60271150ec81c89a73410b840366771d pmc_9315723.pdf 2ab3273e61a1f5c35df15c1c54ab030331e20b92 pmc_9315723.pdf 45c4ea78bbd6eb0e56d90a48ff2c0a6c849f3d7d61921937b8aea748b6b56339 pmc_9315723.pdf Title: Follow Up of the Humoral Response in Healthcare Workers after the Administration of Two Dose of the Anti SARS-CoV-2 Vaccines—Effectiveness in Delta Variant Breakthrough Infections Subject: The implementation of vaccination among healthcare workers (HCWs) allowed the management of the pandemic in a manner that differed from that in the first waves. It has been demonstrated that the mRNA vaccines elicit good humoral responses but that there are still breakthrough infections. In summer 2021, a fifth wave emerged, despite the good coverage of HCWs in Spain. We aimed to study the SARS-CoV-2 IgG antibody levels as a marker to predict the possibility of Delta variant infections after vaccination after a seroepidemiological campaign. Of the 5000 participants, a total of 4902 (98.04%) showed a positive result in the serological anti-S test and only 98 (1.96%) were negative. Among the 4368 fully vaccinated participants, only in five cases was the serology negative. Of the total number of participants that received antibody results during the study, 162 were PCR positive in the subsequent two months. Among these, 151 were fully vaccinated (two doses). Significant differences between antibody BAU/mL levels were found between PCR positive and non-PCR positive participants (p < 0.01). The median of BAU/mL was higher in those vaccinated patients with no infection (1260 BAU/mL; 465–2080) versus infected patients (661 BAU/mL; 361–2080). These data support the idea that vaccines play an important role in the control of the pandemic, especially among HCWs at the time of the Delta variant circulation. More studies with other variants of concern must be performed in order to establish a correlation between the levels of IgG and the new infections. Keywords: humoral response; SARS-CoV-2; Delta variant Author: Gema Fernández-Rivas, Jaume Barallat, Bibiana Quirant-Sánchez, Victoria González, María Doladé, Eva Martinez-Caceres, Monica Piña, Joan Matllo, Ignacio Blanco and Pere-Joan Cardona Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Jun 27 08:59:46 2022 CEST ModDate: Mon Jun 27 09:04:16 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1458377 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IKRGAU+VnURWPalladioL Type 1 Custom yes yes no 10 0 LILIRL+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 FDCBRD+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 LQYARL+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 IOJCNK+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 HOWKDX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 FMPIJG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 80 0 FMPIJI+PalatinoLinotype TrueType WinAnsi yes yes no 83 0 FMPIJK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 86 0 DJQPZW+CMSY10 Type 1 Builtin yes yes no 93 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 97 0 NKZTII+URWPalladioL-BoldItal Type 1 Custom yes yes no 107 0 FMPIJG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 121 0 FMPIJI+PalatinoLinotype TrueType WinAnsi yes yes no 124 0 FMPIJK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 127 0 FMPIJG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 139 0 FMPIJI+PalatinoLinotype TrueType WinAnsi yes yes no 142 0 FMPIJK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 145 0 FMPIJG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 160 0 FMPIJI+PalatinoLinotype TrueType WinAnsi yes yes no 163 0 FMPIJK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 166 0 FMPMLE+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 169 0 CRUZTT+VnURWPalladioL-Italic Type 1 Custom yes yes no 186 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-27 02:38:09 CEST RepresentationInformation: pmc_9315723.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-09-25 02:20:39 CEST Size: 1458377 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 311 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Material and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Laboratory Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Info: Title: Follow Up of the Humoral Response in Healthcare Workers after the Administration of Two Dose of the Anti SARS-CoV-2 Vaccines Effectiveness in Delta Variant Breakthrough Infections Author: Gema Fernández-Rivas, Jaume Barallat, Bibiana Quirant-Sánchez, Victoria González, María Doladé, Eva Martinez-Caceres, Monica Piña, Joan Matllo, Ignacio Blanco and Pere-Joan Cardona Subject: The implementation of vaccination among healthcare workers (HCWs) allowed the management of the pandemic in a manner that differed from that in the first waves. It has been demonstrated that the mRNA vaccines elicit good humoral responses but that there are still breakthrough infections. In summer 2021, a fifth wave emerged, despite the good coverage of HCWs in Spain. We aimed to study the SARS-CoV-2 IgG antibody levels as a marker to predict the possibility of Delta variant infections after vaccination after a seroepidemiological campaign. Of the 5000 participants, a total of 4902 (98.04%) showed a positive result in the serological anti-S test and only 98 (1.96%) were negative. Among the 4368 fully vaccinated participants, only in five cases was the serology negative. Of the total number of participants that received antibody results during the study, 162 were PCR positive in the subsequent two months. Among these, 151 were fully vaccinated (two doses). Significant differences between antibody BAU/mL levels were found between PCR positive and non-PCR positive participants (p < 0.01). The median of BAU/mL was higher in those vaccinated patients with no infection (1260 BAU/mL; 465 2080) versus infected patients (661 BAU/mL; 361 2080). These data support the idea that vaccines play an important role in the control of the pandemic, especially among HCWs at the time of the Delta variant circulation. More studies with other variants of concern must be performed in order to establish a correlation between the levels of IgG and the new infections. 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