aaba722a346fe69c70dbdb3488f51546 pmc_9412260.pdf ae7491d4d1a7e679a61c8455160a5692c929fb4d pmc_9412260.pdf 54f896440302aff264acc4c338e45eea61c6035cdf1bdaf8a93830e563c43029 pmc_9412260.pdf Title: SARS-CoV-2 Vaccination Coverage and Factors Associated with Low Uptake in a Cohort of People Living with HIV Subject: People living with HIV (PLWH) are prioritised for SARS-CoV-2 vaccination due to their vulnerability to severe COVID-19. Therefore, the epidemiological surveillance of vaccination coverage and the timely identification of suboptimally vaccinated PLWH is vital. We assessed SARS-CoV-2 vaccination coverage and factors associated with under-vaccination among PLWH in Catalonia, Spain. As of 11.12.2021, 9945/14942 PLWH (66.6%) had received 1 dose of a SARS-CoV-2 vaccine. Non-Spanish origin (adjusted odds ratio (aOR) 0.64, 95% CI 0.59–0.70), CD4 count of 200–349 cells/L (aOR 0.74, 95% CI 0.64–0.86) or 350–499 cells/L (aOR 0.79, 95% CI 0.70–0.88), detectable plasma HIV-RNA (aOR 0.61 95% CI 0.53–0.70), and previous SARS-CoV-2 diagnosis (aOR 0.58 95% CI 0.51–0.65) were associated with under-vaccination. SARS-CoV-2 diagnosis (437 [9.5%] vs. 323 [3.5%], p < 0.001), associated hospitalisations (10 [2.3%] vs. 0 [0%], p < 0.001), intensive care unit admissions (6 [1.4%] vs. 0 [0%], p < 0.001), and deaths (10 [2.3%] vs. 0 [0%], p < 0.001) were higher among unvaccinated PLWH. Vaccination coverage was lower among PLWH with a CD4 count >200 cells/L, detectable plasma HIV-RNA, previous SARS-CoV-2 diagnosis, and migrants. SARS-CoV-2 diagnosis, associated hospitalisations, and deaths among PLWH were lower among the vaccinated compared with the unvaccinated. SARS-CoV-2 vaccination prioritisation has not completely reached vulnerable PLWH with poorer prognosis. This information can be used to inform public health strategies. Keywords: HIV; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); coronavirus disease 2019 (COVID-19); vaccination; vaccine effectiveness Author: Daniel Kwakye Nomah, Josep Maria Llibre, Yesika Díaz, Sergio Moreno, Jordi Aceiton, Andreu Bruguera, Maria Gutiérrez-Macià, Arkaitz Imaz, Paula Suanzes, Gemma Navarro, Amat Orti, Jose Maria Miro, Jordi Casabona, Juliana Reyes-Urueña and the PISCIS Study Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Aug 19 02:51:45 2022 CEST ModDate: Fri Aug 19 09:16:31 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 647584 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GGHKEL+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 APWKLL+VnURWPalladioL Type 1 Custom yes yes no 15 0 RFECCF+EURM10 Type 1 Builtin yes yes no 19 0 ADWXUB+URWPalladioL-Bold Type 1 Custom yes yes no 23 0 FJLNOU+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 ABFIKS+URWPalladioL-Ital Type 1 Custom yes yes no 32 0 IKKWKP+CMSY10 Type 1 Builtin yes yes no 36 0 SIXRFS+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 54 0 XIRVNA+EURB10 Type 1 Builtin yes yes no 91 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 95 0 JSHJZJ+VnURWPalladioL-Italic Type 1 Custom yes yes no 123 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-09 02:41:17 CEST RepresentationInformation: pmc_9412260.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-09-08 02:18:50 CEST Size: 647584 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 249 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Design and Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Procedures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Characteristics of the Study Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: SARS-CoV-2 Vaccination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Factors Associated with Low Uptake of SARS-CoV-2 Vaccines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: SARS-CoV-2 Outcomes among Vaccinated and Unvaccinated People Living with HIV Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Info: Title: SARS-CoV-2 Vaccination Coverage and Factors Associated with Low Uptake in a Cohort of People Living with HIV Author: Daniel Kwakye Nomah, Josep Maria Llibre, Yesika Díaz, Sergio Moreno, Jordi Aceiton, Andreu Bruguera, Maria Gutiérrez-Macià, Arkaitz Imaz, Paula Suanzes, Gemma Navarro, Amat Orti, Jose Maria Miro, Jordi Casabona, Juliana Reyes-Urueña and the PISCIS Study Group Subject: People living with HIV (PLWH) are prioritised for SARS-CoV-2 vaccination due to their vulnerability to severe COVID-19. Therefore, the epidemiological surveillance of vaccination coverage and the timely identification of suboptimally vaccinated PLWH is vital. We assessed SARS-CoV-2 vaccination coverage and factors associated with under-vaccination among PLWH in Catalonia, Spain. As of 11.12.2021, 9945/14942 PLWH (66.6%) had received 1 dose of a SARS-CoV-2 vaccine. Non-Spanish origin (adjusted odds ratio (aOR) 0.64, 95% CI 0.59 0.70), CD4 count of 200 349 cells/L (aOR 0.74, 95% CI 0.64 0.86) or 350 499 cells/L (aOR 0.79, 95% CI 0.70 0.88), detectable plasma HIV-RNA (aOR 0.61 95% CI 0.53 0.70), and previous SARS-CoV-2 diagnosis (aOR 0.58 95% CI 0.51 0.65) were associated with under-vaccination. SARS-CoV-2 diagnosis (437 [9.5%] vs. 323 [3.5%], p < 0.001), associated hospitalisations (10 [2.3%] vs. 0 [0%], p < 0.001), intensive care unit admissions (6 [1.4%] vs. 0 [0%], p < 0.001), and deaths (10 [2.3%] vs. 0 [0%], p < 0.001) were higher among unvaccinated PLWH. Vaccination coverage was lower among PLWH with a CD4 count >200 cells/L, detectable plasma HIV-RNA, previous SARS-CoV-2 diagnosis, and migrants. SARS-CoV-2 diagnosis, associated hospitalisations, and deaths among PLWH were lower among the vaccinated compared with the unvaccinated. SARS-CoV-2 vaccination prioritisation has not completely reached vulnerable PLWH with poorer prognosis. This information can be used to inform public health strategies. 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