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0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: The transcriptional regulator CtrA controls gene expression in Alphaproteobacteria phages: Evidence for a lytic deferment path眀愀礩㸾㰼⽁‱〶㌠〠刯偡牥湴‱〶〠〠刯偲敶‱〶ㄠ〠刯呩瑬攨References Children: Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Genome data collection Item: Title: Genomic sequence analyses Item: Title: Identification of putative transcription factor-binding sites Item: Title: Computation of normalized positional entropy and Gini coefficient Item: Title: Phylogenetic analysis Item: Title: Statistics and data visualization Item: Title: Electron microscopy Item: Title: Extraction of phage genomic DNA and nuclease assays Item: Title: Growth conditions and strains Item: Title: CtrA purification and electrophoretic mobility shift assay Item: Title: Strain construction and beta-galactosidase assays Item: Title: Genome sequencing, assembly and annotation Item: Title: Results Children: Item: Title: Morphology and genome architecture of Brevundimonas phage vB_BsubS-Delta Item: Title: Phylogenetic analysis of vB_BsubS-Delta Item: Title: Distribution of putative CtrA-binding sites in phage genomes Item: Title: Properties of CtrA-binding sites in LPEG phages Item: Title: Properties of genomic regions with high density of putative CtrA-binding sites Item: Title: CtrA binds specifically to predicted CtrA-binding sites in LPEG phages Item: Title: CtrA regulates gene expression in LPEG phages Item: Title: Discussion Children: Item: Title: Independent evolution of gene regulation by host CtrA in multiple phage genomes Item: Title: CtrA-mediated lytic deferment in Alphaproteobacteria-infecting phages Item: Title: Data availability statement Item: Title: Author contributions Item: Title: Funding Item: Title: Conflict of interest Item: Title: Publisher’s note Item: Title: References Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 306 ImageHeight: 61 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1134 ImageHeight: 833 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3803 ImageHeight: 2188 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3803 ImageHeight: 3838 ColorSpace: RGB 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