21419414b69ccfe856fd948dc26a184b pmc_9473360.pdf 8abb2ad9d1585b344968999f5a37e2fb3d7bfd9f pmc_9473360.pdf e116f81c97dae1d456b933f81482d8cf99f862b755f8a294be02e1822e1bdc0f pmc_9473360.pdf Title: Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes Author: Marcello Scala, Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Tayyaba Khan, Andrea Accogli, Laura Davids, Anna Ruiz, Pietro Chiurazzi, Gabriella Cericola, Björn Schulte, Kristin G. Monaghan, Amber Begtrup, Annalaura Torella, Michele Pinelli, Anne-Sophie Denommé-Pichon, Antonio Vitobello, Caroline Racine, Maria Margherita Mancardi, Courtney Kiss, Andrea Guerin, Wendy Wu, Elisabeth Gabau Vila, Bryan C. Mak, Julian A. Martinez-Agosto, Michael B. Gorin, Bugrahan Duz, Yavuz Bayram, Claudia M. B. Carvalho, Jaime E. Vengoechea, David Chitayat, Tiong Yang Tan, Bert Callewaert, Bernd Kruse, Lynne M. Bird, Laurence Faivre, Marcella Zollino, Saskia Biskup, Undiagnosed Diseases Network, Telethon Undiagnosed Diseases Program, Pasquale Striano, Vincenzo Nigro, Mariasavina Severino, Valeria Capraknagata@inst-hsc.jp Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Sep 5 11:03:46 2022 CEST ModDate: Mon Sep 5 11:03:46 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 612.283 x 790.866 pts Page rot: 0 File size: 2317666 bytes Optimized: yes PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ACIKKA+AdvOT1ab0d708.B Type 1C WinAnsi yes yes no 672 0 ACIKKB+AdvOT1ab0d708.B+fb Type 1C Custom yes yes yes 673 0 ACIKLC+AdvOT1ab0d708.B+20 Type 1C WinAnsi yes yes no 682 0 ACILEP+AdvOTbf7bbdaa Type 1C WinAnsi yes yes no 685 0 ACILFA+AdvOT8163c0db.I Type 1C WinAnsi yes yes no 686 0 ACILFB+AdvOTbf7bbdaa+fb Type 1C Custom yes yes yes 691 0 ACILFC+AdvOTbf7bbdaa+20 Type 1C WinAnsi yes yes no 697 0 ACILGD+AdvOT3c584a2f.B Type 1C WinAnsi yes yes no 416 0 ACILID+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 431 0 ACILIE+AdvTT5843c571+03 Type 1C Custom yes yes yes 423 0 ACILIF+AdvPS4C9543 Type 1C Custom yes yes yes 424 0 ACILJG+AdvOT2a2c8e30.BI Type 1C WinAnsi yes yes no 435 0 ACINLK+AdvOT8163c0db.I+fb Type 1C Custom yes yes yes 438 0 ACJALI+AdvOT8608a8d1+21 Type 1C Custom yes yes yes 439 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-23 02:35:25 CEST RepresentationInformation: pmc_9473360.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-09-24 02:13:42 CEST Size: 2317666 Format: PDF Version: 1.3 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B6' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B11' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B12' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B13' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B14' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B15' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B14' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B16' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B17' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B18' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B19' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B18' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B19' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B20' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B21' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B20' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B18' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B22' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B23' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B24' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B25' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B26' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B27' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B28' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B29' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B30' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B31' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B32' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B33' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B27' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B34' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B18' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B20' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B18' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B19' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B16' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B35' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B36' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B19' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B18' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B37' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B40' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B41' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B42' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B47' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B48' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B49' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B50' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B51' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B52' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B53' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B54' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B55' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B56' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B59' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B45' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B47' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B19' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B45' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B16' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B60' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B61' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B16' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B16' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B16' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B16' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B62' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B63' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B16' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B15' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B16' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B35' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B35' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibawac106-B36' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B10' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B11' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B12' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B13' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B14' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B15' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B16' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B17' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B18' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B19' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B20' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B21' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B22' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B23' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B24' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B25' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B26' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B27' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B28' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B29' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B30' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B31' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B32' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B33' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B34' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B35' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B36' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B37' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B38' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B39' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B40' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B41' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B42' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B43' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B44' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B45' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B46' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B47' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B48' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B49' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B50' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B51' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B52' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B53' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B54' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B55' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bibrefawac106-B56' cannot be found Offset: 2288901 ID: PDF-HUL-122 ErrorMessage: 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edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Patient enrolment and ascertainment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Previously reported cases assessment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Next generation sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Variant identification and analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Plasmids Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Antibodies and histochemical reagents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: GTP-hydrolysis and GTP/GDP-exchange assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Cell culture and transfection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Pull-down assay of GTP-bound RAC3 and the variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Assay of SRF, AP1 and NFkB-mediated gene transcription Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: In utero electroporation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Time-lapse imaging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Quantitative analysis of axon growth Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Immunofluorescence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Patient report Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Neuroimaging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Identification and analyses of RAC3 variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: In vitro biological and biochemical activities of the 11 disorder causative RAC3 variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Possible interaction of the RAC3 variants with various downstream effectors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: In vivo effects of the four RAC3 variants in the Switch II region on neuronal migration and morphology during corticogenesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Time-lapse imaging of migration of cortical neurons expressing the four RAC3 variants in the Switch II region Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Role of PAK1 as a downstream effector of RAC3 in neuronal migration in vivo Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Effects of the four RAC3 variants in the Switch II region on axon development during corticogenesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Web resources Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Appendix 1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Children: Item: Title: Undiagnosed Disease Network Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Telethon Undiagnosed Diseases Program Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Info: Title: Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes Author: Marcello Scala, Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Tayyaba Khan, Andrea Accogli, Laura Davids, Anna Ruiz, Pietro Chiurazzi, Gabriella Cericola, Björn Schulte, Kristin G. Monaghan, Amber Begtrup, Annalaura Torella, Michele Pinelli, Anne-Sophie Denommé-Pichon, Antonio Vitobello, Caroline Racine, Maria Margherita Mancardi, Courtney Kiss, Andrea Guerin, Wendy Wu, Elisabeth Gabau Vila, Bryan C. Mak, Julian A. Martinez-Agosto, Michael B. Gorin, Bugrahan Duz, Yavuz Bayram, Claudia M. B. Carvalho, Jaime E. Vengoechea, David Chitayat, Tiong Yang Tan, Bert Callewaert, Bernd Kruse, Lynne M. Bird, Laurence Faivre, Marcella Zollino, Saskia Biskup, Undiagnosed Diseases Network, Telethon Undiagnosed Diseases Program, Pasquale Striano, Vincenzo Nigro, Mariasavina Severino, Valeria Capraknagata@inst-hsc.jp Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Sep 05 11:33:46 CEST 2022 ModDate: Mon Sep 05 11:33:46 CEST 2022 ID: 0xe9dda1f6a26fe521d35e1d64d3c08491, 0x7835d27c92a3c64599c28841b6588b11 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: ACIKKA+AdvOT1ab0d708.B FontSubset: true FirstChar: 40 LastChar: 246 FontDescriptor: FontName: ACIKKA+AdvOT1ab0d708.B Flags: Serif, Nonsymbolic FontBBox: -73, -273, 1103, 938 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACILGD+AdvOT3c584a2f.B FontSubset: true FirstChar: 49 LastChar: 121 FontDescriptor: FontName: ACILGD+AdvOT3c584a2f.B Flags: Nonsymbolic FontBBox: -76, -277, 1128, 970 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACIKKB+AdvOT1ab0d708.B+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: ACIKKB+AdvOT1ab0d708.B+fb Flags: Symbolic FontBBox: 0, 0, 612, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ACILIE+AdvTT5843c571+03 FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: ACILIE+AdvTT5843c571+03 Flags: Symbolic FontBBox: -444, -235, 880, 891 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ACILIF+AdvPS4C9543 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: ACILIF+AdvPS4C9543 Flags: Symbolic FontBBox: -20, -947, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ACIKLC+AdvOT1ab0d708.B+20 FontSubset: true FirstChar: 134 LastChar: 134 FontDescriptor: FontName: ACIKLC+AdvOT1ab0d708.B+20 Flags: Nonsymbolic FontBBox: -166, -201, 1141, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACILEP+AdvOTbf7bbdaa FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: ACILEP+AdvOTbf7bbdaa Flags: Serif, Nonsymbolic FontBBox: -56, -270, 1072, 926 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACILFA+AdvOT8163c0db.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: ACILFA+AdvOT8163c0db.I Flags: Nonsymbolic FontBBox: -129, -270, 1053, 915 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACILID+AdvOT8608a8d1+22 FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: ACILID+AdvOT8608a8d1+22 Flags: Symbolic FontBBox: 1, -324, 1229, 973 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ACILFB+AdvOTbf7bbdaa+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: ACILFB+AdvOTbf7bbdaa+fb Flags: Symbolic FontBBox: 0, 0, 606, 777 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ACILJG+AdvOT2a2c8e30.BI FontSubset: true FirstChar: 46 LastChar: 118 FontDescriptor: FontName: ACILJG+AdvOT2a2c8e30.BI Flags: Nonsymbolic FontBBox: -117, -273, 1074, 932 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ACINLK+AdvOT8163c0db.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: ACINLK+AdvOT8163c0db.I+fb Flags: Symbolic FontBBox: -129, -263, 536, 777 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ACJALI+AdvOT8608a8d1+21 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: ACJALI+AdvOT8608a8d1+21 Flags: Symbolic FontBBox: -15, -259, 1151, 871 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ACILFC+AdvOTbf7bbdaa+20 FontSubset: true FirstChar: 133 LastChar: 151 FontDescriptor: FontName: ACILFC+AdvOTbf7bbdaa+20 Flags: Nonsymbolic FontBBox: -167, -195, 1136, 777 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes Marcello Scala, Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Tayyaba Khan, Andrea Accogli, Laura Davids, Anna Ruiz, Pietro Chiurazzi, Gabriella Cericola, Björn Schulte, Kristin G. Monaghan, Amber Begtrup, Annalaura Torella, Michele Pinelli, Anne-Sophie Denommé-Pichon, Antonio Vitobello, Caroline Racine, Maria Margherita Mancardi, Courtney Kiss, Andrea Guerin, Wendy Wu, Elisabeth Gabau Vila, Bryan C. Mak, Julian A. Martinez-Agosto, Michael B. Gorin, Bugrahan Duz, Yavuz Bayram, Claudia M. B. Carvalho, Jaime E. Vengoechea, David Chitayat, Tiong Yang Tan, Bert Callewaert, Bernd Kruse, Lynne M. 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