4f4b4c8d127f2ed75df76e403a2cdf8d pmc_9515545.pdf a902dfc9d1b938a2a76e481904b93dbfa74b24f4 pmc_9515545.pdf b67cf2d18c8e386112a37bac0af52313d95a53b41d8e9632103d9f5ad6c4adcb pmc_9515545.pdf Title: Mesenchymal stromal cells induced regulatory B cells are enriched in extracellular matrix genes and IL-10 independent modulators Subject: Regulatory B cells (Breg) are essential players in tolerance and immune homeostasis Keywords: B cell, immunomodulation, mesenchymal stromal cell, regulatory B cell, IL-10 Author: Sergio G. 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referenced object 'B43' cannot be found Offset: 9198690 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B44' cannot be found Offset: 9198690 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B48' cannot be found Offset: 9198690 MIMEtype: application/pdf PDFMetadata: Objects: 565 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Mesenchymal stem cell collection and culture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: B cell isolation from human tonsils Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: MSC and B cell coculture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: iBreg characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: T cell proliferation assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Il-10 Capture assay and cell sorting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: RNAseq and data analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: qPCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: MSC induce B cells enriched in transitional B cell populations with increased IL-10 secretion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: iBreg inhibit T cell proliferation and are stable after MSC coculture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: iBreg have high and stable IL-10+/TNFα+ cell ratios that allow the sorting of IL-10+ populations by flow cytometry for downstr攀愀洀 愀渀愀氀礀猀椀猩㸾൥湤潢樍㔶ㄠ〠潢樼㰯偡牥湴‵㐶‰⁒⽎數琠㔶〠〠刯䑥獴⣾＀猀㌀开㈩⽐牥瘠㔴㜠〠刯呩瑬攨iBreg inhibit T cell proliferation and are stable after MSC coculture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: IL-10+ iBreg are not a distinct B cell functional subset, while IL-10- iBreg are enriched in extracellular matrix and immune r攀最甀氀愀琀椀漀渀 最攀渀攀猩㸾൥湤潢樍㔶〠〠潢樼㰯偡牥湴‵㐶‰⁒⽎數琠㔵㤠〠刯䑥獴⣾＀猀㌀开㌩⽐牥瘠㔶ㄠ〠刯呩瑬攨iBreg have high and stable IL-10+/TNFα+ cell ratios that allow the sorting of IL-10+ populations by flow cytometry for downstr攀愀洀 愀渀愀氀礀猀椀猩㸾൥湤潢樍㔶ㄠ〠潢樼㰯偡牥湴‵㐶‰⁒⽎數琠㔶〠〠刯䑥獴⣾＀猀㌀开㈩⽐牥瘠㔴㜠〠刯呩瑬攨iBreg inhibit T cell proliferation and are stable after MSC coculture Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: MSC induce extracellular matrix genes that are upregulated in iBreg when compared to activated B cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: iBreg inhibition of T cell proliferation is independent of IL-10 direct effect Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Info: Title: Mesenchymal stromal cells induced regulatory B cells are enriched in extracellular matrix genes and IL-10 independent modulators Author: Sergio G. 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FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: Acrobat Distiller 7.0 (Windows) B cell, immunomodulation, mesenchymal stromal cell, regulatory B cell, IL-10 2022-09-09T16:07:54+08:00 2022-09-09T14:49:32+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2022-09-09T16:07:54+08:00 application/pdf Regulatory B cells (Breg) are essential players in tolerance and immune homeostasis Mesenchymal stromal cells induced regulatory B cells are enriched in extracellular matrix genes and IL-10 independent modulators Sergio G. Garcia Noelia Sandoval-Hell&iacute n Marta Clos-Sansalvador Laura Carreras-Planella Miriam Mor&oacute n-Font Dolores Guerrero Francesc E. 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