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Title:          Body weight of newborn and suckling piglets affects their intestinal gene expression
Subject:        doi: skac161
Journal of Animal Science, 9 June 2022
Abstract:
 
Modern hyperprolific sows must deal with large litters (16–20 piglets) which reduce piglet birthweight with a concomitant increase in the proportion of small and intrauterine growth retarded piglets. However, larger litters do not only have a greater variation of piglet weights, but also a greater variation in colostrum and milk consumption within the litter. To further understand the impact that body weight has on piglets, the present study aimed to evaluate the degree of physiological weakness of the smallest piglets at birth and during the suckling period (20 d) compared to their middle-weight littermates through their jejunal gene expression. At birth, light piglets showed a downregulation of genes related to immune response (FAXDC2, HSPB1, PPARGC1α), antioxidant enzymes (SOD2m), digestive enzymes (ANPEP, IDO1, SI), and nutrient transporter (SLC39A4) (P < 0.05) but also a tendency for a higher mRNA expression of GBP1 (inflammatory regulator) and HSD11β1 (stress hormone) genes compared to their heavier littermates (P < 0.10). Excluding HSD11β1 gene, all these intestinal gene expression differences initially observed at birth between light and middle-weight piglets were stabilized at the end of the suckling period, when others appeared. Genes involved in barrier function (CLDN1), pro-inflammatory response (CXCL2, IL6, IDO1), and stress hormone signaling (HSD11β1) over-expressed compared to their middle-weight littermates (P < 0.05). In conclusion, at birth and at the end of suckling period, light body weight piglets seem to have a compromised gene expression and therefore impaired nutrient absorption, immune and stress responses compared to their heavier littermates.
Author:         Sandra Villagómez-Estrada,, José F. Pérez,, Diego Melo-Durán,, Francesc Gonzalez-Solè,, Matilde D’Angelo,, Francisco J. Pérez-Cano,, David Solà-Oriol
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    Title: Body weight of newborn and suckling piglets affects their intestinal gene expression
    Author: Sandra Villagómez-Estrada,, José F. Pérez,, Diego Melo-Durán,, Francesc Gonzalez-Solè,, Matilde D’Angelo,, Francisco J. Pérez-Cano,, David Solà-Oriol
    Subject: doi: skac161
Journal of Animal Science, 9 June 2022
Abstract:
 
Modern hyperprolific sows must deal with large litters (16–2　 瀀椀最氀攀琀猀 眀栀椀挀栀 爀攀搀甀挀攀 瀀椀最氀攀琀 戀椀爀琀栀眀攀椀最栀琀 眀椀琀栀 愀 挀漀渀挀漀洀椀琀愀渀琀 椀渀挀爀攀愀猀攀 椀渀 琀栀攀 瀀爀漀瀀漀爀琀椀漀渀 漀昀 猀洀愀氀氀 愀渀搀 椀渀琀爀愀甀琀攀爀椀渀攀 最爀漀眀琀栀 爀攀琀愀牜ഀ搀攀搀 瀀椀最氀攀琀猀⸀ 䠀漀眀攀瘀攀爀Ⰰ 氀愀爀最攀爀 氀椀琀琀攀爀猀 搀漀 渀漀琀 漀渀氀礀 栀愀瘀攀 愀 最爀攀愀琀攀爀 瘀愀爀椀愀琀椀漀渀 漀昀 瀀椀最氀攀琀 眀攀椀最栀琀猀Ⰰ 戀甀琀 愀氀猀漀 愀 最爀攀愀琀攀爀 瘀愀爀椀愀琀椀漀渀 椀渀 挀漀ostrum and milk consumption within the litter. To further understand the impact that body weight has on piglets, the present st甀搀礀 愀椀洀攀搀 琀漀 攀瘀愀氀甀愀琀攀 琀栀攀 搀攀最爀攀攀 漀昀 瀀栀礀猀椀漀氀漀最椀挀愀氀 眀攀愀欀渀攀猀猀 漀昀 琀栀攀 猀洀愀氀氀攀猀琀 瀀椀最氀攀琀猀 愀琀 戀椀爀琀栀 愀渀搀 搀甀爀椀渀最 琀栀攀 猀甀挀欀氀椀渀最 瀀攀爀椀漀搀 ㈀　⁜ഀ搀 挀漀洀瀀愀爀攀搀 琀漀 琀栀攀椀爀 洀椀搀搀氀攀ⴀ眀攀椀最栀琀 氀椀琀琀攀爀洀愀琀攀猀 琀栀爀漀甀最栀 琀栀攀椀爀 樀攀樀甀渀愀氀 最攀渀攀 攀砀瀀爀攀猀猀椀漀渀⸀ 䄀琀 戀椀爀琀栀Ⰰ 氀椀最栀琀 瀀椀最氀攀琀猀 猀栀漀眀攀搀 愀 搀漀眀渀爀攀最畜ഀ氀愀琀椀漀渀 漀昀 最攀渀攀猀 爀攀氀愀琀攀搀 琀漀 椀洀洀甀渀攀 爀攀猀瀀漀渀猀攀 䘀䄀堀䐀䌀㈀Ⰰ 䠀匀倀䈀㄀Ⰰ 倀倀䄀刀䜀䌀㄃넀Ⰰ 愀渀琀椀漀砀椀搀愀渀琀 攀渀稀礀洀攀猀 匀伀䐀㈀洀Ⰰ 搀椀最攀猀琀椀瘀攀 攀渀稀礀洀攀猀 䄀一倀䔀倀Ⰰ⁜ഀ䤀䐀伀㄀Ⰰ 匀䤀Ⰰ 愀渀搀 渀甀琀爀椀攀渀琀 琀爀愀渀猀瀀漀爀琀攀爀 匀䰀䌀㌀㤀䄀㐀 倀 㰀 　⸀　㔀 戀甀琀 愀氀猀漀 愀 琀攀渀搀攀渀挀礀 昀漀爀 愀 栀椀最栀攀爀 洀刀一䄀 攀砀瀀爀攀猀猀椀漀渀 漀昀 䜀䈀倀㄀ 椀渀昀氀愀洀洀愀琀ry regulator) and HSD11β1 (stress hormone) genes compared to their heavier littermates (P < 0.10). Excluding HSD11β1 gene, a氀氀 琀栀攀猀攀 椀渀琀攀猀琀椀渀愀氀 最攀渀攀 攀砀瀀爀攀猀猀椀漀渀 搀椀昀昀攀爀攀渀挀攀猀 椀渀椀琀椀愀氀氀礀 漀戀猀攀爀瘀攀搀 愀琀 戀椀爀琀栀 戀攀琀眀攀攀渀 氀椀最栀琀 愀渀搀 洀椀搀搀氀攀ⴀ眀攀椀最栀琀 瀀椀最氀攀琀猀 眀攀爀攀 猀琀愀戀椀氀楜ഀ稀攀搀 愀琀 琀栀攀 攀渀搀 漀昀 琀栀攀 猀甀挀欀氀椀渀最 瀀攀爀椀漀搀Ⰰ 眀栀攀渀 漀琀栀攀爀猀 愀瀀瀀攀愀爀攀搀⸀ 䜀攀渀攀猀 椀渀瘀漀氀瘀攀搀 椀渀 戀愀爀爀椀攀爀 昀甀渀挀琀椀漀渀 䌀䰀䐀一㄀Ⰰ 瀀爀漀ⴀ椀渀昀氀愀洀洀愀琀漀爀礀 爀攀猀瀀nse (CXCL2, IL6, IDO1), and stress hormone signaling (HSD11β1) over-expressed compared to their middle-weight littermates (P 㰀 　⸀　㔀⸀ 䤀渀 挀漀渀挀氀甀猀椀漀渀Ⰰ 愀琀 戀椀爀琀栀 愀渀搀 愀琀 琀栀攀 攀渀搀 漀昀 猀甀挀欀氀椀渀最 瀀攀爀椀漀搀Ⰰ 氀椀最栀琀 戀漀搀礀 眀攀椀最栀琀 瀀椀最氀攀琀猀 猀攀攀洀 琀漀 栀愀瘀攀 愀 挀漀洀瀀爀漀洀椀猀攀搀 最攀渀攀 xpression and therefore impaired nutrient absorption, immune and stress responses compared to their heavier littermates.
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  Checksum: fa1fdec5
   Type: CRC32
  Checksum: 31b737c4ab43a5e39ac87d00b6c20df6
   Type: MD5
  Checksum: c84d388f2f1ea979d297f0659d76d135651f65b4
   Type: SHA-1