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Title:           Antiretroviral therapy duration and immunometabolic state determine efficacy of ex vivo dendritic cell-based treatment restoring functional HIV-specific CD8+ T cells in people living with HIV
Subject:         eBioMedicine, 81 (2022) 104090. doi:10.1016/j.ebiom.2022.104090
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      Title: Antiretroviral therapy duration and immunometabolic state determine efficacy of ex vivo dendritic cell-based treatment restoring functional HIV-specific CD8+ T cells in people living with HIV
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        Title: Introduction
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       Item: 
        Title: Methods
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        Children: 
         Item: 
          Title: Experimental design
          Destination: Head4
         Item: 
          Title: Ethics statement
          Destination: Head5
         Item: 
          Title: DC generation and in vitro stimulation
          Destination: Head6
         Item: 
          Title: Isolation of human peripheral blood T lymphocyte populations
          Destination: Head7
         Item: 
          Title: In vitro activation of HIV-1 specific CD8+ T cells from PLWH
          Destination: Head8
         Item: 
          Title: In vitro analysis of CD8+ T cells functionality
          Destination: Head9
         Item: 
          Title: Flow cytometry and fluorometric analyses
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         Item: 
          Title: RNA extraction and qPCR mRNA quantification
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         Item: 
          Title: Analysis of metabolic activity
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         Item: 
          Title: Statistical analysis
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         Item: 
          Title: Role of funders
          Destination: Head14
       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: ART duration determines basal and DC-induced magnitude and polyfunctionality of HIV-specific CD8+ T cell in PLWH
          Destination: Head16
         Item: 
          Title: Differential restoration of cytotoxic function after DC treatment in CD8+ T cells from LT-ARTp and ST-ARTp
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         Item: 
          Title: Differential memory subset distribution and distinct patterns of co-expression of checkpoint inhibitory receptors in CD8+ T cells from ST-ARTp and LT-ARTp
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         Item: 
          Title: Differential induction of glycolytic metabolic activity in CD8+ T cells from PLWH subgroups
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         Item: 
          Title: Combined blockade of checkpoint inhibitory receptors and administration of glycolysis promoting drugs efficiently restores cytotoxic function of CD8+ T cell from ST-ARTp
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        Title: Discussion
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        Title: Contributors
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       Item: 
        Title: Data sharing statement
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        Title: Declaration of interests
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        Title: Acknowledgements
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       Item: 
        Title: Supplementary materials
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          Title: References
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   Type: CRC32
  Checksum: ef234e713911bff90486873cb2295b78
   Type: MD5
  Checksum: 74550b97681ec1e5791234f751394140b1147330
   Type: SHA-1
  Checksum: 44a14b1f86e47440ec3cddaa5952d2e6d474d6b7a0b170e5d0806e04044ed826
   Type: SHA-256