290e7dee77709bc1ae6fff0e6e4124e3 pmc_9414494.pdf 150ee09432f13ca0932752e874159156e85ab6c6 pmc_9414494.pdf b452d1c483e1d0d4e6d42576d049919548670809422e427cb700a40fd8b1f69f pmc_9414494.pdf Title: Reactogenicity to the mRNA-1273 Booster According to Previous mRNA COVID-19 Vaccination Subject: The objective of this study was to assess the local and systemic adverse reactions after the administration of a COVID-19 mRNA-1273 booster between December 2021 and February 2022 by comparing the type of mRNA vaccine used as primary series (mRNA-1273 or BNT162b2) and homologous versus heterologous booster in health care workers (HCW). A cross-sectional study was performed in HCW at a tertiary hospital in Barcelona, Spain. A total of 17% of booster recipients responded to the questionnaire. The frequency of reactogenicity after the mRNA-1273 booster (88.5%) was similar to the mRNA-1273 primary doses (85.8%), and higher than the BNT162b2 primary doses (71.1%). The reactogenicity was similar after receiving a heterologous booster compared to a homologous booster (88.0% vs. 90.2%, p = 0.3), and no statistically significant differences were identified in any local or systemic reactions. A higher frequency of medical leave was identified in the homologous booster dose group vs. the heterologous booster dose group (AOR 1.45; 95% CI: 1.00–2.07; p = 0.045). Our findings could be helpful in improving vaccine confidence toward heterologous combinations in the general population and in health care workers. Keywords: SARS-CoV-2; COVID-19-vaccination; booster dose; mRNA vaccines; adverse reactions; health care workers Author: Oleguer Parés-Badell, Ricardo Zules-Oña, Lluís Armadans, Laia Pinós, Blanca Borrás-Bermejo, Susana Otero, José Ángel Rodrigo-Pendás, Martí Vivet-Escalé, Yolima Cossio-Gil, Antònia Agustí, Cristina Aguilera, Magda Campins and Xavier Martínez-Gómez Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Aug 2 03:31:25 2022 CEST ModDate: Tue Aug 2 09:34:46 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 467022 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ARIQJE+VnURWPalladioL Type 1 Custom yes yes no 10 0 ZOXARD+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 CKMMBV+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 OKGPLN+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 CPTAIT+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 68 0 ZYGMNY+CMSY10 Type 1 Builtin yes yes no 75 0 FNTSBS+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 84 0 FNTSBS+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 90 0 FNTSBS+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 96 0 FNTSBS+PalatinoLinotype-BoldItalic CID TrueType Identity-H yes yes yes 102 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 116 0 KGSZMU+VnURWPalladioL-Italic Type 1 Custom yes yes no 126 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-08-23 02:26:31 CEST RepresentationInformation: pmc_9414494.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-08-05 02:20:50 CEST Size: 467022 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 252 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Children: Item: Title: Statement of Principal Findings Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Strengths and Weaknesses of the Study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Strengths and Weaknesses in Relation to Other Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Meaning of the Study: Possible Mechanisms and Implications for Clinicians or Policymakers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Info: Title: Reactogenicity to the mRNA-1273 Booster According to Previous mRNA COVID-19 Vaccination Author: Oleguer Parés-Badell, Ricardo Zules-Oña, Lluís Armadans, Laia Pinós, Blanca Borrás-Bermejo, Susana Otero, José Ángel Rodrigo-Pendás, Martí Vivet-Escalé, Yolima Cossio-Gil, Antònia Agustí, Cristina Aguilera, Magda Campins and Xavier Martínez-Gómez Subject: The objective of this study was to assess the local and systemic adverse reactions after the administration of a COVID-19 mRNA-1273 booster between December 2021 and February 2022 by comparing the type of mRNA vaccine used as primary series (mRNA-1273 or BNT162b2) and homologous versus heterologous booster in health care workers (HCW). A cross-sectional study was performed in HCW at a tertiary hospital in Barcelona, Spain. A total of 17% of booster recipients responded to the questionnaire. The frequency of reactogenicity after the mRNA-1273 booster (88.5%) was similar to the mRNA-1273 primary doses (85.8%), and higher than the BNT162b2 primary doses (71.1%). The reactogenicity was similar after receiving a heterologous booster compared to a homologous booster (88.0% vs. 90.2%, p = 0.3), and no statistically significant differences were identified in any local or systemic reactions. A higher frequency of medical leave was identified in the homologous booster dose group vs. the heterologous booster dose group (AOR 1.45; 95% CI: 1.00 2.07; p = 0.045). Our findings could be helpful in improving vaccine confidence toward heterologous combinations in the general population and in health care workers. 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