965f88bbcef3fd0c3e121340555c4467  pmc_9226000.pdf
0675632bb1e7567ecf9418924f62474a908e92d0  pmc_9226000.pdf
90c7bc06539832c8b7a30ccfe2aa3366f80c49aff83c740dbf00be878baf7fda  pmc_9226000.pdf

Title:           Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit
Subject:         Communications Biology, doi:10.1038/s42003-022-03568-6
Keywords:        
Author:          David Molina-Granada
Creator:         Springer
Producer:        iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Thu Jun 23 14:56:30 2022 CEST
ModDate:         Thu Jun 23 21:25:45 2022 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           16
Encrypted:       no
Page size:       595.276 x 782.362 pts
Page rot:        0
File size:       2335369 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MNMAMI+AdvOTf23bb480+20              Type 1C           WinAnsi          yes yes no     817  0
MNMAOI+AdvTTda6f6cb8.B               Type 1C           WinAnsi          yes yes no      81  0
MNLPBM+AdvOTea1a7398                 Type 1C           WinAnsi          yes yes no      83  0
MNMABH+AdvTT2876772e+27              Type 1C           Custom           yes yes yes    818  0
MNMAGG+AdvOTea1a7398+fb              Type 1C           Custom           yes yes yes    207  0
MNMAGH+AdvOTcb88df00                 Type 1C           WinAnsi          yes yes no      86  0
MNMALG+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     117  0
MNMALH+AdvOTf23bb480                 Type 1C           WinAnsi          yes yes no     819  0
MNMBFH+AdvOT1ef757c0                 Type 1C           WinAnsi          yes yes no      79  0
MNMBFI+AdvOT1ef757c0+fb              Type 1C           Custom           yes yes yes     80  0
MNMBFG+AdvOT125c650c                 Type 1C           WinAnsi          yes yes no      82  0
MNMBHL+AdvOTb65e897d.B               Type 1C           WinAnsi          yes yes no      84  0
MNMBIL+AdvTTab7e17fd                 Type 1C           WinAnsi          yes yes no      85  0
MNMBFJ+AdvOT7d6df7ab.I               Type 1C           WinAnsi          yes yes no      87  0
MNMBGK+AdvOT1ef757c0+20              Type 1C           WinAnsi          yes yes no      88  0
MNMBPO+AdvOTea1a7398+20              Type 1C           WinAnsi          yes yes no     112  0
MNMBPM+Verdana-Bold                  Type 1C           WinAnsi          yes yes no     113  0
MNMBPN+AdvOT9bd21c25.I               Type 1C           WinAnsi          yes yes no     114  0
MNMBKL+AdvOT1ef757c0+03              Type 1C           Custom           yes yes yes    115  0
MNMBOL+ArialMT                       Type 1C           Custom           yes yes yes    116  0
MNMCBO+AdvOT8608a8d1+02              Type 1C           Custom           yes yes yes    136  0
MNMFEL+AdvOT8608a8d1+03              Type 1C           Custom           yes yes yes    205  0
MNMFEM+AdvOT8608a8d1                 Type 1C           WinAnsi          yes yes no     206  0
BellMT                               Type 1C           WinAnsi          yes no  no     226  0
Verdana                              Type 1C           WinAnsi          yes no  no     227  0
MNNFOJ+AdvOTcb88df00+fb              Type 1C           Custom           yes yes yes    306  0
MNNKCA+AdvTTab7e17fd+20              Type 1C           Custom           yes yes yes    474  0
MNNKCB+AdvOT1ef757c0+21              Type 1C           WinAnsi          yes yes no     475  0
MNNKEC+AdvTTab7e17fd+22              Type 1C           Custom           yes yes no     488  0
MNNKMA+AdvOTb65e897d.B+20            Type 1C           WinAnsi          yes yes no     548  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-05-17 03:29:53 CEST
 RepresentationInformation: pmc_9226000.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-05-17 02:38:12 CEST
  Size: 2335369
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 906
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Most mitochondrial dGTP is tightly bound to’respiratory complex I through the NDUFA10’subunit
      Destination: title_link
      Children: 
       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Mitochondrial dNTP pools are highly asymmetric in mouse tissues or human cells
          Destination: B1
         Item: 
          Title: Most mitochondrial dGTP is bound to protein
          Destination: B2
         Item: 
          Title: dGTP is bound to respiratory chain complex I through NDUFA10’subunit
          Destination: B3
         Item: 
          Title: dGTP binds to the dNK domain of NDUFA10
          Destination: B4
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Cell lines and culture
          Destination: B5
         Item: 
          Title: Mice housing and experimentation
          Destination: B6
         Item: 
          Title: Mitochondria isolation from mouse tissues and mammalian cells
          Destination: B7
         Item: 
          Title: Whole-cell protein extraction
          Destination: B8
         Item: 
          Title: SDS-PAGE and western blot analysis
          Destination: B9
         Item: 
          Title: Blue native polyacrylamide gel electrophoresis (BN-PAGE)
          Destination: B10
         Item: 
          Title: dGTP-affinity purification and pull-down assays
          Destination: B11
         Item: 
          Title: Protein identification by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS)
          Destination: B12
         Item: 
          Title: Complex I immunoprecipitation
          Destination: B13
         Item: 
          Title: ANTI-FLAG immunoprecipitation
          Destination: B14
         Item: 
          Title: Fractionation by sucrose density gradient ultracentrifugation
          Destination: B15
         Item: 
          Title: dNTP extraction
          Destination: B16
         Item: 
          Title: Quantification of dNTPs
          Destination: B17
         Item: 
          Title: Photoaffinity labeling
          Destination: B18
         Item: 
          Title: Electrophoresis mobility assay (EMSA)
          Destination: B19
         Item: 
          Title: MtDNA analysis
          Destination: B20
         Item: 
          Title: Respiratory chain complex I activity
          Destination: B21
         Item: 
          Title: Oxygen consumption determination
          Destination: B22
         Item: 
          Title: Deoxyguanosine kinase activity determination
          Destination: B23
         Item: 
          Title: Structural analysis
          Destination: B24
         Item: 
          Title: Statistics and reproducibility
          Destination: B25
         Item: 
          Title: Multiple alignment
          Destination: B26
       Item: 
        Title: Reporting summary
        Destination: A4
       Item: 
        Title: Data availability
        Destination: M1
       Item: 
        Title: References
        Destination: A5
       Item: 
        Title: References
        Destination: A6
       Item: 
        Title: Acknowledgements
        Destination: A7
       Item: 
        Title: Author contributions
        Destination: A8
       Item: 
        Title: Competing interests
        Destination: A9
       Item: 
        Title: Additional information
        Destination: M3
   Info: 
    Title: Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit
    Author: David Molina-Granada
    Subject: Communications Biology, doi:10.1038/s42003-022-03568-6
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Thu Jun 23 15:26:30 CEST 2022
    ModDate: Thu Jun 23 21:25:45 CEST 2022
   ID: 0x13fc274f9ad79b07fe58f13b757adddf, 0x38e8a0911819ea60c53a545ad3c76d14
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 295
      ImageHeight: 3
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 587
      ImageHeight: 265
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 544
      ImageHeight: 305
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1026
      ImageHeight: 792
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 148
      ImageHeight: 265
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 295
      ImageHeight: 1055
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1346
      ImageHeight: 297
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 898
      ImageHeight: 888
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 898
      ImageHeight: 888
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 136
      ImageHeight: 141
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 450
      ImageHeight: 1774
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 74
      ImageHeight: 24
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 52
      ImageHeight: 5
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 52
      ImageHeight: 4
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 3
      ImageHeight: 3
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1000
      ImageHeight: 991
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1408
      ImageHeight: 1931
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1563
      ImageHeight: 728
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MNMCBO+AdvOT8608a8d1+02
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MNMCBO+AdvOT8608a8d1+02
       Flags: Symbolic
       FontBBox: -62, -302, 843, 843
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MNMFEL+AdvOT8608a8d1+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MNMFEL+AdvOT8608a8d1+03
       Flags: Symbolic
       FontBBox: -479, -364, 854, 927
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MNMFEM+AdvOT8608a8d1
      FontSubset: true
      FirstChar: 181
      LastChar: 181
      FontDescriptor: 
       FontName: MNMFEM+AdvOT8608a8d1
       Flags: Nonsymbolic
       FontBBox: -62, -208, 927, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMAGG+AdvOTea1a7398+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: MNMAGG+AdvOTea1a7398+fb
       Flags: Symbolic
       FontBBox: 0, -197, 750, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MNMBFH+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 35
      LastChar: 242
      FontDescriptor: 
       FontName: MNMBFH+AdvOT1ef757c0
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 947, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMBFI+AdvOT1ef757c0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: MNMBFI+AdvOT1ef757c0+fb
       Flags: Symbolic
       FontBBox: 0, -10, 781, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MNMAOI+AdvTTda6f6cb8.B
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: MNMAOI+AdvTTda6f6cb8.B
       Flags: Nonsymbolic
       FontBBox: -72, -218, 895, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMBFG+AdvOT125c650c
      FontSubset: true
      FirstChar: 77
      LastChar: 77
      FontDescriptor: 
       FontName: MNMBFG+AdvOT125c650c
       Flags: Nonsymbolic
       FontBBox: -31, -197, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNLPBM+AdvOTea1a7398
      FontSubset: true
      FirstChar: 35
      LastChar: 237
      FontDescriptor: 
       FontName: MNLPBM+AdvOTea1a7398
       Flags: Nonsymbolic
       FontBBox: -31, -197, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMBHL+AdvOTb65e897d.B
      FontSubset: true
      FirstChar: 48
      LastChar: 121
      FontDescriptor: 
       FontName: MNMBHL+AdvOTb65e897d.B
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 968, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMBIL+AdvTTab7e17fd
      FontSubset: true
      FirstChar: 43
      LastChar: 61
      FontDescriptor: 
       FontName: MNMBIL+AdvTTab7e17fd
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1072, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMAGH+AdvOTcb88df00
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: MNMAGH+AdvOTcb88df00
       Flags: Nonsymbolic
       FontBBox: -41, -197, 968, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMBFJ+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: MNMBFJ+AdvOT7d6df7ab.I
       Flags: Nonsymbolic
       FontBBox: -135, -250, 1000, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMBGK+AdvOT1ef757c0+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: MNMBGK+AdvOT1ef757c0+20
       Flags: Nonsymbolic
       FontBBox: -135, -187, 1010, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNNKCA+AdvTTab7e17fd+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MNNKCA+AdvTTab7e17fd+20
       Flags: Symbolic
       FontBBox: 19, 0, 989, 906
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MNNKCB+AdvOT1ef757c0+21
      FontSubset: true
      FirstChar: 153
      LastChar: 153
      FontDescriptor: 
       FontName: MNNKCB+AdvOT1ef757c0+21
       Flags: Nonsymbolic
       FontBBox: 0, -20, 822, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: BellMT
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: BellMT
       Flags: Nonsymbolic
       FontBBox: -207, -267, 1059, 913
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Verdana
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Verdana
       Flags: Nonsymbolic
       FontBBox: -560, -303, 1523, 1051
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNNKMA+AdvOTb65e897d.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: MNNKMA+AdvOTb65e897d.B+20
       Flags: Nonsymbolic
       FontBBox: -125, -177, 1052, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNNKEC+AdvTTab7e17fd+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: MNNKEC+AdvTTab7e17fd+22
       Flags: Nonsymbolic
       FontBBox: -156, -218, 937, 947
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: MNMBPO+AdvOTea1a7398+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: MNMBPO+AdvOTea1a7398+20
       Flags: Nonsymbolic
       FontBBox: -93, -197, 843, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMAMI+AdvOTf23bb480+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: MNMAMI+AdvOTf23bb480+20
       Flags: Nonsymbolic
       FontBBox: -93, -197, 843, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMBPM+Verdana-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: MNMBPM+Verdana-Bold
       Flags: Nonsymbolic
       FontBBox: -550, -303, 1707, 1072
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMABH+AdvTT2876772e+27
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MNMABH+AdvTT2876772e+27
       Flags: Symbolic
       FontBBox: 0, -197, 968, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MNMBPN+AdvOT9bd21c25.I
      FontSubset: true
      FirstChar: 78
      LastChar: 121
      FontDescriptor: 
       FontName: MNMBPN+AdvOT9bd21c25.I
       Flags: Nonsymbolic
       FontBBox: -83, -197, 1010, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNNFOJ+AdvOTcb88df00+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MNNFOJ+AdvOTcb88df00+fb
       Flags: Symbolic
       FontBBox: 0, -197, 895, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MNMALH+AdvOTf23bb480
      FontSubset: true
      FirstChar: 40
      LastChar: 242
      FontDescriptor: 
       FontName: MNMALH+AdvOTf23bb480
       Flags: Nonsymbolic
       FontBBox: -31, -197, 968, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MNMBKL+AdvOT1ef757c0+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: MNMBKL+AdvOT1ef757c0+03
       Flags: Symbolic
       FontBBox: -125, -270, 854, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MNMBOL+ArialMT
      FontSubset: true
      FirstChar: 2
      LastChar: 121
      FontDescriptor: 
       FontName: MNMBOL+ArialMT
       Flags: Symbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MNMALG+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: MNMALG+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s42003-022-03568-6</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>David Molina-Granada</rdf:li>
               <rdf:li>Emiliano González-Vioque</rdf:li>
               <rdf:li>Marris G. Dibley</rdf:li>
               <rdf:li>Raquel Cabrera-Pérez</rdf:li>
               <rdf:li>Antoni Vallbona-Garcia</rdf:li>
               <rdf:li>Javier Torres-Torronteras</rdf:li>
               <rdf:li>Leonid A. Sazanov</rdf:li>
               <rdf:li>Michael T. Ryan</rdf:li>
               <rdf:li>Yolanda Cámara</rdf:li>
               <rdf:li>Ramon Martí</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag></rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Communications Biology, doi:10.1038/s42003-022-03568-6</rdf:li>
            </rdf:Alt>
         </dc:description>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2022-06-23T21:25:45+02:00</xmp:ModifyDate>
         <xmp:CreateDate>2022-06-23T18:26:30+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2022-06-23T21:25:45+02:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:9db017d7-0bea-401a-9072-b301164666d0</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:0eb6ca09-5e66-4704-9681-ddc127152e36</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:1cd911fd-e744-4b75-9421-fca96169701d</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2022-06-23T18:27:28+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 473, 683, 475, 715
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 473, 686, 508, 717
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 683, 551, 693
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 683, 551, 693
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 377, 540, 378, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 377, 540, 378, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 386, 540, 387, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 376, 540, 387, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 387, 540, 389, 551
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 119, 524, 120, 535
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 119, 524, 120, 535
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 128, 524, 129, 535
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 118, 524, 129, 535
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 129, 524, 132, 535
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 232, 524, 233, 535
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 232, 524, 233, 535
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 241, 524, 242, 535
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 231, 524, 242, 535
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 242, 524, 244, 535
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 347, 43, 429, 51
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 434, 43, 505, 51
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 378, 23, 458, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 78, 600, 82, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 223, 475, 227, 482
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 217, 433, 221, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 181, 359, 184, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 188, 359, 192, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 95, 286, 98, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 138, 244, 142, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 146, 244, 153, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 271, 108, 278, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 282, 108, 289, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 219, 56, 226, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 516, 705, 523, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 525, 705, 532, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 538, 616, 542, 623
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 545, 616, 549, 623
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 410, 584, 413, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 415, 584, 422, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 424, 584, 431, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 373, 518, 377, 528
       Flags: Print
       AppearanceDictionary: true
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 376, 487, 381, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 460, 438, 464, 445
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 465, 438, 473, 445
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 490, 414, 494, 423
       Flags: Print
       AppearanceDictionary: true
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 384, 386, 391, 393
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 393, 386, 400, 393
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 402, 386, 409, 393
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 427, 307, 431, 315
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 520, 297, 524, 304
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 525, 297, 532, 304
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 533, 244, 540, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 542, 244, 549, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 491, 213, 498, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 487, 161, 494, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 471, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 99, 178, 104, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 62, 168, 67, 177
       Flags: Print
       AppearanceDictionary: true
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 264, 84, 268, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 375, 272, 379, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 344, 136, 349, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 525, 42, 530, 52
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 378, 23, 458, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 277, 180, 282, 189
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 537, 200, 542, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 521, 148, 525, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 471, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 265, 421, 273, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 282, 410, 289, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 267, 400, 275, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 210, 348, 217, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 221, 348, 229, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 122, 306, 129, 313
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 223, 281, 227, 291
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 156, 274, 163, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 182, 250, 187, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 103, 232, 110, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 157, 166, 161, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 190, 114, 194, 124
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 134, 51, 139, 61
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 325, 459, 330, 469
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 517, 355, 522, 364
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 334, 274, 341, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 459, 156, 463, 165
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 323, 93, 328, 103
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 326, 51, 330, 61
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 378, 23, 458, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 113, 126, 118, 135
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 444, 95, 448, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 417, 84, 421, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 442, 53, 447, 62
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 471, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 277, 139, 282, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 220, 97, 224, 107
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 261, 97, 265, 107
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 536, 452, 541, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 436, 379, 441, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 355, 337, 360, 347
       Flags: Print
       AppearanceDictionary: true
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 481, 327, 485, 336
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 345, 288, 352, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 362, 213, 369, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 513, 203, 520, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 474, 182, 481, 189
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 485, 182, 492, 189
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 433, 161, 440, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 442, 161, 449, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 532, 545, 536, 553
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 378, 23, 458, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 471, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 137, 77, 144, 85
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 501, 67, 508, 74
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 449, 46, 457, 53
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 458, 46, 465, 53
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 378, 23, 458, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 547, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 84, 536, 89, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 129, 526, 134, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 261, 526, 265, 535
       Flags: Print
       AppearanceDictionary: true
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 259, 440, 264, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 182, 367, 187, 376
       Flags: Print
       AppearanceDictionary: true
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 64, 315, 68, 324
       Flags: Print
       AppearanceDictionary: true
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 63, 252, 67, 261
       Flags: Print
       AppearanceDictionary: true
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 81, 179, 86, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 335
      Annotation: 
       Subtype: Link
       Rect: 133, 56, 140, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 141, 56, 149, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 340, 592, 348, 599
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 502, 391, 506, 398
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 510, 391, 513, 398
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 362, 349, 366, 357
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 404, 286, 408, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 469, 223, 473, 231
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 477, 223, 484, 231
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 471, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 150, 631, 157, 639
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 161, 631, 168, 639
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 100, 610, 107, 618
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 139, 600, 147, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 185, 590, 193, 597
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 117, 579, 124, 587
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 78, 527, 85, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 158, 495, 165, 503
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 70, 422, 77, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 78, 422, 86, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 270, 391, 277, 398
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 136, 370, 143, 377
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 78, 349, 85, 357
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 200, 199, 205, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 156, 189, 160, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 253
      Annotation: 
       Subtype: Link
       Rect: 68, 87, 76, 95
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 260, 67, 267, 74
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 340, 715, 347, 723
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 349, 715, 356, 723
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 463, 680, 468, 690
       Flags: Print
       AppearanceDictionary: true
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 475, 680, 480, 690
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 511, 680, 515, 690
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 517, 621, 524, 629
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 526, 621, 533, 629
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 524, 349, 531, 357
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 533, 349, 540, 357
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 542, 349, 549, 357
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 343, 276, 350, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 354, 276, 361, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 378, 23, 458, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 543, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 229, 569, 236, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 240, 569, 247, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 84, 548, 91, 555
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 237, 537, 244, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 142, 422, 149, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 151, 422, 158, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 160, 422, 167, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 284, 309, 289, 315
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 102, 284, 108, 290
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 162, 47, 167, 53
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 383, 45, 388, 51
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 471, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 378, 23, 458, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 543, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 263, 335, 269, 341
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 270, 335, 276, 341
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 398, 591, 403, 597
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 368, 541, 373, 547
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 361, 440, 367, 446
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 369, 440, 374, 446
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 486, 266, 492, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 511
      Annotation: 
       Subtype: Link
       Rect: 493, 266, 499, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 471, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 264, 588, 283, 596
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 43, 580, 86, 587
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 223, 580, 291, 587
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 43, 571, 132, 579
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 226, 466, 284, 473
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 174, 442, 179, 447
       Flags: Print
       AppearanceDictionary: true
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 378, 23, 458, 30
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 543, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 337, 446, 460, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 457, 368, 546, 375
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 472, 234, 551, 241
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 303, 225, 346, 232
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 471, 23, 551, 30
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 0bb5d4d2
   Type: CRC32
  Checksum: 965f88bbcef3fd0c3e121340555c4467
   Type: MD5
  Checksum: 0675632bb1e7567ecf9418924f62474a908e92d0
   Type: SHA-1
  Checksum: 90c7bc06539832c8b7a30ccfe2aa3366f80c49aff83c740dbf00be878baf7fda
   Type: SHA-256