f523c8c3f68ec0f3990d554fb7f9f36b pmc_9553213.pdf 282b603c6de0702b16a5109454aeb71bb03d57a1 pmc_9553213.pdf c90ff2f3a288fb3b1b2cd744704dbadb38b36fcedab179e9277cab5f52a601a2 pmc_9553213.pdf Creator: Adobe InDesign CC 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Wed Oct 5 12:21:12 2022 CEST ModDate: Wed Oct 5 12:21:15 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 29 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 2212557 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FVWIKI+AvenirLTStd-Medium Type 1C WinAnsi yes yes yes 1627 0 DSXWIM+AvenirLTStd-MediumOblique Type 1C Custom yes yes yes 1631 0 DSXWIM+AvenirLTStd-Black Type 1C Custom yes yes yes 1632 0 BPTKGQ+AvenirLTStd-Roman Type 1C Custom yes yes yes 1641 0 ALJESS+AvenirLTStd-Heavy Type 1C Custom yes yes yes 1646 0 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SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1680 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams–Beuren syndrome Children: Item: Title: Editor's evaluation Item: Title: Introduction Item: Title: Results Children: Item: Title: CD mice exhibit social and cognitive alterations Item: Title: CD mice show alterations in density and signaling of CB1R Item: Title: JZL184 administration corrects behavioral impairment in CD mice Item: Title: JZL184 administration modifies ECS signaling in CD mice Item: Title: JZL184 treatment has an impact on the cardiovascular phenotype of CD mice Item: Title: JZL184 treatment reverses cardiac transcriptional deficits of CD mice Item: Title: Discussion Item: Title: Materials and methods Children: Item: Title: Animals Item: Title: Drug treatment Item: Title: Behavioral tests Children: Item: Title: Sociability and preference for social novelty Item: Title: Locomotor activity Item: Title: Novel object-recognition test Item: Title: Elevated plus maze Item: Title: Context fear conditioning Item: Title: Barnes maze Item: Title: Endocannabinoid quantification by liquid chromatography–tandem mass spectrometry Item: Title: Cannabinoid receptor autoradiography Item: Title: Labeling of activated Gi/o proteins by [35S]GTPγS-binding assay Item: Title: Tissue preparation for immunofluorescence Item: Title: Brain immunofluorescence and image analysis Item: Title: Protein sample preparation Item: Title: Immunoblot analysis Item: Title: Cardiac real-time qPCR Item: Title: Echocardiogram Item: Title: Heart histology and image analysis Item: Title: Cardiomyocyte analysis Item: Title: Blood pressure assessment Item: Title: RNA-seq analysis Item: Title: Statistics Item: Title: Ethics Item: Title: Acknowledgements Item: Title: Additional information Children: Item: Title: Competing interests Item: Title: Funding Item: Title: Author contributions Item: Title: Author ORCIDs Item: Title: Ethics Item: Title: Decision letter and Author response Item: Title: Additional files Children: Item: Title: Supplementary files Item: Title: References Info: Creator: Adobe InDesign CC 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Wed Oct 05 12:21:12 CEST 2022 ModDate: Wed Oct 05 12:21:15 CEST 2022 ID: 0x1f5b8adbb92f3b4da0223461cf615779, 0x67421be0aca38746b6ccab59f1d4fbfe Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 38 ImageHeight: 27 BitsPerSample: 8 BitsPerSampleUnit: 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