f7cf8432a7dbde5ec0b38b63e591600d pmc_9520301.pdf 20cc2852fa074beea866e7be2c0dda83d7d0860a pmc_9520301.pdf 5199a1ed8d9abeae55af24b810a67d8ab290d29f9d1c2389e573cc1e04c2444a pmc_9520301.pdf Title: Crosstalk of Alzheimer's disease-phenotype, HPA axis, splenic oxidative stress and frailty in late-stages of dementia, with special concerns on the effects of social isolation: A translational neuroscience approach Subject: Coping with emotional stressors strongly impacts older people due to their age-related impaired neuroendocrine and immune systems. Keywords: Alzheimer’s disease, neuroimmunoendocrine crosstalk, aging, 3xTg-AD mice, cognition, neuropsychiatric symptoms, translational neuroscience, social isolation Author: Lydia Giménez-Llort Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Sat Sep 10 11:37:00 2022 CEST ModDate: Sat Sep 10 17:28:55 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2744238 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NZKPIC+MinionPro-Regular Type 1 Custom yes yes no 26 0 JKTNXY+MuseoSans-700 Type 1 Custom yes yes no 27 0 FPMWPQ+MuseoSans-300 Type 1 Custom yes yes no 28 0 HRTBVM+MuseoSans-300Italic Type 1 Custom yes yes no 33 0 QULWBV+MuseoSans-500 Type 1 Custom yes yes no 34 0 AQPVJT+MTSYN Type 1 Builtin yes yes no 199 0 NOIYBL+MinionPro-It Type 1 Custom yes yes no 200 0 XODHDR+RBLMI Type 1 Builtin yes yes no 251 0 MCNQHC+MinionPro-Bold Type 1 Custom yes yes no 255 0 XAYTEH+MTGU Type 1 Builtin yes yes no 350 0 KTOVJQ+MinionPro-BoldIt Type 1 Custom yes yes no 503 0 OUQERI+MTSYB Type 1 Builtin yes yes no 504 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-08-01 02:35:06 CEST RepresentationInformation: pmc_9520301.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-29 02:21:46 CEST Size: 2744238 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 842 FreeObjects: 3 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Crosstalk of Alzheimer's disease-phenotype, HPA axis, splenic oxidative stress and frailty in late-stages of dementia, with special concerns on the effects of social isolation: A translational neuroscience approach Children: Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Animals Item: Title: Social conditions Item: Title: Behavioral assessment Item: Title: Survival, body weight, and mouse clinical frailty index Item: Title: Immunoendocrine status and oxidative stress of liver, kidneys, heart, and spleen Item: Title: Statistics Item: Title: Results Children: Item: Title: Salient behavioral alterations despite phenotypic convergence Item: Title: Survival, physical health, and frailty index Item: Title: Convergence but Alzheimer's disease-dependent crosstalk between HPA axis, behavior, and peripheral organs Item: Title: Discussion Item: Title: Conclusion Item: Title: Data availability statement Item: Title: Ethics statement Item: Title: Author contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Conflict of interest Item: Title: Publisher's note Item: Title: References Info: Title: Crosstalk of Alzheimer's disease-phenotype, HPA axis, splenic oxidative stress and frailty in late-stages of dementia, with special concerns on the effects of social isolation: A translational neuroscience approach Author: Lydia Giménez-Llort Subject: Coping with emotional stressors strongly impacts older people due to their age-related impaired neuroendocrine and immune systems. 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