018d96c08a05c5dbc1975a27f49558a2 pmc_9267596.pdf 106ead198e99e934b9f988b764641ee653ef79e5 pmc_9267596.pdf 6235afd3c90725c77f61e54a7bdc930ffc9a7472c36d2280066017b806dd463c pmc_9267596.pdf Title: Collapsing Glomerulonephritis in a Kidney Transplant Recipient after mRNA SARS-CoV-2 Vaccination Subject: With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mRNA vaccination against SARS-CoV-2, developed nephrotic proteinuria and renal dysfunction, with a biopsy diagnostic of collapsing glomerulonephritis. No other triggers for this glomerulonephritis were identified. Antibodies against the spike protein were negative, but the patient developed a specific T-cell response. The close time between vaccination and the proteinuria suggests a possible determinant role of vaccination. We should be aware of nephropathies appearing after COVID-19 vaccination in kidney transplant recipients also. Keywords: SARS-CoV-2; vaccine; COVID-19; collapsing; glomerulonephritis; mRNA Author: Francisco Gómez Preciado, Rosa Alejandra De Carvalho Ovalles, Sergi Codina, Laura Donadeu, Alexandre Favà, Laura Martinez Valenzuela, Diego Sandoval, Bárbara Fernández-Cidón, Oriol Bestard, Pedro Alia-Ramos, Montserrat Gomà, Edoardo Melilli and Josep M Cruzado Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Jun 24 11:15:59 2022 CEST ModDate: Fri Jun 24 11:31:06 2022 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 6 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 23193445 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NEBEKD+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 UOHDZX+VnURWPalladioL Type 1 Custom yes yes no 15 0 EWPBIE+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 ITFPDG+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 TGLDPA+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 49 0 OQIVQT+EURM10 Type 1 Builtin yes yes no 72 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-05-17 03:29:43 CEST RepresentationInformation: pmc_9267596.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-05-17 02:37:57 CEST Size: 23193445 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 182 FreeObjects: 5 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Case Report Destination: section.2 Item: Title: Discussion Destination: section.3 Item: Title: References Destination: table.caption.4 Info: Title: Collapsing Glomerulonephritis in a Kidney Transplant Recipient after mRNA SARS-CoV-2 Vaccination Author: Francisco Gómez Preciado, Rosa Alejandra De Carvalho Ovalles, Sergi Codina, Laura Donadeu, Alexandre Favà, Laura Martinez Valenzuela, Diego Sandoval, Bárbara Fernández-Cidón, Oriol Bestard, Pedro Alia-Ramos, Montserrat Gomà, Edoardo Melilli and Josep M Cruzado Subject: With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mRNA vaccination against SARS-CoV-2, developed nephrotic proteinuria and renal dysfunction, with a biopsy diagnostic of collapsing glomerulonephritis. No other triggers for this glomerulonephritis were identified. Antibodies against the spike protein were negative, but the patient developed a specific T-cell response. The close time between vaccination and the proteinuria suggests a possible determinant role of vaccination. We should be aware of nephropathies appearing after COVID-19 vaccination in kidney transplant recipients also. 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