fa30c21762c74ccc14702fcfb430aace pmc_9393704.pdf fdf74b6704873ea63f136a9270010e26e881f256 pmc_9393704.pdf ebfc7d1900fba4b08a9377a5ef1287b37d4f1d36e6b5eef2b4c70d4e12fe94a7 pmc_9393704.pdf Title: Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission Subject: Context: Impaired cognition and altered quality of life (QoL) may persist despite long-term remission of Cushing’s disease (CD) Keywords: Cushing’s disease, hypercortisolism, cognition, memory, quality of life Author: Emilie Pupier Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed Aug 3 03:56:59 2022 CEST ModDate: Wed Aug 3 07:17:16 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.389 x 841.663 pts Page rot: 0 File size: 856067 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OODDDN+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 674 0 OODDDO+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 675 0 OODDDP+AdvPSA18C Type 1C WinAnsi yes yes no 676 0 OODDEA+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 677 0 OODDEB+AdvPSA323 Type 1C WinAnsi yes yes no 678 0 OODDEC+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 679 0 OODDED+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 680 0 OODDFD+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 681 0 OODDFE+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 689 0 OODEJA+AdvOT1ef757c0 Type 1C Custom yes yes yes 274 0 OODEJB+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 275 0 OODEJC+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 262 0 OODEKC+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 265 0 OODEIO+AdvTT9b12cd41+22 Type 1C Custom yes yes yes 257 0 OODEIP+AdvTT2c8ce45a+20 Type 1C WinAnsi yes yes no 267 0 OODEMD+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 278 0 OODKIA+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 281 0 OODKLA+AdvTT58d178b9+03 Type 1C Custom yes yes yes 284 0 OODKLB+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 285 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-27 02:37:38 CEST RepresentationInformation: pmc_9393704.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-09-23 02:18:03 CEST Size: 856067 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B10' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B11' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B11' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B12' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B12' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B13' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B15' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B16' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B17' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B19' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B21' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B22' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B23' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B24' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B25' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B26' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B27' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B28' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B29' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B30' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B32' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B33' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B34' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B35' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B36' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B26' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B27' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B29' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B30' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B31' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B37' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B38' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B13' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B39' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B43' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B31' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B37' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B44' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B45' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B46' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B22' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B19' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B21' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B10' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B13' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B43' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B24' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B25' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B47' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B48' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B48' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B49' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B50' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B51' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B51' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B52' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B53' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B54' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B55' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B47' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B56' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B10' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B11' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B10' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B12' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B39' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B41' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B43' cannot be found Offset: 832076 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B46' cannot be found Offset: 832076 MIMEtype: application/pdf PDFMetadata: Objects: 749 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Patients and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Control group Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Cognitive evaluation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Evaluation of depression and anxiety Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Evaluation of QoL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Evaluation of Cushing’s disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Characteristics of patients and controls Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: CD patients in long-term remission have preserved cognitive performance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: CD patients in long-term remission have substantially impaired QoL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Worse QoL is correlated to the duration of exposure to cortisol excess Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Info: Title: Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission Author: Emilie Pupier Subject: Context: Impaired cognition and altered quality of life (QoL) may persist despite long-term remission of Cushing’s disease (CD) Keywords: Cushing’s disease, hypercortisolism, cognition, memory, quality of life Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed Aug 03 03:56:59 CEST 2022 ModDate: Wed Aug 03 07:17:16 CEST 2022 ID: 0xfa8694c2e18420e2a1cd9e50a38370cb, 0x8ea4b12323120c42a6b239398a40ebf7 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2303 ImageHeight: 1571 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: OODEIO+AdvTT9b12cd41+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OODEIO+AdvTT9b12cd41+22 Flags: Symbolic FontBBox: 0, -156, 552, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OODDDN+AdvTTd3a5f740 FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: OODDDN+AdvTTd3a5f740 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODDDO+AdvTTd3a5f740+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: OODDDO+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODDDP+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: OODDDP+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODDEA+AdvTT9b12cd41 FontSubset: true FirstChar: 39 LastChar: 243 FontDescriptor: FontName: OODDEA+AdvTT9b12cd41 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODDEB+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: OODDEB+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODEJC+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: OODEJC+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODDEC+AdvTT2c8ce45a FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: OODDEC+AdvTT2c8ce45a Flags: Serif, Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODDED+AdvTT9b12cd41+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: OODDED+AdvTT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODDFD+AdvTTd168d80a.I FontSubset: true FirstChar: 46 LastChar: 116 FontDescriptor: FontName: OODDFD+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODEKC+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OODEKC+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OODEIP+AdvTT2c8ce45a+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: OODEIP+AdvTT2c8ce45a+20 Flags: Nonsymbolic FontBBox: -125, -166, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODDFE+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OODDFE+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OODEJA+AdvOT1ef757c0 FontSubset: true FirstChar: 2 LastChar: 177 FontDescriptor: FontName: OODEJA+AdvOT1ef757c0 Flags: Serif, Symbolic FontBBox: -20, -250, 947, 854 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OODEJB+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OODEJB+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OODEMD+AdvOTb65e897d.B FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: OODEMD+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODKIA+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: OODKIA+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OODKLA+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: OODKLA+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OODKLB+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OODKLB+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: Acrobat Distiller 7.0 (Windows) Cushing’s disease, hypercortisolism, cognition, memory, quality of life 2022-08-03T13:17:16+08:00 2022-08-03T09:56:59+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2022-08-03T13:17:16+08:00 application/pdf Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission Emilie Pupier Alicia Santos Nicole Etchamendy Aurélie Lavielle Amandine Ferriere Aline Marighetto Eugenia Resmini Daniela Cota Susan M. Webb Antoine Tabarin Context: Impaired cognition and altered quality of life (QoL) may persist despite long-term remission of Cushing’s disease (CD) Cushing&rsquo s disease hypercortisolism cognition memory quality of life uuid:2868a0c9-8d39-4230-8951-e4e1cba04329 uuid:d1893680-3ce5-422a-b385-799bb1d336e1 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 522, 707 Annotation: Subtype: Link Rect: 222, 661, 520, 682 Annotation: Subtype: Link Rect: 222, 636, 512, 657 Annotation: Subtype: Link Rect: 222, 611, 523, 632 Annotation: Subtype: Link Rect: 222, 586, 338, 607 Annotation: Subtype: Link Rect: 56, 39, 142, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Annotation: Subtype: Link Rect: 56, 691, 133, 706 Annotation: Subtype: Link Rect: 56, 494, 161, 501 Annotation: Subtype: Link Rect: 56, 304, 160, 311 Annotation: Subtype: Link Rect: 108, 245, 167, 252 Annotation: Subtype: Link Rect: 56, 236, 140, 243 Annotation: Subtype: Link Rect: 451, 793, 507, 800 Annotation: Subtype: Link Rect: 468, 784, 518, 791 Annotation: Subtype: Link Rect: 447, 774, 535, 781 Annotation: Subtype: Link Rect: 56, 782, 247, 799 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 389, 645, 492, 654 Annotation: Subtype: Link Rect: 168, 481, 172, 490 Destination: 170 Annotation: Subtype: Link Rect: 177, 481, 182, 490 Destination: 170 Annotation: Subtype: Link Rect: 253, 456, 257, 465 Destination: 170 Annotation: Subtype: Link Rect: 264, 456, 269, 465 Destination: 170 Annotation: Subtype: Link Rect: 276, 456, 281, 465 Destination: 170 Annotation: Subtype: Link Rect: 124, 406, 128, 415 Destination: 170 Annotation: Subtype: Link Rect: 133, 406, 138, 415 Destination: 170 Annotation: Subtype: Link Rect: 175, 393, 179, 402 Destination: 170 Annotation: Subtype: Link Rect: 185, 393, 190, 402 Destination: 170 Annotation: Subtype: Link Rect: 196, 393, 201, 402 Destination: 170 Annotation: Subtype: Link Rect: 207, 393, 212, 402 Destination: 170 Annotation: Subtype: Link Rect: 190, 381, 194, 390 Destination: 170 Annotation: Subtype: Link Rect: 199, 381, 203, 390 Destination: 170 Annotation: Subtype: Link Rect: 208, 381, 213, 390 Destination: 170 Annotation: Subtype: Link Rect: 127, 318, 131, 327 Destination: 170 Annotation: Subtype: Link Rect: 138, 318, 147, 327 Destination: null Annotation: Subtype: Link Rect: 154, 318, 163, 327 Destination: null Annotation: Subtype: Link Rect: 178, 293, 183, 302 Destination: 170 Annotation: Subtype: Link Rect: 190, 293, 194, 302 Destination: 170 Annotation: Subtype: Link Rect: 201, 293, 210, 302 Destination: null Annotation: Subtype: Link Rect: 216, 293, 225, 302 Destination: null Annotation: Subtype: Link Rect: 275, 243, 284, 252 Destination: null Annotation: Subtype: Link Rect: 56, 231, 65, 240 Destination: null Annotation: Subtype: Link Rect: 111, 206, 119, 215 Destination: null Annotation: Subtype: Link Rect: 259, 206, 267, 215 Destination: null Annotation: Subtype: Link Rect: 272, 206, 281, 215 Destination: null Annotation: Subtype: Link Rect: 59, 181, 68, 190 Destination: null Annotation: Subtype: Link Rect: 108, 168, 117, 177 Destination: null Annotation: Subtype: Link Rect: 164, 143, 173, 152 Destination: null Annotation: Subtype: Link Rect: 178, 143, 187, 152 Destination: null Annotation: Subtype: Link Rect: 133, 118, 142, 127 Destination: null Annotation: Subtype: Link Rect: 150, 118, 159, 127 Destination: null Annotation: Subtype: Link Rect: 523, 468, 527, 477 Destination: 170 Annotation: Subtype: Link Rect: 532, 468, 536, 477 Destination: 170 Annotation: Subtype: Link Rect: 309, 455, 313, 464 Destination: 170 Annotation: Subtype: Link Rect: 318, 455, 322, 464 Destination: 170 Annotation: Subtype: Link Rect: 327, 455, 335, 464 Destination: null Annotation: Subtype: Link Rect: 340, 455, 349, 464 Destination: null Annotation: Subtype: Link Rect: 447, 791, 538, 798 Annotation: Subtype: Link Rect: 56, 39, 142, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 243, 229, 252, 238 Destination: null Annotation: Subtype: Link Rect: 205, 204, 214, 213 Destination: null Annotation: Subtype: Link Rect: 135, 166, 144, 175 Destination: null Annotation: Subtype: Link Rect: 231, 141, 240, 150 Destination: null Annotation: Subtype: Link Rect: 489, 729, 499, 738 Destination: null Annotation: Subtype: Link Rect: 504, 729, 514, 738 Destination: null Annotation: Subtype: Link Rect: 309, 716, 378, 725 Destination: 170 Annotation: Subtype: Link Rect: 424, 629, 433, 638 Destination: null Annotation: Subtype: Link Rect: 437, 629, 446, 638 Destination: null Annotation: Subtype: Link Rect: 510, 566, 519, 575 Destination: null Annotation: Subtype: Link Rect: 456, 541, 465, 550 Destination: null Annotation: Subtype: Link Rect: 447, 791, 538, 798 Annotation: Subtype: Link Rect: 56, 39, 142, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 211, 441, 237, 450 Destination: 69 Annotation: Subtype: Link Rect: 253, 441, 281, 450 Destination: 78 Annotation: Subtype: Link Rect: 365, 541, 394, 550 Destination: 69 Annotation: Subtype: Link Rect: 447, 791, 538, 798 Annotation: Subtype: Link Rect: 56, 39, 142, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 230, 491, 257, 500 Destination: 78 Annotation: Subtype: Link Rect: 238, 107, 244, 114 Destination: null Annotation: Subtype: Link Rect: 436, 107, 442, 114 Destination: null Annotation: Subtype: Link Rect: 161, 99, 167, 105 Destination: null Annotation: Subtype: Link Rect: 447, 791, 538, 798 Annotation: Subtype: Link Rect: 56, 39, 142, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 368, 704, 395, 713 Destination: 90 Annotation: Subtype: Link Rect: 446, 679, 527, 688 Destination: 170 Annotation: Subtype: Link Rect: 505, 579, 533, 588 Destination: 90 Annotation: Subtype: Link Rect: 447, 791, 538, 798 Annotation: Subtype: Link Rect: 56, 39, 142, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 263, 479, 272, 488 Destination: null Annotation: Subtype: Link Rect: 276, 479, 284, 488 Destination: null Annotation: Subtype: Link Rect: 56, 466, 64, 475 Destination: null Annotation: Subtype: Link Rect: 68, 466, 77, 475 Destination: null Annotation: Subtype: Link Rect: 135, 379, 139, 388 Destination: 170 Annotation: Subtype: Link Rect: 236, 266, 240, 275 Destination: 170 Annotation: Subtype: Link Rect: 245, 266, 253, 275 Destination: null Annotation: Subtype: Link Rect: 259, 266, 268, 275 Destination: null Annotation: Subtype: Link Rect: 272, 266, 281, 275 Destination: null Annotation: Subtype: Link Rect: 139, 229, 147, 238 Destination: null Annotation: Subtype: Link Rect: 151, 229, 160, 238 Destination: null Annotation: Subtype: Link Rect: 164, 229, 172, 238 Destination: null Annotation: Subtype: Link Rect: 275, 191, 284, 200 Destination: null Annotation: Subtype: Link Rect: 56, 179, 65, 188 Destination: null Annotation: Subtype: Link Rect: 119, 154, 128, 163 Destination: null Annotation: Subtype: Link Rect: 312, 704, 316, 713 Destination: 170 Annotation: Subtype: Link Rect: 321, 704, 329, 713 Destination: null Annotation: Subtype: Link Rect: 501, 679, 510, 688 Destination: null Annotation: Subtype: Link Rect: 515, 679, 523, 688 Destination: null Annotation: Subtype: Link Rect: 465, 654, 469, 663 Destination: 170 Annotation: Subtype: Link Rect: 476, 654, 485, 663 Destination: null Annotation: Subtype: Link Rect: 312, 554, 316, 563 Destination: 170 Annotation: Subtype: Link Rect: 429, 491, 434, 500 Destination: 170 Annotation: Subtype: Link Rect: 438, 491, 447, 500 Destination: null Annotation: Subtype: Link Rect: 452, 491, 460, 500 Destination: null Annotation: Subtype: Link Rect: 392, 454, 396, 463 Destination: 170 Annotation: Subtype: Link Rect: 424, 429, 428, 438 Destination: 170 Annotation: Subtype: Link Rect: 433, 429, 437, 438 Destination: 170 Annotation: Subtype: Link Rect: 442, 429, 447, 438 Destination: 170 Annotation: Subtype: Link Rect: 451, 429, 460, 438 Destination: null Annotation: Subtype: Link Rect: 465, 429, 473, 438 Destination: null Annotation: Subtype: Link Rect: 478, 429, 487, 438 Destination: null Annotation: Subtype: Link Rect: 523, 404, 533, 413 Destination: null Annotation: Subtype: Link Rect: 356, 379, 365, 388 Destination: null Annotation: Subtype: Link Rect: 312, 291, 320, 300 Destination: null Annotation: Subtype: Link Rect: 401, 229, 409, 238 Destination: null Annotation: Subtype: Link Rect: 413, 229, 422, 238 Destination: null Annotation: Subtype: Link Rect: 386, 204, 395, 213 Destination: null Annotation: Subtype: Link Rect: 350, 179, 359, 188 Destination: null Annotation: Subtype: Link Rect: 425, 166, 434, 175 Destination: null Annotation: Subtype: Link Rect: 525, 154, 533, 163 Destination: null Annotation: Subtype: Link Rect: 447, 791, 538, 798 Annotation: Subtype: Link Rect: 56, 39, 142, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 210, 729, 219, 738 Destination: null Annotation: Subtype: Link Rect: 134, 641, 143, 650 Destination: null Annotation: Subtype: Link Rect: 249, 616, 257, 625 Destination: null Annotation: Subtype: Link Rect: 190, 504, 194, 513 Destination: 170 Annotation: Subtype: Link Rect: 200, 504, 204, 513 Destination: 170 Annotation: Subtype: Link Rect: 59, 479, 68, 488 Destination: null Annotation: Subtype: Link Rect: 74, 479, 82, 488 Destination: null Annotation: Subtype: Link Rect: 208, 404, 213, 413 Destination: 170 Annotation: Subtype: Link Rect: 218, 404, 226, 413 Destination: null Annotation: Subtype: Link Rect: 231, 404, 240, 413 Destination: null Annotation: Subtype: Link Rect: 245, 404, 254, 413 Destination: null Annotation: Subtype: Link Rect: 259, 404, 268, 413 Destination: null Annotation: Subtype: Link Rect: 272, 404, 281, 413 Destination: null Annotation: Subtype: Link Rect: 312, 704, 320, 713 Destination: null Annotation: Subtype: Link Rect: 447, 791, 538, 798 Annotation: Subtype: Link Rect: 56, 39, 142, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 355, 700, 538, 709 Annotation: Subtype: Link Rect: 309, 688, 481, 697 Annotation: Subtype: Link Rect: 79, 463, 138, 470 Annotation: Subtype: Link Rect: 113, 436, 172, 443 Annotation: Subtype: Link Rect: 167, 409, 222, 416 Annotation: Subtype: Link Rect: 129, 390, 183, 397 Annotation: Subtype: Link Rect: 213, 363, 272, 370 Annotation: Subtype: Link Rect: 109, 328, 172, 335 Annotation: Subtype: Link Rect: 79, 293, 142, 300 Annotation: Subtype: Link Rect: 56, 258, 119, 265 Annotation: Subtype: Link Rect: 56, 223, 116, 230 Annotation: Subtype: Link Rect: 79, 196, 168, 203 Annotation: Subtype: Link Rect: 69, 161, 150, 168 Annotation: Subtype: Link Rect: 157, 134, 249, 141 Annotation: Subtype: Link Rect: 182, 99, 241, 106 Annotation: Subtype: Link Rect: 468, 487, 538, 494 Annotation: Subtype: Link Rect: 309, 479, 333, 486 Annotation: Subtype: Link Rect: 495, 460, 538, 467 Annotation: Subtype: Link Rect: 309, 452, 356, 459 Annotation: Subtype: Link Rect: 309, 417, 400, 424 Annotation: Subtype: Link Rect: 514, 390, 538, 397 Annotation: Subtype: Link Rect: 309, 382, 340, 389 Annotation: Subtype: Link Rect: 358, 355, 430, 362 Annotation: Subtype: Link Rect: 511, 328, 538, 335 Annotation: Subtype: Link Rect: 309, 320, 370, 327 Annotation: Subtype: Link Rect: 309, 285, 397, 292 Annotation: Subtype: Link Rect: 381, 258, 449, 265 Annotation: Subtype: Link Rect: 493, 239, 538, 246 Annotation: Subtype: Link Rect: 309, 231, 322, 238 Annotation: Subtype: Link Rect: 514, 204, 538, 211 Annotation: Subtype: Link Rect: 309, 196, 379, 203 Annotation: Subtype: Link Rect: 309, 161, 370, 168 Annotation: Subtype: Link Rect: 343, 134, 416, 141 Annotation: Subtype: Link Rect: 396, 107, 538, 114 Annotation: Subtype: Link Rect: 309, 99, 391, 106 Annotation: Subtype: Link Rect: 447, 791, 538, 798 Annotation: Subtype: Link Rect: 56, 39, 142, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 262, 735, 286, 742 Annotation: Subtype: Link Rect: 56, 727, 123, 734 Annotation: Subtype: Link Rect: 259, 708, 286, 715 Annotation: Subtype: Link Rect: 56, 700, 113, 707 Annotation: Subtype: Link Rect: 262, 681, 286, 688 Annotation: Subtype: Link Rect: 56, 673, 237, 680 Annotation: Subtype: Link Rect: 231, 646, 286, 653 Annotation: Subtype: Link Rect: 176, 611, 231, 618 Annotation: Subtype: Link Rect: 56, 568, 155, 575 Annotation: Subtype: Link Rect: 196, 549, 257, 556 Annotation: Subtype: Link Rect: 134, 530, 202, 537 Annotation: Subtype: Link Rect: 262, 503, 286, 510 Annotation: Subtype: Link Rect: 56, 495, 135, 502 Annotation: Subtype: Link Rect: 240, 468, 286, 475 Annotation: Subtype: Link Rect: 56, 460, 70, 467 Annotation: Subtype: Link Rect: 56, 425, 151, 432 Annotation: Subtype: Link Rect: 89, 390, 159, 397 Annotation: Subtype: Link Rect: 56, 363, 137, 370 Annotation: Subtype: Link Rect: 196, 329, 270, 336 Annotation: Subtype: Link Rect: 348, 735, 385, 742 Annotation: Subtype: Link Rect: 448, 708, 536, 715 Annotation: Subtype: Link Rect: 321, 681, 421, 688 Annotation: Subtype: Link Rect: 444, 654, 511, 661 Annotation: Subtype: Link Rect: 463, 627, 533, 634 Annotation: Subtype: Link Rect: 389, 592, 457, 599 Annotation: Subtype: Link Rect: 472, 565, 532, 572 Annotation: Subtype: Link Rect: 409, 538, 486, 545 Annotation: Subtype: Link Rect: 355, 503, 414, 510 Annotation: Subtype: Link Rect: 309, 476, 403, 483 Annotation: Subtype: Link Rect: 362, 449, 452, 456 Annotation: Subtype: Link Rect: 416, 430, 474, 437 Annotation: Subtype: Link Rect: 321, 403, 408, 410 Annotation: Subtype: Link Rect: 492, 374, 538, 381 Annotation: Subtype: Link Rect: 309, 366, 322, 373 Annotation: Subtype: Link Rect: 463, 339, 516, 346 Annotation: Subtype: Link Rect: 411, 310, 501, 317 Annotation: Subtype: Link Rect: 447, 791, 538, 798 Annotation: Subtype: Link Rect: 56, 39, 142, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Checksum: fa6a46b4 Type: CRC32 Checksum: fa30c21762c74ccc14702fcfb430aace Type: MD5 Checksum: fdf74b6704873ea63f136a9270010e26e881f256 Type: SHA-1