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Le Tourneau Subject: ESMO Open, 7 (2022) 100576. doi:10.1016/j.esmoop.2022.100576 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Oct 13 21:36:57 CEST 2022 ModDate: Thu Oct 13 21:37:32 CEST 2022 ID: 0xbdc0a1af5d7af5f8c92f7b66fd275572, 0x296fb4ef9fb7f14c8123cb82b9a0f810 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: LHKBPJ+Arial-BoldMT Encoding: Identity-H ToUnicode: true Font: BaseFont: LHKBPG+ArialMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: LHKBEM+AdvTT7b515deb+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: LHKBEM+AdvTT7b515deb+20 Flags: Nonsymbolic FontBBox: -83, -187, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LHKBKC+AdvTT26e64a0d.BI FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: LHKBKC+AdvTT26e64a0d.BI Flags: Nonsymbolic FontBBox: -93, -187, 958, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LHKBKD+AdvP4C4E51 FontSubset: 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1359, 998 FontFile2: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: LHKBPJ+Arial-BoldMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LHKBPJ+Arial-BoldMT Flags: Symbolic FontBBox: -628, -376, 2000, 1056 FontFile2: true Font: BaseFont: LHKBPG+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LHKBPG+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile2: true XMP: application/pdf doi:10.1016/j.esmoop.2022.100576 Two phase I studies of BI 836880, a vascular endothelial growth factor/angiopoietin-2 inhibitor, administered once every 3 weeks or once weekly in patients with advanced solid tumors C. Le Tourneau H. Becker R. Claus E. Elez F. Ricci R. Fritsch Y. Silber A. Hennequin J. Tabernero G. Jayadeva D. Luedtke M. He N. Isambert Vascular endothelial growth factor angiopoietin-2 advanced solid tumors phase I nanobody ESMO Open, 7 (2022) 100576. doi:10.1016/j.esmoop.2022.100576 The Author(s) journal ESMO Open © 2022 The Author(s). Published by Elsevier Ltd on behalf of European Society for Medical Oncology. 2059-7029 7 5 October 2022 100576 100576 10.1016/j.esmoop.2022.100576 https://doi.org/10.1016/j.esmoop.2022.100576 2010-04-23 true 10.1016/j.esmoop.2022.100576 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.esmoop.2022.100576 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2022-10-14T00:36:57+05:30 2022-10-14T00:37:32+05:30 2022-10-14T00:37:32+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:c8f08459-2283-4101-bb77-db1b68f2ac63 uuid:7f7da2fe-ced0-4d02-b7e3-9d17153c84cb http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 114, 590, 114, 592 Annotation: Subtype: Link Rect: 114, 593, 117, 602 Destination: 631 Annotation: Subtype: Link Rect: 117, 593, 121, 602 Destination: 631 Annotation: Subtype: Link Rect: 164, 590, 164, 592 Annotation: Subtype: Link Rect: 164, 593, 168, 602 Destination: 631 Annotation: Subtype: Link Rect: 205, 590, 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