00ee4d5d4e50099c3cc80e1c672f4e84 pmc_9230542.pdf 4043c13b4e30d31f34a9c1f5fd93f33fc65f13b2 pmc_9230542.pdf 005ea408f4ee0024d3de0a73e5e165a3deeb5ee1d49c70f7aa5b330b394122ea pmc_9230542.pdf Title: Neurocognitive Profile of the Post-COVID Condition in Adults in Catalonia—A Mixed Method Prospective Cohort and Nested Case–Control Study: Study Protocol Subject: The diagnosis of the post-COVID condition is usually achieved by excluding other diseases; however, cognitive changes are often found in the post-COVID disorder. Therefore, monitoring and treating the recovery from the post-COVID condition is necessary to establish biomarkers to guide the diagnosis of symptoms, including cognitive impairment. Our study employs a prospected cohort and nested case–control design with mixed methods, including statistical analyses, interviews, and focus groups. Our main aim is to identify biomarkers (functional and structural neural changes, inflammatory and immune status, vascular and vestibular signs and symptoms) easily applied in primary care to detect cognitive changes in post-COVID cases. The results will open up a new line of research to inform diagnostic and therapeutic decisions with special considerations for cognitive impairment in the post-COVID condition. Keywords: post-COVID condition; cognitive symptoms; neuropsychologic symptoms; quality of life; retinography; posturography; magnetic resonance imaging; immune response; inflammation Author: Rosalia Dacosta-Aguayo, Noemí Lamonja-Vicente, Carla Chacón, Lucia Amalía Carrasco-Ribelles, Pilar Montero-Alia, Anna Costa-Garrido, Rosa García-Sierra, Victor M. López-Lifante, Eduard Moreno-Gabriel, Marta Massanella, Josep Puig, Jose A. Muñoz-Moreno, Lourdes Mateu, Anna Prats, Carmina Rodríguez, Maria Mataró, Julia G. Prado, Eva Martínez-Cáceres, Concepción Violán and Pere Torán-Monserrat Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue May 31 04:33:21 2022 CEST ModDate: Tue May 31 04:59:48 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 606647 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IYSVYD+VnURWPalladioL Type 1 Custom yes yes no 10 0 SVFKTK+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 SJKLLF+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 ALHTNI+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 PRJKGQ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 QDCWHF+EURM10 Type 1 Builtin yes yes no 68 0 PXTEMV+CMSY10 Type 1 Builtin yes yes no 78 0 LAMAHO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 85 0 LAMAIP+PalatinoLinotype CID TrueType Identity-H yes yes yes 88 0 LAMAJA+PalatinoLinotype TrueType WinAnsi yes yes no 94 0 LAMAKC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 97 0 LAMBGO+Arial CID TrueType Identity-H yes yes yes 100 0 LRJSKZ+VnURWPalladioL-Italic Type 1 Custom yes yes no 125 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-07-27 02:28:32 CEST RepresentationInformation: pmc_9230542.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-07-13 07:27:24 CEST Size: 606647 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 384 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4923ab24 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Children: Item: Title: Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Participants, Exposure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Recruitment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Sample Size and Sampling Procedure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Demographical and Clinical Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Clinical Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Neurocognitive Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Neuroimaging and Neurophysiological Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Inflammatory and Immunology Markers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Lifestyle-Related Variables Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Statistical Analysis Plan Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Children: Item: Title: Quantitative Methodology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Integration of Quantitative and Qualitative Approaches Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Ethical Considerations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Children: Item: Title: Expected Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Impact Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Public Health Policies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Scientific Impact Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Economic Impact Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Innovation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Strengths and Limitations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Info: Title: Neurocognitive Profile of the Post-COVID Condition in Adults in Catalonia A Mixed Method Prospective Cohort and Nested Case Control Study: Study Protocol Author: Rosalia Dacosta-Aguayo, Noemí Lamonja-Vicente, Carla Chacón, Lucia Amalía Carrasco-Ribelles, Pilar Montero-Alia, Anna Costa-Garrido, Rosa García-Sierra, Victor M. López-Lifante, Eduard Moreno-Gabriel, Marta Massanella, Josep Puig, Jose A. Muñoz-Moreno, Lourdes Mateu, Anna Prats, Carmina Rodríguez, Maria Mataró, Julia G. Prado, Eva Martínez-Cáceres, Concepción Violán and Pere Torán-Monserrat Subject: The diagnosis of the post-COVID condition is usually achieved by excluding other diseases; however, cognitive changes are often found in the post-COVID disorder. Therefore, monitoring and treating the recovery from the post-COVID condition is necessary to establish biomarkers to guide the diagnosis of symptoms, including cognitive impairment. Our study employs a prospected cohort and nested case control design with mixed methods, including statistical analyses, interviews, and focus groups. Our main aim is to identify biomarkers (functional and structural neural changes, inflammatory and immune status, vascular and vestibular signs and symptoms) easily applied in primary care to detect cognitive changes in post-COVID cases. The results will open up a new line of research to inform diagnostic and therapeutic decisions with special considerations for cognitive impairment in the post-COVID condition. Keywords: post-COVID condition; cognitive symptoms; neuropsychologic symptoms; quality of life; retinography; posturography; magnetic resonance imaging; immune response; inflammation Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue May 31 04:33:21 CEST 2022 ModDate: Tue May 31 04:59:48 CEST 2022 ID: 0x9661da4fe1586784e5d8fb0eb8140ec5, 0x9661da4fe1586784e5d8fb0eb8140ec5 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: SJKLLF+URWPalladioL-Roma FontSubset: true FirstChar: 1 LastChar: 252 FontDescriptor: FontName: SJKLLF+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QDCWHF+EURM10 FontSubset: true FirstChar: 11 LastChar: 12 FontDescriptor: FontName: QDCWHF+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: ALHTNI+URWPalladioL-Ital FontSubset: true FirstChar: 39 LastChar: 122 FontDescriptor: FontName: ALHTNI+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IYSVYD+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 242 FontDescriptor: FontName: IYSVYD+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PRJKGQ+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 226 FontDescriptor: FontName: PRJKGQ+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LRJSKZ+VnURWPalladioL-Italic FontSubset: true FirstChar: 160 LastChar: 226 FontDescriptor: FontName: LRJSKZ+VnURWPalladioL-Italic Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PXTEMV+CMSY10 FontSubset: true FirstChar: 15 LastChar: 21 FontDescriptor: FontName: PXTEMV+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: SVFKTK+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: SVFKTK+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 104, 323, 152, 332 Annotation: Subtype: Link Rect: 34, 311, 143, 320 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 126, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 147, 87 Annotation: Subtype: Link Rect: 34, 756, 150, 792 Annotation: Subtype: Link Rect: 515, 756, 560, 792 Annotation: Subtype: Link Rect: 295, 642, 306, 655 Annotation: Subtype: Link Rect: 538, 642, 549, 655 Annotation: Subtype: Link Rect: 361, 629, 372, 643 Annotation: Subtype: Link Rect: 504, 629, 515, 643 Annotation: Subtype: Link Rect: 171, 616, 182, 630 Annotation: Subtype: Link Rect: 297, 616, 309, 630 Annotation: Subtype: Link Rect: 367, 616, 378, 630 Annotation: Subtype: Link Rect: 156, 604, 167, 617 Annotation: Subtype: Link Rect: 429, 604, 440, 617 Annotation: Subtype: Link Rect: 539, 604, 550, 617 Annotation: Subtype: Link Rect: 459, 591, 470, 605 Annotation: Subtype: Link Rect: 112, 17, 266, 28 Annotation: Subtype: Link Rect: 406, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 468, 87, 487 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 342, 565, 519, 577 Annotation: Subtype: Link Rect: 260, 530, 267, 539 ActionDest: 122 Annotation: Subtype: Link Rect: 344, 517, 351, 526 ActionDest: 122 Annotation: Subtype: Link Rect: 454, 505, 461, 514 ActionDest: 122 Annotation: Subtype: Link Rect: 201, 492, 208, 501 ActionDest: 122 Annotation: Subtype: Link Rect: 466, 455, 473, 464 ActionDest: 122 Annotation: Subtype: Link Rect: 327, 417, 334, 426 ActionDest: 122 Annotation: Subtype: Link Rect: 274, 404, 281, 413 ActionDest: 122 Annotation: Subtype: Link Rect: 269, 304, 276, 313 ActionDest: 130 Annotation: Subtype: Link Rect: 465, 266, 472, 275 ActionDest: 130 Annotation: Subtype: Link Rect: 327, 241, 334, 250 ActionDest: 130 Annotation: Subtype: Link Rect: 334, 241, 346, 250 ActionDest: 130 Annotation: Subtype: Link Rect: 370, 204, 382, 212 ActionDest: 130 Annotation: Subtype: Link Rect: 385, 203, 397, 212 ActionDest: 130 Annotation: Subtype: Link Rect: 239, 191, 251, 200 ActionDest: 130 Annotation: Subtype: Link Rect: 254, 191, 266, 200 ActionDest: 130 Annotation: Subtype: Link Rect: 369, 103, 381, 112 ActionDest: 130 Annotation: Subtype: Link Rect: 384, 103, 396, 112 ActionDest: 130 Annotation: Subtype: Link Rect: 411, 90, 423, 99 ActionDest: 130 Annotation: Subtype: Link Rect: 424, 90, 436, 99 ActionDest: 130 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 201, 735, 213, 744 ActionDest: 133 Annotation: Subtype: Link Rect: 214, 735, 226, 744 ActionDest: 133 Annotation: Subtype: Link Rect: 470, 710, 482, 719 ActionDest: 133 Annotation: Subtype: Link Rect: 519, 698, 531, 707 ActionDest: 133 Annotation: Subtype: Link Rect: 531, 698, 543, 707 ActionDest: 133 Annotation: Subtype: Link Rect: 544, 698, 556, 707 ActionDest: 133 Annotation: Subtype: Link Rect: 275, 622, 287, 631 ActionDest: 133 Annotation: Subtype: Link Rect: 544, 610, 556, 619 ActionDest: 133 Annotation: Subtype: Link Rect: 460, 597, 472, 606 ActionDest: 133 Annotation: Subtype: Link Rect: 475, 597, 487, 606 ActionDest: 133 Annotation: Subtype: Link Rect: 544, 560, 556, 569 ActionDest: 133 Annotation: Subtype: Link Rect: 508, 535, 520, 544 ActionDest: 133 Annotation: Subtype: Link Rect: 221, 522, 233, 531 ActionDest: 133 Annotation: Subtype: Link Rect: 493, 509, 504, 519 ActionDest: 133 Annotation: Subtype: Link Rect: 507, 497, 519, 506 ActionDest: 133 Annotation: Subtype: Link Rect: 522, 497, 534, 506 ActionDest: 133 Annotation: Subtype: Link Rect: 200, 459, 212, 468 ActionDest: 133 Annotation: Subtype: Link Rect: 241, 447, 253, 456 ActionDest: 133 Annotation: Subtype: Link Rect: 254, 447, 266, 456 ActionDest: 133 Annotation: Subtype: Link Rect: 202, 434, 214, 443 ActionDest: 133 Annotation: Subtype: Link Rect: 313, 409, 325, 418 ActionDest: 133 Annotation: Subtype: Link Rect: 394, 384, 406, 393 ActionDest: 133 Annotation: Subtype: Link Rect: 544, 359, 556, 368 ActionDest: 133 Annotation: Subtype: Link Rect: 391, 346, 403, 355 ActionDest: 133 Annotation: Subtype: Link Rect: 448, 334, 460, 343 ActionDest: 133 Annotation: Subtype: Link Rect: 484, 321, 496, 330 ActionDest: 133 Annotation: Subtype: Link Rect: 307, 296, 319, 305 ActionDest: 133 Annotation: Subtype: Link Rect: 476, 283, 488, 293 ActionDest: 133 Annotation: Subtype: Link Rect: 205, 258, 217, 267 ActionDest: 133 Annotation: Subtype: Link Rect: 409, 246, 421, 255 ActionDest: 136 Annotation: Subtype: Link Rect: 193, 208, 205, 217 ActionDest: 136 Annotation: Subtype: Link Rect: 208, 208, 220, 217 ActionDest: 136 Annotation: Subtype: Link Rect: 467, 208, 479, 217 ActionDest: 136 Annotation: Subtype: Link Rect: 263, 158, 275, 167 ActionDest: 130 Page: Sequence: 4 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 328, 670, 335, 682 ActionDest: 75 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 357, 81, 369, 90 ActionDest: 136 Annotation: Subtype: Link Rect: 223, 68, 235, 77 ActionDest: 136 Annotation: Subtype: Link Rect: 424, 68, 436, 77 ActionDest: 136 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 404, 735, 416, 744 ActionDest: 136 Annotation: Subtype: Link Rect: 316, 723, 328, 732 ActionDest: 136 Annotation: Subtype: Link Rect: 395, 647, 407, 656 ActionDest: 136 Annotation: Subtype: Link Rect: 201, 635, 213, 644 ActionDest: 136 Annotation: Subtype: Link Rect: 390, 635, 402, 644 ActionDest: 136 Annotation: Subtype: Link Rect: 232, 622, 244, 631 ActionDest: 136 Annotation: Subtype: Link Rect: 364, 622, 376, 631 ActionDest: 136 Annotation: Subtype: Link Rect: 474, 622, 486, 631 ActionDest: 136 Annotation: Subtype: Link Rect: 313, 610, 325, 619 ActionDest: 136 Annotation: Subtype: Link Rect: 380, 597, 392, 606 ActionDest: 136 Annotation: Subtype: Link Rect: 385, 585, 397, 594 ActionDest: 136 Annotation: Subtype: Link Rect: 328, 572, 340, 581 ActionDest: 136 Annotation: Subtype: Link Rect: 496, 572, 508, 581 ActionDest: 136 Annotation: Subtype: Link Rect: 318, 559, 330, 568 ActionDest: 136 Annotation: Subtype: Link Rect: 499, 559, 511, 568 ActionDest: 136 Annotation: Subtype: Link Rect: 301, 547, 313, 556 ActionDest: 136 Annotation: Subtype: Link Rect: 256, 522, 268, 531 ActionDest: 136 Annotation: Subtype: Link Rect: 279, 471, 291, 481 ActionDest: 136 Annotation: Subtype: Link Rect: 436, 107, 448, 116 ActionDest: 136 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 544, 735, 556, 744 ActionDest: 136 Annotation: Subtype: Link Rect: 381, 698, 393, 707 ActionDest: 136 Annotation: Subtype: Link Rect: 315, 673, 327, 682 ActionDest: 136 Annotation: Subtype: Link Rect: 263, 542, 278, 554 ActionDest: 107 Annotation: Subtype: Link Rect: 536, 242, 558, 253 ActionDest: 110 Annotation: Subtype: Link Rect: 406, 228, 428, 240 ActionDest: 107 Annotation: Subtype: Link Rect: 533, 228, 555, 240 ActionDest: 107 Annotation: Subtype: Link Rect: 291, 216, 313, 228 ActionDest: 110 Annotation: Subtype: Link Rect: 260, 203, 282, 215 ActionDest: 110 Annotation: Subtype: Link Rect: 383, 203, 405, 215 ActionDest: 110 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 320, 735, 332, 744 ActionDest: 136 Annotation: Subtype: Link Rect: 523, 584, 535, 594 ActionDest: 136 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 505, 497, 517, 506 ActionDest: 136 Annotation: Subtype: Link Rect: 520, 497, 532, 506 ActionDest: 136 Annotation: Subtype: Link Rect: 377, 434, 389, 443 ActionDest: 136 Annotation: Subtype: Link Rect: 392, 434, 404, 443 ActionDest: 136 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 184, 172, 221, 183 Annotation: Subtype: Link Rect: 99, 150, 136, 160 Annotation: Subtype: Link Rect: 324, 127, 362, 137 Annotation: Subtype: Link Rect: 257, 103, 295, 114 Annotation: Subtype: Link Rect: 175, 80, 212, 91 Annotation: Subtype: Link Rect: 520, 69, 557, 80 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 200, 688, 237, 698 Annotation: Subtype: Link Rect: 404, 664, 441, 675 Annotation: Subtype: Link Rect: 288, 641, 326, 652 Annotation: Subtype: Link Rect: 380, 618, 417, 629 Annotation: Subtype: Link Rect: 235, 584, 272, 594 Annotation: Subtype: Link Rect: 278, 584, 314, 594 Annotation: Subtype: Link Rect: 59, 550, 96, 560 Annotation: Subtype: Link Rect: 102, 550, 138, 560 Annotation: Subtype: Link Rect: 113, 515, 150, 525 Annotation: Subtype: Link Rect: 232, 491, 269, 502 Annotation: Subtype: Link Rect: 109, 458, 146, 468 Annotation: Subtype: Link Rect: 520, 434, 557, 445 Annotation: Subtype: Link Rect: 59, 400, 96, 410 Annotation: Subtype: Link Rect: 412, 376, 450, 387 Annotation: Subtype: Link Rect: 505, 353, 543, 364 Annotation: Subtype: Link Rect: 166, 320, 203, 330 Annotation: Subtype: Link Rect: 152, 284, 190, 295 Annotation: Subtype: Link Rect: 196, 284, 232, 295 Annotation: Subtype: Link Rect: 464, 273, 502, 284 Annotation: Subtype: Link Rect: 508, 273, 544, 284 Annotation: Subtype: Link Rect: 294, 251, 332, 261 Annotation: Subtype: Link Rect: 108, 216, 145, 226 Annotation: Subtype: Link Rect: 151, 216, 187, 226 Annotation: Subtype: Link Rect: 342, 204, 380, 215 Annotation: Subtype: Link Rect: 519, 181, 557, 192 Annotation: Subtype: Link Rect: 59, 170, 95, 180 Annotation: Subtype: Link Rect: 396, 147, 433, 157 Annotation: Subtype: Link Rect: 338, 112, 375, 123 Annotation: Subtype: Link Rect: 469, 89, 507, 100 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 59, 711, 96, 721 Annotation: Subtype: Link Rect: 145, 687, 183, 698 Annotation: Subtype: Link Rect: 59, 665, 96, 675 Annotation: Subtype: Link Rect: 195, 641, 233, 652 Annotation: Subtype: Link Rect: 239, 641, 275, 652 Annotation: Subtype: Link Rect: 90, 607, 127, 617 Annotation: Subtype: Link Rect: 443, 583, 480, 594 Annotation: Subtype: Link Rect: 486, 583, 522, 594 Annotation: Subtype: Link Rect: 494, 572, 531, 583 Annotation: Subtype: Link Rect: 453, 549, 490, 560 Annotation: Subtype: Link Rect: 496, 549, 533, 560 Annotation: Subtype: Link Rect: 220, 515, 257, 525 Annotation: Subtype: Link Rect: 263, 515, 299, 525 Annotation: Subtype: Link Rect: 167, 480, 205, 491 Annotation: Subtype: Link Rect: 59, 446, 96, 456 Annotation: Subtype: Link Rect: 288, 434, 325, 445 Annotation: Subtype: Link Rect: 331, 434, 367, 445 Annotation: Subtype: Link Rect: 199, 411, 236, 422 Annotation: Subtype: Link Rect: 242, 411, 278, 422 Annotation: Subtype: Link Rect: 520, 388, 557, 399 Annotation: Subtype: Link Rect: 505, 365, 542, 376 Annotation: Subtype: Link Rect: 239, 342, 277, 353 Annotation: Subtype: Link Rect: 460, 319, 497, 330 Annotation: Subtype: Link Rect: 411, 296, 449, 307 Annotation: Subtype: Link Rect: 216, 273, 254, 284 Annotation: Subtype: Link Rect: 203, 239, 240, 249 Annotation: Subtype: Link Rect: 356, 204, 394, 215 Annotation: Subtype: Link Rect: 321, 181, 358, 192 Annotation: Subtype: Link Rect: 190, 159, 227, 169 Annotation: Subtype: Link Rect: 401, 135, 439, 146 Annotation: Subtype: Link Rect: 445, 135, 481, 146 Annotation: Subtype: Link Rect: 278, 112, 315, 123 Annotation: Subtype: Link Rect: 321, 112, 357, 123 Annotation: Subtype: Link Rect: 288, 89, 326, 100 Annotation: Subtype: Link Rect: 332, 89, 368, 100 Annotation: Subtype: Link Rect: 104, 67, 141, 77 Annotation: Subtype: Link Rect: 147, 67, 183, 77 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 401, 722, 439, 733 Annotation: Subtype: Link Rect: 190, 699, 228, 710 Annotation: Subtype: Link Rect: 109, 665, 146, 675 Annotation: Subtype: Link Rect: 163, 630, 200, 640 Annotation: Subtype: Link Rect: 303, 607, 341, 617 Annotation: Subtype: Link Rect: 347, 607, 383, 617 Annotation: Subtype: Link Rect: 339, 583, 377, 594 Annotation: Subtype: Link Rect: 519, 572, 557, 583 Annotation: Subtype: Link Rect: 59, 561, 95, 571 Annotation: Subtype: Link Rect: 434, 549, 471, 560 Annotation: Subtype: Link Rect: 324, 526, 362, 537 Annotation: Subtype: Link Rect: 108, 481, 145, 491 Annotation: Subtype: Link Rect: 288, 399, 325, 410 Annotation: Subtype: Link Rect: 257, 365, 294, 376 Annotation: Subtype: Link Rect: 390, 330, 427, 341 Annotation: Subtype: Link Rect: 117, 297, 155, 307 Annotation: Subtype: Link Rect: 327, 273, 364, 284 Annotation: Subtype: Link Rect: 370, 273, 406, 284 Annotation: Subtype: Link Rect: 321, 250, 359, 261 Annotation: Subtype: Link Rect: 59, 182, 96, 192 Annotation: Subtype: Link Rect: 102, 182, 138, 192 Annotation: Subtype: Link Rect: 385, 158, 423, 169 Annotation: Subtype: Link Rect: 429, 158, 465, 169 Annotation: Subtype: Link Rect: 309, 146, 560, 157 Annotation: Subtype: Link Rect: 56, 135, 129, 146 Annotation: Subtype: Link Rect: 253, 112, 290, 123 Checksum: dfbf3c05 Type: CRC32 Checksum: 00ee4d5d4e50099c3cc80e1c672f4e84 Type: MD5 Checksum: 4043c13b4e30d31f34a9c1f5fd93f33fc65f13b2 Type: SHA-1