63c055ba14a5312eb9632900e7ed9e1b pmc_9518492.pdf 15307ce468e43676ec76bf69e705fe94ef721119 pmc_9518492.pdf 236553833105795cd7f157546437fd2b3ea1282108a745cc389ef14301add8ad pmc_9518492.pdf Title: Excellent Response to OnabotulinumtoxinA: Different Definitions, Different Predictors Subject: The identification of patients who can benefit the most from the available preventive treatments is important in chronic migraine. We explored the rate of excellent responders to onabotulinumtoxinA in a multicenter European study and explored the predictors of such response, according to different definitions. A pooled analysis on chronic migraineurs treated with onabotulinumtoxinA and followed-up for, at least, 9 months was performed. Excellent responders were defined either as patients with a 75% decrease in monthly headache days (percent-based excellent responders) or as patients with <4 monthly headache days (frequency-based excellent responders). The characteristics of excellent responders at the baseline were compared with the ones of patients with a <30% decrease in monthly headache days. Percent-based excellent responders represented about 10% of the sample, whilst frequency-based excellent responders were about 5% of the sample. Compared with non-responders, percent-based excellent responders had a higher prevalence of medication overuse and a higher excellent response rate even after the 1st and the 2nd injection. Females were less like to be frequency-based excellent responders. Chronic migraine sufferers without medication overuse and of female sex may find fewer benefits with onabotulinumtoxinA. Additionally, the excellent response status is identifiable after the first cycle. Keywords: chronic migraine; onabotulinumtoxinA; predictors of response; excellent responders Author: Raffaele Ornello, Carlo Baraldi, Fayyaz Ahmed, Andrea Negro, Anna Maria Miscio, Antonio Santoro, Alicia Alpuente, Antonio Russo, Marcello Silvestro, Sabina Cevoli, Nicoletta Brunelli, Fabrizio Vernieri, Licia Grazzi, Luca Pani, Anna Andreou, Giorgio Lambru, Ilaria Frattale, Katharina Kamm, Ruth Ruscheweyh, Marco Russo, Paola Torelli, Elena Filatova, Nina Latysheva, Anna Gryglas-Dworak, Marcin Straburzynski, Calogera Butera, Bruno Colombo, Massimo Filippi, Patricia Pozo-Rosich, Paolo Martelletti, Simona Guerzoni and Simona Sacco Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Sep 6 05:26:11 2022 CEST ModDate: Tue Sep 6 05:54:14 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 515979 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YQSTVO+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 EQIDMJ+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 GPZNDY+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 YWQWLZ+VnURWPalladioL Type 1 Custom yes yes no 23 0 LWQXII+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 42 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 45 0 JQBQZH+CMSY10 Type 1 Builtin yes yes no 67 0 JLZORU+EURM10 Type 1 Builtin yes yes no 77 0 UWUZYW+URWPalladioL-BoldItal Type 1 Custom yes yes no 84 0 ILQQKA+CMBSY10 Type 1 Builtin yes yes no 88 0 CNGNGO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 101 0 CNGNHA+PalatinoLinotype TrueType WinAnsi yes yes no 104 0 CNGNHC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 107 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-10-29 02:22:41 CEST RepresentationInformation: pmc_9518492.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-10-06 02:15:23 CEST Size: 515979 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 306 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4923ab24 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Children: Item: Title: Study Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Variables and Response Categories Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Children: Item: Title: Baseline Features Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Rates of Excellent Responders and Total Responders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Comparison between Percent-Based Excellent Responders and Non-Responders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Comparison between Frequency-Based Excellent Responders and Non-Responders during the Third BT-A Cycle Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Info: Title: Excellent Response to OnabotulinumtoxinA: Different Definitions, Different Predictors Author: Raffaele Ornello, Carlo Baraldi, Fayyaz Ahmed, Andrea Negro, Anna Maria Miscio, Antonio Santoro, Alicia Alpuente, Antonio Russo, Marcello Silvestro, Sabina Cevoli, Nicoletta Brunelli, Fabrizio Vernieri, Licia Grazzi, Luca Pani, Anna Andreou, Giorgio Lambru, Ilaria Frattale, Katharina Kamm, Ruth Ruscheweyh, Marco Russo, Paola Torelli, Elena Filatova, Nina Latysheva, Anna Gryglas-Dworak, Marcin Straburzynski, Calogera Butera, Bruno Colombo, Massimo Filippi, Patricia Pozo-Rosich, Paolo Martelletti, Simona Guerzoni and Simona Sacco Subject: The identification of patients who can benefit the most from the available preventive treatments is important in chronic migraine. We explored the rate of excellent responders to onabotulinumtoxinA in a multicenter European study and explored the predictors of such response, according to different definitions. A pooled analysis on chronic migraineurs treated with onabotulinumtoxinA and followed-up for, at least, 9 months was performed. Excellent responders were defined either as patients with a 75% decrease in monthly headache days (percent-based excellent responders) or as patients with <4 monthly headache days (frequency-based excellent responders). The characteristics of excellent responders at the baseline were compared with the ones of patients with a <30% decrease in monthly headache days. Percent-based excellent responders represented about 10% of the sample, whilst frequency-based excellent responders were about 5% of the sample. Compared with non-responders, percent-based excellent responders had a higher prevalence of medication overuse and a higher excellent response rate even after the 1st and the 2nd injection. Females were less like to be frequency-based excellent responders. Chronic migraine sufferers without medication overuse and of female sex may find fewer benefits with onabotulinumtoxinA. Additionally, the excellent response status is identifiable after the first cycle. 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