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SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 951 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: A faecal microbiota signature with high specificity for pancreatic cancer Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Children: Item: Title: Subject recruitment and sample collection Item: Title: Sample processing Item: Title: 16S rRNA amplicon sequencing Item: Title: 16S rRNA amplicon data processing Item: Title: Shotgun metagenomic sequencing Item: Title: Metagenome data processing Item: Title: Microbiome data statistical analyses Item: Title: Multivariable statistical modelling and model evaluation Item: Title: External validation of the metagenomic classifiers Item: Title: Subspecies and strain-level analyses Item: Title: Fluorescence in situ hybridisation microscopy Item: Title: Results Children: Item: Title: PDAC is associated with moderate shifts in microbiome composition when controlling for confounding factors in shotgun metagenomic data Item: Title: High-accuracy metagenomic classifiers capture specific faecal microbiome signatures in patients with PDAC Item: Title: Combination of metagenomic classifiers with antigen CA19-9 levels increases accuracy Item: Title: Performance of metagenome-based classifiers generalises to independent validation cohorts Item: Title: PDAC harbours characteristic bacteria, consistent with oral and gut microbiome communities Item: Title: Links between oral, intestinal and pancreatic microbiomes Item: Title: Discussion Item: Title: References Info: Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe 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