a5ad02b9d24a4bb4e6f3c3d9996b6d08 pmc_9572450.pdf fcd431500c7fe2cf748b2f45751d52e79647860c pmc_9572450.pdf bd9d5d7dbd8b5fadb12303112e22767f49091e748db00ec994bc80cc4bbe6618 pmc_9572450.pdf Title: Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors Subject: In recent decades, traditional eating habits have been replaced by a more globalized diet, rich in saturated fatty acids and simple sugars. Extensive evidence shows that these dietary factors contribute to cognitive health impairment as well as increase the incidence of metabolic diseases such as obesity and diabetes. However, how these nutrients modulate synaptic function and neuroplasticity is poorly understood. We review the Western, ketogenic, and paleolithic diets for their effects on cognition and correlations with synaptic changes, focusing mainly (but not exclusively) on animal model studies aimed at tracing molecular alterations that may contribute to impaired human cognition. We observe that memory and learning deficits mediated by high-fat/high-sugar diets, even over short exposure times, are associated with reduced arborization, widened synaptic cleft, narrowed post-synaptic zone, and decreased activity-dependent synaptic plasticity in the hippocampus, and also observe that these alterations correlate with deregulation of the AMPA-type glutamate ionotropic receptors (AMPARs) that are crucial to neuroplasticity. Furthermore, we explored which diet-mediated mechanisms modulate synaptic AMPARs and whether certain supplements or nutritional interventions could reverse deleterious effects, contributing to improved learning and memory in older people and patients with Alzheimer’s disease. Keywords: diet; cognition; memory; learning; hippocampus; synaptic function; neuroplasticity; BDNF; AMPARs; neurodegeneration Author: Rut Fadó, Anna Molins, Rocío Rojas and Núria Casals Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Oct 10 05:06:31 2022 CEST ModDate: Mon Oct 10 05:21:27 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 36 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1219154 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VNCSUO+VnURWPalladioL Type 1 Custom yes yes no 10 0 FSFCJB+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 KFERKW+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 WJMJRS+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 FXKWJE+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 VLQJHP+EURM10 Type 1 Builtin yes yes no 68 0 GZXEVF+CMSY10 Type 1 Builtin yes yes no 78 0 MBCBTD+wasy8 Type 1 Builtin yes yes no 82 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-20 02:31:25 CEST RepresentationInformation: pmc_9572450.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-10-27 02:16:44 CEST Size: 1219154 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1038 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Western Diet Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Cognition Studies in Animal Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Synaptic Function and Neuroplasticity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Other Mechanisms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: High-Fat Diet Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Cognition Studies with Mixed and Saturated Fats Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Cognition Studies with Polyunsaturated Fats Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Synaptic Function and Neuroplasticity with Mixed and Saturated Fats Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Synaptic Function and Neuroplasticity with Polyunsaturated Fats Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Other Mecanisms of Hippocampal Damage with Mixed and Saturated Fats Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: High-Sugar Diet Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Cognition Studies in Animal Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Synaptic Function and Neuroplasticity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Insulin Resistance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Other Mechanisms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Ketogenic Diet Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Children: Item: Title: Cognition Studies in Humans Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Cognition Studies in Animal Models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Synaptic Function and Neuroplasticity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Insulin Resistance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Paleo(lithic) Diet Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Info: Title: Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors Author: Rut Fadó, Anna Molins, Rocío Rojas and Núria Casals Subject: In recent decades, traditional eating habits have been replaced by a more globalized diet, rich in saturated fatty acids and simple sugars. Extensive evidence shows that these dietary factors contribute to cognitive health impairment as well as increase the incidence of metabolic diseases such as obesity and diabetes. However, how these nutrients modulate synaptic function and neuroplasticity is poorly understood. We review the Western, ketogenic, and paleolithic diets for their effects on cognition and correlations with synaptic changes, focusing mainly (but not exclusively) on animal model studies aimed at tracing molecular alterations that may contribute to impaired human cognition. We observe that memory and learning deficits mediated by high-fat/high-sugar diets, even over short exposure times, are associated with reduced arborization, widened synaptic cleft, narrowed post-synaptic zone, and decreased activity-dependent synaptic plasticity in the hippocampus, and also observe that these alterations correlate with deregulation of the AMPA-type glutamate ionotropic receptors (AMPARs) that are crucial to neuroplasticity. Furthermore, we explored which diet-mediated mechanisms modulate synaptic AMPARs and whether certain supplements or nutritional interventions could reverse deleterious effects, contributing to improved learning and memory in older people and patients with Alzheimer’s disease. 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