24716b2b10e08d5fe206d53bb6424a39 pmc_9509186.pdf e8df543e16a218975b5d8b41f109558ed1e9c46d pmc_9509186.pdf e6f5e446843dc17aeda7de55fe265fc147a9944da549230453beffe24cc7a3a3 pmc_9509186.pdf Title: OP.21.00909 1522..1532 Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed Aug 31 05:58:55 2022 CEST ModDate: Sat Sep 3 11:53:19 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 584.957 x 782.986 pts Page rot: 0 File size: 441052 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KBBOCD+AdvTT3d29b194.B Type 1C WinAnsi yes yes no 256 0 KBBOKB+AdvTT4350c63d Type 1C WinAnsi yes yes no 264 0 KBBOKC+AdvOTb03e4648.B Type 1C WinAnsi yes yes no 265 0 KBBOLD+AdvOTb03e4648.B+fb Type 1C Custom yes yes yes 266 0 KBBOMD+AdvOT8a0d451b.B Type 1C WinAnsi yes yes no 267 0 KBBONE+AdvOTd710a12c Type 1C WinAnsi yes yes no 268 0 KBBONF+AdvOTd710a12c+fb Type 1C Custom yes yes yes 269 0 KBBOOG+AdvOTd710a12c+20 Type 1C WinAnsi yes yes no 279 0 KBBPEE+AdvOT53f3fec7 Type 1C WinAnsi yes yes no 282 0 KBBPFF+AdvOT53f3fec7+fb Type 1C Custom yes yes yes 285 0 KBBOCD+AdvTT3d29b194.B Type 1C WinAnsi yes yes no 131 0 KBBOKB+AdvTT4350c63d Type 1C WinAnsi yes yes no 122 0 KBBOKC+AdvOTb03e4648.B Type 1C WinAnsi yes yes no 129 0 KBBOLD+AdvOTb03e4648.B+fb Type 1C Custom yes yes yes 130 0 KBBOMD+AdvOT8a0d451b.B Type 1C WinAnsi yes yes no 126 0 KBBONE+AdvOTd710a12c Type 1C WinAnsi yes yes no 127 0 KBBONF+AdvOTd710a12c+fb Type 1C Custom yes yes yes 123 0 KBBOOG+AdvOTd710a12c+20 Type 1C WinAnsi yes yes no 132 0 KBBPEE+AdvOT53f3fec7 Type 1C WinAnsi yes yes no 133 0 KBBPFF+AdvOT53f3fec7+fb Type 1C Custom yes yes yes 128 0 KBCANO+AdvOTa82dc243.I Type 1C WinAnsi yes yes no 138 0 KBCAMN+AdvOT463cc31e Type 1C WinAnsi yes yes no 139 0 KBCBFM+AdvOT8a0d451b.B+fb Type 1C Custom yes yes yes 140 0 KBCBHM+AdvOT9d186844 Type 1C WinAnsi yes yes no 144 0 KBCCCJ+Univers Type 1C WinAnsi yes yes no 152 0 KBCCCK+Univers-Condensed Type 1C WinAnsi yes yes no 154 0 KBCCPG+Helvetica-Bold Type 1C WinAnsi yes yes no 156 0 KBCDID+AdvOT53f3fec7+20 Type 1C WinAnsi yes yes no 157 0 KBCDJE+AdvOTb03e4648.B+20 Type 1C WinAnsi yes yes no 158 0 KBCEBC+AdvPSUnvNCp Type 1C WinAnsi yes yes no 161 0 KBCFCM+AdvPS480274 Type 1C WinAnsi yes yes no 162 0 KBCGDH+AdvOT72cf81eb.BI Type 1C WinAnsi yes yes no 165 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-12-15 02:30:38 CET RepresentationInformation: pmc_9509186.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-10-06 02:15:57 CEST Size: 441052 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b10' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b11' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b10' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b11' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b12' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b16' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b17' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b11' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b18' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b19' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b20' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b21' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b22' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b23' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b25' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b26' cannot be found Offset: 429537 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'b29' cannot be found Offset: 429537 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 315 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: APPENDIX Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Children: Item: Title: INTRODUCTION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: METHODS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Data Extraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: RESULTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: Regulatory Review and Expedited Programs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Time to Subsequent Regulatory Approval Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Association With Clinical Benefit Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: DISCUSSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: REFERENCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: APPENDIX Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: APPENDIX Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: op.21.00909ReCAP.pdf Children: Item: Title: APPENDIX Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Info: Title: OP.21.00909 1522..1532 Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed Aug 31 06:28:55 CEST 2022 ModDate: Sat Sep 03 12:23:19 CEST 2022 ID: 0x1ab8330de3450c66012d92dc21aa8696, 0x09ad1fd013d1e64ea0be418b5967170d Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: KBBOCD+AdvTT3d29b194.B FontSubset: true FirstChar: 45 LastChar: 118 FontDescriptor: FontName: KBBOCD+AdvTT3d29b194.B Flags: Nonsymbolic FontBBox: -52, -218, 927, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBPFF+AdvOT53f3fec7+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KBBPFF+AdvOT53f3fec7+fb Flags: Symbolic FontBBox: 0, 0, 500, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KBBOKC+AdvOTb03e4648.B FontSubset: true FirstChar: 37 LastChar: 169 FontDescriptor: FontName: KBBOKC+AdvOTb03e4648.B Flags: Nonsymbolic FontBBox: -52, -218, 927, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBOLD+AdvOTb03e4648.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KBBOLD+AdvOTb03e4648.B+fb Flags: Symbolic FontBBox: 0, 0, 500, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KBBOCD+AdvTT3d29b194.B FontSubset: true FirstChar: 65 LastChar: 89 FontDescriptor: FontName: KBBOCD+AdvTT3d29b194.B Flags: Nonsymbolic FontBBox: -52, -218, 927, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBOOG+AdvOTd710a12c+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: KBBOOG+AdvOTd710a12c+20 Flags: Nonsymbolic FontBBox: -166, -145, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBPEE+AdvOT53f3fec7 FontSubset: true FirstChar: 39 LastChar: 180 FontDescriptor: FontName: KBBPEE+AdvOT53f3fec7 Flags: Nonsymbolic FontBBox: -10, -218, 947, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBOKB+AdvTT4350c63d FontSubset: true FirstChar: 97 LastChar: 117 FontDescriptor: FontName: KBBOKB+AdvTT4350c63d Flags: Serif, Nonsymbolic FontBBox: -31, -302, 895, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBOKC+AdvOTb03e4648.B FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: KBBOKC+AdvOTb03e4648.B Flags: Nonsymbolic FontBBox: -52, -218, 927, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBOLD+AdvOTb03e4648.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KBBOLD+AdvOTb03e4648.B+fb Flags: Symbolic FontBBox: 0, 0, 500, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KBCANO+AdvOTa82dc243.I FontSubset: true FirstChar: 80 LastChar: 118 FontDescriptor: FontName: KBCANO+AdvOTa82dc243.I Flags: Nonsymbolic FontBBox: -52, -270, 1041, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBOMD+AdvOT8a0d451b.B FontSubset: true FirstChar: 44 LastChar: 119 FontDescriptor: FontName: KBBOMD+AdvOT8a0d451b.B Flags: Nonsymbolic FontBBox: -31, -218, 895, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBCAMN+AdvOT463cc31e FontSubset: true FirstChar: 44 LastChar: 53 FontDescriptor: FontName: KBCAMN+AdvOT463cc31e Flags: Nonsymbolic FontBBox: -20, -239, 989, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBONE+AdvOTd710a12c FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: KBBONE+AdvOTd710a12c Flags: Nonsymbolic FontBBox: -31, -208, 895, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBCBFM+AdvOT8a0d451b.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KBCBFM+AdvOT8a0d451b.B+fb Flags: Symbolic FontBBox: 9, 0, 489, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KBBONF+AdvOTd710a12c+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KBBONF+AdvOTd710a12c+fb Flags: Symbolic FontBBox: 0, 0, 500, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KBCBHM+AdvOT9d186844 FontSubset: true FirstChar: 53 LastChar: 53 FontDescriptor: FontName: KBCBHM+AdvOT9d186844 Flags: Nonsymbolic FontBBox: -20, -239, 927, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBOOG+AdvOTd710a12c+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: KBBOOG+AdvOTd710a12c+20 Flags: Nonsymbolic FontBBox: -166, -145, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBCCCJ+Univers FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: KBCCCJ+Univers Flags: Nonsymbolic FontBBox: -168, -250, 992, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBPEE+AdvOT53f3fec7 FontSubset: true FirstChar: 39 LastChar: 121 FontDescriptor: FontName: KBBPEE+AdvOT53f3fec7 Flags: Nonsymbolic FontBBox: -10, -218, 947, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBCCCK+Univers-Condensed FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: KBCCCK+Univers-Condensed Flags: Nonsymbolic FontBBox: -166, -250, 1000, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBCCPG+Helvetica-Bold FontSubset: true FirstChar: 65 LastChar: 69 FontDescriptor: FontName: KBCCPG+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBPFF+AdvOT53f3fec7+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KBBPFF+AdvOT53f3fec7+fb Flags: Symbolic FontBBox: 0, 0, 500, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KBCDID+AdvOT53f3fec7+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: KBCDID+AdvOT53f3fec7+20 Flags: Nonsymbolic FontBBox: -166, -135, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBCDJE+AdvOTb03e4648.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: KBCDJE+AdvOTb03e4648.B+20 Flags: Nonsymbolic FontBBox: -166, -145, 1000, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBCEBC+AdvPSUnvNCp FontSubset: true FirstChar: 110 LastChar: 110 FontDescriptor: FontName: KBCEBC+AdvPSUnvNCp Flags: Nonsymbolic FontBBox: 0, -218, 989, 760 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBCFCM+AdvPS480274 FontSubset: true FirstChar: 67 LastChar: 67 FontDescriptor: FontName: KBCFCM+AdvPS480274 Flags: Nonsymbolic FontBBox: 0, -208, 1354, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBCGDH+AdvOT72cf81eb.BI FontSubset: true FirstChar: 80 LastChar: 80 FontDescriptor: FontName: KBCGDH+AdvOT72cf81eb.BI Flags: Nonsymbolic FontBBox: -52, -270, 1072, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBOKB+AdvTT4350c63d FontSubset: true FirstChar: 97 LastChar: 117 FontDescriptor: FontName: KBBOKB+AdvTT4350c63d Flags: Serif, Nonsymbolic FontBBox: -31, -302, 895, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBONF+AdvOTd710a12c+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: KBBONF+AdvOTd710a12c+fb Flags: Symbolic FontBBox: 0, 0, 500, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KBBOMD+AdvOT8a0d451b.B FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: KBBOMD+AdvOT8a0d451b.B Flags: Nonsymbolic FontBBox: -31, -218, 895, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KBBONE+AdvOTd710a12c FontSubset: true FirstChar: 37 LastChar: 169 FontDescriptor: FontName: KBBONE+AdvOTd710a12c Flags: Nonsymbolic FontBBox: -31, -208, 895, 947 FontFile3: true Encoding: WinAnsiEncoding XMP: Acrobat Distiller 7.0 (Windows) 2022-09-03T15:23:19+05:30 2022-08-31T09:28:55+05:30 Arbortext Advanced Print Publisher 9.1.510/W Unicode 2022-09-03T15:23:19+05:30 application/pdf OP.21.00909 1522..1532 uuid:eadebd49-1383-4afc-845b-42671f3f562d uuid:13b0faed-bc5e-467f-9322-1cfc89e92628 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 370, 741, 419, 750 Annotation: Subtype: Link Rect: 139, 171, 246, 179 Annotation: Subtype: Link Rect: 36, 164, 81, 172 Annotation: Subtype: Link Rect: 36, 154, 69, 162 Annotation: Subtype: Link Rect: 36, 122, 103, 130 Annotation: Subtype: Link Rect: 36, 112, 44, 120 Annotation: Subtype: Link Rect: 49, 82, 104, 90 Annotation: Subtype: Link Rect: 36, 72, 96, 80 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 228, 100, 232, 108 Destination: 79 Annotation: Subtype: Link Rect: 234, 100, 237, 108 Destination: 79 Annotation: Subtype: Link Rect: 231, 76, 234, 84 Destination: 79 Annotation: Subtype: Link Rect: 506, 236, 509, 245 Destination: 79 Annotation: Subtype: Link Rect: 511, 236, 514, 245 Destination: 79 Annotation: Subtype: Link Rect: 431, 212, 434, 220 Destination: 79 Annotation: Subtype: Link Rect: 474, 162, 477, 171 Destination: 79 Annotation: Subtype: Link Rect: 383, 113, 387, 121 Destination: 79 Annotation: Subtype: Link Rect: 36, 102, 103, 110 Annotation: Subtype: Link Rect: 36, 92, 44, 100 Annotation: Subtype: Link Rect: 49, 82, 104, 90 Annotation: Subtype: Link Rect: 36, 72, 96, 80 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 204, 721, 211, 730 Destination: null Annotation: Subtype: Link Rect: 243, 709, 249, 718 Destination: null Annotation: Subtype: Link Rect: 122, 280, 158, 289 Destination: 111 Annotation: Subtype: Link Rect: 337, 709, 344, 718 Destination: null Annotation: Subtype: Link Rect: 381, 686, 388, 694 Destination: null Annotation: Subtype: Link Rect: 499, 686, 502, 694 Destination: 79 Annotation: Subtype: Link Rect: 504, 686, 510, 694 Destination: null Annotation: Subtype: Link Rect: 512, 686, 518, 694 Destination: null Annotation: Subtype: Link Rect: 449, 674, 456, 682 Destination: null Annotation: Subtype: Link Rect: 418, 626, 425, 634 Destination: null Annotation: Subtype: Link Rect: 427, 626, 433, 634 Destination: null Annotation: Subtype: Link Rect: 408, 273, 437, 283 Destination: 51 Annotation: Subtype: Link Rect: 483, 273, 518, 283 Destination: 114 Annotation: Subtype: Link Rect: 496, 84, 527, 93 Destination: 59 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 341, 682, 362, 691 Destination: 59 Annotation: Subtype: Link Rect: 356, 399, 377, 408 Destination: 70 Annotation: Subtype: Link Rect: 423, 399, 459, 408 Destination: 117 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 257, 183, 264, 192 Destination: null Annotation: Subtype: Link Rect: 175, 112, 182, 120 Destination: null Annotation: Subtype: Link Rect: 538, 415, 545, 423 Destination: null Annotation: Subtype: Link Rect: 493, 112, 499, 120 Destination: null Annotation: Subtype: Link Rect: 473, 76, 479, 84 Destination: null Annotation: Subtype: Link Rect: 481, 76, 488, 84 Destination: null Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 226, 112, 233, 120 Destination: null Annotation: Subtype: Link Rect: 235, 112, 241, 120 Destination: null Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 168, 471, 271, 478 Annotation: Subtype: Link Rect: 317, 581, 441, 589 Annotation: Subtype: Link Rect: 326, 325, 458, 332 Annotation: Subtype: Link Rect: 249, 314, 350, 321 Annotation: Subtype: Link Rect: 93, 295, 393, 302 Annotation: Subtype: Link Rect: 280, 264, 519, 271 Annotation: Subtype: Link Rect: 277, 253, 484, 260 Annotation: Subtype: Link Rect: 113, 234, 492, 241 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 527, 732, 548, 739 Annotation: Subtype: Link Rect: 93, 723, 546, 730 Annotation: Subtype: Link Rect: 93, 715, 222, 722 Annotation: Subtype: Link Rect: 431, 704, 548, 711 Annotation: Subtype: Link Rect: 93, 695, 192, 702 Annotation: Subtype: Link Rect: 172, 676, 548, 683 Annotation: Subtype: Link Rect: 93, 668, 130, 675 Annotation: Subtype: Link Rect: 413, 529, 545, 536 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 306, 690, 358, 697 Annotation: Subtype: Link Rect: 369, 690, 483, 697 Annotation: Subtype: Link Rect: 477, 678, 524, 685 Page: Label: 10 Page: Label: 11 Page: Label: 12 Checksum: d3557429 Type: CRC32 Checksum: 24716b2b10e08d5fe206d53bb6424a39 Type: MD5 Checksum: e8df543e16a218975b5d8b41f109558ed1e9c46d Type: SHA-1