8cf13ec78c88a868a16d856240d631b8 pmc_9484258.pdf 35ec020ed067180d6fd1d7c3ce508c3679a210a9 pmc_9484258.pdf 60fcd0df7b6347d36c315a9d641c9d7daa84277a9cc57c83941cf65a1275ee3c pmc_9484258.pdf Title: IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation Subject: The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure Keywords: IRF7, JAK-STAT signalling, HIV-1 cure strategies, latency reversal agents, innate immunity Author: Ifeanyi Jude Ezeonwumelu; Edurne García-Vidal; Eudald Felip; Maria C. Puertas; Bruna Oriol-Tordera; Lucía Gutiérrez-Chamorro; André Gohr; Marta Ruiz-Riol; Marta Massanella; Bonaventura Clotet; Javier Martinez-Picado; Roger Badia; Eva Riveira-Muñoz; Ester Ballana Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Mon Sep 5 11:58:45 2022 CEST ModDate: Mon Sep 5 11:58:45 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.389 x 841.663 pts Page rot: 0 File size: 6951807 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DEEMDP+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 617 0 DEEMEA+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 618 0 DEEMEB+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 619 0 DEEMEC+AdvPSA18C Type 1C WinAnsi yes yes no 620 0 DEEMED+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 621 0 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indirect destination - referenced object 'B59' cannot be found Offset: 6929841 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B60' cannot be found Offset: 6929841 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B61' cannot be found Offset: 6929841 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 709 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Fedratinib is a potent antiviral agent in acute HIV infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Fedratinib induces HIV-1 reactivation in the absence of immune activation in CD4+ T lymphocytes ex vivo Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Gene expression changes following JAK2i treatment are comparable to common LRAs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Fedratinib upregulates IRF7 expression despite blockade of JAK-STAT signalling and cytokine production Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Induction of IRF7 expression positively correlates with latency reversal modulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: IRF7 is a general regulator of HIV-1 latency Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Fedratinib is a potent antiviral agent in acute HIV infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Primary cultures and cell lines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Patients and samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Viral strains Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Generation of non-clonal HIV latently infected cells and viral reactivation assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Compounds and drug treatments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: VIP-SPOT assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Ex vivo reactivation of primary CD4+ T cells from PWH Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Immunophenotypic characterization of PBMCs by flow cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: RNA interference Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Quantitative RT-polymerase chain reaction (qRT-PCR) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: RNA-sequencing and library preparation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Transcriptomic analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Immunoblot Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Interferon signalling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Tat-dependent viral expression of HIV-1 LTR promoter Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Viral infection and antiviral activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Info: Title: IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation Author: Ifeanyi Jude Ezeonwumelu; Edurne García-Vidal; Eudald Felip; Maria C. Puertas; Bruna Oriol-Tordera; Lucía Gutiérrez-Chamorro; André Gohr; Marta Ruiz-Riol; Marta Massanella; Bonaventura Clotet; Javier Martinez-Picado; Roger Badia; Eva Riveira-Muñoz; Ester Ballana Subject: The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure Keywords: IRF7, JAK-STAT signalling, HIV-1 cure strategies, latency reversal agents, innate immunity Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Mon Sep 05 11:58:45 CEST 2022 ModDate: Mon Sep 05 11:58:45 CEST 2022 ID: 0x2f258035617063ce10cea8e2dafcae2d, 0x68c5a6a4201d264fb7e6a4ea98d09643 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg 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Puertas; Bruna Oriol-Tordera; Lucía Gutiérrez-Chamorro; André Gohr; Marta Ruiz-Riol; Marta Massanella; Bonaventura Clotet; Javier Martinez-Picado; Roger Badia; Eva Riveira-Muñoz; Ester Ballana The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure uuid:f3c4c214-b572-4a4a-a982-7af16cfbd9ec uuid:8069ccbb-8436-47c8-b397-ff088254602a Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 481, 707 Annotation: Subtype: Link Rect: 222, 661, 469, 682 Annotation: Subtype: Link Rect: 222, 636, 453, 657 Annotation: Subtype: Link Rect: 222, 611, 428, 632 Annotation: Subtype: Link Rect: 56, 39, 136, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Annotation: Subtype: Link Rect: 56, 691, 133, 706 Annotation: Subtype: Link Rect: 56, 539, 118, 546 Annotation: Subtype: Link Rect: 56, 521, 121, 528 Annotation: Subtype: Link Rect: 56, 322, 166, 329 Annotation: Subtype: Link Rect: 96, 245, 155, 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