b8492d012d7bc377488b6be0ea683e65  pmc_9568571.pdf
d947a6057e5b5b0d4e65613b9313d67bfe43aea5  pmc_9568571.pdf
0443e1e3b50ea004fe8b584c6c38498072dcf02e4fe6366e149d5edfb51a7225  pmc_9568571.pdf

Title:          Rapid and accurate quantification of isomiRs by RT-qPCR
Subject:        Scientific Reports, https://doi.org/10.1038/s41598-022-22298-7
Author:         Sandra Franco 
Creator:        Springer
Producer:       Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:   Fri Oct 14 09:08:30 2022 CEST
ModDate:        Fri Oct 14 10:26:41 2022 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          8
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      1689277 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
SILBDJ+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    370  0
MinionPro-Regular                    Type 1C           Custom           yes no  yes     28  0
SYNQHO+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes     96  0
Corbel-BoldItalic                    TrueType          WinAnsi          yes no  yes    371  0
IRDKXI+Corbel-Bold                   CID TrueType      Identity-H       yes yes yes     31  0
Corbel2                              TrueType          WinAnsi          yes no  yes     32  0
TPRDVM+Corbel                        CID TrueType      Identity-H       yes yes yes     33  0
Corbel3                              CID TrueType      Identity-H       yes no  yes    411  0
MinionPro-It                         Type 1C           WinAnsi          yes no  yes     29  0
MinionPro-Bold                       Type 1C           Custom           yes no  yes     30  0
Corbel4                              TrueType          WinAnsi          yes no  yes     41  0
TimesNewRomanPSMT2                   TrueType          WinAnsi          yes no  yes    193  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-06-20 02:31:33 CEST
 RepresentationInformation: pmc_9568571.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-10-27 02:17:08 CEST
  Size: 1689277
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 435
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Rapid and accurate quantification of isomiRs by RT-qPCR
      Children: 
       Item: 
        Title: Results
       Item: 
        Title: Discussion
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Study sample cohort. 
         Item: 
          Title: RNA extraction. 
         Item: 
          Title: RT-qPCR. 
         Item: 
          Title: miR sequence data. 
         Item: 
          Title: Statistical analyses. 
       Item: 
        Title: References
   Info: 
    Title: Rapid and accurate quantification of isomiRs by RT-qPCR
    Author: Sandra Franco 
    Subject: Scientific Reports, https://doi.org/10.1038/s41598-022-22298-7
    Creator: Springer
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Fri Oct 14 09:38:30 CEST 2022
    ModDate: Fri Oct 14 10:26:41 CEST 2022
   ID: 0x4a82ed1ae72fdf79c364670b473f5ac5, 0xc659667c6efc8255cbc006f09a58679d
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 462
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 479
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1181
      ImageHeight: 576
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 531
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 561
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 531
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: SYNQHO+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: TPRDVM+Corbel
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: IRDKXI+Corbel-Bold
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: SILBDJ+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: SILBDJ+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: Corbel2
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Corbel2
       Flags: Nonsymbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: TimesNewRomanPSMT2
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: TimesNewRomanPSMT2
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: Corbel-BoldItalic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Corbel-BoldItalic
       Flags: Nonsymbolic, Italic
       FontBBox: -494, -239, 1194, 952
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: SYNQHO+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: SYNQHO+TimesNewRomanPSMT
       Flags: Serif, Symbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
     Font: 
      BaseFont: ZMXPLA+Corbel
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ZMXPLA+Corbel
       Flags: Symbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
     Font: 
      BaseFont: IRDKXI+Corbel-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: IRDKXI+Corbel-Bold
       Flags: Symbolic
       FontBBox: -556, -239, 1155, 952
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2022-10-14T12:38:30+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2022-10-14T10:26:41+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2022-10-14T10:26:41+02:00</xmp:MetadataDate>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1038/s41598-022-22298-7</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Nature Publishing Group UK</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Scientific Reports, https://doi.org/10.1038/s41598-022-22298-7</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Rapid and accurate quantification of isomiRs by RT-qPCR</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Sandra Franco </rdf:li>
               <rdf:li>Raquel Pluvinet </rdf:li>
               <rdf:li>Jose Francisco Sanchez-Herrero </rdf:li>
               <rdf:li>Lauro Sumoy </rdf:li>
               <rdf:li>Miguel Angel Martinez </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1038/s41598-022-22298-7</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1038/s41598-022-22298-7</prism:url>
         <prism:doi>10.1038/s41598-022-22298-7</prism:doi>
         <prism:issn>2045-2322</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Scientific Reports</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1038/s41598-022-22298-7</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:38a2ca00-4468-4b99-b06a-e7b92690166a</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:7a755244-1336-4d6f-9fd4-483473227cc2</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:d437039a-0f1a-4800-a067-22840d551e91</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2022-10-14T12:39:31+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:51e9188f-ae3d-4e72-8cca-c94adeac3c21</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2022-10-14T12:40:05+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 414, 351, 417, 339
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 450, 341, 453, 329
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 276, 291, 278, 279
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 499, 281, 501, 269
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 503, 281, 506, 269
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 525, 241, 528, 229
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 366, 201, 369, 189
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 370, 201, 373, 189
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 259, 171, 262, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 393, 141, 399, 129
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 426, 131, 431, 119
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 433, 131, 438, 119
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 474, 111, 480, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 537, 101, 543, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 544, 101, 550, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 481, 675, 556, 658
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 470, 279, 476, 266
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 477, 279, 483, 266
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 428, 269, 433, 256
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 296, 187, 301, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 534, 167, 540, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 352, 127, 357, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 270, 117, 275, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 536, 87, 540, 74
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 261, 272, 265, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 289, 242, 295, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 175, 222, 179, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 546, 192, 551, 180
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 431, 152, 434, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 490, 112, 495, 100
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 172, 246, 176, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 394, 226, 398, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 381, 206, 387, 194
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 437, 196, 442, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 103
      Annotation: 
       Subtype: Link
       Rect: 259, 84, 262, 72
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 263, 84, 269, 72
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 272, 84, 277, 72
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 302, 55, 304, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 306, 55, 311, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 313, 55, 318, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 320, 55, 325, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 489, 534, 495, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 496, 534, 502, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 522, 504, 527, 492
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 429, 454, 435, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 181, 444, 184, 432
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 185, 444, 191, 432
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 193, 444, 198, 432
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 200, 444, 206, 432
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 309, 414, 314, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 483, 384, 488, 372
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 446, 334, 452, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 440, 324, 445, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 332, 314, 337, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 386, 304, 392, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 473, 294, 478, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 444, 284, 450, 272
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 538, 264, 543, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 221, 244, 227, 232
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 228, 244, 234, 232
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 175, 234, 180, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 182, 234, 187, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 191, 234, 196, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 529, 224, 534, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 528, 214, 534, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 546, 72, 552, 60
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 316, 575, 322, 563
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 546, 724, 552, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 349, 500, 354, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 546, 410, 552, 398
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 274, 190, 280, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 180
      Annotation: 
       Subtype: Link
       Rect: 233, 58, 355, 46
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 276, 393, 410, 383
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 482, 61, 554, 51
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 169, 53, 221, 43
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 499, 611, 554, 599
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 601, 260, 589
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 351, 571, 443, 559
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 358, 461, 517, 449
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: d0e10b89
   Type: CRC32
  Checksum: b8492d012d7bc377488b6be0ea683e65
   Type: MD5
  Checksum: d947a6057e5b5b0d4e65613b9313d67bfe43aea5
   Type: SHA-1