fd6c32d346bd080617f291014f3899d5 pmc_9181457.pdf 1465739922be64d3d9007397f3a402d1fdf80746 pmc_9181457.pdf 3ebe74a2fee0c64c949a35f761617b86c1e5c82e39401d56ed915da74356889a pmc_9181457.pdf Title: Quality of Life in Older Patients after a Heart Failure Hospitalization: Results from the SENECOR Study Subject: Background: Information about health-related quality of life (HRQoL) in heart failure (HF) in older adults is scarce. Methods: We aimed to describe the HRQoL of the SENECOR study cohort, a single-center, randomized trial comparing the effects of multidisciplinary intervention by a geriatrician and a cardiologist (intervention group) to that of a cardiologist alone (control group) in older patients with a recent HF hospitalization. Results: HRQoL was assessed by the short version of the disease-specific Kansas Cardiomyopathy Questionnaire (KCCQ-12) in 141 patients at baseline and was impaired (KCCQ-12 < 75) in almost half of the cohort. Women comprised 50% of the population, the mean age was 82.2 years, and two-thirds of patients had preserved ejection fraction. Comorbidities were highly prevalent. Patients with impaired HRQoL had a worse NYHA functional class, a lower NT-proBNP, a lower Barthel index, and a higher Clinical Frailty Scale. One-year all-cause mortality was 22.7%, significantly lower in the group with good-to-excellent HRQoL (14.5% vs. 30.6%; hazard ratio 0.28; 95% confidence interval 0.10–0.78; p = 0.014). In the group with better HRQoL, all-cause hospitalization was lower, and there was a trend towards lower HF hospitalization. Conclusions: The KCCQ-12 questionnaire can provide inexpensive prognostic information even in older patients with HF. (Funded by grant Primitivo de la Vega, Fundación MAPFRE. ClinicalTrials number, NCT03555318). Keywords: quality of life; heart failure; older patients; prognosis Author: Daniele Luiso, Marta Herrero-Torrus, Neus Badosa, Cristina Roqueta, Sonia Ruiz-Bustillo, Laia C. Belarte-Tornero, Sandra Valdivielso-Moré, Ronald O. Morales, Olga Vázquez and Núria Farré Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Jun 1 10:32:14 2022 CEST ModDate: Wed Jun 1 10:39:59 2022 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 911089 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HZQANX+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 VADHIA+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 QTNGKH+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 YFNERV+VnURWPalladioL Type 1 Custom yes yes no 23 0 YUQEMP+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 49 0 NKGANE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 83 0 NKGAOF+PalatinoLinotype TrueType WinAnsi yes yes no 86 0 NKGAOH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 89 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 96 0 JGMOZW+CMSY10 Type 1 Builtin yes yes no 100 0 NKGANE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 120 0 NKGAOF+PalatinoLinotype TrueType WinAnsi yes yes no 123 0 NKGAOH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 126 0 NKGDMI+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 129 0 NKGANE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 140 0 NKGAOF+PalatinoLinotype TrueType WinAnsi yes yes no 143 0 NKGAOH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 146 0 NKGDMI+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 149 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-06-12 02:45:12 CEST RepresentationInformation: pmc_9181457.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-30 02:38:56 CEST Size: 911089 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 285 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Quality-of-Life Assessment Destination: subsection.2.2 Item: Title: Study Outcome Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Quality of Life in Older Patients after a Heart Failure Hospitalization: Results from the SENECOR Study Author: Daniele Luiso, Marta Herrero-Torrus, Neus Badosa, Cristina Roqueta, Sonia Ruiz-Bustillo, Laia C. Belarte-Tornero, Sandra Valdivielso-Moré, Ronald O. Morales, Olga Vázquez and Núria Farré Subject: Background: Information about health-related quality of life (HRQoL) in heart failure (HF) in older adults is scarce. Methods: We aimed to describe the HRQoL of the SENECOR study cohort, a single-center, randomized trial comparing the effects of multidisciplinary intervention by a geriatrician and a cardiologist (intervention group) to that of a cardiologist alone (control group) in older patients with a recent HF hospitalization. Results: HRQoL was assessed by the short version of the disease-specific Kansas Cardiomyopathy Questionnaire (KCCQ-12) in 141 patients at baseline and was impaired (KCCQ-12 < 75) in almost half of the cohort. Women comprised 50% of the population, the mean age was 82.2 years, and two-thirds of patients had preserved ejection fraction. Comorbidities were highly prevalent. Patients with impaired HRQoL had a worse NYHA functional class, a lower NT-proBNP, a lower Barthel index, and a higher Clinical Frailty Scale. One-year all-cause mortality was 22.7%, significantly lower in the group with good-to-excellent HRQoL (14.5% vs. 30.6%; hazard ratio 0.28; 95% confidence interval 0.10 0.78; p = 0.014). In the group with better HRQoL, all-cause hospitalization was lower, and there was a trend towards lower HF hospitalization. Conclusions: The KCCQ-12 questionnaire can provide inexpensive prognostic information even in older patients with HF. (Funded by grant Primitivo de la Vega, Fundación MAPFRE. ClinicalTrials number, NCT03555318). 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