mol213146-bib-0106 Destination: lmol213146-bib-0106 Item: Title: mol213146-bib-0107 Destination: lmol213146-bib-0107 Item: Title: mol213146-bib-0108 Destination: lmol213146-bib-0108 Item: Title: mol213146-bib-0109 Destination: lmol213146-bib-0109 Item: Title: mol213146-bib-0110 Destination: lmol213146-bib-0110 Item: Title: mol213146-bib-0111 Destination: lmol213146-bib-0111 Item: Title: mol213146-bib-0112 Destination: lmol213146-bib-0112 Item: Title: mol213146-bib-0113 Destination: lmol213146-bib-0113 Item: Title: mol213146-bib-0114 Destination: lmol213146-bib-0114 Item: Title: mol213146-bib-0115 Destination: lmol213146-bib-0115 Item: Title: mol213146-bib-0116 Destination: lmol213146-bib-0116 Item: Title: mol213146-bib-0117 Destination: lmol213146-bib-0117 Item: Title: mol213146-bib-0118 Destination: lmol213146-bib-0118 Item: Title: mol213146-bib-0119 Destination: lmol213146-bib-0119 Item: Title: mol213146-bib-0120 Destination: lmol213146-bib-0120 Item: Title: mol213146-bib-0121 Destination: lmol213146-bib-0121 Item: Title: mol213146-bib-0122 Destination: lmol213146-bib-0122 Item: Title: mol213146-bib-0123 Destination: lmol213146-bib-0123 Item: Title: mol213146-bib-0124 Destination: lmol213146-bib-0124 Item: Title: mol213146-bib-0125 Destination: lmol213146-bib-0125 Item: Title: mol213146-bib-0126 Destination: lmol213146-bib-0126 Item: Title: mol213146-bib-0127 Destination: lmol213146-bib-0127 Item: Title: mol213146-bib-0128 Destination: lmol213146-bib-0128 Item: Title: mol213146-bib-0129 Destination: lmol213146-bib-0129 Item: Title: mol213146-bib-0130 Destination: lmol213146-bib-0130 Item: Title: mol213146-bib-0131 Destination: lmol213146-bib-0131 Item: Title: mol213146-bib-0132 Destination: lmol213146-bib-0132 Item: Title: mol213146-bib-0133 Destination: lmol213146-bib-0133 Item: Title: mol213146-bib-0134 Destination: lmol213146-bib-0134 Item: Title: mol213146-bib-0135 Destination: lmol213146-bib-0135 Item: Title: mol213146-bib-0136 Destination: lmol213146-bib-0136 Item: Title: mol213146-bib-0137 Destination: lmol213146-bib-0137 Item: Title: mol213146-bib-0138 Destination: lmol213146-bib-0138 Info: Title: Dual inhibition of TGF‐β and PD‐L1: a novel approach to cancer treatment Creator: Arbortext Advanced Print Publisher 9.1.531/W Unicode Producer: Acrobat Distiller 10.1.16 (Windows) CreationDate: Wed Jun 01 05:55:48 CEST 2022 ModDate: Wed Jun 01 05:55:48 CEST 2022 ID: 0xe5918feda8fe6145998a2192554bda5f, 0x333cd56c5937753d111e27a821993ab9 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1680 ImageHeight: 158 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 40 ImageHeight: 35 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1938 ImageHeight: 1062 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 132 ImageHeight: 20 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 52 ImageHeight: 20 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 132 ImageHeight: 20 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 383 ImageHeight: 25 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 49 ImageHeight: 21 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 81 ImageHeight: 25 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 747 ImageHeight: 25 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 66 ImageHeight: 20 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 203 ImageHeight: 43 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 119 ImageHeight: 43 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 115 ImageHeight: 20 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 496 ImageHeight: 48 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 246 ImageHeight: 48 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 409 ImageHeight: 53 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 231 ImageHeight: 25 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 381 ImageHeight: 48 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 50 ImageHeight: 20 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1939 ImageHeight: 1030 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 103 ImageHeight: 43 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 80 ImageHeight: 20 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 62 ImageHeight: 20 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 109 ImageHeight: 43 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: PLALIJ+AdvPSUnv-B FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: PLALIJ+AdvPSUnv-B Flags: Nonsymbolic FontBBox: -145, -218, 1000, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PLBLPN+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 160 FontDescriptor: FontName: PLBLPN+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PLALIK+AdvPSMP13 FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: PLALIK+AdvPSMP13 Flags: Nonsymbolic FontBBox: 0, -302, 958, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PLBLPM+AdvTimes-b FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: PLBLPM+AdvTimes-b Flags: Nonsymbolic FontBBox: -168, -210, 1002, 766 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PLALJK+AdvTTec369687 FontSubset: true FirstChar: 43 LastChar: 62 FontDescriptor: FontName: PLALJK+AdvTTec369687 Flags: Nonsymbolic FontBBox: -72, -208, 927, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PLBAGH+MyriadPro-Bold FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: PLBAGH+MyriadPro-Bold Flags: Symbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PLALJL+AdvTimes FontSubset: true FirstChar: 37 LastChar: 245 FontDescriptor: FontName: PLALJL+AdvTimes Flags: Serif, Nonsymbolic FontBBox: -217, -212, 1005, 766 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: PLBAGG+MyriadPro-Regular FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: PLBAGG+MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PLALJM+AdvTTec369687+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: PLALJM+AdvTTec369687+20 Flags: Nonsymbolic FontBBox: -208, -208, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PLALJN+AdvPSSym FontSubset: true FirstChar: 2 LastChar: 170 FontDescriptor: FontName: PLALJN+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PLALJO+AdvPSUnv-LO FontSubset: true FirstChar: 77 LastChar: 121 FontDescriptor: FontName: PLALJO+AdvPSUnv-LO Flags: Nonsymbolic FontBBox: -145, -187, 1135, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PLAMCN+AdvTTec369687+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: PLAMCN+AdvTTec369687+22 Flags: Symbolic FontBBox: -156, -208, 802, 906 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PLALEG+AdvPSUnv FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PLALEG+AdvPSUnv Flags: Nonsymbolic FontBBox: -156, -229, 1000, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PLAPFM+MyriadPro-Bold FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: PLAPFM+MyriadPro-Bold Flags: Symbolic, ForceBold FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PLALEH+AdvPS-UVBL FontSubset: true FirstChar: 45 LastChar: 223 FontDescriptor: FontName: PLALEH+AdvPS-UVBL Flags: Nonsymbolic FontBBox: -145, -208, 1000, 802 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: PLAMCM+AdvTimes-i FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: PLAMCM+AdvTimes-i Flags: Nonsymbolic FontBBox: -253, -211, 1078, 766 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PLAPEL+MyriadPro-Regular FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: PLAPEL+MyriadPro-Regular Flags: Symbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PLALEI+AdvPSMP11 FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: PLALEI+AdvPSMP11 Flags: Nonsymbolic FontBBox: 0, -302, 989, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PLAPEK+HelveticaNeueLTStd-MdCn FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: PLAPEK+HelveticaNeueLTStd-MdCn Flags: Nonsymbolic FontBBox: -164, -216, 1031, 951 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PLALII+AdvPSUnv-L FontSubset: true FirstChar: 30 LastChar: 150 FontDescriptor: FontName: PLALII+AdvPSUnv-L Flags: Nonsymbolic FontBBox: -145, -187, 1000, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PLAOLN+HelveticaNeueLTStd-BdCn FontSubset: true FirstChar: 32 LastChar: 223 FontDescriptor: FontName: PLAOLN+HelveticaNeueLTStd-BdCn Flags: Nonsymbolic, ForceBold FontBBox: -164, -224, 1066, 961 FontFile3: true Encoding: MacRomanEncoding XMP: 2022-06-02T07:19:16+05:30 2022-06-02T07:19:16+05:30 2022-06-02T07:19:16+05:30 Acrobat Distiller 10.1.7 (Windows) 10.1002/1878-0261.13146 10.1002/(ISSN)1878-0261 3 VoR 10.1002/1878-0261.13146 application/pdf Dual inhibition of TGF‐β and PD‐L1: a novel approach to cancer treatment uuid:cb897b2f-a2bc-448e-9498-520921d432f7 uuid:cd22e6c4-52fd-440b-8728-0254883c1160 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 130, 646, 134, 656 Destination: 855 Annotation: Subtype: Link Rect: 134, 642, 136, 652 Annotation: Subtype: Link Rect: 134, 641, 136, 651 Annotation: Subtype: Link Rect: 136, 642, 144, 653 Annotation: Subtype: Link Rect: 227, 646, 231, 656 Destination: 855 Annotation: Subtype: Link Rect: 362, 646, 366, 656 Destination: 855 Annotation: Subtype: Link Rect: 449, 646, 453, 656 Destination: 855 Annotation: Subtype: Link Rect: 115, 634, 120, 644 Destination: 855 Annotation: Subtype: Link Rect: 206, 634, 210, 644 Destination: 855 Annotation: Subtype: Link Rect: 255, 634, 259, 644 Destination: 855 Annotation: Subtype: Link Rect: 346, 634, 356, 644 Destination: 855 Annotation: Subtype: Link Rect: 474, 634, 478, 644 Destination: 855 Annotation: Subtype: Link Rect: 478, 630, 480, 640 Annotation: Subtype: Link Rect: 478, 629, 480, 639 Annotation: Subtype: Link Rect: 480, 630, 488, 641 Annotation: Subtype: Link Rect: 78, 387, 145, 395 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 96, 593, 108, 603 Destination: 263 Annotation: Subtype: Link Rect: 72, 497, 76, 507 Destination: 263 Annotation: Subtype: Link Rect: 286, 414, 291, 423 Destination: 263 Annotation: Subtype: Link Rect: 110, 378, 114, 387 Destination: 263 Annotation: Subtype: Link Rect: 208, 354, 220, 364 Destination: 263 Annotation: Subtype: Link Rect: 72, 306, 83, 316 Destination: 263 Annotation: Subtype: Link Rect: 252, 282, 264, 292 Destination: 263 Annotation: Subtype: Link Rect: 253, 223, 262, 232 Destination: 263 Annotation: Subtype: Link Rect: 253, 223, 267, 232 Destination: 263 Annotation: Subtype: Link Rect: 166, 187, 187, 196 Destination: 263 Annotation: Subtype: Link Rect: 244, 163, 249, 172 Destination: 34 Annotation: Subtype: Link Rect: 257, 163, 266, 172 Destination: 263 Annotation: Subtype: Link Rect: 263, 151, 272, 160 Destination: 263 Annotation: Subtype: Link Rect: 72, 115, 81, 124 Destination: 263 Annotation: Subtype: Link Rect: 226, 91, 240, 100 Destination: 263 Annotation: Subtype: Link Rect: 226, 91, 248, 100 Destination: 263 Annotation: Subtype: Link Rect: 516, 654, 536, 664 Destination: 295 Annotation: Subtype: Link Rect: 438, 619, 458, 628 Destination: 295 Annotation: Subtype: Link Rect: 406, 559, 431, 568 Destination: 295 Annotation: Subtype: Link Rect: 406, 559, 440, 568 Destination: 295 Annotation: Subtype: Link Rect: 317, 511, 322, 520 Destination: 263 Annotation: Subtype: Link Rect: 533, 451, 538, 461 Destination: 34 Annotation: Subtype: Link Rect: 317, 439, 353, 449 Destination: 263 Annotation: Subtype: Link Rect: 458, 403, 468, 413 Destination: 295 Annotation: Subtype: Link Rect: 402, 367, 411, 377 Destination: 295 Annotation: Subtype: Link Rect: 526, 320, 536, 329 Destination: 295 Annotation: Subtype: Link Rect: 526, 272, 536, 281 Destination: 295 Annotation: Subtype: Link Rect: 488, 224, 505, 233 Destination: 263 Annotation: Subtype: Link Rect: 416, 152, 432, 162 Destination: 263 Annotation: Subtype: Link Rect: 332, 104, 342, 114 Destination: 295 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 259, 334, 268, 344 Destination: 295 Annotation: Subtype: Link Rect: 56, 227, 68, 236 Destination: 263 Annotation: Subtype: Link Rect: 221, 191, 233, 200 Destination: 263 Annotation: Subtype: Link Rect: 498, 286, 520, 296 Destination: 295 Annotation: Subtype: Link Rect: 444, 239, 453, 248 Destination: 295 Annotation: Subtype: Link Rect: 372, 107, 381, 117 Destination: 295 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 250, 571, 259, 580 Destination: 295 Annotation: Subtype: Link Rect: 259, 379, 268, 389 Destination: 295 Annotation: Subtype: Link Rect: 247, 320, 269, 329 Destination: 295 Annotation: Subtype: Link Rect: 122, 260, 136, 269 Destination: 295 Annotation: Subtype: Link Rect: 122, 260, 146, 269 Destination: 295 Annotation: Subtype: Link Rect: 133, 128, 142, 138 Destination: 332 Annotation: Subtype: Link Rect: 269, 81, 278, 90 Destination: 332 Annotation: Subtype: Link Rect: 515, 630, 536, 640 Destination: 332 Annotation: Subtype: Link Rect: 379, 595, 389, 604 Destination: 332 Annotation: Subtype: Link Rect: 514, 583, 524, 592 Destination: 332 Annotation: Subtype: Link Rect: 404, 535, 413, 544 Destination: 332 Annotation: Subtype: Link Rect: 396, 475, 405, 485 Destination: 332 Annotation: Subtype: Link Rect: 428, 415, 443, 425 Destination: 332 Annotation: Subtype: Link Rect: 428, 415, 452, 425 Destination: 332 Annotation: Subtype: Link Rect: 526, 391, 536, 401 Destination: 332 Annotation: Subtype: Link Rect: 504, 344, 513, 353 Destination: 332 Annotation: Subtype: Link Rect: 502, 308, 511, 317 Destination: 332 Annotation: Subtype: Link Rect: 317, 260, 326, 269 Destination: 332 Annotation: Subtype: Link Rect: 450, 224, 459, 233 Destination: 332 Annotation: Subtype: Link Rect: 333, 176, 343, 186 Destination: 332 Annotation: Subtype: Link Rect: 417, 128, 426, 138 Destination: 332 Annotation: Subtype: Link Rect: 380, 81, 390, 90 Destination: 332 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 266, 666, 275, 676 Destination: 332 Annotation: Subtype: Link Rect: 56, 571, 65, 580 Destination: 332 Annotation: Subtype: Link Rect: 195, 511, 204, 520 Destination: 332 Annotation: Subtype: Link Rect: 209, 379, 231, 389 Destination: 367 Annotation: Subtype: Link Rect: 81, 320, 95, 329 Destination: 367 Annotation: Subtype: Link Rect: 81, 320, 105, 329 Destination: 367 Annotation: Subtype: Link Rect: 231, 284, 253, 293 Destination: 367 Annotation: Subtype: Link Rect: 147, 176, 156, 186 Destination: 367 Annotation: Subtype: Link Rect: 301, 690, 322, 700 Destination: 367 Annotation: Subtype: Link Rect: 439, 571, 460, 580 Destination: 367 Annotation: Subtype: Link Rect: 349, 463, 358, 473 Destination: 367 Annotation: Subtype: Link Rect: 414, 415, 435, 425 Destination: 367 Annotation: Subtype: Link Rect: 511, 332, 520, 341 Destination: 367 Annotation: Subtype: Link Rect: 485, 224, 494, 233 Destination: 367 Annotation: Subtype: Link Rect: 326, 188, 335, 198 Destination: 367 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 109, 678, 118, 688 Destination: 367 Annotation: Subtype: Link Rect: 95, 607, 109, 616 Destination: 367 Annotation: Subtype: Link Rect: 95, 607, 118, 616 Destination: 367 Annotation: Subtype: Link Rect: 284, 547, 293, 556 Destination: 367 Annotation: Subtype: Link Rect: 72, 403, 81, 413 Destination: 367 Annotation: Subtype: Link Rect: 258, 355, 267, 365 Destination: 403 Annotation: Subtype: Link Rect: 199, 260, 220, 269 Destination: 403 Annotation: Subtype: Link Rect: 242, 236, 258, 245 Destination: 263 Annotation: Subtype: Link Rect: 190, 188, 212, 198 Destination: 295 Annotation: Subtype: Link Rect: 92, 152, 113, 162 Destination: 295 Annotation: Subtype: Link Rect: 167, 116, 176, 126 Destination: 403 Annotation: Subtype: Link Rect: 351, 690, 360, 700 Destination: 295 Annotation: Subtype: Link Rect: 350, 595, 359, 604 Destination: 403 Annotation: Subtype: Link Rect: 446, 535, 450, 544 Destination: 107 Annotation: Subtype: Link Rect: 317, 451, 326, 461 Destination: 403 Annotation: Subtype: Link Rect: 317, 403, 326, 413 Destination: 295 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 91, 690, 101, 700 Destination: 403 Annotation: Subtype: Link Rect: 105, 547, 115, 556 Destination: 403 Annotation: Subtype: Link Rect: 248, 487, 257, 496 Destination: 403 Annotation: Subtype: Link Rect: 492, 702, 497, 712 Destination: 139 Annotation: Subtype: Link Rect: 476, 654, 485, 664 Destination: 403 Annotation: Subtype: Link Rect: 301, 607, 311, 616 Destination: 403 Annotation: Subtype: Link Rect: 510, 523, 520, 532 Destination: 403 Annotation: Subtype: Link Rect: 301, 463, 323, 473 Destination: 403 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 127, 642, 137, 652 Destination: 403 Annotation: Subtype: Link Rect: 211, 595, 244, 604 Destination: 403 Annotation: Subtype: Link Rect: 100, 535, 114, 544 Destination: 403 Annotation: Subtype: Link Rect: 100, 535, 123, 544 Destination: 403 Annotation: Subtype: Link Rect: 169, 511, 179, 520 Destination: 403 Annotation: Subtype: Link Rect: 201, 439, 227, 449 Destination: 403 Annotation: Subtype: Link Rect: 201, 439, 236, 449 Destination: 403 Annotation: Subtype: Link Rect: 270, 415, 291, 425 Destination: 403 Annotation: Subtype: Link Rect: 147, 332, 173, 341 Destination: 403 Annotation: Subtype: Link Rect: 141, 116, 166, 126 Destination: 295 Annotation: Subtype: Link Rect: 211, 92, 225, 102 Destination: 443 Annotation: Subtype: Link Rect: 277, 81, 291, 90 Destination: 443 Annotation: Subtype: Link Rect: 461, 642, 474, 652 Destination: 443 Annotation: Subtype: Link Rect: 401, 619, 415, 628 Destination: 443 Annotation: Subtype: Link Rect: 518, 511, 527, 520 Destination: 332 Annotation: Subtype: Link Rect: 465, 499, 478, 508 Destination: 443 Annotation: Subtype: Link Rect: 374, 415, 383, 425 Destination: 295 Annotation: Subtype: Link Rect: 527, 379, 536, 389 Destination: 332 Annotation: Subtype: Link Rect: 414, 320, 423, 329 Destination: 295 Annotation: Subtype: Link Rect: 433, 176, 463, 186 Destination: 443 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 318, 607, 330, 614 Destination: 477 Annotation: Subtype: Link Rect: 483, 586, 495, 593 Destination: 477 Annotation: Subtype: Link Rect: 318, 575, 330, 583 Destination: 443 Annotation: Subtype: Link Rect: 511, 565, 524, 572 Destination: 477 Annotation: Subtype: Link Rect: 318, 544, 330, 551 Destination: 477 Annotation: Subtype: Link Rect: 318, 502, 330, 509 Destination: 477 Annotation: Subtype: Link Rect: 318, 471, 330, 478 Destination: 477 Annotation: Subtype: Link Rect: 318, 429, 330, 436 Destination: 443 Annotation: Subtype: Link Rect: 318, 397, 330, 405 Destination: 443 Annotation: Subtype: Link Rect: 318, 366, 330, 373 Destination: 443 Annotation: Subtype: Link Rect: 318, 335, 330, 342 Destination: 443 Annotation: Subtype: Link Rect: 318, 303, 330, 311 Destination: 477 Annotation: Subtype: Link Rect: 318, 261, 330, 269 Destination: 477 Annotation: Subtype: Link Rect: 318, 209, 330, 216 Destination: 443 Annotation: Subtype: Link Rect: 318, 157, 330, 164 Destination: 443 Annotation: Subtype: Link Rect: 318, 136, 326, 143 Destination: 332 Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 205, 176, 209, 186 Destination: 206 Annotation: Subtype: Link Rect: 221, 176, 240, 186 Destination: 443 Annotation: Subtype: Link Rect: 221, 176, 254, 186 Destination: 443 Annotation: Subtype: Link Rect: 153, 128, 158, 138 Destination: 206 Annotation: Subtype: Link Rect: 167, 128, 181, 138 Destination: 403 Annotation: Subtype: Link Rect: 167, 128, 224, 138 Destination: 403 Annotation: Subtype: Link Rect: 167, 128, 238, 138 Destination: 403 Annotation: Subtype: Link Rect: 490, 140, 504, 150 Destination: 443 Annotation: Subtype: Link Rect: 334, 658, 342, 666 Destination: 332 Annotation: Subtype: Link Rect: 334, 637, 342, 645 Destination: 332 Annotation: Subtype: Link Rect: 334, 616, 342, 624 Destination: 295 Annotation: Subtype: Link Rect: 334, 596, 342, 603 Destination: 295 Annotation: Subtype: Link Rect: 334, 575, 346, 582 Destination: 443 Annotation: Subtype: Link Rect: 334, 543, 346, 551 Destination: 443 Annotation: Subtype: Link Rect: 334, 522, 346, 530 Destination: 443 Annotation: Subtype: Link Rect: 334, 512, 346, 519 Destination: 443 Annotation: Subtype: Link Rect: 334, 501, 346, 509 Destination: 443 Annotation: Subtype: Link Rect: 334, 470, 346, 478 Destination: 443 Annotation: Subtype: Link Rect: 334, 439, 342, 446 Destination: 295 Annotation: Subtype: Link Rect: 334, 407, 342, 415 Destination: 332 Annotation: Subtype: Link Rect: 334, 386, 342, 394 Destination: 332 Annotation: Subtype: Link Rect: 334, 365, 342, 373 Destination: 332 Annotation: Subtype: Link Rect: 334, 345, 342, 352 Destination: 295 Annotation: Subtype: Link Rect: 334, 292, 342, 300 Destination: 295 Annotation: Subtype: Link Rect: 334, 271, 346, 279 Destination: 477 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 80, 690, 95, 700 Destination: 443 Annotation: Subtype: Link Rect: 56, 630, 104, 640 Destination: 403 Annotation: Subtype: Link Rect: 56, 630, 118, 640 Destination: 403 Annotation: Subtype: Link Rect: 115, 427, 124, 437 Destination: 332 Annotation: Subtype: Link Rect: 153, 403, 163, 413 Destination: 332 Annotation: Subtype: Link Rect: 56, 284, 77, 293 Destination: 403 Annotation: Subtype: Link Rect: 407, 344, 519, 353 Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 123, 346, 296, 355 Annotation: Subtype: Link Rect: 69, 334, 294, 343 Annotation: Subtype: Link Rect: 69, 322, 289, 331 Annotation: Subtype: Link Rect: 152, 138, 294, 147 Annotation: Subtype: Link Rect: 85, 127, 109, 136 Annotation: Subtype: Link Rect: 168, 92, 256, 101 Annotation: Subtype: Link Rect: 85, 81, 161, 90 Annotation: Subtype: Link Rect: 393, 680, 536, 689 Annotation: Subtype: Link Rect: 330, 669, 355, 677 Annotation: Subtype: Link Rect: 393, 623, 523, 631 Annotation: Subtype: Link Rect: 330, 577, 498, 586 Annotation: Subtype: Link Rect: 447, 543, 535, 551 Annotation: Subtype: Link Rect: 330, 531, 406, 540 Annotation: Subtype: Link Rect: 349, 497, 467, 505 Annotation: Subtype: Link Rect: 472, 474, 540, 482 Annotation: Subtype: Link Rect: 330, 462, 425, 471 Annotation: Subtype: Link Rect: 412, 416, 536, 425 Annotation: Subtype: Link Rect: 436, 371, 529, 379 Annotation: Subtype: Link Rect: 331, 359, 394, 368 Annotation: Subtype: Link Rect: 501, 313, 528, 322 Annotation: Subtype: Link Rect: 331, 302, 421, 311 Annotation: Subtype: Link Rect: 402, 268, 522, 276 Annotation: Subtype: Link Rect: 331, 256, 375, 265 Annotation: Subtype: Link Rect: 398, 210, 536, 219 Annotation: Subtype: Link Rect: 331, 199, 344, 208 Annotation: Subtype: Link Rect: 412, 164, 528, 173 Annotation: Subtype: Link Rect: 331, 153, 372, 162 Annotation: Subtype: Link Rect: 452, 119, 540, 127 Annotation: Subtype: Link Rect: 331, 107, 403, 116 Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 197, 691, 265, 700 Annotation: Subtype: Link Rect: 70, 680, 154, 689 Annotation: Subtype: Link Rect: 241, 634, 268, 643 Annotation: Subtype: Link Rect: 70, 623, 177, 631 Annotation: Subtype: Link Rect: 194, 565, 262, 574 Annotation: Subtype: Link Rect: 70, 554, 126, 563 Annotation: Subtype: Link Rect: 133, 520, 242, 528 Annotation: Subtype: Link Rect: 70, 508, 139, 517 Annotation: Subtype: Link Rect: 124, 462, 278, 471 Annotation: Subtype: Link Rect: 124, 416, 274, 425 Annotation: Subtype: Link Rect: 131, 359, 278, 368 Annotation: Subtype: Link Rect: 115, 313, 272, 322 Annotation: Subtype: Link Rect: 239, 268, 266, 276 Annotation: Subtype: Link Rect: 70, 256, 172, 265 Annotation: Subtype: Link Rect: 84, 199, 261, 208 Annotation: Subtype: Link Rect: 234, 164, 275, 173 Annotation: Subtype: Link Rect: 70, 153, 162, 162 Annotation: Subtype: Link Rect: 156, 119, 264, 127 Annotation: Subtype: Link Rect: 70, 107, 141, 116 Annotation: Subtype: Link Rect: 452, 691, 519, 700 Annotation: Subtype: Link Rect: 315, 680, 398, 689 Annotation: Subtype: Link Rect: 360, 634, 510, 643 Annotation: Subtype: Link Rect: 315, 588, 496, 597 Annotation: Subtype: Link Rect: 329, 531, 463, 540 Annotation: Subtype: Link Rect: 329, 462, 459, 471 Annotation: Subtype: Link Rect: 449, 405, 517, 414 Annotation: Subtype: Link Rect: 315, 394, 415, 402 Annotation: Subtype: Link Rect: 378, 313, 496, 322 Annotation: Subtype: Link Rect: 315, 302, 345, 311 Annotation: Subtype: Link Rect: 377, 268, 504, 276 Annotation: Subtype: Link Rect: 315, 256, 370, 265 Annotation: Subtype: Link Rect: 456, 187, 483, 196 Annotation: Subtype: Link Rect: 315, 176, 469, 185 Annotation: Subtype: Link Rect: 315, 130, 496, 139 Thumb: true Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 110, 691, 291, 700 Annotation: Subtype: Link Rect: 207, 657, 281, 666 Annotation: Subtype: Link Rect: 86, 646, 193, 654 Annotation: Subtype: Link Rect: 148, 588, 275, 597 Annotation: Subtype: Link Rect: 86, 577, 140, 586 Annotation: Subtype: Link Rect: 144, 439, 272, 448 Annotation: Subtype: Link Rect: 86, 428, 138, 437 Annotation: Subtype: Link Rect: 227, 394, 254, 402 Annotation: Subtype: Link Rect: 86, 382, 240, 391 Annotation: Subtype: Link Rect: 109, 245, 290, 253 Annotation: Subtype: Link Rect: 171, 199, 267, 208 Annotation: Subtype: Link Rect: 86, 187, 285, 196 Annotation: Subtype: Link Rect: 86, 176, 287, 185 Annotation: Subtype: Link Rect: 86, 164, 273, 173 Annotation: Subtype: Link Rect: 86, 153, 114, 162 Annotation: Subtype: Link Rect: 221, 119, 289, 127 Annotation: Subtype: Link Rect: 86, 107, 157, 116 Annotation: Subtype: Link Rect: 331, 657, 523, 666 Annotation: Subtype: Link Rect: 331, 623, 512, 631 Annotation: Subtype: Link Rect: 443, 565, 535, 574 Annotation: Subtype: Link Rect: 331, 554, 389, 563 Annotation: Subtype: Link Rect: 403, 474, 535, 482 Annotation: Subtype: Link Rect: 331, 462, 356, 471 Annotation: Subtype: Link Rect: 452, 359, 526, 368 Annotation: Subtype: Link Rect: 331, 348, 438, 356 Annotation: Subtype: Link Rect: 393, 313, 520, 322 Annotation: Subtype: Link Rect: 331, 302, 385, 311 Annotation: Subtype: Link Rect: 510, 256, 537, 265 Annotation: Subtype: Link Rect: 331, 245, 477, 253 Annotation: Subtype: Link Rect: 394, 199, 482, 208 Annotation: Subtype: Link Rect: 331, 187, 401, 196 Annotation: Subtype: Link Rect: 345, 119, 490, 127 Thumb: true Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 220, 691, 277, 700 Annotation: Subtype: Link Rect: 70, 680, 170, 689 Annotation: Subtype: Link Rect: 137, 646, 271, 654 Annotation: Subtype: Link Rect: 128, 565, 269, 574 Annotation: Subtype: Link Rect: 70, 554, 83, 563 Annotation: Subtype: Link Rect: 133, 497, 271, 505 Annotation: Subtype: Link Rect: 70, 485, 88, 494 Annotation: Subtype: Link Rect: 110, 428, 257, 437 Annotation: Subtype: Link Rect: 70, 416, 101, 425 Annotation: Subtype: Link Rect: 70, 371, 231, 379 Annotation: Subtype: Link Rect: 141, 325, 229, 334 Annotation: Subtype: Link Rect: 70, 313, 135, 322 Annotation: Subtype: Link Rect: 183, 210, 272, 219 Annotation: Subtype: Link Rect: 70, 199, 149, 208 Annotation: Subtype: Link Rect: 137, 153, 225, 162 Annotation: Subtype: Link Rect: 70, 142, 135, 150 Annotation: Subtype: Link Rect: 459, 703, 516, 712 Annotation: Subtype: Link Rect: 315, 691, 409, 700 Annotation: Subtype: Link Rect: 325, 577, 481, 586 Annotation: Subtype: Link Rect: 409, 531, 497, 540 Annotation: Subtype: Link Rect: 315, 520, 381, 528 Annotation: Subtype: Link Rect: 386, 451, 475, 460 Annotation: Subtype: Link Rect: 315, 439, 381, 448 Annotation: Subtype: Link Rect: 400, 359, 508, 368 Annotation: Subtype: Link Rect: 315, 348, 364, 356 Annotation: Subtype: Link Rect: 400, 279, 520, 288 Annotation: Subtype: Link Rect: 315, 268, 359, 276 Annotation: Subtype: Link Rect: 405, 199, 512, 208 Annotation: Subtype: Link Rect: 315, 187, 359, 196 Annotation: Subtype: Link Rect: 436, 142, 524, 150 Annotation: Subtype: Link Rect: 315, 130, 381, 139 Annotation: Subtype: Link Rect: 431, 96, 519, 104 Annotation: Subtype: Link Rect: 315, 84, 384, 93 Thumb: true Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 238, 680, 294, 689 Annotation: Subtype: Link Rect: 86, 669, 181, 677 Annotation: Subtype: Link Rect: 184, 634, 272, 643 Annotation: Subtype: Link Rect: 86, 623, 155, 631 Annotation: Subtype: Link Rect: 236, 565, 292, 574 Annotation: Subtype: Link Rect: 86, 554, 206, 563 Annotation: Subtype: Link Rect: 157, 508, 292, 517 Annotation: Subtype: Link Rect: 86, 497, 134, 505 Annotation: Subtype: Link Rect: 261, 439, 288, 448 Annotation: Subtype: Link Rect: 86, 428, 207, 437 Annotation: Subtype: Link Rect: 214, 325, 282, 334 Annotation: Subtype: Link Rect: 86, 313, 163, 322 Annotation: Subtype: Link Rect: 251, 256, 292, 265 Annotation: Subtype: Link Rect: 86, 245, 206, 253 Annotation: Subtype: Link Rect: 192, 187, 281, 196 Annotation: Subtype: Link Rect: 86, 176, 159, 185 Annotation: Subtype: Link Rect: 499, 691, 540, 700 Annotation: Subtype: Link Rect: 331, 680, 468, 689 Annotation: Subtype: Link Rect: 398, 623, 526, 631 Annotation: Subtype: Link Rect: 331, 611, 383, 620 Annotation: Subtype: Link Rect: 397, 543, 529, 551 Annotation: Subtype: Link Rect: 331, 531, 360, 540 Annotation: Subtype: Link Rect: 487, 474, 529, 482 Annotation: Subtype: Link Rect: 331, 462, 468, 471 Annotation: Subtype: Link Rect: 398, 428, 526, 437 Annotation: Subtype: Link Rect: 331, 416, 383, 425 Annotation: Subtype: Link Rect: 421, 382, 513, 391 Annotation: Subtype: Link Rect: 331, 371, 421, 379 Annotation: Subtype: Link Rect: 425, 336, 532, 345 Annotation: Subtype: Link Rect: 331, 325, 380, 334 Annotation: Subtype: Link Rect: 416, 279, 504, 288 Annotation: Subtype: Link Rect: 331, 268, 371, 276 Annotation: Subtype: Link Rect: 394, 222, 531, 230 Annotation: Subtype: Link Rect: 331, 210, 355, 219 Annotation: Subtype: Link Rect: 331, 164, 480, 173 Annotation: Subtype: Link Rect: 425, 119, 513, 127 Annotation: Subtype: Link Rect: 331, 107, 361, 116 Thumb: true Page: Label: 17 Annotations: Annotation: Subtype: Link Rect: 138, 691, 267, 700 Annotation: Subtype: Link Rect: 95, 657, 276, 666 Annotation: Subtype: Link Rect: 71, 611, 252, 620 Annotation: Subtype: Link Rect: 248, 554, 275, 563 Annotation: Subtype: Link Rect: 71, 543, 193, 551 Annotation: Subtype: Link Rect: 133, 485, 260, 494 Annotation: Subtype: Link Rect: 71, 474, 125, 482 Annotation: Subtype: Link Rect: 188, 416, 256, 425 Annotation: Subtype: Link Rect: 71, 405, 179, 414 Annotation: Subtype: Link Rect: 113, 256, 268, 265 Annotation: Subtype: Link Rect: 71, 187, 232, 196 Annotation: Subtype: Link Rect: 71, 153, 252, 162 Annotation: Subtype: Link Rect: 133, 119, 260, 127 Annotation: Subtype: Link Rect: 71, 107, 125, 116 Annotation: Subtype: Link Rect: 378, 703, 505, 712 Annotation: Subtype: Link Rect: 316, 691, 370, 700 Annotation: Subtype: Link Rect: 340, 646, 521, 654 Annotation: Subtype: Link Rect: 316, 611, 497, 620 Annotation: Subtype: Link Rect: 340, 565, 521, 574 Annotation: Subtype: Link Rect: 437, 531, 511, 540 Annotation: Subtype: Link Rect: 316, 520, 423, 528 Annotation: Subtype: Link Rect: 378, 485, 505, 494 Annotation: Subtype: Link Rect: 316, 474, 370, 482 Annotation: Subtype: Link Rect: 378, 439, 505, 448 Annotation: Subtype: Link Rect: 316, 428, 370, 437 Annotation: Subtype: Link Rect: 395, 394, 521, 402 Annotation: Subtype: Link Rect: 316, 382, 370, 391 Annotation: Subtype: Link Rect: 457, 325, 524, 334 Annotation: Subtype: Link Rect: 316, 313, 397, 322 Annotation: Subtype: Link Rect: 383, 245, 524, 253 Annotation: Subtype: Link Rect: 316, 233, 329, 242 Thumb: true Page: Label: 18 Annotations: Annotation: Subtype: Link Rect: 122, 691, 271, 700 Annotation: Subtype: Link Rect: 160, 623, 249, 631 Annotation: Subtype: Link Rect: 87, 611, 177, 620 Annotation: Subtype: Link Rect: 101, 543, 269, 551 Annotation: Subtype: Link Rect: 123, 474, 266, 482 Annotation: Subtype: Link Rect: 87, 405, 248, 414 Annotation: Subtype: Link Rect: 233, 348, 290, 356 Annotation: Subtype: Link Rect: 87, 336, 192, 345 Annotation: Subtype: Link Rect: 227, 279, 295, 288 Annotation: Subtype: Link Rect: 87, 268, 168, 276 Annotation: Subtype: Link Rect: 394, 680, 521, 689 Annotation: Subtype: Link Rect: 332, 669, 386, 677 Annotation: Subtype: Link Rect: 417, 623, 528, 631 Annotation: Subtype: Link Rect: 332, 611, 507, 620 Annotation: Subtype: Link Rect: 332, 600, 522, 608 Annotation: Subtype: Link Rect: 332, 588, 487, 597 Annotation: Subtype: Link Rect: 505, 543, 532, 551 Annotation: Subtype: Link Rect: 332, 531, 532, 540 Annotation: Subtype: Link Rect: 332, 520, 392, 528 Annotation: Subtype: Link Rect: 473, 474, 500, 482 Annotation: Subtype: Link Rect: 332, 462, 486, 471 Annotation: Subtype: Link Rect: 356, 382, 537, 391 Annotation: Subtype: Link Rect: 453, 256, 527, 265 Annotation: Subtype: Link Rect: 332, 245, 439, 253 Thumb: true Checksum: d08a1949 Type: CRC32 Checksum: e095a785045af36d04b2be6898faee8f Type: MD5 Checksum: 18efe878a1b9b8f0be70ee0f4454a4b029edc177 Type: SHA-1 Checksum: 7a71804033c5fd45416a49ad4a9fed3cd59b2b4ec90d456ce18ff33b2651f484 Type: SHA-256