ded9ce8f0a85c3831cab593bf35307dd  pmc_9592345.pdf
49d212d702eb056bdbce911eb2f558d4a7c5a858  pmc_9592345.pdf
42fe3b237d79fb3b6e5c0f001deb41164ba314fcbad2e1ae3f758f98633c59ab  pmc_9592345.pdf

Creator:        Adobe InDesign 15.1 (Windows)
Producer:       Adobe PDF Library 15.0
CreationDate:   Wed Oct 19 20:46:46 2022 CEST
ModDate:        Wed Oct 19 20:46:49 2022 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          7
Encrypted:      no
Page size:      594 x 792 pts
Page rot:       0
File size:      513239 bytes
Optimized:      yes
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
HelveticaNeueLTStd-MdEx              Type 1C           WinAnsi          yes no  yes    228  0
HelveticaNeueLTStd-Md                Type 1C           WinAnsi          yes no  yes    229  0
HelveticaNeueLTStd-Hv                Type 1C           WinAnsi          yes no  yes    230  0
HelveticaNeueLTStd-Lt                Type 1C           Custom           yes no  yes    231  0
HelveticaNeueLTStd-BdEx              Type 1C           WinAnsi          yes no  yes    242  0
SabonLTStd-Roman                     Type 1C           Custom           yes no  yes    247  0
HelveticaNeueLTStd-LtIt              Type 1C           Custom           yes no  yes    252  0
OYDEDQ+Avenir-Roman                  Type 1C           WinAnsi          yes yes no     278  0
OYDEDQ+AkzidenzGroteskBE-Md          Type 1C           WinAnsi          yes yes no     281  0
HelveticaNeueLTStd-Bd                Type 1C           WinAnsi          yes no  yes    173  0
HelveticaNeueLTStd-BdCn              Type 1C           WinAnsi          yes no  yes    175  0
HelveticaNeueLTStd-LtCn              Type 1C           Custom           yes no  yes    166  0
HelveticaNeueLTStd-LtCnO             Type 1C           WinAnsi          yes no  yes    164  0
SabonLTStd-Italic                    Type 1C           WinAnsi          yes no  yes    180  0
HelveticaNeueLTStd-BdCnO             Type 1C           WinAnsi          yes no  yes    182  0
XFTIUY+Calibri-Bold                  Type 1C           WinAnsi          yes yes no     186  0
XFTIUY+Calibri                       Type 1C           Custom           yes yes no     185  0
SabonLTStd-Bold                      Type 1C           WinAnsi          yes no  yes    187  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-12-21 02:25:36 CET
 RepresentationInformation: pmc_9592345.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-12-15 02:17:33 CET
  Size: 513239
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF, ISO PDF/A-1, Level B
  PDFMetadata: 
   Objects: 314
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseNone
    Language: en-US
   Info: 
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0
    CreationDate: Wed Oct 19 21:16:46 CEST 2022
    ModDate: Wed Oct 19 21:16:49 CEST 2022
   ID: 0x838348d1f666c647976d4ec66aff0bb2, 0x41be40445608e74aa2cd3b130ae631c4
   Filters: 
    FilterPipeline: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: HelveticaNeueLTStd-MdEx
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-MdEx
       Flags: Nonsymbolic
       FontBBox: -172, -220, 1159, 978
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-LtCnO
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-LtCnO
       Flags: Nonsymbolic, Italic
       FontBBox: -173, -272, 1066, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Md
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Md
       Flags: Nonsymbolic
       FontBBox: -165, -221, 1066, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Hv
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Hv
       Flags: Nonsymbolic
       FontBBox: -169, -234, 1096, 951
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-LtCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-LtCn
       Flags: Nonsymbolic
       FontBBox: -167, -204, 1000, 927
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Lt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Lt
       Flags: Nonsymbolic
       FontBBox: -166, -214, 1050, 967
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Bd
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Bd
       Flags: Nonsymbolic
       FontBBox: -166, -218, 1078, 975
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-BdCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-BdCn
       Flags: Nonsymbolic
       FontBBox: -164, -224, 1066, 961
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-BdEx
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-BdEx
       Flags: Nonsymbolic
       FontBBox: -145, -213, 1163, 984
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: SabonLTStd-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: SabonLTStd-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -146, -228, 1059, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-BdCnO
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-BdCnO
       Flags: Nonsymbolic, Italic
       FontBBox: -171, -271, 1116, 961
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: SabonLTStd-Roman
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: SabonLTStd-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -165, -228, 1000, 944
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: XFTIUY+Calibri
      FontSubset: true
      FirstChar: 31
      LastChar: 121
      FontDescriptor: 
       FontName: XFTIUY+Calibri
       Flags: Nonsymbolic
       FontBBox: -503, -307, 1240, 1026
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: XFTIUY+Calibri-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 110
      FontDescriptor: 
       FontName: XFTIUY+Calibri-Bold
       Flags: Nonsymbolic
       FontBBox: -519, -306, 1240, 1039
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: SabonLTStd-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: SabonLTStd-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -163, -228, 1000, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-LtIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-LtIt
       Flags: Nonsymbolic, Italic
       FontBBox: -165, -214, 1099, 951
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 6.0-c002 79.164460, 2020/05/12-16:04:17        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <xmp:CreateDate>2022-10-20T00:16:46+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2022-10-20T00:16:49+05:30</xmp:MetadataDate>
         <xmp:ModifyDate>2022-10-20T00:16:49+05:30</xmp:ModifyDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmpMM:InstanceID>uuid:ec508999-606e-4507-9ea6-ca5babb3f055</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>xmp.did:07801174072068118C149D4CFFA16D8F</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:e1566c5c-9326-0d4b-819d-f344af9f97d8</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:568cfde1-4c50-8d48-bf7a-624608bb3311</stRef:instanceID>
            <stRef:documentID>xmp.did:568cfde1-4c50-8d48-bf7a-624608bb3311</stRef:documentID>
            <stRef:originalDocumentID>xmp.did:07801174072068118C149D4CFFA16D8F</stRef:originalDocumentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign 15.1 (Windows)</stEvt:softwareAgent>
                  <stEvt:changed>/</stEvt:changed>
                  <stEvt:when>2022-10-20T00:16:46+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <dc:format>application/pdf</dc:format>
         <pdf:Producer>Adobe PDF Library 15.0</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 154, 637, 157, 625
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 159, 637, 162, 625
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 164, 637, 167, 625
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 169, 637, 174, 625
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 174, 637, 178, 625
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 177, 638, 190, 625
      Annotation: 
       Subtype: Link
       Rect: 337, 637, 340, 625
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 342, 637, 343, 625
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 463, 637, 467, 625
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 469, 637, 472, 625
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 474, 637, 477, 625
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 173, 311, 175, 300
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 287, 291, 290, 280
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 292, 291, 295, 280
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 231, 271, 234, 260
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 236, 271, 239, 260
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 273, 261, 276, 250
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 277, 261, 280, 250
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 282, 261, 287, 250
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 289, 261, 295, 250
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 550, 331, 556, 320
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 426, 321, 432, 310
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 433, 321, 439, 310
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 356, 271, 362, 260
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 427, 251, 433, 240
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 386, 168, 465, 160
      Annotation: 
       Subtype: Link
       Rect: 505, 147, 532, 139
      Annotation: 
       Subtype: Link
       Rect: 312, 138, 502, 130
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 72, 739, 78, 729
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 79, 739, 85, 729
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 187, 709, 193, 699
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 196, 709, 202, 699
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 70, 689, 76, 679
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 77, 689, 83, 679
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 85, 689, 91, 679
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 104, 649, 110, 639
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 112, 649, 118, 639
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 160, 609, 166, 599
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 49, 569, 55, 559
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 199, 559, 205, 549
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 206, 559, 212, 549
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 195, 539, 201, 529
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 204, 539, 210, 529
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 515, 559, 521, 549
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 456, 439, 485, 429
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 370, 429, 493, 419
      Annotation: 
       Subtype: Link
       Rect: 500, 429, 506, 419
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 429, 399, 434, 389
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 437, 399, 443, 389
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 100, 57, 104, 49
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 106, 57, 110, 49
       ActionDest: 138
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 135, 629, 258, 619
      Annotation: 
       Subtype: Link
       Rect: 61, 509, 184, 499
      Annotation: 
       Subtype: Link
       Rect: 148, 229, 154, 219
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 215, 135, 297, 125
      Annotation: 
       Subtype: Link
       Rect: 51, 125, 92, 115
      Annotation: 
       Subtype: Link
       Rect: 322, 739, 352, 729
       ActionDest: 89
      Annotation: 
       Subtype: Link
       Rect: 339, 609, 361, 599
       ActionDest: 89
      Annotation: 
       Subtype: Link
       Rect: 491, 559, 521, 549
       ActionDest: 103
      Annotation: 
       Subtype: Link
       Rect: 525, 479, 555, 469
       ActionDest: 103
      Annotation: 
       Subtype: Link
       Rect: 322, 359, 351, 349
       ActionDest: 136
      Annotation: 
       Subtype: Link
       Rect: 468, 125, 474, 115
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 475, 125, 481, 115
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 550, 105, 556, 95
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 550, 85, 556, 75
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 550, 65, 556, 55
       ActionDest: 138
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 192, 51, 197, 40
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 199, 51, 205, 40
       ActionDest: 138
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 238, 420, 244, 409
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 245, 420, 251, 409
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 68, 390, 74, 379
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 75, 390, 81, 379
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 168, 300, 174, 289
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 118, 150, 124, 139
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 281, 120, 287, 109
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 289, 120, 295, 109
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 154, 100, 160, 89
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 181, 60, 187, 49
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 372, 460, 378, 449
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 543, 430, 548, 419
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 550, 430, 556, 419
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 464, 340, 470, 329
       ActionDest: 138
      Annotation: 
       Subtype: Link
       Rect: 417, 270, 423, 259
       ActionDest: 138
    Page: 
     Sequence: 6
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 255, 181, 297, 172
      Annotation: 
       Subtype: Link
       Rect: 69, 172, 199, 163
      Annotation: 
       Subtype: Link
       Rect: 478, 703, 558, 694
      Annotation: 
       Subtype: Link
       Rect: 330, 694, 380, 685
      Annotation: 
       Subtype: Link
       Rect: 418, 613, 558, 604
      Annotation: 
       Subtype: Link
       Rect: 330, 604, 484, 595
      Annotation: 
       Subtype: Link
       Rect: 535, 226, 558, 217
      Annotation: 
       Subtype: Link
       Rect: 330, 217, 455, 208
      Annotation: 
       Subtype: Link
       Rect: 404, 154, 558, 145
      Annotation: 
       Subtype: Link
       Rect: 330, 145, 467, 136
  Checksum: a9588e3c
   Type: CRC32
  Checksum: ded9ce8f0a85c3831cab593bf35307dd
   Type: MD5
  Checksum: 49d212d702eb056bdbce911eb2f558d4a7c5a858
   Type: SHA-1