62d0230c0df489b1c4f4d12fed6ea546 pmc_9276968.pdf 744a46f4095711c94d19316d00abb2cea630dda9 pmc_9276968.pdf f546857884ac15df6c8ae860e0181b19ab55dbd90bea44562d67c783f22f2f8b pmc_9276968.pdf Title: Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study Subject: Background: Two years since the onset of the COVID-19 pandemic no predictive algorithm has been generally adopted for clinical management and in most algorithms the contribution of laboratory variables is limited Keywords: SARS-CoV-2 infection, predictive risk-profile, clinical laboratory tests, cytokines, chemokines, acute phase reactants, CXCL10, flow cytometry Author: Adrián Sánchez-Montalvá Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Fri Jun 24 06:27:32 2022 CEST ModDate: Fri Jun 24 06:46:07 2022 CEST Tagged: no UserProperties: no Suspects: no Form: 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Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Patients and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Clinical Laboratory Tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Immunological Tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Overall Clinical Features of HUVH Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Predictive Power of Current Clinical Laboratory Tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Improving Interpretation of Current Clinical Laboratory Tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Predictive Power of Laboratory Variables During Hospitalization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Selection of a Core Panel of Clinical Laboratory Tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Comparison With the Two Validation Cohorts Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Prediction Performance of Immunological Tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Hospital Vall d’Hebron COVID-19 Immune Profile Group Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Info: Title: Exposing and Overcoming Limitations of Clinical 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Encoding: WinAnsiEncoding Font: BaseFont: BPEJBK+AdvOT7d6df7ab.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BPEJBK+AdvOT7d6df7ab.I+fb Flags: Symbolic FontBBox: -156, -250, 802, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: BPEJBF+AdvOTb65e897d.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: BPEJBF+AdvOTb65e897d.B+fb Flags: Symbolic FontBBox: 0, -10, 843, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: Acrobat Distiller 7.0 (Windows) SARS-CoV-2 infection, predictive risk-profile, clinical laboratory tests, cytokines, chemokines, acute phase reactants, CXCL10, flow cytometry 2022-06-24T12:46:07+08:00 2022-06-24T12:27:32+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2022-06-24T12:46:07+08:00 application/pdf Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study Adrián Sánchez-Montalvá Daniel &Aacute lvarez-Sierra M&oacute nica Mart&iacute nez-Gallo Janire Perurena-Prieto Iria Arrese-Muñoz Juan Carlos Ruiz-Rodr&iacute guez Juan Espinosa-Pereiro Pau Bosch-Nicolau Xavier Mart&iacute nez-G&oacute mez Andrés Antón Ferran Mart&iacute nez-Valle Mar Riveiro-Barciela Albert Blanco-Grau Francisco Rodr&iacute guez-Frias Pol Castellano-Escuder Elisabet Poyatos-Canton Jordi Bas-Minguet Eva Mart&iacute nez-Cáceres Alex Sánchez-Pla Coral Zurera-Egea Aina Teniente-Serra Manuel Hernández-González Ricardo Pujol-Borrell the &ldquo Hospital Vall d&rsquo Hebron Group for the study of COVID-19 immune profile&rdquo Background: Two years since the onset of the COVID-19 pandemic no predictive algorithm has been generally adopted for clinical management and in most algorithms the contribution of laboratory variables is limited SARS-CoV-2 infection predictive risk-profile clinical laboratory tests cytokines chemokines acute phase reactants CXCL10 flow cytometry uuid:9d18ff95-4614-4480-a6ba-95cbe3c1c0b3 uuid:596ec389-a2a5-4129-8582-ae06cba47fe1 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 602, 547, 623 Annotation: Subtype: Link Rect: 175, 579, 475, 600 Annotation: Subtype: Link Rect: 175, 556, 527, 577 Annotation: Subtype: Link Rect: 175, 533, 531, 554 Annotation: Subtype: Link Rect: 175, 510, 410, 531 Annotation: Subtype: Link Rect: 45, 29, 116, 36 Annotation: Subtype: Link Rect: 125, 29, 183, 36 Annotation: Subtype: Link Rect: 425, 29, 549, 36 Annotation: Subtype: Link Rect: 87, 612, 158, 620 Annotation: Subtype: Link Rect: 113, 473, 158, 480 Annotation: Subtype: Link Rect: 73, 453, 158, 460 Annotation: Subtype: Link Rect: 57, 64, 158, 71 Annotation: Subtype: Link Rect: 475, 736, 549, 743 Annotation: Subtype: Link Rect: 475, 728, 549, 735 Annotation: Subtype: Link Rect: 448, 720, 549, 727 Annotation: Subtype: Link Rect: 45, 726, 229, 742 Annotation: Subtype: Link Rect: 521, 678, 549, 706 Page: 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